Hearing Evaluation in Solid Waste Workers

Introduction: Hearing loss at work is currently considered the most common cause of permanent hearing loss in adults and one of the most important health problems with economic and psychosocial consequences. The present study has the aim to investigate the prevalence and the determinants of hearing loss among electro production workers. Material and methods: Eight-three (83) solid waste workers underwent audiometric test in the facilities of the Integrated Solid Waste Management Facility (OEDA). For the assessment of hearing, the findings of the audiometers were evaluated, first with the performance of the diagnosis on the pathological findings and then with the use of diagnostic criteria (NIOSH, OYDOS) and includes occupational history, otoscopy and audiogram. Findings: Statistical analysis has shown that 23% of solid waste workers had sensorineural hearing loss located mainly at 4000 Hz. Multivariate analysis confirmed that the intensity of occupational exposure to noise appears to be the strongest predictor of noise-induced hearing loss (p=0.02326) followed by the years of work (p=0.02728). Particularly, the analysis with the NIOSH criterion (probability of having a positive NIOSH criterion in at least 1 of both ears) increased by 1.33 times/year or 32.84%/year on average. Finally, no univariate statistically significant associations were found with any of the two criteria and smoking, BMI, hypertension or tinnitus Estimating exposure through self-reported data is not sufficient and accurate and in fact workers who are exposed to higher risk measures tend to underestimate the risk. Conclusion: Our findings indicate that solid waste workers are occupationally exposed to high levels of noise, and present high rates of noise-induced hearing loss (NIHL). It is necessary to estimate the noise exposure with appropriate measurements in the work environment (individual sound exposure of employees and environmental measurements in the workplace) and take appropriate measures.                                        &nbsp

EXPLORING THE ADOPTION OF UBIQUITOUS INFORMATION SYSTEMS WITHIN THE MUSEUM CONTEXT

Wireless and mobile technologies are gradually enabling the provision of innovative information services within almost all environments. This study explores the adoption of ubiquitous museum information systems that can significantly enhance and enrich the museum visit. We draw on traditional IS adoption theories and theories from Museum Studies to develop our theoretical model which is empirically tested through a survey addressed to museum visitors (n=118). Model hypotheses are tested through Partial Least Squares modelling. The results show that Performance Expectancy and Personal Innovativeness still represent the core predictors toward the adoption of museum information systems. However, we also report on the predictive strength of two context-related factors, Invisibility and Interaction, which appear to play a particular role toward the formulation of favourable user perceptions. The paper concludes with implications on the design of museum information systems and specific suggestions for future research

Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy

X-linked Charcot-Marie-Tooth disease type 1 (CMT1X) is a demyelinating neuropathy resulting from loss-of-function mutations affecting the GJB1/connexin 32 (Cx32) gene. We previously showed functional and morphological improvement in Gjb1-null mice following AAV9-mediated delivery of human Cx32 driven by the myelin protein zero (Mpz) promoter in Schwann cells. However, CMT1X mutants may interfere with virally delivered wild-type (WT) Cx32. To confirm the efficacy of this vector also in the presence of CMT1X mutants, we delivered AAV9-Mpz-GJB1 by lumbar intrathecal injection in R75W/Gjb1-null and N175D/Gjb1-null transgenic lines expressing Golgi-retained mutations, before and after the onset of the neuropathy. Widespread expression of virally delivered Cx32 was demonstrated in both genotypes. Re-establishment of WT Cx32 function resulted in improved muscle strength and increased sciatic nerve motor conduction velocities in all treated groups from both mutant lines when treated before as well as after the onset of the neuropathy. Furthermore, morphological analysis showed improvement of myelination and reduction of inflammation in lumbar motor roots and peripheral nerves. In conclusion, this study provides proof of principle for a clinically translatable gene therapy approach to treat CMT1X before and after the onset of the neuropathy, even in the presence of endogenously expressed Golgi-retained Cx32 mutants

On the use of polymer gels for assessing the total geometrical accuracy in clinical Gamma Knife radiosurgery applications

The nearly tissue equivalent MRI properties and the unique ability of registering 3D dose distributions of polymer gels were exploited to assess the total geometrical accuracy in clinical Gamma Knife applications, taking into account the combined effect of the unit’s mechanical accuracy, dose delivery precision and the geometrical distortions inherent in MR images used for irradiation planning. Comparison between planned and experimental data suggests that the MR-related distortions due to susceptibility effects dominate the total clinical geometrical accuracy which was found within 1 mm. The dosimetric effect of the observed sub-millimetre uncertainties on single shot GK irradiation plans was assessed using the target percentage coverage criterion, and a considerable target dose underestimation was found

Management of KPC-Producing Klebsiella pneumoniae Infections

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7

Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7, are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to utilize the regenerative potential of muscle stem cells for therapeutic purposes so far failed. We previously established the existence of human PAX7-positive cell colonies with high regenerative potential. We now identified PAX7-negative human muscle-derived cell colonies also positive for the myogenic markers desmin and MYF5. These include cells from a patient with a homozygous PAX7 c.86-1G > A mutation (PAX7null). Single cell and bulk transcriptome analysis show high intra- and inter-donor heterogeneity and reveal the endothelial cell marker CLEC14A to be highly expressed in PAX7null cells. All PAX7-negative cell populations, including PAX7null, form myofibers after transplantation into mice, and regenerate muscle after reinjury. Transplanted PAX7neg cells repopulate the satellite cell niche where they re-express PAX7, or, strikingly, CLEC14A. In conclusion, transplanted human cells do not depend on PAX7 for muscle regeneration

Towards a grapho-phonologically parsed corpus of medieval Scots:Database design and technical solutions

This paper presents a newly constructed corpus of sound-to-spelling mappings in medieval Scots, which stems from the work of the From Inglis to Scots (FITS) project. We have developed a systematic approach to the relationships between individual spellings and proposed sound values, and recorded these mutual links in a relational database. In this paper, we introduce the theoretical underpinnings of sound-to-spelling and spelling-to-sound mappings, and show how a Scots root morpheme undergoes grapho-phonological parsing, the analytical procedure that is employed to break down spelling sequences into sound units. We explain the data collection and annotation for the FITS Corpus (Alcorn et al., forthcoming), drawing attention to the extensive meta-data which accompany each analysed unit of spelling and sound. The database records grammatical and lexical information about the root, the positional arrangement of segments within the root, labels for the nuclei, vowels and consonants, the morphological context, and extra-linguistic detail of the text a given root was taken from (date, place and text type). With this wealth of information, the FITS corpus is capable of answering complex queries about the sound and spelling systems of medieval Scots. We also suggest how our methodology can be transferred to other non-standardised spelling systems

On the implementation of a recently proposed dosimetric formalism to a robotic radiosurgery system

The aim of this work is to implement a recently proposed dosimetric formalism for nonstandard fields to the calibration and small field output factor measurement of a robotic stereotactic radiosurgery system