Pandangan Ekonomi Islam Tentang Investasi Murabahah Logam Mulia (Studi pada Cabang Pegadaian Syariah Istiqlal Manado)

Penelitian ini bertujuan untuk mengetahui bagaimana pandangan ekonomi Islam tentang investasi murabahah logam mulia di Cabang Pegadaian Syariah Istiqlal Manado. Penulis menemukan bahwa peoses transaksi murabahah melalui logam mulia untuk investasi abadi (MULIA) pada Cabang Pegadaian Syariah Istiqlal Manado dimulai dari transaksi pemesanan, transaksi pembelian ke pemasok kemusian transaksi pembayaran dan pelunasan. Akad yang selama ini digunakan oleh Pegadaian Syariah terhadap barang jaminan (marhun) adalah wadiah al-amanah, sebab barang yang dijadikan agunan/jaminan disimpan rapi dan diperkenankan membuka segel bagi penerima titipan sampai pemberi titipan atau pemberi gadai (rahin) mengambilnya. Hal tersebut dilakukan untuk menjaga keamanan terhadap barang jaminan. Pandangan hokum ekonomi Islam terhadap investasi logam mulia pada Pegadaian Syariah Istiqlal Manado dibolehkan sebab sistem yang digunakan sama dengan sistem pegadaian yaitu melakukan kesepakatan atau akad dan tidak membebani kedua pihak dan melakukan kontrak yang sah tanpa ada paksaan dan penipuan. Persyaratan dan prosedur pemberian pinjaman atau pembiayaan telah ditentukan oleh pegadaian syariah berdasarkan kaidah-kaidah Hukum Islam: persyaratan sederhana, prosedur mudah, akad secara tertulis, pembiayaan/hutang dengan jaminan berang yang sudah dibeli, tidak dipungut bunga, keuntungan/margin dan isi perjanjian ditentukan oleh kedua belah pihak serta pembiayaan tidak mengandung gharar

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Optimization of Cutting Parameters of Multiple Performance Characteristics in End Milling of AlSi/AIN MMC - Taguchi Method and Grey Relational Analysis

The main objective of this paper is to investigate and optimize the cutting parameters on multiple performance characteristics in end milling of Aluminium Silicon alloy reinforced with Aluminium Nitride (AlSi/AlN MMC) using Taguchi method and Grey relational analysis (GRA). The fabrication of AlSi/AlN MMC was made via stir casting with various volume fraction of particles reinforcement (10%, 15% and 20%). End milling machining was done under dry cutting condition by using two types of cutting tool (uncoated & PVD TiAlN coated carbide). Eighteen experiments (L18) orthogonal array with five factors (type of tool, cutting speed, feed rate, depth of cut, and volume fraction of particles reinforcement) were implemented. The analysis of optimization using GRA concludes that the better results for the combination of lower surface roughness, longer tool life, lower cutting force and higher material removal could be achieved when using uncoated carbide with cutting speed 240m/min, feed 0.4mm/tooth, depth of cut 0.3mm and 15% volume fraction of AlN particles reinforcement. The study confirmed that with a minimum number of experiments, Taguchi method is capable to design the experiments and optimized the cutting parameters for these performance characteristics using GRA for this newly develop material under investigation

Pemanfaatan Limbah Kulit Telur Menjadi Suplemen Penambah Gizi Bagi Masyarakat di Desa Paddingin Kecamatan Sanrobone Kabupaten Takalar

Empowerment of rural communities, especially the community of partner villages or assisted villages, is a community service carried out by Universitas Muslim Indonesia Lecturers as a form of the Tri Dharma of higher education. One of the partner villages or villages assisted by the Universitas Muslim Indonesia where we serve, is Paddingin Village, Sanrobone District, Takalar Regency, where one of our service programs is to provide counseling to village communities about the use of eggshell waste as nutritional supplements. In addition to being easy to obtain and cheap to process, eggshells have a high content of calcium so that the flour produced from processing eggshells can be used as a supplement to increase the nutrition of rural communitie

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research