Reductions in tree-ring widths of silver fir (Abies alba Mill.) as an indicator of air pollution in southern Poland

The aim of the study was to investigate how the emission of pollutants to the atmosphere from the late 19th century until modern times has been recorded in rings of silver fir trees growing in southern Poland. Samples were collected from 24 firs growing in the Beskid Niski Mountains (Western Carpathians). Using a Pressler borer, a single core was collected from each tree. Within the samples, tree-ring widths were measured. On this basis, reductions of tree-ring widths were calculated and subsequently divided into three classes according to their severity. Study results indicate that growth reductions at the site studied were influenced by the pollution emitted from the now-defunct Central Industrial Region, which developed most rapidly from 1920 to 1940, and began to decline after World War II. These emissions were probably responsible for reductions in the trees sampled in the years 1928–1947. On the other hand, reductions of tree-ring widths dating from 1951 to 1989 were caused by the post-war development of heavy industry throughout Poland, and in particular in the Upper Silesian Industrial Region, which developed at its most rapid rate from 1960 to 1990. The results obtained demonstrate that reductions of tree-ring widths in the silver firs studied are related to industrial air pollution in the 20th century. As industrial production declined and environmentally friendly technologies were introduced in the early 1990s, air pollution levels decreased and an increase in tree-ring widths followed in the silver firs studied. Further reductions of tree-ring widths have been observed in recent years (since 2009), which may be caused by air pollution due to low-stack emissions from domestic boilers. The analysis conducted demonstrates that a reduction in tree-ring widths in silver fir is a sensitive bioindicator of air pollution

Microstructure and Properties of Experimental Mg-9Al-5RE-1Zn-Mn Magnesium Alloy

In this paper, an experimental Mg-Al-RE-type magnesium alloy, named AEZ951, is presented. The chemical composition of the investigated alloy was ca. 9 wt% Al, 5 wt% RE (rare earth elements), 0.7 wt% Zn and 3 wt% Mn. The experimental material was gravity cast into a cold steel mould. Microstructure analyses were carried out by light microscopy, along with X-ray phase analysis and scanning electron microscopy with an energy-dispersive X-ray spectrometer (SEM + EDX). Detailed investigations disclosed the presence of primary dendrites of an α(Mg) solid solution and Al11RE3, ɣ and Al10RE2Mn7 intermetallic compounds in the alloy microstructure. The volume fraction of the Al11RE3 phase and α+ɣ eutectic was also presented. The hardness, impact strength, tensile strength as well as the yield strength of the alloy were examined in tests at room temperature. The examined experimental Mg-Al-RE-type magnesium alloy exhibited higher mechanical properties than the commercial AZ91 alloy (cast in the same conditions)

Niszczenie naturalnych odcinków koryt rzecznych na skutek niewłaściwej zabudowy – przykład dolin Czadeczki i Krężelki (Beskid Śląski)

Channels of Czadeczka and Krężelka rivers (Beskidzie Śląski Mts) are at present subjected to regulation because of which these rivers have lost their natural character, partially still preserved. The reasons for the river regulation have been analysed. Using archival maps, the buildings erection time has been analysed on valley floors, in the immediate vicinity of river channels for the period 1790–2012. Next, the distribution of existing buildings has been compared with hydraulic structures in the channels developed in order to regulate the Czadeczka and the Krężelka reaches, such as: concrete and stone embankments reinforcing the channel banks, check dams on channel bottoms. Results indicate a strong correlation between the number of buildings on valley floors in the 20th century and channel regulation. The mechanism of destroying rare, preserved natural river reaches is based on irrational permission allowing construction of buildings in areas threatened by floods and lateral erosion of rivers. Consequently, the inhabitants, in fear of floods and erosion of land or house foundations, seek river regulation that gives them a false sense of security. Natural river reaches are destroyed though efficient protection against floods and lateral erosion is still not provided and the range of possible losses increases even more due to continued building erection

Dendrochronological dating as the basis for developing a landslide hazard map – An example from the Western Carpathians, Poland

Most landslide hazard maps are developed on the basis of an area’s susceptibility to a land-slide occurrence, but dendrochronological techniques allows one to develop maps based on past land-slide activity. The aim of the study was to use dendrochronological techniques to develop a landslide hazard map for a large area, covering 3.75 km2. We collected cores from 131 trees growing on 46 sampling sites, measured tree-ring width, and dated growth eccentricity events (which occur when tree rings of different widths are formed on opposite sides of a trunk), recording the landslide events which had occurred over the previous several dozen years. Then, the number of landslide events per decade was calculated at every sampling site. We interpolated the values obtained, added layers with houses and roads, and developed a landslide hazard map. The map highlights areas which are poten-tially safe for existing buildings, roads and future development. The main advantage of a landslide hazard map developed on the basis of dendrochronological data is the possibility of acquiring long se-ries of data on landslide activity over large areas at a relatively low cost. The main disadvantage is that the results obtained relate to the measurement of anatomical changes and the macroscopic charac-teristics of the ring structure occurring in the wood of tilted trees, and these factors merely provide in-direct information about the time of the landslide event occurrence

