Mobilizing for what? Polarized citizens and electoral turnout in transitioning Tunisia

In countries that have recently transitioned to democracy, what factors most drive citizens to mobilize and participate in early elections? Many comparative studies on democratization and elections stress the vital importance of early elections in new democracies – with voter turnout inexorably linked to a democracy’s long-term stability and legitimacy – however, much of this literature focuses on aggregate rather than individual-level behaviour, and very little targets the Middle East/North Africa region. This study closely examines individual voting behaviour in democratizing Tunisia’s critical second election in 2014. We argue that amidst great uncertainty, the polarizing issues of national and political identity created systematic disparities in participation – with the most ideologically polarized citizens/social groups more likely to vote. Using original data from a survey conducted in Tunisia right after its November 2014 elections, we find that Tunisians were sharply divided in their support for democracy, the previous regime, and Islamic governance. Specifically, Tunisians who were more ideologically polarized along its secular-Islamist divide and those more satisfied with the new democratic system were more likely to vote – overall suggesting somewhat uneven electoral participation in this critical election and, therefore, the potential for the kind of instability conducive to democratic breakdown

‘Wars of others’: National Cleavages and Attitudes Toward External Conflicts

Why do individuals sympathize with others’ wars, an antecedent of the decision to become a foreign fighter? By collecting original public opinion data from Lebanon, in 2015, and Turkey in 2017, about the actors of conflict in Syria, we test the argument that an ethno-religious cleavage at home shapes the proclivity of individuals to support others’ wars. Individuals may perceive a war abroad as endangering political and social balance of power at home – and hence own survival. Therefore, when transnational identities map onto a national cleavage, as in the Sunni–Shia cleavage in Lebanon, and Turk – Kurd cleavage in Turkey, individuals are more disposed to show sympathy for others’ wars both to help their kin and to protect the balance of power at home. Our findings imply that efforts to end the trend toward citizens becoming foreign fighters must start at home by mending the relations between ethnic and religious groups

ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients

BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and function in a Dock8-deficient mouse model. In this study, we sought to test whether DOCK8 is required for the function and maintenance of ILC subsets in humans

ILC3 deficiency and generalized ILC abnormalities in DOCK8‐deficient patients

BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and function in a Dock8-deficient mouse model. In this study, we sought to test whether DOCK8 is required for the function and maintenance of ILC subsets in humans

Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency

Background Biallelic loss-of-function mutations in CARMIL2 cause combined immunodeficiency associated with dermatitis, inflammatory bowel disease (IBD), and EBV-related smooth muscle tumors. Clinical and immunological characterizations of the disease with long-term follow-up and treatment options have not been previously reported in large cohorts. We sought to determine the clinical and immunological features of CARMIL2 deficiency and long-term efficacy of treatment in controlling different disease manifestations. Methods The presenting phenotypes, long-term outcomes, and treatment responses were evaluated prospectively in 15 CARMIL2-deficient patients, including 13 novel cases. Lymphocyte subpopulations, protein expression, regulatory T (Treg), and circulating T follicular helper (cT(FH)) cells were analyzed. Three-dimensional (3D) migration assay was performed to determine T-cell shape. Results Mean age at disease onset was 38 +/- 23 months. Main clinical features were skin manifestations (n = 14, 93%), failure to thrive (n = 10, 67%), recurrent infections (n = 10, 67%), allergic symptoms (n = 8, 53%), chronic diarrhea (n = 4, 27%), and EBV-related leiomyoma (n = 2, 13%). Skin manifestations ranged from atopic and seborrheic dermatitis to psoriasiform rash. Patients had reduced proportions of memory CD4(+) T cells, Treg, and cT(FH) cells. Memory B and NK cells were also decreased. CARMIL2-deficient T cells exhibited reduced T-cell proliferation and cytokine production following CD28 co-stimulation and normal morphology when migrating in a high-density 3D collagen gel matrix. IBD was the most severe clinical manifestation, leading to growth retardation, requiring multiple interventional treatments. All patients were alive with a median follow-up of 10.8 years (range: 3-17 years). Conclusion This cohort provides clinical and immunological features and long-term follow-up of different manifestations of CARMIL2 deficiency

Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency

Background Biallelic loss-of-function mutations in CARMIL2 cause combined immunodeficiency associated with dermatitis, inflammatory bowel disease (IBD), and EBV-related smooth muscle tumors. Clinical and immunological characterizations of the disease with long-term follow-up and treatment options have not been previously reported in large cohorts. We sought to determine the clinical and immunological features of CARMIL2 deficiency and long-term efficacy of treatment in controlling different disease manifestations. Methods The presenting phenotypes, long-term outcomes, and treatment responses were evaluated prospectively in 15 CARMIL2-deficient patients, including 13 novel cases. Lymphocyte subpopulations, protein expression, regulatory T (Treg), and circulating T follicular helper (cT(FH)) cells were analyzed. Three-dimensional (3D) migration assay was performed to determine T-cell shape. Results Mean age at disease onset was 38 +/- 23 months. Main clinical features were skin manifestations (n = 14, 93%), failure to thrive (n = 10, 67%), recurrent infections (n = 10, 67%), allergic symptoms (n = 8, 53%), chronic diarrhea (n = 4, 27%), and EBV-related leiomyoma (n = 2, 13%). Skin manifestations ranged from atopic and seborrheic dermatitis to psoriasiform rash. Patients had reduced proportions of memory CD4(+) T cells, Treg, and cT(FH) cells. Memory B and NK cells were also decreased. CARMIL2-deficient T cells exhibited reduced T-cell proliferation and cytokine production following CD28 co-stimulation and normal morphology when migrating in a high-density 3D collagen gel matrix. IBD was the most severe clinical manifestation, leading to growth retardation, requiring multiple interventional treatments. All patients were alive with a median follow-up of 10.8 years (range: 3-17 years). Conclusion This cohort provides clinical and immunological features and long-term follow-up of different manifestations of CARMIL2 deficiency