1,674 research outputs found
Research in Brief - Pushing Education: Parental Engagement, Educational Aspirations and College Access
This qualitative study explores the counterstories of educational engagement experiences for five parents who have a high school student in a college access program that is designed for students with a financial need and/or no family history of college. This study uses the ecologies of parental engagement (EPE) framework to explore family engagement in traditional academic settings but also nonacademic settings. Data were collected through semi-structured interviews and one focus group. Their counterstories challenge the notion that parents from lower socioeconomic backgrounds and/or no to little family history of college are disinterested or disengaged in their student’s education. The data reveal that the family members are highly engaged in their student’s educational experiences in academic settings, nonacademic settings (home, community organizations, and neighborhoods), and in the college access program. Furthermore, the findings reveal that the college access program serves as an alternative space for family engagement
Pushing Education: Parental Engagement, Educational Aspirations and College Access
This qualitative study explores the counterstories of educational engagement experiences for five parents who have a high school student in a college access program that is designed for students with a financial need and/or no family history of college. This study uses the ecologies of parental engagement (EPE) framework to explore family engagement in traditional academic settings but also nonacademic settings. Data were collected through semi-structured interviews and one focus group. Their counterstories challenge the notion that parents from lower socioeconomic backgrounds and/or no to little family history of college are disinterested or disengaged in their student’s education. The data reveal that the family members are highly engaged in their student’s educational experiences in academic settings, nonacademic settings (home, community organizations, and neighborhoods), and in the college access program. Furthermore, the findings reveal that the college access program serves as an alternative space for family engagement
The place where curses are manufactured : four poets of the Vietnam War
The Vietnam War was unique among American wars. To pinpoint its uniqueness, it was necessary to look for a non-American voice that would enable me to articulate its distinctiveness and explore the American character as observed by an Asian. Takeshi Kaiko proved to be most helpful. From his novel, Into a Black Sun, I was able to establish a working pair of 'bookends' from which to approach the poetry of Walter McDonald, Bruce Weigl, Basil T. Paquet and Steve Mason. Chapter One is devoted to those seemingly mismatched 'bookends,' Walt Whitman and General William C. Westmoreland, and their respective anthropocentric and technocentric visions of progress and the peculiarly American concept of the "open road" as they manifest themselves in Vietnam. In Chapter, Two, I analyze the war poems of Walter McDonald. As a pilot, writing primarily about flying, his poetry manifests General Westmoreland's technocentric vision of the 'road' as determined by and manifest through technology. Chapter Three focuses on the poems of Bruce Weigl. The poems analyzed portray the literal and metaphorical descent from the technocentric, 'numbed' distance of aerial warfare to the world of ground warfare, and the initiation of a 'fucking new guy,' who discovers the contours of the self's interior through a set of experiences that lead from from aerial insertion into the jungle to the degradation of burning human
feces. Chapter Four, devoted to the thirteen poems of Basil T. Paquet, focuses on the continuation of the descent begun in Chapter Two. In his capacity as a medic, Paquet's entire body of poems details his quotidian tasks which entail tending the maimed, the mortally wounded and the dead. The final chapter deals with Steve Mason's JohnnY's Song, and his depiction of the plight of Vietnam veterans back in "The World" who are still trapped inside the interior landscape of their individual "ghettoes" of the soul created by their war-time experiences
Treatment for inclusion body myositis
