Understanding Public Opinions on Social Media about ChatGPT – A deep Learning Approach for Sentiment Analysis

User-generated multimedia content—photos, text, videos, and audio—is becoming more and more common on social networking sites to allow individuals to express their thoughts. One of the largest and most advanced social media platform discussing ChatGPT is Twitter. This is because Twitter updates are constantly being produced and have a limited duration. The deep learning method for sentiment analysis of Twitter data about ChatGPT evaluation is presented in this research. This study used 4-class labels (sadness, joy, fear, and anger) from public Twitter data stored in the Kaggle database. The proposed deep learning strategy significantly improves the efficiency metrics determined by the use of the attention layer in current LSTM-RNN approaches, increasing accuracy by 20% and precision by 10-12%, but recall only 12-13%. Out of 18000 ChatGPT-related tweets, positive, neutral, and negative sentiments accounted for a respective 45%, 30%, and 35%. It is determined that the suggested deep learning technique for ChatGPT review sentiment categorization is effective, realistic, and fast to deploy

ANTI-INFLAMMATORY, ANTI-NOCICEPTIVE AND ANTIPYRETIC POTENTIAL OF TERMINALIA CITRINA FRUIT EXTRACTS

Background: Plants and herbs have long been used as remedies without scientific evidences. The objective of the present study was to explore the anti-inflammatory, anti-nociceptive and antipyretic potential of ethanolic and aqueous extracts of Terminalia citrina fruits in mice. Materials and Methods: Extracts of Terminalia citrina fruits were evaluated at doses of 200mg/kg, 400mg/kg and 600mg/kg in albino mice for preventive effect in inflammatory edema, peripheral pain sensation and pyrexia. Carrageenan induced paw edema method was utilized to evaluate anti-inflammatory activity. Analgesic appraisal of extracts was demonstrated using acetic acid induced writhing model of pain. Antipyretic potential was determined by brewer’s yeast induced pyrexia model. Statistical analysis was conducted by ANOVA following post hoc test. Results: Both extracts exhibited significant and dose-dependent anti-inflammatory, analgesic and antipyretic activities. The ethanolic extract was more effective in reducing inflammatory edema, pyrexia and pain sensation than aqueous extracts in all tested doses. Conclusion: It can be concluded that fruit extracts of Terminalia citrina may be effective in reducing inflammation, pyrexia and pain sensation in animals

The Reading Preferences of Primary School Children in Lahore

The scope of this study aims at investigating reading preferences of children of Lahore city, which is the capital of Punjab province-Pakistan. It was assumed that proper attention towards providing reading opportunities to primary school students (First -Fifth grade) in Pakistan is vital while inculcating reading habits at that tender age. The study was conducted on 300 primary school students. A target group of 300 primary school students was selected for this study. Mainly survey method based on administered questionnaire was used to collect quantitative data from young students. The findings suggested that the children prefer to read locally published printed material in English. Respondents were found interested in reading short stories. (Fiction books, narrating adventure stories remained their favorite. On basis of the findings, the study furnishes suggestions for parents, teachers and school librarians, along with the local publishers for playing their effective role in developing reading habits and addresses the barriers in this regard

The Reading Preferences of Primary School Children in Lahore

The scope of this study aims at investigating reading preferences of children of Lahore city, which is the capital of Punjab province - Pakistan. It was assumed that proper attention towards providing reading opportunities to primary school students (First - Fifth grade) in Pakistan is vital while inculcating reading habits at that tender age. The study was conducted on 300 primary school students. A target group of 300 primary school students was select ed for this study. Mainly survey method based on administered questionnaire was used to collect quantitative data from young students. The findings suggested that the children prefer to read locally published printed material in English. Respondents were f ound interested in reading short stories. (Fiction books, narrating adventure stories remained their favorite. On basis of the findings, the study furnishes suggestions for parents, teachers and school librarians, along with the local publishers for playin g their effective role in developing reading habits and addresses the barriers in this regard

Investigating the role of economic integration and financial development: Rebound effect and green ICT in BRICS

The increasing trend of information and communication technology (ICT) forced researchers and policymakers to check the direct and indirect effects of information and communication technology on environmental quality. This study explores the relationship between information and Communication Technology and ecological quality by including the ICT and the interaction term of ICT with financial development indicators. The study uses the data for the BRICS (Brazile, Russia, India, China, and South Africa) economies from 1996 to 2020. This study is a pioneering effort to identify the independent and overlapping effects of information and communication technology (ICT) and financial development indicators on environmental quality. Further, the study uniquely tried to explore the shape of a modified environmental Kuznets curve (EKC) based on ICT by introducing the squared term of ICT in the model. Driscoll Kraay's standard error analysis confirmed a positive significant relationship between ICT and environmental quality. Our findings, among other things, show that in Brazil, China, and South Africa, the finance, environment, and the effects of ICT interact, whereas, in India and Russia, there is no such evidence. To increase the benefits of ICT to the environment, policymakers in Brazil, China, and South Africa should take additional steps to improve their financial sectors. The ICT-based environmental Kuznets curve validated the inverted U shape EKC hypothesis. The study findings suggested that green innovation and technology should be introduced in information and communication technology to mitigate the harmful effect of human activities on the environment

Inferring Therapeutic Targets in <i>Candida albicans</i> and Possible Inhibition through Natural Products: A Binding and Physiological Based Pharmacokinetics Snapshot

Despite being responsible for invasive infections, fungal pathogens have been underrepresented in computer aided therapeutic target mining and drug design. Excess of Candida albicans causes candidiasis, causative of thrush and vaginal infection due to off-balance. In this study, we attempted to mine drug targets (n = 46) using a subtractive proteomic approach in this pathogenic yeast and screen natural products with inhibition potential against fructose-bisphosphate aldolase (FBA) of the C. albicans. The top compound selected on the basis of best docking score from traditional Indian medicine/Ayurvedic library was (4-Hydroxybenzyl)thiocarbamic acid, from the ZINC FBA inhibitor library was ZINC13507461 (IUPAC name: [(2R)-2-hydroxy-3-phosphonooxypropyl] (9E,12E)-octadeca-9,12-dienoate), and from traditional Tibetan medicine/Sowa rigpa was Chelerythrine (IUPAC name: 1,2-Dimethoxy-12-methyl-9H-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium), compared to the control (2E)-1-(4-nitrophenyl)-2-[(4-nitrophenyl)methylidene]hydrazine. No Ames toxicity was predicted for prioritized compounds while control depicted this toxicity. (4-Hydroxybenzyl)thiocarbamic acid showed hepatotoxicity, while Chelerythrine depicted hERG inhibition, which can lead to QT syndrome, so we recommend ZINC13507461 for further testing in lab. Pharmacological based pharmacokinetic modeling revealed that it has low bioavailability and hence, absorption in healthy state. In cirrhosis and renal impairment, absorption and plasma accumulation increased so we recommend further investigation into this occurrence and recommend high dosage in further tests to increase bioavailability

Social Health Protection in Pakistan Emerging Evidence and Way Forward: A Scoping Review

Social health protection (SHP) refers to government and non-governmental programs and policies that help individuals and families cope with and overcome impoverishing health expenditures1. Evidence suggests that establishing robust SHP systems is critical for achieving universal health coverage and protecting vulnerable populations from catastrophic healthcare costs