88 research outputs found
Improved optical activation of ion-implanted Zn acceptors in GaN by annealing under N2 overpressure
We investigated the properties of ion-implanted GaN:Zn annealed under various conditions using photoluminescence (PL) and high resolution x-ray diffraction (HRXRD). Epitaxial GaN/sapphire of high optical quality was ion-implanted with a 1013 cmâ2 dose of Zn+ ions at 200 keV. The sample was capped with 200 Ă
of SiNx and then diced into numerous pieces which were annealed under varied conditions in an attempt to optically activate the Zn. Annealing was performed in a tube furnace under flowing N2, an atmospheric pressure MOCVD reactor under flowing NH3 or N2, and under an N2 overpressure of 190 atm. The observed improvement in the optical quality of GaN:Zn annealed under N2 overpressure yields further insights into the trade-off between defect annealing and N loss from the GaN crysta
Efficient optical activation of ion-implanted Zn acceptors in GaN by annealing under 10 kbar N2 overpressure
We continue our investigations into the optical activation of Zn-implanted GaN annealed under ever higher N2 overpressure. The samples studied were epitaxial GaN/sapphire layers of good optical quality which were implanted with a 1013 cmâ2 dose of Zn+ ions at 200 keV, diced into equivalent pieces and annealed under 10 kbar of N2. The N2 overpressure permitted annealing at temperatures up to 1250°C for 1 hr without GaN decomposition. The blue Zn-related photoluminescence (PL) signal rises sharply with increasing anneal temperature. The Zn-related PL intensity in the implanted sample annealed at 1250°C exceeded that of the epitaxially doped GaN:Zn standard proving that high temperature annealing of GaN under kbar N2 overpressure can effectively remove implantation damage and efficiently activate implanted dopants in GaN. We propose a lateral LED device which could be fabricated using ion implanted dopants activated by high temperature annealing at high pressur
Cavity-enhanced simultaneous dressing of quantum dot exciton and biexciton states
The authors acknowledge financial support of the Deutsche Forschungsgemeinschaft (DFG) within the SFB/TRR21 and the projects MI500/23-1 and Ka2318/4-1, and the Natural Sciences and Engineering Research Council of Canada.We demonstrate the simultaneous dressing of both vacuum-to-exciton and exciton-to-biexciton transitions of a single semiconductor quantum dot in a high-Q micropillar cavity, using photoluminescence spectroscopy. Resonant two-photon excitation of the biexciton is achieved by spectrally tuning the quantum dot emission with respect to the cavity mode. The cavity couples to both transitions and amplifies the Rabi-frequency of the likewise resonant cw laser, driving the transitions. We observe strong-field splitting of the emission lines, which depend on the driving Rabi field amplitude and the cavity-laser detuning. A dressed state theory of a driven 4-level atom correctly predicts the distinct spectral transitions observed in the emission spectrum, and a detailed description of the emission spectra is further provided through a polaron master equation approach which accounts for cavity coupling and acoustic phonon interactions of the semiconductor medium.PostprintPeer reviewe
The surprisingly low carbon mass in the debris disk around HD 32297
Gas has been detected in a number of debris disks. It is likely secondary,
i.e. produced by colliding solids. Here, we report ALMA Band 8 observations of
neutral carbon in the CO-rich debris disk around the 15--30 Myr old A-type star
HD 32297. We find that C is located in a ring at 110 au with a FWHM
of 80 au, and has a mass of M.
Naively, such a surprisingly small mass can be accumulated from CO
photo-dissociation in a time as short as 10 yr. We develop a simple
model for gas production and destruction in this system, properly accounting
for CO self-shielding and shielding by neutral carbon, and introducing a
removal mechanism for carbon gas. We find that the most likely scenario to
explain both C and CO observations, is one where the carbon gas is rapidly
removed on a timescale of order a thousand years and the system maintains a
very high CO production rate of 15 M Myr, much higher
than the rate of dust grind-down. We propose a possible scenario to meet these
peculiar conditions: the capture of carbon onto dust grains, followed by rapid
CO re-formation and re-release. In steady state, CO would continuously be
recycled, producing a CO-rich gas ring that shows no appreciable spreading over
time. This picture might be extended to explain other gas-rich debris disks.Comment: accepted for publication in the Ap
Why Do Developers Get Password Storage Wrong? A Qualitative Usability Study
Passwords are still a mainstay of various security systems, as well as the
cause of many usability issues. For end-users, many of these issues have been
studied extensively, highlighting problems and informing design decisions for
better policies and motivating research into alternatives. However, end-users
are not the only ones who have usability problems with passwords! Developers
who are tasked with writing the code by which passwords are stored must do so
securely. Yet history has shown that this complex task often fails due to human
error with catastrophic results. While an end-user who selects a bad password
can have dire consequences, the consequences of a developer who forgets to hash
and salt a password database can lead to far larger problems. In this paper we
present a first qualitative usability study with 20 computer science students
to discover how developers deal with password storage and to inform research
into aiding developers in the creation of secure password systems
Protocol for an individual patient data meta-analysis on blood pressure targets after cardiac arrest