Background Inclusion body myositis (IBM) is a late-onset inflammatory muscle disease (myopathy) associated with progressive proximal and distal limb muscle atrophy and weakness. Treatment options have attempted to target inflammatory and atrophic features of this condition (for example with immunosuppressive and immunomodulating drugs, anabolic steroids, and antioxidant treatments), although as yet there is no known effective treatment for reversing or minimising the progression of inclusion body myositis. In this review we have considered the benefits, adverse effects, and costs of treatment in targeting cardinal effects of the condition, namely muscle atrophy, weakness, and functional impairment. Objectives To assess the effects of treatment for IBM. Search methods On 7 October 2014 we search ed the Cochrane Neuromuscular Disease Group Specialized Register, the Cochrane Central Register for Controlled Trials (CENTRAL), MEDLINE, and EMBASE. Additionally in November 2014 we searched clinical trials registries for ongoing or completed but unpublished trials. Selection criteria We considered randomised or quasi-randomised trials, including cross-over trials, of treatment for IBM in adults compared to placebo or any other treatment for inclusion in the review. We specifically excluded people with familial IBM and hereditary inclusion body myopathy, but we included people who had connective tissue and autoimmune diseases associated with IBM, which may or may not be identified in trials. We did not include studies of exercise therapy or dysphagia management, which are topics of other Cochrane systematic reviews. Data collection and analysis We used standard Cochrane methodological procedures. Main results The review included 10 trials (249 participants) using different treatment regimens. Seven of the 10 trials assessed single agents, and 3 assessed combined agents. Many of the studies did not present adequate data for the reporting of the primary outcome of the review, which was the percentage change in muscle strength score at six months. Pooled data from two trials of interferon beta-1a (n = 58) identified no important difference in normalised manual muscle strength sum scores from baseline to six months (mean difference (MD) -0.06, 95% CI -0.15 to 0.03) between IFN beta-1a and placebo (moderate-quality evidence). A single trial of methotrexate (MTX) (n = 44) provided moderate-quality evidence that MTX did not arrest or slow disease progression, based on reported percentage change in manual muscle strength sum scores at 12 months. None of the fully published trials were adequately powered to detect a treatment effect. We assessed six of the nine fully published trials as providing very low-quality evidence in relation to the primary outcome measure. Three trials (n = 78) compared intravenous immunoglobulin (combined in one trial with prednisone) to a placebo, but we were unable to perform meta-analysis because of variations in study analysis and presentation of trial data, with no access to the primary data for re-analysis. Other comparisons were also reported in single trials. An open trial of anti-T lymphocyte immunoglobulin (ATG) combined with MTX versus MTX provided very low-quality evidence in favour of the combined therapy, based on percentage change in quantitative muscle strength sum scores at 12 months (MD 12.50%, 95% CI 2.43 to 22.57). Data from trials of oxandrolone versus placebo, azathioprine (AZA) combined with MTX versus MTX, and arimoclomol versus placebo did not allow us to report either normalised or percentage change in muscle strength sum scores. A complete analysis of the effects of arimoclomol is pending data publication. Studies of simvastatin and bimagrumab (BYM338) are ongoing. All analysed trials reported adverse events. Only 1 of the 10 trials interpreted these for statistical significance. None of the trials included prespecified criteria for significant adverse events. Authors\u27 conclusions Trials of interferon beta-1a and MTX provided moderate-quality evidence of having no effect on the progression of IBM. Overall trial design limitations including risk of bias, low numbers of participants, and short duration make it difficult to say whether or not any of the drug treatments included in this review were effective. An open trial of ATG combined with MTX versus MTX provided very low-quality evidence in favour of the combined therapy based on the percentage change data given. We were unable to draw conclusions from trials of IVIg, oxandrolone, and AZA plus MTX versus MTX. We need more randomised controlled trials that are larger, of longer duration, and that use fully validated, standardised, and responsive outcome measures
Long-term monitoring reveals carbon–nitrogen metabolism key to microcystin production in eutrophic lakes
Radio Variability of Radio Quiet and Radio Loud Quasars
The majority of quasars are weak in their radio emission, with flux densities
comparable to those in the optical, and energies far lower. A small fraction,
about 10%, are hundreds to thousands of times stronger in the radio.
Conventional wisdom holds that there are two classes of quasars, the radio
quiets and radio louds, with a deficit of sources having intermediate power.
