Charaterization of CFRP with Lockin Thermography

Thermal waves are suited for non-contacting inspection of near-surface areas of solids [1]. The reason for this depth limitation is the strong attenuation of this modulated thermal diffusion process. The resulting depth range is frequency dependent, hence it has been pointed out very early that thermal waves allow for depth profiling by variation of modulation frequency [2, 3]

Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries

<p>Abstract</p> <p>Background</p> <p>Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, antioxidant, anticancer, hypocholesterolemic, and neuroprotective properties. Our objective in this study was to determine the extent to which tocotrienols inhibit platelet aggregation and reduce coronary thrombosis, a major risk factor for stroke in humans. The present study was carried out to determine the comparative effects of α-tocopherol, α-tocotrienol, or tocotrienol rich fraction (TRF; a mixture of α- + γ- + δ-tocotrienols) on <it>in vivo platelet thrombosis </it>and <it>ex vivo </it>platelet aggregation (PA) after intravenous injection in anesthetized dogs, by using a mechanically stenosed circumflex coronary artery model (Folts' cyclic flow model).</p> <p>Results</p> <p>Collagen-induced platelet aggregation (PA) in platelet rich plasma (PRP) was decreased markedly after treatment with α-tocotrienol (59%; <b><it>P </it></b>< 0.001) and TRF (92%; <b><it>P </it></b>< 0.001). α-Tocopherol treatment was less effective, producing only a 22% (<b><it>P </it></b>< 0.05) decrease in PA. Adenosine diphosphate-induced (ADP) PA was also decreased after treatment with α-tocotrienol (34%; <b><it>P </it></b>< 0.05) and TRF (42%; <b><it>P </it></b>< 0.025). These results also indicate that intravenously administered tocotrienols were significantly better than tocopherols in inhibiting cyclic flow reductions (CFRs), a measure of the acute platelet-mediated thrombus formation. Tocotrienols (TRF) given intravenously (10 mg/kg), abolished CFRs after a mean of 68 min (range 22 -130 min), and this abolition of CFRs was sustained throughout the monitoring period (50 - 160 min).</p> <p>Next, pharmacokinetic studies were carried out and tocol levels in canine plasma and platelets were measured. As expected, α-Tocopherol treatment increased levels of total tocopherols in post- vs pre-treatment specimens (57 vs 18 μg/mL in plasma, and 42 vs 10 μg/mL in platelets). However, treatment with α-tocopherol resulted in slightly decreased levels of tocotrienols in post- vs pre-treatment samples (1.4 vs 2.9 μg/mL in plasma and 2.3 vs 2.8 μg/mL in platelets). α-Tocotrienol treatment increased levels of both tocopherols and tocotrienols in post- vs pre-treatment samples (tocopherols, 45 vs 10 μg/mL in plasma and 28 vs 5 μg/mL in platelets; tocotrienols, 2.8 vs 0.9 μg/mL in plasma and 1.28 vs 1.02 μg/mL in platelets). Treatment with tocotrienols (TRF) also increased levels of tocopherols and tocotrienols in post- vs pre-treatment samples (tocopherols, 68 vs 20 μg/mL in plasma and 31.4 vs 7.9 μg/mL in platelets; tocotrienols, 8.6 vs 1.7 μg/mL in plasma and 3.8 vs 3.9 μg/mL in platelets).</p> <p>Conclusions</p> <p>The present results indicate that intravenously administered tocotrienols inhibited acute platelet-mediated thrombus formation, and collagen and ADP-induced platelet aggregation. α-Tocotrienols treatment induced increases in α-tocopherol levels of 4-fold and 6-fold in plasma and platelets, respectively. Interestingly, tocotrienols (TRF) treatment induced a less pronounced increase in the levels of tocotrienols in plasma and platelets, suggesting that intravenously administered tocotrienols may be converted to tocopherols. Tocotrienols, given intravenously, could potentially prevent pathological platelet thrombus formation and thus provide a therapeutic benefit in conditions such as stroke and myocardial infarction.</p

