Limb Necrosis in a Lung Cancer Case Presenting with Widespread Thrombosis

The malignancies are commonly associated with enhanced thrombotic vascular events. The thrombotic events are also increased in lung cancer subtypes. Even, the systemic mortal thrombotic disorders were reported in the literature. We report a case of a nonsmall-cell carcinoma patient who progressed with widespread thrombosis

Bir yüzbaşının gözünden Kıbrıs Barış Harekâtı

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Özer, Abdürrahim

Colchicine for cardiovascular therapy: A drug interaction perspective and a safety meta-analysis

Objective: In this study, we aimed to overview the drug interactions between colchicine and cardiovascular drugs and performed a meta-analysis to evaluate the safety profile of colchicine in cardiovascular treatment

The Value Of Mean Platelet Volume In The Determination Of Community Acquired Pneumonia In Children

Background Mean platelet volume (MPV) is a reflection of platelet size, which has been shown to correlate with platelet function and activation. The aim of this study was to evaluate whether MPV could be used for the diagnostic tool of community-acquired pneumonia (CAP) and for making the decision for hospitalization. Methods The computerized records of children aged 1 to 18 years who were diagnosed with CAP based on WHO criteria were evaluated. A standard protocol was followed, and patients with severe CAP were hospitalized. CAP patients were divided into two groups based on disease severity. The control group consisted of age and gender matched healthy children during the study period. Values for hemoglobin, white blood cell count (WBC), platelet count, MPV and C-reactive protein (CRP) obtained on first presentation were recorded for each patient. Results A total of 196 patients were diagnosed with CAP during the study period, 108 (55.1%) of which had severe disease, which required hospitalization (Group 1a), while the remaining 88 (44.9%) were followed-up as outpatients (Group 1b). The control group consisted of 100 healthy children (Group 2). Patients with CAP had lower MPV values than their healthy counterparts (7.1±0.68 vs. 8.31±1.2 fL; p<0.001). MPV value was significantly higher in hospitalized CAP patients compared to outpatients (7.32±0.71 vs. 6.83±0.5 fL; p=0.012). ROC curve analysis suggested that MPV level cut-off point for making a diagnosis of CAP was 8.1 fL, with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 91%, 51%, 80.8% and 70.5%, respectively. Conclusions Our findings suggest that MPV may be a useful predictor for diagnosed CAP but low specificity and NPV rates may lead to the false-negative diagnosis.PubMedWoSScopu

Determination and clinical correlation of markers of inflammation in unvaccinated patients with varicella-zoster infection

BACKGROUND: Chicken pox is commonly known as a benign exenthamatous disease of childhood, occasionally neurologic or hemorrhagic complications, or even death may ensue. Early predictors of severity of disease have yet to be identified. TNF-alpha and IL-6 stimulate virus-specific immunoglobulin production and it has been postulated that determination of levels of these cytokines may be useful as a prognostic factor. PATIENTS AND METHODS: Patients who were diagnosed with a varicella-zoster virus (VZV) infection in the Outpatient Clinic of the Department of Pediatric Infectious Diseases were evaluated for eligibility. Laboratory assays included an evaluation of complete blood counts, erythrocyte-sedimentation rate (ESR), c reactive protein (CRP), and the number of tumor necrosis factor-alpha/interleukin- 6-(TNF-alpha/IL-6-) producing mononuclear cells as determined by flow cytometry. RESULTS: A total of 339 patients (320 with chickenpox and 19 with shingles) were enrolled. Blood samples could only be obtained from 81 of the 320 patients with chickenpox. Patients were also divided into three groups depending on the number of skin (vesicular) lesions. (group 1, = 50 lesions; group 2, 51-100 lesions; group 3, >100 lesions). Correlation analyses did not reveal the presence of a statistically significant correlation between number of skin lesions with either of white blood cells (WBC) count (p = 0.231), ESR (p = 0.879) or CRP (p = 0.373). The mean percentage of TNF-alpha-producing mononuclear cells was significantly higher in group 2 compared to group 3 (p = 0.003). A similar difference was observed with regard to IL-6- producing mononuclear cells, albeit bordering on statistical significance (p = 0.058). CONCLUSIONS: Decreased expression of the cytokines TNF-alpha and IL-6 may be responsible for the development of a more severe clinical picture in patients with VZV infection, and determination of intracellular levels of these cytokines may be of benefit for early identification of patients who may have a more severe clinical course

Length of hospital stay and management of facial cellulitis of odontogenic origin in children

PURPOSE: This study's purpose was to assess characteristics of pediatric patients with odontogenic-based facial cellulitis, treatment strategies, and their relationship to length of stay (LOS). METHODS: This retrospective study was performed on individuals younger than 18 years old who were hospitalized for facial cellulitis of odontogenic origin (FCOO). Medical records were reviewed for all patients with a discharge diagnosis of FCOO or buccal cellulitis. Patients' clinical characteristics were evaluated and assessed for their relationship to LOS. RESULTS: A total of 106 children were diagnosed with FCOO. LOS was significantly shorter in patients who had a tooth extracted within 48 hours versus patients who had a tooth extracted at 48 hours or longer (P=.007). LOS was significantly shorter in patients with upper face and left face infections than lower face infections (P=.01) and right face infections (P=.01), respectively. Patients with a primary first molar infection had the shortest LOS; patients with a white blood cell count less than 10,000 cells/mm3 had shorter LOS. CONCLUSIONS: Early tooth extraction may decrease the length of stay in management of pediatric facial cellulitis of odontogenic origin. The type of tooth involved and white blood cell count at admission have a significant impact on length of stay