The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients

Reverse dipper hypertension and neutrophil to lymphocyte ratio (NLR) has been investigated as a predictor for cardiovascular risk. The relationship between NLR and other circadien blood pressure (BP) patterns has been showed. The aim of this study was to investigate the relation between NLR and BP reverse dipper pattern in patients with hypertension. 144 hypertensive patients (66 males, 78 females) were enrolled the study. BP patterns were evaluated with 24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividing neutrophil count to lymhocyte count. There was significantly increased NLR in reverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040 ). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021) and diastolic BP( r=-0,160; p=0,057). Our study provides a possible association between NLR and reverse dipper pattern, but to report NLR as an independent predictor of reverse dipper pattern further studies are requiredRevers dipper hipertansiyon ve nötrofil/lenfositoranı(NLR),kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır.NLR ve diğer sirkadyen kanbasıncı paternleri arasındaki ilişki gösterilmiştir.Bu çalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile revers dipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir.Çalışmaya 144 (66erkek,78kadın) hipertansif hasta alındı.Kan basıncı paternleri 24 saat ambulatuar kan basıncı ile değerlendirildi.Nötrofil lenfosit oranı,nötrofil sayısı lenfosit sayısına bölünerek ölçüldü.Revers dipper hipertansiyonlularda dipper hipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı. (sırasıyla2.36±1,68ve1,81±0,69,p=0,040). Nötrofil lenfosit oranı ile sistolik (r=-0,193;p=0.021vediyastolik(r=-0,160;p=0,057)kan basıncı düşme oranları arasında negatif korelasyon vardı.Çalışmamız NLR ve revers dipper patern arasında olası bir ilişki sunmaktadır ancak nötrofil lenfositoranını,revers dipper paternin bağımsız öngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir

Rola krążącego sTWEAK w patogenezie choroby Hashimoto — badanie pilotażowe

  Introduction: We aimed to investigate the role of sTWEAK in the pathogenesis of Hashimoto’s thyroiditis, which is a chronic inflammatory autoimmune disease. Material and methods: A total of 80 patients were included in the study, 60 of whom were newly diagnosed with Hashimoto’s thyroiditis (20 patients in each of the euthyroid, subclinical hypothyroid, and overt hypothyroid subgroups), and 20 of whom were healthy volunteers. Thyroid function tests and autoantibodies were measured using the electro-chemiluminescence immunoassay method, and sTWEAK, IL-17A, IL-12, and TGF-beta1 were measured using enzyme-linked immunosorbent assay method. Results: The Hashimoto’s Thyroiditis group had lower levels of sTWEAK and TGF-beta1, but had higher levels of IL-12 and IL-17A as compared to the control group. Of these, only the difference between IL-17A levels reached statistical significance (2.1 pg/mL vs. 1.8 pg/mL, respectively; p < 0.001). While the levels of sTWEAK were similar in the control, euthyroid, and subclinical groups, the overt hypothyroidism group had lower level of sTWEAK than that of subclinical hypothyroidism (687.6 ± 153.3 pg/mL vs. 888.2 ± 374.4 pg/mL, respectively; p = 0.03). A negative correlation was determined between sTWEAK level and anti-TPO (r = –0.533, p = 0.028) and IL-17A (r = –0.600, p = 0.005) levels in the overt hypothyroidism group. Conclusions: The reduced levels of sTWEAK with progression of Hashimoto’s Thyroiditis and the significant correlation between the sTWEAK levels and anti-TPO found in this study suggest that sTWEAK plays an active role in chronic inflammation in the pathogenesis of Hashimoto’s Thyroiditis and in the progression of autoimmunity. (Endokrynol Pol 2016; 67 (6): 562–566)    Wstęp: Badanie przeprowadzono w celu ustalenia roli sTWEAK w patogenezie zapalenia tarczycy Hashimoto, przewlekłej zapalnej choroby autoimmunologicznej. Materiał i metody: Do badania włączono łącznie 80 chorych, w tym 60 osób z nowo rozpoznaną chorobą Hashimoto (po 20 chorych w podgrupach z eutyreozą, subkliniczną niedoczynnością tarczycy i jawną niedoczynnością tarczycy) i 20 zdrowych ochotników. Badania czynności tarczycy oraz oznaczenia stężenia autoprzeciwciał przeprowadzono przy użyciu metod elektrochemiluminescencji, a stężenia sTWEAK, IL-17A, IL-12 i TGF-beta1 oznaczono za pomocą testów enzymatycznych. Wyniki: W grupie osób z chorobą Hashimoto stężenia sTWEAK i TGF-beta1 były niższe, a stężenia IL-12 i IL-17A wyższe niż w grupie kontrolnej. Jednak tylko różnice między stężeniami IL-17A osiągnęły poziom istotności statystycznej (odpowiednio 2,1 pg/ml vs. 1,8 pg/ml; p < 0,001). Podczas gdy stężenia sTWEAK były podobne w grupach kontrolnej, z eutyreozą i z subkliniczną niedoczynnością tarczycy, stężenia sTWEAK w grupie z jawną niedoczynnością tarczycy były niższe niż u osób z subkliniczną niedoczynnością tarczycy (odpowiednio 687,6 ± 153,3 pg/ml vs. 888,2 ± 374,4 pg/ml; p = 0,03). Stwierdzono ujemną korelację między stężeniem sTWEAK a stężeniami przeciwciał przeciw TPO (r = –0,533; p = 0,028) oraz IL-17A (r = –0,600; p = 0.005) w grupie z jawną niedoczynnością tarczycy. Wnioski: Obniżanie się stężenia sTWEAK z progresją choroby Hashimoto oraz istotna korelacja między stężeniem sTWEAK a stężeniem przeciwciał przeciw TPO stwierdzone w tym badaniu wskazują, że sTWEAK odgrywa aktywną rolę w przewlekłym zapaleniu w patogenezie choroby Hashimoto, a także w progresji autoagresji. (Endokrynol Pol 2016; 67 (6): 562–566)