The Hydromagnetic Interior of a Solar Quiescent Prominence. I. Coupling between Force-balance and Steady Energy-transport

This series of papers investigates the dynamic interior of a quiescent prominence revealed by recent {\it Hinode} and {\it SDO/AIA} high-resolution observations. This first paper is a study of the static equilibrium of the Kippenhahn-Schl\"{u}ter diffuse plasma slab, suspended vertically in a bowed magnetic field, under the frozen-in condition and subject to a theoretical thermal balance among an optically-thin radiation, heating, and field-aligned thermal conduction. The everywhere-analytical solutions to this nonlinear problem are an extremely restricted subset of the physically admissible states of the system. For most values of the total mass frozen into a given bowed field, force-balance and steady energy-transport cannot both be met without a finite fraction of the total mass having collapsed into a cold sheet of zero thickness, within which the frozen-in condition must break down. An exact, resistive hydromagnetic extension of the Kippenhahn-Schl\"{u}ter slab is also presented, resolving the mass-sheet singularity into a finite-thickness layer of steadily-falling dense fluid. Our hydromagnetic result suggests that the narrow, vertical prominence $H_{\alpha}$ threads may be falling across magnetic fields, with optically-thick cores much denser and ionized to much lower degrees than conventionally considered. This implication is discussed in relation to (i) the recent {\it SDO/AIA} observations of quiescent prominences that are massive and yet draining mass everywhere in their interiors, (ii) the canonical range of $5-60 G$ determined from spectral-polarimetric observations of prominence magnetic fields over the years and (iii) the need for a more realistic multi-fluid treatment.Comment: 45 pages, 14 figure

Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch

The bacterial flagellar switch that controls the direction of flagellar rotation during chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation. Here, we used high-resolution optical microscopy to observe switching of single motors and uncover the stochastic multistate nature of the switch. Our observations are in detailed quantitative agreement with a recent general model of allosteric cooperativity that exhibits conformational spread—the stochastic growth and shrinkage of domains of adjacent subunits sharing a particular conformational state. We expect that conformational spread will be important in explaining cooperativity in other large signaling complexes

Structure and Dynamics of the Sun's Open Magnetic Field

The solar magnetic field is the primary agent that drives solar activity and couples the Sun to the Heliosphere. Although the details of this coupling depend on the quantitative properties of the field, many important aspects of the corona - solar wind connection can be understood by considering only the general topological properties of those regions on the Sun where the field extends from the photosphere out to interplanetary space, the so-called open field regions that are usually observed as coronal holes. From the simple assumptions that underlie the standard quasi-steady corona-wind theoretical models, and that are likely to hold for the Sun, as well, we derive two conjectures on the possible structure and dynamics of coronal holes: (1) Coronal holes are unique in that every unipolar region on the photosphere can contain at most one coronal hole. (2) Coronal holes of nested polarity regions must themselves be nested. Magnetic reconnection plays the central role in enforcing these constraints on the field topology. From these conjectures we derive additional properties for the topology of open field regions, and propose several observational predictions for both the slowly varying and transient corona/solar wind.Comment: 26 pages, 6 figure

Coordinated X-ray optical and radio observations of YZ Canis Minoris

Coordinated X ray, optical, and radio observations of the flare star YZ CMi are reported. Twenty-two minor optical flares and twelve radio events were recorded. No major optical flares, greater than 3 magnitudes, were observed. Although no flare related X ray emission was observed, the measured upper limits in this band enable meaningful comparisons with published flare star models. Three of the five models predicting the relative X ray to optical or radio flare luminosities are in serious disagreement with the observations. For the largest optical flare with coincident X ray coverage, the 3 sigma upper limit on X ray emission in the 0.15 to 0.8 keV band is 8.7 x 10 to the 28th power erg/s, corresponding to a ratio of X ray to B-band luminosity of less than 0.3. Based on the present results, the contribution of the flares UV Ceti flare stars to the galactic component of the diffuse soft X ray background is less than 0.2 percent