Modelling of wave climate and sediment transport patterns at a tideless embayed beach, Pirita Beach, Estonia

Nearshore sand transport patterns along the tideless, embayed Pirita beach, Tallinn, Estonia, have been investigated utilizing high-resolution modelling of wave processes combined with bathymetric surveys and sediment textural analyses of the nearshore sea floor. Textural analysis showed the mean grain size is about 0.12 mm. Fine sand (0.063–0.125 mm) accounts for about 77% of the sediments. Coarser-grained sand (0.28 mm) dominates along the waterline. Based upon the spatial distribution of the mean grain size and basic features of the local wave activity, properties of the Dean Equilibrium Beach Profile were determined. Alongshore sediment transport was calculated based upon a long-term time series of wave properties along the beach, and the CERC formula applied to about 500 m long beach sectors. The time series of wave fields and the properties of the local wave climate were modelled using a triple nested WAM wave model with an extended spectral range for short waves. The model is forced by open sea wind data from Kalbådagrund for the years 1981–2002. Results indicate that typical closure depth at Pirita is 2.5 m. The width and mean slope of the equilibrium profile are 250 m and 1:100, respectively. Southward transport dominates in the northern sections of the beach whereas no prevailing transport direction exists in the southern sections. This pattern has several nontrivial implications for the planning of beach protection activities

Place Marketing Implementation in Different Administrative Subdivisions: Estonian Case Study

The principal scope of this paper is to construct the chain-of-marketing that regards the implementation of a place marketing strategy, in particular regional tourism and development policy. For a few decades place marketing has been mostly a marketing viewpoint for urban areas in the context of tourism in cities or metropols. Smaller rural areas and country-sides have not got so much attention and place marketing is not much used as a strategic tool to improve development in such areas. Place marketing is usually seen as a tourism improvement for tourists, but actually the target audience is much wider. The starting point of the paper was the assumption that the quality of place marketing in these rural areas is not good and strategically elaborated. By comparing three different case studies, Tartu Rural Development Association (Example 1), 4P area in Central-Estonia (Example 2) and Attractions in Municipality of Konguta (Example 3), worst and best practices have been identified, and an answer to the question whether there exists such a thing as ideally sized and structured geographical area that deals with place marketing on the regional level has been sough

Detection of a balanced translocation carrier through trophectoderm biopsy analysis: a case report

Balanced translocation carriers are burdened with fertility issues due to improper chromosome segregation in gametes, resulting in either implantation failure, miscarriage or birth of a child with chromosomal disorders. At the same time, these individuals are typically healthy with no signs of developmental problems, hence they often are unaware of their condition. Yet, because of difficulties in conceiving, balanced translocation carriers often turn to assisted reproduction, some of whom may also undergo preimplantation genetic testing for aneuploidy (PGT-A) to improve the likelihood of achieving a successful pregnancy.Peer reviewe

Konverents "Digitaalraamatukogu ja selle kasutaja III, 2005"

● Digitaalraamatukogud Eestis - kas kogude või teenuste võrk? / Mihkel Reial ● Kas Eesti teadusraamatukogude koondportaal on võimalik? / Jüri Järs ● Eesti Teadusinfosüsteem / Hannes Alekand ● Teadustekstid on-line / Mare Kõiva ● Mäluastutuste digitaalsed andmekogud: mida teha üheskoos? / Priit Pirsko ● Tarkvaralahendusi raamatukogudele / Andres Jatsa ● Infosüsteemid raamatukogudes, raamatukogude vahel ja raamatukogude ümber - piirangud ja võimalused sidustamisel / Kalju Kill Kas

Effect of yeast culture on milk production and metabolic and reproductive performance of early lactation dairy cows

<p>Abstract</p> <p>Background</p> <p>The main objective of this study was to estimate the effect of supplementation with <it>Saccaromyces cerevisiae (SC</it>) (Yea-Sacc^®1026) on milk production, metabolic parameters and the resumption of ovarian activity in early lactation dairy cows.</p> <p>Methods</p> <p>The experiment was conducted during 2005/2006 in a commercial tied-house farm with an average of 200 milking Estonian Holstein Friesian cows. The late pregnant multiparous cows (n = 46) were randomly divided into two groups; one group received 10 g yeast culture from two weeks before to 14 weeks after calving. The groups were fed a total mixed ration with silages and concentrates. Milk recording data and blood samples for plasma metabolites were taken. Resumption of luteal activity was determined using milk progesterone (P₄) measurements. Uterine bacteriology and ovarian ultrasonography (US) were performed and body condition scores (BCS) and clinical disease occurrences were recorded. For analysis, the statistical software Stata 9.2 and R were used to compute Cox proportional hazard and linear mixed models.</p> <p>Results</p> <p>The average milk production per cow did not differ between the groups (32.7 ± 6.4 vs 30.7 ± 5.3 kg/day in the SC and control groups respectively), but the production of milk fat (<it>P </it>< 0.001) and milk protein (<it>P </it>< 0.001) were higher in the SC group. There was no effect of treatment on BCS. The analysis of energy-related metabolites in early lactation showed no significant differences between the groups. In both groups higher levels of β-hydroxybutyrate (BHB) appeared from days 14 to 28 after parturition and the concentration of non-esterfied fatty acid (NEFA) was higher from days 1–7 post partum (PP). According to US and P₄results, all cows in both groups ovulated during the experimental period. The resumption of ovarian activity (first ovulations) and time required for elimination of bacteria from the uterus did not differ between the groups.</p> <p>Conclusion</p> <p>Supplementation with SC had an effect on milk protein and fat production, but did not influence the milk yield. No effects on PP metabolic status, bacterial elimination from the uterus nor the resumption of ovarian activity were found.</p

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

A case report and follow-up of the first live birth after heterotopic transplantation of cryopreserved ovarian tissue in Eastern Europe

BackgroundOvarian insufficiency is a major concern for long-term cancer survivors. Although semen freezing is well established to preserve male fertility, the possibilities to secure post-cancer female fertility are mostly limited to oocyte or embryo freezing. These methods require time-consuming ovarian stimulation with or without in vitro fertilization (IVF) that evidently delays cancer therapy. Ovarian tissue cryopreservation and subsequent thawed tissue autotransplantation are considered the most promising alternative strategy for restoring the fertility of oncology patients, which has not yet received the full clinical acceptance. Therefore, all successful cases are needed to prove its reliability and safety.Case presentationHere we report a single case in Estonia, where a 28-year-old woman with malignant breast neoplasm had ovarian cortex cryopreserved before commencing gonadotoxic chemo- and radiotherapy. Two years after cancer therapy, the patient underwent heterotopic ovarian tissue transplantation into the lateral pelvic wall. The folliculogenesis was stimulated in the transplanted tissue by exogenous follicle-stimulating hormone and oocytes were collected under ultrasound guidance for IVF and embryo transfer. The healthy boy was born after full-term gestation in 2014, first in Eastern Europe.ConclusionDespite many countries have reported the first implementation of the ovarian tissue freezing and transplantation protocols, the data is still limited on the effectiveness of heterotopic ovarian transplant techniques. Thus, all case reports of heterotopic ovarian tissue transplantation and long-term follow-ups to describe the children's health are valuable source of clinical experience.Peer reviewe