727 research outputs found
Development of wirelessly-powered, extracranial brain activator (ECBA) in a large animal model for the future non-invasive human neuromodulation
As transcranial electrical stimulation (tES) is an emerging and promising technique for neuromodulation, we developed a novel device; wirelessly-powered, extracranial brain activator (ECBA), which is mounted subcutaneously, and its neuromodulation effect was investigated. The oscillatory changes in electrocorticography (EcoG) were analyzed from two types of stimulation. Two weeks prior to the recording experiment, we underwent surgery for implantation of subdural strips and ECBA module over centroparietal regions of anesthetized beagles. Low-frequency stimulation (LFS) and subsequent high-frequency stimulation (HFS) protocols (600 pulses respectively) were applied. Then, the power changes before and after each stimulation in five different bands were compared. A significantly larger voltage difference with subcutaneous than transcutaneous stimulation measured at EcoG channels indicated a substantial current attenuation between the skin and skull. Compared with the baseline, all subjects showed consistently decreased delta power and increased gamma power after HFS. LFS also induced a similar, but opposite, pattern of power change in four beagles. The results from this study indicate that LFS and HFS with our novel ECBA can consistently and effectively modulate neural activity of the cortex, inducing neural inhibition and facilitation functions, respectively. Future studies are necessary to further ensuring a consistent efficacy and long-term safety.11Ysciescopu
Kondo effect in systems with dynamical symmetries
This paper is devoted to a systematic exposure of the Kondo physics in
quantum dots for which the low energy spin excitations consist of a few
different spin multiplets . Under certain conditions (to be
explained below) some of the lowest energy levels are nearly
degenerate. The dot in its ground state cannot then be regarded as a simple
quantum top in the sense that beside its spin operator other dot (vector)
operators are needed (in order to fully determine its quantum
states), which have non-zero matrix elements between states of different spin
multiplets . These "Runge-Lenz"
operators do not appear in the isolated dot-Hamiltonian (so in some sense they
are "hidden"). Yet, they are exposed when tunneling between dot and leads is
switched on. The effective spin Hamiltonian which couples the metallic electron
spin with the operators of the dot then contains new exchange terms,
beside the ubiquitous ones . The operators and generate a
dynamical group (usually SO(n)). Remarkably, the value of can be controlled
by gate voltages, indicating that abstract concepts such as dynamical symmetry
groups are experimentally realizable. Moreover, when an external magnetic field
is applied then, under favorable circumstances, the exchange interaction
involves solely the Runge-Lenz operators and the corresponding
dynamical symmetry group is SU(n). For example, the celebrated group SU(3) is
realized in triple quantum dot with four electrons.Comment: 24 two-column page
Ab initio atomistic thermodynamics and statistical mechanics of surface properties and functions
Previous and present "academic" research aiming at atomic scale understanding
is mainly concerned with the study of individual molecular processes possibly
underlying materials science applications. Appealing properties of an
individual process are then frequently discussed in terms of their direct
importance for the envisioned material function, or reciprocally, the function
of materials is somehow believed to be understandable by essentially one
prominent elementary process only. What is often overlooked in this approach is
that in macroscopic systems of technological relevance typically a large number
of distinct atomic scale processes take place. Which of them are decisive for
observable system properties and functions is then not only determined by the
detailed individual properties of each process alone, but in many, if not most
cases also the interplay of all processes, i.e. how they act together, plays a
crucial role. For a "predictive materials science modeling with microscopic
understanding", a description that treats the statistical interplay of a large
number of microscopically well-described elementary processes must therefore be
applied. Modern electronic structure theory methods such as DFT have become a
standard tool for the accurate description of individual molecular processes.
Here, we discuss the present status of emerging methodologies which attempt to
achieve a (hopefully seamless) match of DFT with concepts from statistical
mechanics or thermodynamics, in order to also address the interplay of the
various molecular processes. The new quality of, and the novel insights that
can be gained by, such techniques is illustrated by how they allow the
description of crystal surfaces in contact with realistic gas-phase
environments.Comment: 24 pages including 17 figures, related publications can be found at
http://www.fhi-berlin.mpg.de/th/paper.htm
Balanço do nitrogênio e fósforo em solo com cultivo orgânico de hortaliças após a incorporação de biomassa de guandu.
