Physiological effects of oral glucosamine on joint health: Current status and consensus on future research priorities

The aim of this paper was to provide an overview of the current knowledge and understanding of the potential beneficial physiological effects of glucosamine (GlcN) on joint health. The objective was to reach a consensus on four critical questions and to provide recommendations for future research priorities. To this end, nine scientists from Europe and the United States were selected according to their expertise in this particular field and were invited to participate in the Hohenheim conference held in August 2011. Each expert was asked to address a question that had previously been posed by the chairman of the conference. Based on a systematic review of the literature and the collection of recent data, the experts documented the effects of GlcN on cartilage ageing, metabolic/kinetic and maintenance of joint health as well as reduction of risk of OA development. After extensive debate and discussion the expert panel addressed each question and a general consensus statement was developed, agreeing on the current state-of-the-art and future areas for basic and clinical studies. This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissuesHenrotin is the founder of Artialis SA a spin-off of the University of Liège. His research has been supported by educational grant from Bioiberica, Nestle, Royal Canin, Expanscience, Danone and BioXtract. The other authors have no conflict of interest related to the subject of this paper. A. Mobasheri acknowledges the financial support of The Wellcome Trust, the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs; grant number: Mobasheri. A. 28102007), the Biotechnology and Biological Sciences Research Council (BBSRC; grants BBSRC/S/M/2006/ 13141 and BB/G018030/1) and the Engineering and Physical Sciences Research Council (EPSRC). Y Henrotin, H Weinans and A. Mobasheri are members of the D-BOARD Consortium funded by European Commission Framework 7 Programme (EU FP7) and wish to acknowledge funding from the Commission in relation to project number 305815, (Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases, HEALTH.2012.2.4.5-2)

Physiological effects of oral glucosamine on joint health: Current status and consensus on future research priorities

The aim of this paper was to provide an overview of the current knowledge and understanding of the potential beneficial physiological effects of glucosamine (GlcN) on joint health. The objective was to reach a consensus on four critical questions and to provide recommendations for future research priorities. To this end, nine scientists from Europe and the United States were selected according to their expertise in this particular field and were invited to participate in the Hohenheim conference held in Aug

Perapion connexum (Schilsky, 1902) (Coleoptera, Apionidae) in Central Europe, a case of plant expansion chase

Perapion connexum (Schilsky) is recorded for the first time from Hungary and Kyrgyzstan, and new distribution data from Ukraine and Russia are provided. Preliminary placements of this weevil in faunal checklists for Poland and Slovakia are here documented with detailed data. Its occurrence in Austria based on older evidence, is discussed. The neophytic and invasive in Central Europe sorrel Rumex confertus Willd. is confirmed to be its unique host plant in Poland. Morphology of the newcoming weevil is described and illustrated, and the key to all Central European species of Perapion is presented

Perapion connexum (Schilsky, 1902) (Coleoptera, Apionidae) in Central Europe, a case of plant expansion chase

Perapion connexum (Schilsky) is recorded for the first time from Hungary and Kyrgyzstan, and new distribution data from Ukraine and Russia are provided. Preliminary placements of this weevil in faunal checklists for Poland and Slovakia are here documented with detailed data. Its occurrence in Austria based on older evidence, is discussed. The neophytic and invasive in Central Europe sorrel Rumex confertus Willd. is confirmed to be its unique host plant in Poland. Morphology of the newcoming weevil is described and illustrated, and the key to all Central European species of Perapion is presented

Hypoglyptus undefined-a

<i>Hypoglyptus</i> sp. <p>A member of this very rarely collected genus was found while sifting plant litter under cushion plants on limestone rocks (no. 4). Another specimen was found while beating shrubs and herbs along a roadside (no. 48). Based on the key by Pic (1906), a reliable determination at species-level was not possible (Fig. 4A). Further investigations are needed to determine this species.</p>Published as part of <i>Germann, Christoph, Müller, Gerd, Müller, Ursula & Schön, Karel, 2015, An annotated checklist of the weevil fauna of Samos Island with new records for Greece (Coleoptera, Curculionoidea), pp. 1-26 in Contributions to Natural History 27</i> on page 14, DOI: 10.5169/seals-787075, <a href="http://zenodo.org/record/5851450">http://zenodo.org/record/5851450</a&gt

Styphlus oros

<i>Styphlus oros</i> (REITTER, 1889) (Fig. 11) and <i>S. penicillus</i> SCHöNHERR, 1826. <p> <i>S. penicillus</i> was beaten during the night from the <i>Reichardia</i> cf. <i>picroides</i> (Asteraceae) at a beach. Bayer & al. (2007) reported on finds of the similar <i>S. jonicus</i> (Reitter, 1899) from an undetermined Asteraceae, but also from numerous finds on Fabaceae.</p> <p> With <i>Styphlus oros</i> another species of the genus was sifted from leaf litter in two specimens in an olive orchard near Kamara (no. 16). The habitat lies within the immediate surroundings of an olive tree, where several <i>Hieracium</i> sp. (Asteraceae) were growing, their possible host plant. Another specimen was sifted from leaf litter under cushion plants on the Oros Kerkis.</p>Published as part of <i>Germann, Christoph, Müller, Gerd, Müller, Ursula & Schön, Karel, 2015, An annotated checklist of the weevil fauna of Samos Island with new records for Greece (Coleoptera, Curculionoidea), pp. 1-26 in Contributions to Natural History 27</i> on page 13, DOI: 10.5169/seals-787075, <a href="http://zenodo.org/record/5851450">http://zenodo.org/record/5851450</a&gt

Otiorhynchus ovalipennis

<i>Otiorhynchus ovalipennis</i> (BOHEMAN, 1843) <p>Apart from normally sized specimens, apparently bigger and exclusively female specimens (Figs 4C–D) were collected near Koumaradei (no. 12). Presumably, these represent a polyploid parthenogenetic population.</p>Published as part of <i>Germann, Christoph, Müller, Gerd, Müller, Ursula & Schön, Karel, 2015, An annotated checklist of the weevil fauna of Samos Island with new records for Greece (Coleoptera, Curculionoidea), pp. 1-26 in Contributions to Natural History 27</i> on page 10, DOI: 10.5169/seals-787075, <a href="http://zenodo.org/record/5851450">http://zenodo.org/record/5851450</a&gt

Neocoenorrhinus pseudocribrum

<i>Neocoenorrhinus</i> cf. <i>pseudocribrum</i> (LEGALOV, 2002) <p> No biological data is known for this species, except that specimens were collected on young <i>Quercus</i> trees (Skuhrovec & al. 2012). All four presently recorded specimens were collected near the sea shore on flowering <i>Quercus coccifera</i> with a beating tray.</p>Published as part of <i>Germann, Christoph, Müller, Gerd, Müller, Ursula & Schön, Karel, 2015, An annotated checklist of the weevil fauna of Samos Island with new records for Greece (Coleoptera, Curculionoidea), pp. 1-26 in Contributions to Natural History 27</i> on page 16, DOI: 10.5169/seals-787075, <a href="http://zenodo.org/record/5851450">http://zenodo.org/record/5851450</a&gt

Traction bogie fo rnarrow gauge tram

The article describes the research and development of a traction, rotating bogie for a low-floor tram. It draws attention to problems that had to be resolved during development