General consequences of the violated Feynman scaling

The problem of scaling of the hadronic production cross sections represents an outstanding question in high energy physics especially for interpretation of cosmic ray data. A comprehensive analysis of the accelerator data leads to the conclusion of the existence of breaked Feynman scaling. It was proposed that the Lorentz invariant inclusive cross sections for secondaries of a given type approaches constant in respect to a breaked scaling variable x sub s. Thus, the differential cross sections measured in accelerator energy can be extrapolated to higher cosmic ray energies. This assumption leads to some important consequences. The distribution of secondary multiplicity that follows from the violated Feynman scaling using a similar method of Koba et al is discussed

Environmental Decision-making utilizing a Web GIS to Monitor Hazardous Industrial Emissions in the Valencian community of Spain

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.Air pollution is a critical issue in contemporary times. For this reason, officials and environmental managers are in need of suitable tools for visualization, manipulation and analysis of environmental data. Environmental concerns in Europe have encouraged the European Environmental Agency (EEA) to create the European Pollutant Release and Transfer Register (E-PRTR). The E-PRTR is vital and valuable because society will benefit if the data are used to improve monitoring and consequently advance environmental management. However, the data are not accessible in an interoperable way, which complicates their use and does not allow for a contribution to environmental monitoring. This paper describes a Web GIS system developed for the monitoring of industrial emissions using environmental data released by the EEA. Four research objectives are addressed: (1) design and create an interoperable spatial database to store environmental data, (2) develop a Web GIS to manipulate the spatial database, facilitate air pollution monitoring and enhance risk assessment, (3) implement OGC standards to provide data interoperability and integration into a Web GIS, (4) create a model to simulate distribution of air pollutants and assess a population’s exposure to industrial emissions. The proposed approach towards interoperability is an adoption of servicebased architecture for implementation of a three-tier Web GIS application. This system’s prototype is developed using open source tools for the Valencian Community of Spain

Towards social paradigms for mobile context-aware computing in smart cities

Ponència presentada a la 11ª Conferencia Ibérica de Sistemas y Tecnologías de Información (CISTI 2016) celebrada a Gran Canaria els dies 15-18 de juny de 2016Mobile context-aware computing is an essential component of the smart cities infrastructure. Attempts were made to develop a model that can effectively represent a system in device to support context-aware behavior. The purpose of this paper is to identify deficiencies of the previously developed model and propose solutions to improve it.The authors gratefully acknowledge funding from the European Commission through the GEO-C project (H2020- MSCA-ITN-2014, Grant Agreement Number 642332, http://www.geo-c.eu/). Carlos Granell has been partly funded by the Ramón y Cajal Programme (grant numbers RYC-2014- 16913

Bonnet pairs and isothermic surfaces

In this note we classify all Bonnet pairs on a simply connected domain. Our main intent was to apply what we call a quaternionic function theory to a concrete problem in differential geometry. The ideas are simple: conformal immersions into quaternions or imaginary quaternions take the place of chart maps for a Riemann surface. Starting from a reference immersion we construct all conformal immersions of a given (simply connected) Riemann surface (up to translational periods) by spin transformations. With this viewpoint in mind we discuss how to construct all Bonnet pairs on a simply connected domain from isothermic surfaces and vice versa. Isothermic surfaces are solutions to a certain soliton equation and thus a simple dimension count tells us that we obtain Bonnet pairs which are not part of any of the classical Bonnet families. The corresponcence between Bonnet pairs and isothermic surfaces is explicit and to each isothermic surface we obtain a 4-parameter family of Bonnet pairs

Sociology Paradigms for Dynamic Integration of Devices into a Context-Aware System

Ubiquitous and m obile context - aware computing is an essential component of the smart cities infrastructure. Widely available wireless networks, the maturity level of distributed computing and the increasing number of mobile devices have significantly influenced the human experience with computing. In the present paper, we discuss the need for a model that will be able to represent a formal structure of a context - aware system in a device . The core functionality of the model is expected to expose context - aware behaviour and support dynamic integration of mobile devices and context - aware behaviour. The major contribution of this work is to identify deficiencies of the existing model which is using the notions from sociology such as Role, Ownership and Responsibility.The authors gratefully acknowledge funding from the European Commission through the GEO-C project (H2020-MSCA-ITN-2014, Grant Agreement Number 642332, http://www.geo-c.eu/)

E2E Program

United States Department of Homeland Security University of Alaska Anchorag

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy.

Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to demonstrate the utility of a pan-cancer, rapid, inexpensive, whole genome NGS of cfDNA approach (PRINCe) as a precision oncology screening strategy via ultra-low coverage (~0.01x) tumor content determination through genome-wide copy number alteration (CNA) profiling. We applied PRINCe to a retrospective cohort of 124 cfDNA samples from 100 patients with advanced cancers, including 76 men with metastatic castration-resistant prostate cancer (mCRPC), enabling cfDNA tumor content approximation and actionable focal CNA detection, while facilitating concordance analyses between cfDNA and tissue-based NGS profiles and assessment of cfDNA alteration associations with mCRPC treatment outcomes. Therapeutically relevant focal CNAs were present in 42 (34%) cfDNA samples, including 36 of 93 (39%) mCRPC patient samples harboring AR amplification. PRINCe identified pre-treatment cfDNA CNA profiles facilitating disease monitoring. Combining PRINCe with routine targeted NGS of cfDNA enabled mutation and CNA assessment with coverages tuned to cfDNA tumor content. In mCRPC, genome-wide PRINCe cfDNA and matched tissue CNA profiles showed high concordance (median Pearson correlation = 0.87), and PRINCe detectable AR amplifications predicted reduced time on therapy, independent of therapy type (Kaplan-Meier log-rank test, chi-square = 24.9, p < 0.0001). Our screening approach enables robust, broadly applicable cfDNA-based precision oncology for patients with advanced cancer through scalable identification of therapeutically relevant CNAs and pre-/post-treatment genomic profiles, enabling cfDNA- or tissue-based precision oncology workflow optimization