Background Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods This systematic review and meta-analysis will be conducted based on a systematic search of relevant major medical databases from their inception onwards, including MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as clinical trial registries. We will identify randomised controlled trials published in the English language that compare targeting a MAP higher than 65-70 mmHg in CA patients using vasopressors, inotropes and intravenous fluids. The data extraction will be performed separately by two authors (a third author will be involved in case of disagreement), followed by a bias assessment with the Cochrane Risk of Bias tool using an eight-step procedure for assessing if thresholds for clinical significance are crossed. The outcomes will be all-cause mortality, functional long-term outcomes and serious adverse events. We will contact the authors of the identified trials to request individual anonymised patient data to enable individual patient data meta-analysis, aggregate data meta-analyses, trial sequential analyses and multivariable regression, controlling for baseline characteristics. The certainty of the evidence will be assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. We will register this systematic review with Prospero and aim to redo it when larger trials are published in the near future. Conclusions This protocol defines the performance of a systematic review on whether a higher MAP after cardiac arrest improves patient outcome. Repeating this systematic review including more data likely will allow for more certainty regarding the effect of the intervention and possible sub-groups differences.Peer reviewe
Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Repeat expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Expanded sense and antisense repeat RNA transcripts in C9orf72 are translated into five dipeptide-repeat proteins (DPRs) in an AUG-independent manner. We previously identified the heterogeneous ribonucleoprotein (hnRNP) A3 as an interactor of the sense repeat RNA that reduces its translation into DPRs. Furthermore, we found that hnRNPA3 is depleted from the nucleus and partially mislocalized to cytoplasmic poly-GA inclusions in C9orf72 patients, suggesting that poly-GA sequesters hnRNPA3 within the cytoplasm. We now demonstrate that hnRNPA3 also binds to the antisense repeat RNA. Both DPR production and deposition from sense and antisense RNA repeats are increased upon hnRNPA3 reduction. All DPRs induced DNA double strand breaks (DSB), which was further enhanced upon reduction of hnRNPA3. Poly-glycine-arginine and poly-proline-arginine increased foci formed by phosphorylated Ataxia Telangiectasia Mutated (pATM), a major sensor of DSBs, whereas poly-glycine-alanine (poly-GA) evoked a reduction of pATM foci. In dentate gyri of C9orf72 patients, lower nuclear hnRNPA3 levels were associated with increased DNA damage. Moreover, enhanced poly-GA deposition correlated with reduced pATM foci. Since cytoplasmic pATM deposits partially colocalized with poly-GA deposits, these results suggest that poly-GA, the most frequent DPR observed in C9orf72 patients, differentially causes DNA damage and that poly-GA selectively sequesters pATM in the cytoplasm inhibiting its recruitment to sites of DNA damage. Thus, mislocalization of nuclear hnRNPA3 caused by poly-GA leads to increased poly-GA production, which partially depletes pATM, and consequently enhances DSB
Aircraft Noise and Quality of Life around Frankfurt Airport
In a survey of 2,312 residents living near Frankfurt Airport aircraft noise annoyance and disturbances as well as environmental (EQoL) and health-related quality of life (HQoL) were assessed and compared with data on exposure due to aircraft, road traffic, and railway noise. Results indicate higher noise annoyance than predicted from general exposure-response curves. Beside aircraft sound levels source-related attitudes were associated with reactions to aircraft noise. Furthermore, aircraft noise affected EQoL in general, although to a much smaller extent. HQoL was associated with aircraft noise annoyance, noise sensitivity and partly with aircraft noise exposure, in particular in the subgroup of multimorbid residents. The results suggest a recursive relationship between noise and health, yet this cannot be tested in cross-sectional studies. Longitudinal studies would be recommendable to get more insight in the causal paths underlying the noise-health relationship
Radial decoupling of small and large dust grains in the transitional disk RX J1615.3-3255
We present H-band (1.6 {\mu}m) scattered light observations of the
transitional disk RX J1615.3-3255, located in the ~1 Myr old Lupus association.
From a polarized intensity image, taken with the HiCIAO instrument of the
Subaru Telescope, we deduce the position angle and the inclination angle of the
disk. The disk is found to extend out to 68 12 AU in scattered light and
no clear structure is observed. Our inner working angle of 24 AU does not allow
us to detect a central decrease in intensity similar to that seen at 30 AU in
the 880 {\mu}m continuum observations. We compare the observations with
multiple disk models based on the Spectral Energy Distribution (SED) and submm
interferometry and find that an inner rim of the outer disk at 30 AU containing
small silicate grains produces a polarized intensity signal which is an order
of magnitude larger than observed. We show that a model in which the small dust
grains extend smoothly into the cavity found for large grains is closer to the
actual H-band observations. A comparison of models with different dust size
distributions suggests that the dust in the disk might have undergone
significant processing compared to the interstellar medium.Comment: 8 pages, 7 figures, 4 tables. Accepted for publication in A&
IVOA Recommendation: Spectrum Data Model 1.1
We present a data model describing the structure of spectrophotometric
datasets with spectral and temporal coordinates and associated metadata. This
data model may be used to represent spectra, time series data, segments of SED
(Spectral Energy Distributions) and other spectral or temporal associations.Comment: http://www.ivoa.ne
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