Os objetivos deste trabalho foram avaliar os efeitos de faixas de guandu (Cajanus cajan) e da incorporação da biomassa proveniente de sua poda na fertilidade do solo e na produtividade de três hortaliças sob cultivo orgânico. O delineamento usado foi de blocos casualizados completos em esquema de parcelas subsubdivididas com três repetições. As produtividades de beterraba, cenoura e feijão-de-vagem não foram afetadas pelos tratamentos. Nas parcelas onde não houve incorporação da biomassa de guandu, o balanço de nitrogênio no sistema foi negativo, ao passo que com a incorporação, esse balanço foi positivo. Embora tenha ocorrido balanço positivo para o fósforo nas parcelas sem a incorporação de biomassa de guandu, houve um aumento significativo na absorção desse elemento pelas hortaliças quando o material foi incorporado. O sistema de cultivo em aléias de guandu pode representar uma prática vantajosa para os produtores orgânicos, por contribuir na manutenção da fertilidade do solo
Best-Effort Patching for Multicast True VoD Service
A multicast Video-on-Demand (VoD) system allows clients to share a server stream by batching their requests, and hence, improves channel utilization. However, it is very difficult to equip such a VoD system with full support for interactive VCR functions which are important to a growing number of Internet applications. In order to eliminate service (admission) latency, patching was proposed to enable an existing multicast session to dynamically add new clients, and requests can be served without delay if patching channels are available. A true VoD (TVoD) service should support not only zero-delay client admission but also continuous VCR-like interactivity. However, the conventional patching is only suitable for admission control. We propose a new patching scheme, called Best-Effort Patching (BEP), that offers a TVoD service in terms of both request admission and VCR interactivity. Moreover, by using a novel dynamic merging algorithm, BEP significantly improves the efficiency of TVoD interactivity, especially for popular videos. We also model and evaluate the efficiency of the dynamic merging algorithm. It is shown that BEP outperforms the conventional TVoD interaction protocols.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47328/1/11042_2005_Article_6851.pd
Aligned silk-based 3-D architectures for contact guidance in tissue engineering
An important challenge in the biomaterials field is to mimic the structure of functional tissues via cell and extracellular matrix (ECM) alignment and anisotropy. Toward this goal, silk-based scaffolds resembling bone lamellar structure were developed using a freeze-drying technique. The structure could be controlled directly by solute concentration and freezing parameters, resulting in lamellar scaffolds with regular morphology. Different post-treatments, such as methanol, water annealing and steam sterilization, were investigated to induce water stability. The resulting structures exhibited significant differences in terms of morphological integrity, structure and mechanical properties. The lamellar thicknesses were ∼2.6 μm for the methanol-treated scaffolds and ∼5.8 μm for water-annealed. These values are in the range of those reported for human lamellar bone. Human bone marrow-derived mesenchymal stem cells (hMSC) were seeded on these silk fibroin lamellar scaffolds and grown under osteogenic conditions to assess the effect of the microstructure on cell behavior. Collagen in the newly deposited ECM was found aligned along the lamellar architectures. In the case of methanol-treated lamellar structures, the hMSC were able to migrate into the interior of the scaffolds, producing a multilamellar hybrid construct. The present morphology constitutes a useful pattern onto which hMSC cells attach and proliferate for guided formation of a highly oriented extracellular matrix.A.L.O. wishes to thank financial support from the Portuguese Foundation for Science and Technology (SFRH/BPD/39102/2007) under POCTI Program. This work was partially supported by FCT through POCTI and/or FEDER programs and by the NIH [DE017207, EB003210 and EB002520]
Study of Hadronic Five-Body Decays of Charmed Mesons
We study the decay of D+ and Ds+ mesons into charged five body final states,
and report the discovery of the decay mode D+ -> K+K-Pi+Pi+Pi-, as well as
measurements of the decay modes D+ -> K-Pi+Pi+Pi+Pi-, Ds+ -> K+K-Pi+Pi+Pi-, Ds+
-> PhiPi+Pi+Pi- and D+/Ds+ -> Pi+Pi+Pi+Pi-Pi-. An analysis of the resonant
substructure is also included, with evidence suggesting that both decays
proceed primarily through an a1 vector resonance.Comment: 11 pages, 3 figure
Study of the D^0 \to pi^-pi^+pi^-pi^+ decay
Using data from the FOCUS (E831) experiment at Fermilab, we present new
measurements for the Cabibbo-suppressed decay mode . We measure the branching ratio .
An amplitude analysis has been performed, a first for this channel, in order to
determine the resonant substructure of this decay mode. The dominant component
is the decay , accounting for 60% of the decay rate.
The second most dominant contribution comes from the decay , with a fraction of 25%. We also study the
line shape and resonant substructure. Using the helicity formalism for the
angular distribution of the decay , we measure
a longitudinal polarization of %.Comment: 38 pages, 8 figures. accepted for publication in Physical Review
Evidence for a narrow dip structure at 1.9 GeV/c in diffractive photoproduction
A narrow dip structure has been observed at 1.9 GeV/c in a study of
diffractive photoproduction of the final state performed by the
Fermilab experiment E687.Comment: The data of Figure 6 can be obtained by downloading the raw data file
e687_6pi.txt. v5 (2nov2018): added Fig. 7, the 6 pion energy distribution as
requested by a reade
Charm System Tests of CPT and Lorentz Invariance with FOCUS
We have performed a search for CPT violation in neutral charm meson
oscillations. While flavor mixing in the charm sector is predicted to be small
by the Standard Model, it is still possible to investigate CPT violation
through a study of the proper time dependence of a CPT asymmetry in right-sign
decay rates for and \d0b\to K^+\pi^-. This asymmetry is
related to the CPT violating complex parameter and the mixing parameters
and : . Our 95% confidence
level limit is . Within the
framework of the Standard Model Extension incorporating general CPT violation,
we also find 95% confidence level limits for the expressions involving
coefficients of Lorentz violation of GeV, GeV, and GeV,
where is the factor which incorporates mixing parameters ,
and the doubly Cabibbo suppressed to Cabibbo favored relative strong phase
.Comment: 12 pages 5 figure
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