Regular and chaotic interactions of two BPS dyons at low energy

We identify and analyze quasiperiodic and chaotic motion patterns in the time evolution of a classical, non-Abelian Bogomol'nyi-Prasad-Sommerfield (BPS) dyon pair at low energies. This system is amenable to the geodesic approximation which restricts the underlying SU(2) Yang-Mills-Higgs dynamics to an eight-dimensional phase space. We numerically calculate a representative set of long-time solutions to the corresponding Hamilton equations and analyze quasiperiodic and chaotic phase space regions by means of Poincare surfaces of section, high-resolution power spectra and Lyapunov exponents. Our results provide clear evidence for both quasiperiodic and chaotic behavior and characterize it quantitatively. Indications for intermittency are also discussed.Comment: 22 pages, 6 figures (v2 contains a few additional references, a new paragraph on intermittency and minor stylistic corrections to agree with the published version

Problems of innovative receptivity of personnel of enterprises of industrial automation

Стаття присвячена аналізу галузі промислової автоматики (ПА), позначенню та з’ясовуванню проблематики у підприємств ПА для поліпшення інноваційної діяльності (ІД) шляхом комплексного підвищення інноваційної сприйнятливості (ІС) персоналу в системі управління персоналом. Показана динаміка виробничих економічних показників українських підприємств ПА за 2011-2017 рр., запропоновані рекомендації по підвищенню ІС персоналу. Наведено аналіз техніко-економічних показників підприємств ПА. Приведений загальний огляд реалізації продукції (товарів, послуг за видами економічної діяльності) на Україні за період 2010-2017 рр. Для дослідження приведена методологія порівняльного аналізу. Результати дослідження показують виявлення проблем підприємств ПA, які полягають у збільшенні реалізованої продукції і зниженні прибутку, що говорить про необхідність підвищення IС персоналу в системі управління персоналом.The article is devoted to the analysis of industrial areas in particular the field of industrial automation (ІA), the identification and clarification of problems in PA enterprises, to improve innovation activity (IА) through a comprehensive increase in the innovative receptivity (IR) of personnel in the personnel management system. The industrial enterprises of Ukraine and in particular industry of ІА now experiences heavy times of competitive activity with foreign companies and in particular with more cheap commodities from China. Not to lose the positions and occupy new markets it is needed not only to watch after novelties in the field of productive but also in the sphere of personnel and increase of him ІR for the increase of competitiveness. The dynamics of the production of economic indicators of the Ukrainian enterprises of IA for 2011-2017 is shown, recommendations for increasing the executive personnel are offered. The analysis of technical and economic indicators of IA enterprises is given. And also provides a general overview of the sale of products (goods, services by type of economic activity) in Ukraine for the period 2010-2017. For research methodology over of comparative analysis is brought. Research results are exposures of problems of enterprises of IA such as an increase of the realized products and decline of profit, that talks at the necessity of increase of IR of personnel, in control system by a personnel. Innovative activity of every enterprise of industrial automation (IA) is important for the increase of competitiveness and increase arrived. The innovative oriented skilled personnel failing in the Ukrainian enterprises, what called to provide development and increase of efficiency of activity of enterprises. For development normatively of technical documentation on a management and development of personnel experience of front-rank world companies is poorly used what track is adapted to take into account taking into account Ukrainian realities. To the necessity of development of control system by a personnel with the purpose of leading to of them to the standards of front-rank world companies

Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer : results from the Breast International Group Trial 1-98

The androgen receptor (AR) is an emerging prognostic marker and therapeutic target in breast cancer. AR is expressed in 60-80% of breast cancers, with higher prevalence among estrogen receptor-positive (ER+) tumors. Androgen treatment inhibits ER signaling in ER+/AR+ breast cancer cell lines, and AR expression is associated with improved survival for this subtype in epidemiologic studies. However, whether AR expression modifies the efficacy of selective ER modulators or aromatase inhibitors for ER+ cancers remains unclear

Expression of phosphorylated ribosomal protein S6 in mesothelioma patients - correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project

Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Although histology and pathologic stage are important prognostic factors, better prognostic biomarkers are needed. The ribosomal protein S6 is a downstream target of the phosphatidylinositol 3-kinase (PI3K) pathway involved in protein synthesis and cell proliferation. In previous studies, low phosphorylated S6 (pS6) immunoreactivity was significantly correlated with longer progression-free survival (PFS) and overall survival (OS) in PM patients. We aimed to correlate pS6 expression to clinical data in a large multi-centre PM cohort as part of the European Thoracic Oncology Platform (ETOP) Mesoscape project. Tissue Micro Arrays (TMAs) of PM were constructed and expression of pS6 was evaluated by a semi-quantitatively aggregate H-score. Expression results were correlated to patient characteristics as well as OS/PFS. pS6 IHC results of 364 patients from 9 centres, diagnosed between 1999 and 2017 were available. The primary histology of included tumours was epithelioid (70.3%), followed by biphasic (24.2%) and sarcomatoid (5.5%). TMAs included both treatment-naïve and tumour tissue taken after induction chemotherapy. High pS6 expression (181 patients with H-score>1.41) was significantly associated with less complete resection. In the overall cohort, OS/PFS were not significantly different between pS6-low and pS6-high patients. In a subgroup analysis non-epithelioid (biphasic and sarcomatoid) patients with high pS6 expression showed a significantly shorter OS (p < 0.001, 10.7 versus 16.9 months) and PFS (p < 0.001, 6.2 versus 10.8 months). In subgroup analysis, in non-epithelioid PM patients high pS6 expression was associated with significantly shorter OS and PFS. These exploratory findings suggest a clinically relevant PI3K pathway activation in non-epithelioid PM which might lay the foundation for future targeted treatment strategies