Dendrochronology as a source of data for landslide activity maps - an example from Beskid Żywiecki Mountains (Western Carpathians, Poland)

We applied dendrochronological methods for dating landslide activity in the study area (3.75 km2), on the slopes of Sucha Mountain (1040 m a.s.l.), in the Beskid Żywiecki Mountains, in the Western Carpathians. 46 sampling sites were distributed throughout the study area. At each site we sampled 1-3 coniferous trees: Norway spruces (Picea abies Karst.) and/or silver firs (Abies alba Mill.). From each tree 2 cores were sampled: one from the upslope and the other from the downslope side of the stem. Based on tree-ring widths measured for opposite sides of stems we have calculated eccentricity index values and dated past landslide events. Mean frequency of landslides was obtained for each sampling site. Finally, the data was interpolated into a map of landslide activity. Inverse Distance Weighting (IDW) interpolation has been applied. For most of the study area we found medium (19 sites) and low (23 sites) levels of landslide activity. The highest level of activity was recorded for the largest landslide slope and for the one small landslide. The study conducted on Sucha Mountain has shown that dendrochronology can be an effective method for analysing landslide activity and may be useful in further studies, including those for landslide hazard and risk assessments

Meckel-Gruber syndrome: An update on diagnosis, clinical management, and research advances

© 2017 Hartill, Szymanska, Sharif, Wheway and Johnson. Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary cilium. Conditions that are caused by mutations in ciliary genes are collectively termed the ciliopathies, and MKS represents the most severe condition in this group of disorders. The primary cilium is a microtubule-based organelle, projecting from the apical surface of vertebrate cells. It acts as an "antenna" that receives and transduces chemosensory and mechanosensory signals, but also regulates diverse signaling pathways, such as Wnt and Shh, that have important roles during embryonic development. Most MKS proteins localize to a distinct ciliary compartment called the transition zone (TZ) that regulates the trafficking of cargo proteins or lipids. In this review, we provide an up-to-date summary of MKS clinical features, molecular genetics, and clinical diagnosis. MKS has a highly variable phenotype, extreme genetic heterogeneity, and displays allelism with other related ciliopathies such as Joubert syndrome, presenting significant challenges to diagnosis. Recent advances in genetic technology, with the widespread use of multi-gene panels for molecular testing, have significantly improved diagnosis, genetic counseling, and the clinical management of MKS families. These include the description of some limited genotype-phenotype correlations. We discuss recent insights into the molecular basis of disease in MKS, since the functions of some of the relevant ciliary proteins have now been determined. A common molecular etiology appears to be disruption of ciliary TZ structure and function, affecting essential developmental signaling and the regulation of secondary messengers

Assessment of landslide hazard from tree-ring eccentricity and from compression wood - a comparison

We have compared maps of landslide activity and hazard, developed with the use of two different dendrochronological indicators: tree-ring eccentricity and reaction (compression) wood. The maps were prepared based on 125 Norway spruce (Picea abies L. Karst.) trees growing at 44 sampling points, distributed over an area of 3.75 km2. In general, the two maps show similar patterns of landslide activity. However, tree-ring eccentricity yielded a greater number of dated events (246) compared to compression wood (129). Besides the differences in the absolute values of dating results, the general landslide activity and hazard zonation based on both disturbances are similar. Both growth disturbances develop as a result of stem tilting. Eccentricity develops after slight tilting, while compression wood is developed when tilting is more significant. Because of the differences in the strength of disturbing factors, which cause the development of compression wood and growth eccentricity, the best approach would be to combine the results of dating obtained from the two methods. The dendrochronological analysis of tree growth disturbances (eccentric growth and compression wood) is a promising approach for determining landslide hazards in forested mountain areas and can be applied in spatial management

Cosmological perturbation theory and quantum gravity

It is shown how cosmological perturbation theory arises from a fully quantized perturbative theory of quantum gravity. Central for the derivation is a non-perturbative concept of gauge-invariant local observables by means of which perturbative invariant expressions of arbitrary order are generated. In particular, in the linearised theory, first order gauge-invariant observables familiar from cosmological perturbation theory are recovered. Explicit expressions of second order quantities are presented as well

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo

Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention. Here we report the development of highly potent and orally bioavailable small-molecule inhibitors of the menin-MLL interaction, MI-463 and MI-503, and show their profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia. Finally, we demonstrate the efficacy of these compounds in primary samples derived from MLL leukemia patients. Overall, we demonstrate that pharmacologic inhibition of the menin-MLL interaction represents an effective treatment for MLL leukemias in vivo and provide advanced molecular scaffold for clinical lead identification