Book Review: Disability History: Konstruktionen von Behinderung in der Geschichte. Eine Einführung. [“Disability History: An Introduction to Historical Constructions of Disability”]

Title: Disability History: Konstruktionen von Behinderung in der Geschichte. Eine Einführung. [“Disability History: An Introduction to Historical Constructions of Disability”] Editors: Elsbeth Bösl, Anne Klein, Anne Waldschmidt Reviewer: Katharina Heyer, Ph.D. Publisher:Bielefeld (Germany): Transcript Publishers, 2010 Paper: ISBN: 978-3-8376-1361-2 Cost: Euro 26.80, 255 page

Center on Disability Studies eNewsletter, December 2023

As the year draws to a close and the holiday season is upon us, I want to extend my gratitude to our partners, collaborators, participants, students, and stakeholders on behalf of CDS. We genuinely appreciate the collective efforts that continually contribute to the success of our projects and initiatives. Looking ahead, we're gearing up for our Pac Rim Conference in February 2024, centered around the theme "Beyond Access: Building a Culture of Belonging," a concept we're deeply passionate about. This ethos guides our efforts within our unit and throughout our projects. Additionally, I encourage you to read about Dr. Steve Brown and his impactful legacy on CDS, within the AUCD network, and on Disability Culture. We celebrate his life and honor his memory

High- and Low-Mass Star Forming Regions from Hierarchical Gravitational Fragmentation. High local Star Formation Rates with Low Global Efficiencies

We investigate the properties of "star forming regions" in a previously published numerical simulation of molecular cloud formation out of compressive motions in the warm neutral atomic interstellar medium, neglecting magnetic fields and stellar feedback. In this simulation, the velocity dispersions at all scales are caused primarily by infall motions rather than by random turbulence. We study the properties (density, total gas+stars mass, stellar mass, velocity dispersion, and star formation rate) of the cloud hosting the first local, isolated "star formation" event in the simulation and compare them with those of the cloud formed by a later central, global collapse event. We suggest that the small-scale, isolated collapse may be representative of low- to intermediate-mass star-forming regions, while the large-scale, massive one may be representative of massive star forming regions. We also find that the statistical distributions of physical properties of the dense cores in the region of massive collapse compare very well with those from a recent survey of the massive star forming region in the Cygnus X molecular cloud. The star formation efficiency per free-fall time (SFE_ff) of the high-mass SF clump is low, ~0.04. This occurs because the clump is accreting mass at a high rate, not because its specific SFR (SSFR) is low. This implies that a low value of the SFE_ff does not necessarily imply a low SSFR, but may rather indicate a large gas accretion rate. We suggest that a globally low SSFR at the GMC level can be attained even if local star forming sites have much larger values of the SSFR if star formation is a spatially intermittent process, so that most of the mass in a GMC is not participating of the SF process at any given time.Comment: Accepted by ApJ. Revised version, according to exchanges with referee. Original results unchanged. Extensive new discussion on the low global efficiency vs. high local efficiency of star formation. Abstract abridge

Improving In Vitro Generated Cartilage-Carrier-Constructs by Optimizing Growth Factor Combination

The presented study is focused on the generation of osteochondral implants for cartilage repair, which consist of bone substitutes covered with in vitro engineered cartilage. Re-differentiation of expanded porcine cells was performed in alginate gel followed by cartilage formation in high-density cell cultures. In this work, different combinations of growth factors for the stimulation of re-differentiation and cartilage formation have been tested to improve the quality of osteochondral implants. It has been demonstrated that supplementation of the medium with growth factors has significant effects on the properties of the matrix. The addition of the growth factors IGF-I (100 ng/mL) and TGF-β1 (10 ng/mL) during the alginate culture and the absence of any growth factors during the high-density cell culture led to significantly higher GAG to DNA ratios and Young’s Moduli of the constructs compared to other combinations. The histological sections showed homogenous tissue and intensive staining for collagen type II

Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients

Mutations in the filamin C gene (FLNC) cause a myofibrillar myopathy (MFM), morphologically characterized by focal myofibrillar destruction and abnormal accumulation of several proteins within skeletal muscle fibres. We studied 31 patients from four German families to evaluate the phenotype of filaminopathy. All patients harboured the same p.W2710X mutation in FLNC. Haplotype analysis suggested a founder mutation in these German filaminopathy families. The mean age at onset of clinical symptoms was 44 +/− 6 years (range, 24-57 years). Slowly progressive muscle weakness was mostly pronounced proximally, initially affecting the lower extremities and involving the upper extremities in the course of disease progression, similar to the distribution of weakness seen in limb-girdle muscular dystrophies (LGMD). Patients frequently developed respiratory muscle weakness. About one-third of the patients showed cardiac abnormalities comprising conduction blocks, tachycardia, diastolic dysfunction and left ventricular hypertrophy indicating a cardiac involvement in filaminopathy. Serum creatine kinase levels varied from normal up to 10-fold of the upper limit. Magnetic resonance imaging studies showed a rather homogenous pattern of muscle involvement in the lower extremities differing from that in other types of MFM. Myopathological features included perturbation of myofibrillar alignment, accumulation of granulofilamentous material similar to that seen in primary desminopathies and abnormal intracellular protein deposits typical of MFM. Decreased activities of oxidative enzymes and fibre hypertrophy seem to be early features, whereas dystrophic changes were present in advanced stages of filaminopathy. Rimmed vacuoles were detected in only a few cases. The intracellular aggregates were composed of a variety of proteins including filamin C, desmin, myotilin, Xin, dystrophin and sarcoglycans. Therapy is so far limited to symptomatic treatment. The German filaminopathy cohort, the largest group of patients studied so far, shares phenotypic features with LGMD and presents with characteristic histopathological findings of MF

In Vitro Generation of Cartilage-Carrier-Constructs on Hydroxylapatite Ceramics with Different Surface Structures

Tissue engineering approaches for healing cartilage defects are partly limited by the inability to fix cartilage to bone during implantation. To overcome this problem, cartilage can be - already in vitro - generated on a ceramic carrier which serves as bone substitute. In this study, the influence of a hydroxylapatite carrier and its surface structure on the quality of tissue engineered cartilage was investigated. Application of the carrier reduced significantly biomechanical and biochemical properties of the generated tissue. In addition, slight changes in the quality of the formed matrix, in the adhesive strength between cartilage and biomaterial and in attachment and proliferation of a chondrocyte monolayer could be observed for commercial grade carriers, with respect to modified topographies obtained by smooth grinding/polishing. These first results demonstrated an influence of the carrier and its surface structure, but further research is needed for explaining the described effects and for optimization of cartilage-carrier-constructs

Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide

The polyamine system has been implicated in a number of psychiatric conditions, which display both alterations in polyamine levels and altered expression of genes related to polyamine metabolism. Studies have identified associations between genetic variants in spermidine/spermine N1-acetyltransferase (SAT1) and both anxiety and suicide, and several polymorphisms appear to play important roles in determining gene expression.We genotyped 63 polymorphisms, spread across four polyaminergic genes (SAT1, spermine synthase (SMS), spermine oxidase (SMOX), and ornithine aminotransferase like-1 (OATL1)), in 1255 French-Canadian individuals who have been followed longitudinally for 22 years. We assessed univariate associations with anxiety, mood disorders, and attempted suicide, as assessed during early adulthood. We also investigated the involvement of gene-environment interactions in terms of childhood abuse, and assessed internalizing and externalizing symptoms as endophenotypes mediating these interactions. Overall, each gene was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1). Several SAT1 polymorphisms displayed disease-specific risk alleles, and polymorphisms in this gene were involved in gene-gene interactions with SMS to confer risk for anxiety disorders, as well as gene-environment interactions between childhood physical abuse and mood disorders. Externalizing behaviors demonstrated significant mediation with regards to the association between OATL1 and attempted suicide, however there was no evidence that externalizing or internalizing behaviors were appropriate endophenotypes to explain the associations with mood or anxiety disorders. Finally, childhood sexual abuse did not demonstrate mediating influences on any of our outcomes.These results demonstrate that genetic variants in polyaminergic genes are associated with psychiatric conditions, each of which involves a set of separate and distinct risk alleles. As several of these polymorphisms are associated with gene expression, these findings may provide mechanisms to explain the alterations in polyamine metabolism which have been observed in psychiatric disorders

Book Review: Disability in Twentieth-Century German Culture

Author: Carol Poore Reviewer: Katharina Heyer, Ph.D. Publisher: Ann Arbor, MI: University of Michigan, 2007 Cloth: ISBN: 978-0-472-11595-2 Cost: $70.00 Paper: ISBN: 978-0-472-03381-2 Cost: 24.95, 432 page

Eating in Public: Intellectual Disability and the Capacity for Citizenship

Reviewing: STACY SIMPLICAN, THE CAPACITY CONTRACT: INTELLECTUAL DISABILITY AND THE QUESTION OF CITIZENSHIP (UNIVERSITY OF MINNESOTA PRESS 2015)