Foot Characteristics in Association With Inversion Ankle Injury

Objective: To review the literature that provides information to assist in analyzing the role of the foot in acute and chronic lateral ankle injury. Data Sources: We searched MEDLINE, CINAHL, Institute for Scientific Information's Web of Science, and SPORT Discus from 1965–2005 using the terms lateral, ankle, ligament, injury, risk factors, foot, subtalar joint, talocrural joint, gait analysis, and foot biomechanics. Data Synthesis: We found substantial information on the incidence and treatment of lateral ankle sprains in sport but very few articles that focused on risk factors associated with these injuries and even less information on the foot as it relates to this condition. Moreover, little information was available regarding the risk factors associated with the development of chronic instability after a lateral ankle sprain. We critically analyzed the foot articulations and the foot's role in the mechanism of injury to assist our clinical synopsis. Conclusions/Recommendations: An in-depth review of the foot complex in relation to lateral ankle sprains strongly suggested its importance when treating and preventing inversion ankle trauma. Throughout the literature, the only static foot measurements that show a significant correlation to this condition are an identified cavovarus deformity, increased foot width, and increased calcaneal eversion range of motion. Authors also provided dynamic measurements of the foot, which produced several significant findings that we discuss. Although our findings offer some insight into the relationship between foot characteristics and lateral ankle injuries, future research is needed to confirm the results of this review and expand this area of investigation

Humans in the Loop

From lethal drones to cancer diagnostics, humans are increasingly working with complex and artificially intelligent algorithms to make decisions which affect human lives, raising questions about how best to regulate these human-in-the-loop systems. We make four contributions to the discourse. First, contrary to the popular narrative, law is already profoundly and often problematically involved in governing human-in-the-loop systems: it regularly affects whether humans are retained in or removed from the loop. Second, we identify the MABA-MABA trap, which occurs when policymakers attempt to address concerns about algorithmic incapacities by inserting a human into a decision-making process. Regardless of whether the law governing these systems is old or new, inadvertent or intentional, it rarely accounts for the fact that human-machine systems are more than the sum of their parts: they raise their own problems and require their own distinct regulatory interventions. But how to regulate for success? Our third contribution is to highlight the panoply of roles humans might be expected to play, to assist regulators in understanding and choosing among the options. For our fourth contribution, we draw on legal case studies and synthesize lessons from human factors engineering to suggest regulatory alternatives to the MABA-MABA approach. Namely, rather than carelessly placing a human in the loop, policymakers should regulate the human-in-the-loop system

Humans in the Loop

From lethal drones to cancer diagnostics, humans are increasingly working with complex and artificially intelligent algorithms to make decisions which affect human lives, raising questions about how best to regulate these “human-in-the-loop” systems. We make four contributions to the discourse. First, contrary to the popular narrative, law is already profoundly and often problematically involved in governing human-in-the-loop systems: it regularly affects whether humans are retained in or removed from the loop. Second, we identify “the MABA-MABA trap,” which occurs when policymakers attempt to address concerns about algorithmic incapacities by inserting a human into a decisionmaking process. Regardless of whether the law governing these systems is old or new, inadvertent or intentional, it rarely accounts for the fact that human-machine systems are more than the sum of their parts: they raise their own problems and require their own distinct regulatory interventions. But how to regulate for success? Our third contribution is to highlight the panoply of roles humans might be expected to play, to assist regulators in understanding and choosing among the options. For our fourth contribution, we draw on legal case studies and synthesize lessons from human factors engineering to suggest regulatory alternatives to the MABA-MABA approach. Namely, rather than carelessly placing a human in the loop, policymakers should regulate the human-in-the-loop system

On knottings in the physical Hilbert space of LQG as given by the EPRL model

We consider the EPRL spin foam amplitude for arbitrary embedded two-complexes. Choosing a definition of the face- and edge amplitudes which lead to spin foam amplitudes invariant under trivial subdivisions, we investigate invariance properties of the amplitude under consistent deformations, which are deformations of the embedded two-complex where faces are allowed to pass through each other in a controlled way. Using this surprising invariance, we are able to show that in the physical Hilbert space as defined by the sum over all spin foams contains no knotting classes of graphs anymore.Comment: 22 pages, 14 figure

