Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII

A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide, showed low nanomolar inhibitory activity against the tumor associated carbonic anhydrases IX and XII

Thermoluminescence characterization of Ag-doped Li2B4O7 single crystal materials

In this study, the thermoluminescence (TL) characteristics of Ag-doped and undoped lithium tetraborate (Li2B4O7, LTB) materials, grown using the Czochralski method, were reported. The TL properties of LTB:Ag, such as glow curve structure, dose response, fading and reproducibility, were investigated. The glow curve of the Li2B4O7:Ag single crystal consists of four peaks located at approximately 75, 130, 190 and 275°C; in undoped LTB, the single crystal shows a broad glow curve with peaks at 65, 90, 125, 160 and 190°C using a heating rate of 5°C/s in the 50–350°C temperature region. The high temperature peak of Ag-doped sample at 275°C has a nonlinear dose response within the range from 33 mGy to 9 Gy. There is a linear response in the range of 33–800 mGy; after which, a sublinear region appears up to 9 Gy for Ag-doped LTB single crystal. For undoped single crystal, the dose response is supralinear for low doses and linear for the region between 1 and 9 Gy. The thermal fading ratio of the undoped material is almost 60% for the high temperature peak after 7 days. Ag-doped LTB single crystal exhibits different behaviour over a period of 7 days. Copyright © 2016 John Wiley & Sons, Ltd

Synthesis and molecular docking studies of 5-trifluoromethoxy-2-indolinones as cholinesterase dual inhibitors

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Adsorption of thorium (IV) ions by metal ion doped ZnO nanomaterial prepared with combustion synthesis: Empirical modelling and process optimization by response surface methodology (RSM)

Environmental problems have reached enormous dimensions, driving efforts to remove and recycle waste from energy and industrial production. In particular, removing the radionuclide contamination that occurs as the nuclear industry grows is difficult and costly, but it is vital. Technologic and economical methods and advanced facilities are needed for the separation and purification of radioactive elements arising from the nuclear industry and uranium and thorium mining. With the adsorption method, which is the most basic separation and recovery method, the use of high-capacity nanomaterials has recently gained great importance in reducing the activity of the waste, reducing its volume by transforming it into solid form, and recovering and removing liquid radioactive wastes that might harm the ecological environment. This study aimed to determine the adsorption properties of metal ion-doped nano ZnO (nano-ZnO:Al) material synthesized by the microwave-assisted gel combustion method for the adsorption of thorium (IV) from aqueous media. First, characterization processes such as XRD, SEM, BET and zeta potential were performed to observe changes in the host ZnO adsorbent structure caused by the doping process. Later, this was optimized via the response surface method (RSM), which is widely used in the characterization of the adsorption properties of thorium (IV) from aqueous solutions. Such characterization is commonly used in industrial research. We tested how pH (3-8), temperature (20-60 degrees C), Th (IV) concentration (25-125 mg/L) and adsorbent amount (0.01-0.1 g) affect adsorption efficiency. The best possible combinations of these parameters were determined by RSM. It was calculated by RSM that the design fits the second order (quadratic) model using the central composite design (CCD) for the design of experimental conditions. R-2 and R-2 adjusted values from the parameters showing the model fit were 0.9923 and 0.9856, respectively. According to the model, the experimental adsorption capacity was 192.3 mg/g for the doped-ZnO nanomaterial under the theoretically specified optimum conditions. Also, the suitability of Th (IV) adsorption to isotherms was examined and thermodynamic parameters were calculated.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1001-120M235]; Turkish Atomic Energy Authority (TAEK)Ministry of Energy & Natural Resources - TurkeyThe authors acknowledge grants from the Scientific and Technological Research Council of Turkey (TUBITAK, project number: 1001-120M235). All radionuclide adsorption experiments performed in the study were carried out in Ege University Institute of Nuclear Sciences, which is also a partner in the project, accredited by the Turkish Atomic Energy Authority (TAEK)

Eu3+ and Dy3+ doped La2MoO6 and La2Mo2O9 phosphors: Synthesis and luminescence properties

We report a detailed structural analysis and properties of the photoluminescence (PL) and thermoluminescence (TL) spectra of Eu3+ and Dy3+ incorporated into novel La2MoO6 and La2Mo2O9 phosphors synthesized successfully through gel combustion synthesis. The formation of a tetragonal phase and a cubic structure were verified for La2MoO6 and La2Mo2O9 phosphors via X-ray diffraction (XRD) studies. Dy doped samples exhibited blue and green emissions at 480 nm (F-4(9/2) -> H-6(15/2)) and 572 nm (F-4(9/2) -> H-6(13/2)), and also Eu doped samples showed a sharp emission peaks at 612 and 619 nm (D-5(0) -> F-7(2)) upon 349 nm pulse laser excitation. Peak shape (PS) technique was utilised to determine activation energy, frequency factor and order of kinetics associated with the main glow curves in undoped and Eu and Dy doped samples after X-ray irradiation. The present findings suggest that Eu and Dy incorporated La2MoO6 and La2Mo2O9 phosphors are highly auspicious candidates for applications in solid-state lighting

Synthesis and beta particle excited thermoluminescence of BaSiF6 phosphor

BaSiF6 phosphor was synthesized by a gel combustion method. The crystalline size was found to be 54.17 +/- 4.36 nm using Williamson-Hall (W-H) approximation. The TL data collected by means of a combination of a commercial BG39 and HC575/25 filters was studied to evaluate basic kinetic parameters. Three TL glow peaks of BaSiF6 phosphors are centered at around 84, 190 and 322 degrees C. T-m-T-stop, various heating rate (VHR) and computerized glow-curve deconvolution (CGCD) method were utilized to analyse collected data. Our findings indicate that luminescence process in scrutinized material may obey second order kinetics. The TL dose response of the TL glow peaks exhibits a linear characteristic up to 100 Gy. Deconvolution of the glow curve reveals that the number of the component TL glow peaks in the complex glow curve is composed of well-isolated six overlapping glow peaks. The FOM value is 2.32