The state of truth in the context of globalization

Motivation: This article addresses the issue of the functioning of modern societies in the context of worldview transformations related to globalization processes. Whether today’s globalization processes — the dissemination of specific models, designs, systems, tools and narrations in socio-cultural-economic-political dimensions — have significantly redefined the notion of truth and strengthened (or perhaps weakened) its validity (phenomenon)? The main motivation to undertake this research was the desire to show the role and the strengthening of value (truth) in social practice, in particular in relation to scientific and economic practice.Aim: The purpose of the article is to answer the question how globalization (in the socio-economic-cultural aspect) affects new ways of redefining the truth, treated as the axiological basis of scientific practice. The economic aspect has been taken into account in particular in the context of the establishment of a new (technological) approach to truth based on globalization processes taking place within the framework of network economics and on-demand economy. The literature review reconstructs two historically significant ways of redefining truth as the base value for scientific practice (autotelic and socio-useful) in order to show the breadth of socio-economic changes associated with the new definition of truth (as a technological value). The article is theoretical, based on philosophical considerations, recognized in a cultural perspective; the humanistic interpretation was applied.Results: The result of the research is to show: 1. the continuity of the process of redefining the truth, 2. the need to take into account the axiological context in relation to new types of economic practice

Nanomechanics of Ig-like domains of human contactin (BIG-2)

Contactins are modular extracellular cell matrix proteins that are present in the brain, and they are responsible for the proper development and functioning of neurons. They contain six immunoglobulin-like IgC2 domains and four fibronectin type III repeats. The interactions of contactin with other proteins are poorly understood. The mechanical properties of all IgC2 domains of human contactin 4 were studied using a steered molecular dynamics approach and CHARMM force field with an explicit TIP3P water environment on a 10-ns timescale. Force spectra of all domains were determined computationally and the nanomechanical unfolding process is described. The domains show different mechanical stabilities. The calculated maxima of the unfolding force are in the range of 900–1700 pN at a loading rate of 7 N/s. Our data indicate that critical regions of IgC2 domains 2 and 3, which are responsible for interactions with tyrosine phosphatases and are important in nervous system development, are affected by even weak mechanical stretching. Thus, tensions present in the cell may modulate cellular activities related to contactin function. The present data should facilitate the interpretation of atomic force microscope single-molecule spectra of numerous proteins with similar IgC2 motives

Post-Rickertowska wartość w teoriach literatury

In this article I would like to present a short overview of the methods try to recognize problems in those disciplines and think about how many of the findings Rickert (especially the value) could be indicated in modern theories of literature in their philosophical foundations. The humanistic interpretation was used.Głównym celem artykułu jest przedstawienie w krótkim zarysie, jak wiele z ustaleń Rickerta (dotyczących zwłaszcza wartości) dałoby się wskazać we współczesnych teoriach literatury w ich filozoficznych podstawach w kontekście sporu o odrębność metodologiczną nauk humanistycznych. Zastosowano interpretację humanistyczną

Renewable energy potential and its exploitation on a regional scale : based on the region CENTROPE

The renewable energy sector expands continuously due to ambitious energy goals for 2020 declared by the EU, however its expansion is hampered by several barriers in the field of costs, regulation and market performance. This study elaborates renewable energy potentials in the region Centrope and identifies in the next step possible factors affecting the successful development of renewable energy sector in the named region. The results showed that lack of information deriving from deviations in energy potentials on national and regional scale become incorporated in national energy policies and feed-in tariff laws leading to ineffective exploitation of renewable energy potentials on a regional scale. Additionally it was observed that centralized policies as found in the Czech Republic, Slovakia and Hungary enhance this process due to missing authorized regional autonomy, which could counteract and have an agenda regarding the exploitation of renewable energy potentials. Therefore it is recommended to enlarge regional autonomy in order to facilitate the development of renewable energy sector and provide more flexible feed-in tariffs taking into account deviations in renewable energy potentials on a regional scale