Polymer quantization of the free scalar field and its classical limit

Building on prior work, a generally covariant reformulation of free scalar field theory on the flat Lorentzian cylinder is quantized using Loop Quantum Gravity (LQG) type `polymer' representations. This quantization of the {\em continuum} classical theory yields a quantum theory which lives on a discrete spacetime lattice. We explicitly construct a state in the polymer Hilbert space which reproduces the standard Fock vacuum- two point functions for long wavelength modes of the scalar field. Our construction indicates that the continuum classical theory emerges under coarse graining. All our considerations are free of the "triangulation" ambiguities which plague attempts to define quantum dynamics in LQG. Our work constitutes the first complete LQG type quantization of a generally covariant field theory together with a semi-classical analysis of the true degrees of freedom and thus provides a perfect infinite dimensional toy model to study open issues in LQG, particularly those pertaining to the definition of quantum dynamics.Comment: 58 page

Humans in the Loop

From lethal drones to cancer diagnostics, humans are increasingly working with complex and artificially intelligent algorithms to make decisions which affect human lives, raising questions about how best to regulate these “human-in-the-loop” systems. We make four contributions to the discourse. First, contrary to the popular narrative, law is already profoundly and often problematically involved in governing human-in-the-loop systems: it regularly affects whether humans are retained in or removed from the loop. Second, we identify “the MABA-MABA trap,” which occurs when policymakers attempt to address concerns about algorithmic incapacities by inserting a human into a decisionmaking process. Regardless of whether the law governing these systems is old or new, inadvertent or intentional, it rarely accounts for the fact that human-machine systems are more than the sum of their parts: they raise their own problems and require their own distinct regulatory interventions. But how to regulate for success? Our third contribution is to highlight the panoply of roles humans might be expected to play, to assist regulators in understanding and choosing among the options. For our fourth contribution, we draw on legal case studies and synthesize lessons from human factors engineering to suggest regulatory alternatives to the MABA-MABA approach. Namely, rather than carelessly placing a human in the loop, policymakers should regulate the human-in-the-loop system

Plantio comprobatório de canjarana (Cabralea canjerana subsp. canjerana).

bitstream/item/101394/1/PA-1999-Carvalho-PlantioComprobatorio.pd

Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy

Most fluorescent proteins exhibit multiexponential fluorescence decays, indicating a heterogeneous excited state population. FRET between fluorescent proteins should therefore involve multiple energy transfer pathways. We recently demonstrated the FRET pathways between EGFP and mCherry (mC), upon the dimerization of 3-phosphoinositide dependent protein kinase 1 (PDK1), to be highly restricted. A mechanism for FRET restriction based on a highly unfavorable κ(2) orientation factor arising from differences in donor-acceptor transition dipole moment angles in a far from coplanar and near static interaction geometry was proposed. Here this is tested via FRET to mC arising from the association of glutathione (GSH) and glutathione S-transferase (GST) with an intrinsically homogeneous and more mobile donor Oregon Green 488 (OG). A new analysis of the acceptor window intensity, based on the turnover point of the sensitized fluorescence, is combined with donor window intensity and anisotropy measurements which show that unrestricted FRET to mC takes place. However, a long-lived anisotropy decay component in the donor window reveals a GST-GSH population in which FRET does not occur, explaining previous discrepancies between quantitative FRET measurements of GST-GSH association and their accepted values. This reinforces the importance of the local donor-acceptor environment in mediating energy transfer and the need to perform spectrally resolved intensity and anisotropy decay measurements in the accurate quantification of fluorescent protein FRET

Platelet-activating factor mediates trinitrobenzene induced dysmotility in the left colon

We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn onto the serosal surface of the colon to evaluate colonic motility. TNB administration increased tissue levels of PAF and increased the average force of each colonic contraction. Pretreatment with the PAF receptor antagonist WEB-2170 prior to TNB infusion decreased tissue concentrations of PAF and ameliorated the altered motility parameters seen with TNB alone. These results suggest that PAF is stimulated by TNB and may participate in colonic dysmotility during inflammatory states