MEME GÖRÜNTÜLEMEDE MAMOGRAFİNİN YERİ VE GÜNCEL YAKLAŞIMLAR

Mamografi genellikle 40 yaş ve üstü kadınlarda meme kanserinde ana tarama yöntemi olarak kullanılmakta olup, erken teşhis, buna bağlı yaşam beklentisi ve tedavi başarı oranlarını yükseltmektedir (Swedish Organised Service Screening Evaluation Group, 2006)

DEVRALMANIN DEVRALAN İŞLETMELERİN HİSSE SENEDİ GETİRİLERİ ÜZERİNDEKI ETKİSİ: SERMAYE PİYASASI KURULU İZNİ İLE GERÇEKLEŞEN DEVRALMALARIN DEVRALAN İŞLETMELERİN HİSSE SENEDİ GETİRİ ORANLARI ÜZERİNDEKİ ETKİSİNİN İNCELENMESİ

Birleşme, hukuki açıdan bağımsız, iki ya da daha fazla firmanın ekonomik ve hukuki yönden bütünleşmesini ifade eder. Satın alma ise, firmanın tüm aktif ve pasifleriyle birlikte satın alan firmaya devredilmesidir. Literatürde birleşme ve satın alma kavramları birbiri yerine kullanılmaktadır. Firmalar büyüme, sinerji yaratma, rekabet avantajı sağlama, çeşitlendirme, firma değerini artırma gibi nedenlerle birleşmeye yönelirler. Birleşme ve satın almalar bazı durumlarda satın alan firma hissedarları, bazı durumlarda ise satın alınan firma hissedarları lehine olmaktadır.Birleşmeden elde edilen kazanç, birleşmenin türüne ve ödeme şekline bağlı olarak da değişmektedir. Bu araştırmada, İMKB'de işlem görüp, SPK izniyle satın alma işlemi gerçekleştiren 40 firmanın halka sunulan bilgileri doğrultusunda, satın alma sonrası elde tutma anormal getirileri ve kümülatif anormal getirileri hesaplanmıştır.Firmaların satın alma sonrası anormal getirilerinin istatistiksel olarak anlamlı olmadığı sonucuna ulaşılmıştır. Ayrıca satın alan firmaların ödemede kullandığı dört yöntemin; satın alma sonrası 1 aylık, 3 aylık, 6 aylık, 1 yıllık ve 2 yıllık elde tutma anormal getiri oranları ortalamaları ve kümülatif anormal getiri oranları ortalamaları açısından bir farlılık yaratmadığı belirlenmiştir. Anormal getirileri hesaplamada kullanılan yöntemlerin de satın alma sonrası getiriler de bir farklılık yaratmadığı belirlenmiştir

