14 research outputs found
Hipermídia Adaptativa potencializando a inclusão digital
Neste artigo propomos o uso da hipermídia adaptativa como potencializador na construção de interfaces inclusivas que possibilitam a personalização da comunidade virtual VIDE (VIvenciando na reDE). Trata-se de uma pesquisa bibliográfica que culminou na implementação de técnicas de adaptação de apresentação e de navegação com vistas a possibilitar uma melhor interação aos diferentes usuários da VIDE, auxiliando-os de forma dinâmica quanto à navegabilidade e à usabilidade, levando em conta suas características
Impact of Glycemic and Blood Pressure Variability on Surrogate Measures of Cardiovascular Outcomes in Type 2 Diabetic Patients
OBJECTIVE—The effect of glycemic variability (GV) on cardiovascular risk has not been fully
clarified in type 2 diabetes. We evaluated the effect of GV, blood pressure (BP), and oxidative
stress on intima-media thickness (IMT), left ventricular mass index (LVMI), flow-mediated dilation
(FMD), and sympathovagal balance (low frequency [LF]/high frequency [HF] ratio) in 26
type 2 diabetic patients (diabetes duration 4.41 6 4.81 years; HbA1c 6.70 6 1.25%) receiving
diet and/or metformin treatment, with no hypotensive treatment or complications.
RESEARCH DESIGN AND METHODS—Continuous glucose monitoring (CGM) data
were used to calculate mean amplitude of glycemic excursion (MAGE), continuous overall net
glycemic action (CONGA)-2, mean blood glucose (MBG), mean postprandial glucose excursion
(MPPGE), and incremental area under the curve (IAUC). Blood pressure (BP), circadian rhythm,
and urinary 15-F2t-isoprostane (8-iso-prostaglandin F2a [PGF2a]) were also evaluated. Subjects
were divided into dipper (D) and nondipper (ND) groups according to DBP.
RESULTS—IMT and LVMIwere increased inNDversusD(0.7760.08 vs. 0.6860.13 [P=0.04]
and 67 6 14 vs. 55 6 11 [P = 0.03], respectively). MBG, MAGE, and IAUC were significantly
associated with LF/HF ratio at night (r = 0.50, P = 0.01; r = 0.40, P = 0.04; r = 0.41, P = 0.04,
respectively), MPPGE was negatively associated with FMD (r =20.45, P = 0.02), andCONGA-2was positively associatedwith LVMI (r=0.55, P=0.006).TheDsystolic BP was negatively associated with IMT (r =20.43, P = 0.03) andwith LVMI (r =20.52, P = 0.01). Urinary 8-iso-PGF2a was positively associated with LVMI (r = 0.68 P , 0.001).
CONCLUSIONS—An impaired GV and BP variability is associated with endothelial and
cardiovascular damage in short-term diabetic patients with optimal metabolic control. Oxidative
stress is the only independent predictor of increased LV mass and correlates with glucose and BP variability
Synthesen in der Carotinoid-Reihe XXIV. Versuche zur Darstellung des 3,4-3′,4′-Bisdehydro-β-carotins
A weather-based model for predicting early season inoculum build-up and spike infection by the wheat blast pathogen.
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