Modele wychowania seksualnego w rodzinach pochodzenia współczesnych kobiet na tle przemian obyczajowych w sferze seksualności

The paper attempts to present the transformations in sexual morality and their significance for the sexual upbringing of men and women. The results of the research presented herein allow us to analyze the models of sexual upbringing implemented in the families of origin of modern young women. It also verifies whether there are differences between men and women in the realm of sexual upbringing in their families of origin and if there are differences in their sexual functioning within a partnership depending on the model of sexual upbringing in the family of origin.The paper attempts to present the transformations in sexual morality and their significance for the sexual upbringing of men and women. The results of the research presented herein allow us to analyze the models of sexual upbringing implemented in the families of origin of modern young women. It also verifies whether there are differences between men and women in the realm of sexual upbringing in their families of origin and if there are differences in their sexual functioning within a partnership depending on the model of sexual upbringing in the family of origin

Chapter 12 Individual Work Pricing by Non-fungible Personal Tokens (“NFT Gig Tokens”) – a New Opportunity for Gig Workers

The COVID-19 pandemic transformed the way people operate in all fields of their activity – individual, social, economic, cultural, civic, to name the most essential spheres. One of the crucial changes to the rules existing within pre-pandemic societies was the modification of the work environment and principles (Ralph et al., 2020; Masood et al., 2022). The patterns developed within the gig economy, which are based on the idea of flexibility and the use of technological communication platforms, proved to be the most common response to the change (Diab- Bahman & Al-Enzi, 2020). When it comes to specific problems that were highlighted by the pandemic, the issue of labour pricing occurred to be of concern. The development of online communication tools created new opportunities to provide services and share results of one’s work via the Internet. It is worth noting that even before the COVID-19, the issue of work valuation was crucial for some groups, for example, for artists. The token became an important way of work monetisation both for them and the new services providers. More and more one hears about artists converting their artworks (the results of their work) into non-fungible tokens (NFT tokens). But will only celebrities (artists, actors, and influencers) use this tool in the future? This question occurred to be an extremely relevant matter in a (post)pandemic world. It seems that NFT gig tokens are an answer to the challenges occurring on the labour market, related to the popularisation of the employment model in the gig economy and the issue of valuing work offered by gig workers

Struktura i uwarunkowania afektywne go komponentu postaw politycznych studentów

It is indisputable that emotions predominate in shaping political attitudes. This is corroborated by the development of political marketing, whose techniques and means are mainly directed at voters’ emotions. The paper presents the results of research into the affective component in the political attitudes of university students. To a large extent the analysis confirms the hypothesis that religious organizations have a significant impact on developing a positive emotional attitude towards right-wing politicians and parties, whereas the media strongly influence the emergence of similar attitudes towards liberal political entities. Advocates of the right wing declare their commitment to national values and patriotism, while demonstrating a relatively passive attitude to politics. The respondents whose opinions indicate liberal sympathies emphasize their satisfaction with life and intention to be active in the field of politics. The important conclusion to be drawn from this research is that the family contin- ues to have a significant impact on the emotional political attachments of the young, whereas the influence of school in this regard is definitely limited.It is indisputable that emotions predominate in shaping political attitudes. This is corroborated by the development of political marketing, whose techniques and means are mainly directed at voters’ emotions. The paper presents the results of research into the affective component in the political attitudes of university students. To a large extent the analysis confirms the hypothesis that religious organizations have a significant impact on developing a positive emotional attitude towards right-wing politicians and parties, whereas the media strongly influence the emergence of similar attitudes towards liberal political entities. Advocates of the right wing declare their commitment to national values and patriotism, while demonstrating a relatively passive attitude to politics. The respondents whose opinions indicate liberal sympathies emphasize their satisfaction with life and intention to be active in the field of politics. The important conclusion to be drawn from this research is that the family contin- ues to have a significant impact on the emotional political attachments of the young, whereas the influence of school in this regard is definitely limited