Are there really two separate populations, and if so, is the physics of the
radio emission fundamentally different between them? This paper addresses the
second question, through a study of radio variability across the full range of
radio power, from quiet to loud. The basic findings are that the root mean
square amplitude of variability is independent of radio luminosity or
radio-to-optical flux density ratio, and that fractionally large variations can
occur on timescales of months or less in both radio quiet and radio loud
quasars. Combining this with similarities in other indicators, such as radio
spectral index and the presence of VLBI-scale components, leads to the
suggestion that the physics of radio emission in the inner regions of all
quasars is essentially the same, involving a compact, partially opaque core
together with a beamed jet.Comment: 32 pages, 9 figures. Astrophysical Journal, in pres
The optically-powerful quasar E1821+643 is associated with a 300-kpc scale FRI radio structure
We present a deep image of the optically-powerful quasar E1821+643 at 18cm
made with the Very Large Array (VLA). This image reveals radio emission, over
280 kpc in extent, elongated way beyond the quasar's host galaxy. Its radio
structure has decreasing surface brightness with increasing distance from the
bright core, characteristic of FRI sources (Fanaroff & Riley 1974). Its radio
luminosity at 5GHz falls in the classification for `radio-quiet' quasars (it is
only 10^23.9 W/Hz/sr; see e.g. Kellermann et al 1994). Its radio luminosity at
151MHz (which is 10^25.3 W/Hz/sr) is at the transition luminosity observed to
separate FRIs and FRIIs. Hitherto, no optically-powerful quasar had been found
to have a conventional FRI radio structure. For searches at low-frequency this
is unsurprising given current sensitivity and plausible radio spectral indices
for radio-quiet quasars. We demonstrate the inevitability of the extent of any
FRqI radio structures being seriously under-estimated by existing targetted
follow-up observations of other optically-selected quasars, which are typically
short exposures of z > 0.3 objects, and discuss the implications for the
purported radio bimodality in quasars.
The nature of the inner arcsec-scale jet in E1821+643, together with its
large-scale radio structure, suggest that the jet-axis in this quasar is
precessing (cf. Galactic jet sources such as SS433). A possible explanation for
this is that its central engine is a binary whose black holes have yet to
coalesce. The ubiquity of precession in `radio-quiet' quasars, perhaps as a
means of reducing the observable radio luminosity expected in highly-accreting
systems, remains to be established.Comment: Accepted by ApJ Letters; higher quality versions of figures available
at http://www-astro.physics.ox.ac.uk/~km
Periventricular lesions and MS diagnostic criteria in young adults with typical clinically isolated syndromes.
In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions. We investigated the effect of varying the required number of periventricular lesions and found that the best combination of specificity and sensitivity for clinically definite MS was seen for ⩾1 periventricular lesion using both the McDonald 2010 and MAGNIMS 2016 criteria
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Variable responses of human and non-human primate gut microbiomes to a Western diet
BACKGROUND: The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models, including non-human primates. However, due to unique aspects of human diet and physiology, it is likely that host-gut microbe interactions operate differently in humans and non-human primates. RESULTS: Here, we show that the human microbiome reacts differently to a high-protein, high-fat Western diet than that of a model primate, the African green monkey, or vervet (Chlorocebus aethiops sabaeus). Specifically, humans exhibit increased relative abundance of Firmicutes and reduced relative abundance of Prevotella on a Western diet while vervets show the opposite pattern. Predictive metagenomics demonstrate an increased relative abundance of genes associated with carbohydrate metabolism in the microbiome of only humans consuming a Western diet. CONCLUSIONS: These results suggest that the human gut microbiota has unique properties that are a result of changes in human diet and physiology across evolution or that may have contributed to the evolution of human physiology. Therefore, the role of animal models for understanding the relationship between the human gut microbiota and host metabolism must be re-focused.P40 OD010965 - NIH HHS; P40 RR019963 - NCRR NIH HHS; P51 OD011132 - NIH HHS; R01 RR016300 - NCRR NIH HHS; 5R01RR016300 - NCRR NIH HH
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