BEYİN TÜMÖRÜ TANISI İÇİN YAPAY ZEKA STRATEJİLERİ MR'DA SEGMENTASYON VE SINIFLANDIRMA STRATEJİLERİ

Beyin tümörü, toplumda her geçen gün daha yaygın hale gelen en ölümcül hastalıklardan biridir. Yapılan istatistiksel çalışmalarda beyin tümörünün dünyadaki yayılımının her geçen gün daha geniş kitlelere ulaştığı görülmektedir (Kaplan, 2020)

Evaluation of Rosenmuller Fossa with cone beam computed tomography: A retrospective radio-anatomical study

Background: Rosenmuller fossa (RF) is known as a lateral pharyngeal recess, is bilaterally located beneath the skull base and behind the torus tubarius. Nasopharyngeal carcinoma is most commonly located in the RF. The purpose of this study is to evaluation of RF with cone beam computed tomography Methods: A total of 150 subjects (80 females, 70 males, 6-88 years) were included in the study. Subjects were divided into age groups (6- 20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years, over 60 years) and gender. Result: There is no statistically significant difference between class (RF type) and gender (p = 0.086). There is a statistically significant association between the categories of age group and class variables (p = 0.015). RF type 1 was more common in the 6-20 age and 21-30 age groups, whereas RF type 3 was more common in the 41-50 age and 51-60 age groups. Conclusion: When the literature was investigated, it was not found a study evaluating RF with cone beam computed tomography. When considering clinical significance, RF should be searched and examined in larger populations. KEYWORDS  Cone beam computed tomography, Rosenmuller  Fossa, Nasopharyngeal Carcinom

New applications and developments in the neutron shielding

Shielding neutrons involve three steps that are slowing neutrons, absorption of neutrons, and impregnation of gamma rays. Neutrons slow down with thermal energy by hydrogen, water, paraffin, plastic. Hydrogenated materials are also very effective for the absorption of neutrons. Gamma rays are produced by neutron (radiation) retention on the neutron shield, inelastic scattering, and degradation of activation products. If a source emits gamma rays at various energies, high-energy gamma rays sometimes specify shielding requirements. Multipurpose Materials for Neutron Shields; Concrete, especially with barium mixed in, can slow and absorb the neutrons, and shield the gamma rays. Plastic with boron is also a good multipurpose shielding material. In this study; new applications and developments in the area of neutron shielding will be discussed in terms of different materials

Identification and Synthesis of a Male-Produced Pheromone for the Neotropical Root Weevil Diaprepes abbreviatus

An unsaturated hydroxy-ester pheromone was isolated from the headspace and feces of male Diaprepes abbreviatus, identified, and synthesized. The pheromone, methyl (E)-3-(2-hydroxyethyl)-4-methyl-2-pentenoate, was discovered by gas chromatography-coupled electroantennogram detection (GC-EAD), and identified by gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). The synthesis yielded an 86:14 mixture of methyl (E)-3-(2-hydroxyethyl)-4-methyl-2-pentenoate (active) and methyl (Z)-3-(2-hydroxyethyl)-4-methyl-2-pentenoate (inactive), along with a lactone breakdown product. The activity of the synthetic E-isomer was confirmed by GC-EAD, GC-MS, NMR, and bioassays. No antennal response was observed to the Z-isomer or the lactone. In a two-choice olfactometer bioassay, female D. abbreviatus moved upwind towards the synthetic pheromone or natural pheromone more often compared with clean air. Males showed no clear preference for the synthetic pheromone. This pheromone, alone or in combination with plant volatiles, may play a role in the location of males by female D. abbreviatus