Dziecięcy guz Abrikossoffa w rzadkiej lokalizacji

  Abrikossoff tumor is an uncommon neoplasm of soft tissue, mostly benign but cases of aggressive malignant form with metastases were also reported. GCT can occur at any area of the body (head and neck are the most common but also limbs and vulva). Local surgical excision with wide margin is a treatment of choice but possibility of recurrence, multiple location and malignancy in time must be considered. This report presents a rare pediatric case with Abrikossoff tumor.Abrikossoff tumor is an uncommon neoplasm of soft tissue, mostly benign but cases of aggressive malignant form with metastases were also reported. GCT can occur at any area of the body (head and neck are the most common but also limbs and vulva). Local surgical excision with wide margin is a treatment of choice but possibility of recurrence, multiple location and malignancy in time must be considered. This report presents a rare pediatric case with Abrikossoff tumor

Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review

Introduction and purpose Obesity, a pervasive global pandemic intricately linked to various comorbidities, necessitates a comprehensive and nuanced approach. This article delves into the intricate realm of obesity guidelines, underscoring the significance of lifestyle modifications, preventive measures for childhood obesity, population-based strategies, clinical management protocols, and vigilant monitoring. GLP-1 drugs, originally designed for type 2 diabetes management, exhibit multifaceted effects beyond glycemic control. They influence appetite regulation, gastric emptying dynamics, and potentially contribute to cardiovascular health improvements. However, the commendable effects come with a caveat - potential side effects necessitating careful consideration in clinical decision-making. Despite gaining popularity through celebrity endorsements, this article firmly underscores the need to view GLP-1 pharmacotherapy as a recommended intervention rather than a miraculous solution. A brief description of the state of knowledge Integral to the obesity discourse is the imperative to address weight stigma, demanding evidence-based approaches in both clinical and public health domains. The narrative extends into the future landscape of obesity pharmacotherapy, contemplating the potential role of probiotics. Emphasizing the necessity for long-term studies and randomized trials, it positions probiotics as a low-risk alternative with significant potential in mitigating obesity while simultaneously addressing concerns related to antibiotic resistance. Summary The pursuit of a balanced and effective approach to obesity management necessitates a nuanced understanding of medical interventions, consideration of societal perceptions, and exploration of innovative possibilities within the evolving landscape of healthcare

The Condyloma acuminata - the review of the treatment methods

Introduction and purpose: Condyloma acuminata, a benign manifestation of HPV infection, is a common sexually transmitted disease. Condyloma acuminata most commonly affects the anogenital area, but can also occur in the oral cavity. Macroscopically the lesions present as raised, fleshy papules, sometimes flat and broad, pedicled or cauliflower-like. Generally, the lesions are multiple, and as they grow, tend to coalesce into larger ones. Due to the lack of symptoms, condyloma acuminata are often found incidentally during routine medical appointments, e.g. in gynecologist’s offices. Additional symptoms and signs are pain, minor bleeding and pruritus. Patients suffering from condyloma acuminata are often in psychological and psychosexual distress.  This work aims to provide a summary of the currently available treatment options based on scientific reports to date. A brief description of the state of knowledge: Among the factors that increase the risk of the HPV infection are age, lifestyle, promiscuity, smoking, HIV infection, a history of chlamydia or gonorrhea infections. To date, no treatment algorithm has been developed for condyloma acuminata. Two vaccines are on offer as primary prevention, Gardasil and Cervarix. The available treatment options are divided into two main groups: patient-administered and physician administered. Surgical methods have the highest therapeutic efficacy. Condyloma acuminata has a high recurrence rate. Usually, a multi-session combination treatment is needed to reach total remission. Summary (conclusions): The treatment of condyloma acuminata includes personalized targets due to their diverse clinical picture and the limitations of certain patient groups. The available treatment options do not exhaust the needs of patients suffering from condyloma acuminata. Further research into the effectiveness of specific treatments is advisable