Aggregation and settling in aqueous polydisperse alumina nanoparticle suspensions

Nanoparticle suspensions (also called nanofluids) are often polydisperse and tend to settle with time. Settling kinetics in these systems are known to be complex and hence challenging to understand. In this work, polydisperse spherical alumina (Al2O3) nanoparticles in the size range of ~10-100nm were dispersed in water and examined for aggregation and settling behaviour near its isoelectric point (IEP). A series of settling experiments were conducted and the results were analysed by photography and by Small Angle X-ray Scattering (SAXS). The settling curve obtained from standard bed height measurement experiments indicated two different types of behaviour, both of which were also seen in the SAXS data. But the SAXS data were remarkably able to pick out the rapid settling regime as a result of the high temporal resolution (10s) used. By monitoring the SAXS intensity, it was further possible to record the particle aggregation process for the first time. Optical microscopy images were produced on drying and dried droplets extracted from the suspension at various times. Dried deposits showed the rapid decrease in the number of very large particles with time which qualitatively validates the SAXS prediction, and therefore its suitability as a tool to study unstable polydisperse colloids. Keywords: Nanoparticles, nanofluids, polydisperse, aggregation, settling, alumina, microscopy, SAX

Expression of phosphorylated ribosomal protein S6 in mesothelioma patients - correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project

Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Although histology and pathologic stage are important prognostic factors, better prognostic biomarkers are needed. The ribosomal protein S6 is a downstream target of the phosphatidylinositol 3-kinase (PI3K) pathway involved in protein synthesis and cell proliferation. In previous studies, low phosphorylated S6 (pS6) immunoreactivity was significantly correlated with longer progression-free survival (PFS) and overall survival (OS) in PM patients. We aimed to correlate pS6 expression to clinical data in a large multi-centre PM cohort as part of the European Thoracic Oncology Platform (ETOP) Mesoscape project. Tissue Micro Arrays (TMAs) of PM were constructed and expression of pS6 was evaluated by a semiquantitatively aggregate H-score. Expression results were correlated to patient characteristics as well as OS/PFS. pS6 IHC results of 364 patients from 9 centres, diagnosed between 1999 and 2017 were available. The primary histology of included tumours was epithelioid (70.3%), followed by biphasic (24.2%) and sarcomatoid (5.5%). TMAs included both treatment-naive and tumour tissue taken after induction chemotherapy. High pS6 expression (181 patients with H-score>1.41) was significantly associated with less complete resection. In the overall cohort, OS/PFS were not significantly different between pS6-low and pS6-high patients. In a subgroup analysis nonepithelioid (biphasic and sarcomatoid) patients with high pS6 expression showed a significantly shorter OS (p< 0.001, 10.7 versus 16.9 months) and PFS (p < 0.001, 6.2 versus 10.8 months). In subgroup analysis, in non-epithelioid PM patients high pS6 expression was associated with significantly shorter OS and PFS. These exploratory findings suggest a clinically relevant PI3K pathway activation in non-epithelioid PM which might lay the foundation for future targeted treatment strategies

Prospective Environmental Life Cycle Assessment of Nanosilver T-Shirts

A cradle-to-grave life cycle assessment (LCA) is performed to compare nanosilver T-shirts with conventional T-shirts with and without biocidal treatment. For nanosilver production and textile incorporation, we investigate two processes: flame spray pyrolysis (FSP) and plasma polymerization with silver co-sputtering (PlaSpu). Prospective environmental impacts due to increased nanosilver T-shirt commercialization are estimated with six scenarios. Results show significant differences in environmental burdens between nanoparticle production technologies: The "cradle-to-gate" climate footprint of the production of a nanosilver T-shirt is 2.70 kg of CO2-equiv (FSP) and 7.67-166 kg of CO2-equiv (PlaSpu, varying maturity stages). Production of conventional T-shirts with and without the biocide triclosan has emissions of 2.55 kg of CO2-equiv (contribution from triclosan insignificant). Consumer behavior considerably affects the environmental impacts during the use phase. Lower washing frequencies can compensate for the increased climate footprint of FSP nanosilver T-shirt production. The toxic releases from washing and disposal in the life cycle of T-shirts appear to be of minor relevance. By contrast, the production phase may be rather significant due to toxic silver emissions at the mining site if high silver quantities are require