7 research outputs found
The Origin and Evolution of Mutations in Acute Myeloid Leukemia
- Author
- Alldredge Patricia A.
- Baty Jack D.
- Chen Ken
- Cook Lisa L.
- Delehaunty Kim D.
- Demeter Ryan T.
- Ding Li
- DiPersio John F.
- Dooling David J.
- Fulton Lucinda A.
- Fulton Robert S.
- Graubert Timothy A.
- Harris Christopher C.
- Heath Sharon E.
- Hundal Jasreet
- Kalicki-Veizer Joelle M.
- Kandoth Cyriac
- Klco Jeffery M.
- Koboldt Daniel C.
- Kulkarni Shashikant
- Lamprecht Tamara L.
- Larson David E.
- Ley Timothy J.
- Lin Ling
- Link Daniel C.
- Liu Fulu
- Lu Charles
- Magrini Vincent J.
- Mardis Elaine R.
- McGrath Sean D.
- McLellan Michael D.
- McMichael Joshua F.
- Miller Christopher A.
- Nagarajan Rakesh
- O’Laughlin Michelle D.
- Payton Jacqueline E.
- Reed Jerry P.
- Schmidt Heather K.
- Shannon William D.
- Swift Gary W.
- Tomasson Michael H.
- Varghese Nobish
- Vickery Tammi L.
- Walker Jason R.
- Wallis John W.
- Walter Matthew J.
- Wartman Lukas D.
- Watson Mark A.
- Welch John S.
- Westervelt Peter
- Wilson Richard K.
- Wylie Todd N.
- Xia Jun
- Zhang Qunyuan
- Publication venue
- Elsevier Inc.
- Publication date
- 20/07/2012
- Field of study
SummaryMost mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced the genomes of M3-AML samples with a known initiating event (PML-RARA) versus the genomes of normal karyotype M1-AML samples and the exomes of hematopoietic stem/progenitor cells (HSPCs) from healthy people. Collectively, the data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is “captured” as the clone expands. In many cases, only one or two additional, cooperating mutations are needed to generate the malignant founding clone. Cells from the founding clone can acquire additional cooperating mutations, yielding subclones that can contribute to disease progression and/or relapse
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
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- Babbage Sarah
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- Baker Dan
- Baker M.
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- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
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- Batzer Mark
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- Baynes Caroline
- Bayul Tashi
- Beall Keith
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- Beard Susan
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- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
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- Bonnett Ralph
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- Borowsky Mark
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- Brandriff Brigitte F.
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- Branscomb Elbert
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- Brettin Thomas
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- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
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- Cao Yuzhu
- Caoile Chenier
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- Cardenas Lolo
- Cardenas Veronica
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- Carder Paul
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- Carrano Anthony V.
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- Carter Kelvin
- Carter Nigel
- Caruso Lauren
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- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
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- Chen Ellson
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- Chen Shu
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- Chen Xiaoyun
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- Chen Yiyu
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- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
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- Chin Sylvia
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- Chissoe Stephanie
- Chiu Sally
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- Christopoulos Constantine
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- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
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- Collins Philip
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- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
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- Crew Victor
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- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
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- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
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- Curwen Valery
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- D\u27Souza Lisa Marie
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- Dalin Eillen
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- Dathorne Stephanie R.
- Daum Christopher
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- Davidson Stuart
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- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
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- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
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- Dhongsar Chemey
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- Dias Victoria
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- Dibling Catherine
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- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
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- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
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- Douthwaite Karen J.
- Down Thomas
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- Du Hui
- Du Yutao
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- Dugan-Rocha Shannon
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- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
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- Eichler Evan
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- Escotto Michael
- Eugene Craig S.
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- Finley Maria C.
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- Fitzgerald Mike
- Flack Tina
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- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
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- Floyd Yvonne
- Foley Karen
- Folta Peg
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- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
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- Fowler John
- Fox Jessica
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- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
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- Garcia Ricardo M, III
- Garcia-Martinez Antonio
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- Gardner Alison
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- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
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- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
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- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
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- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
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- Gil Isaias
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- Gillet Will
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- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
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- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
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- Graham Joe
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- Grant Michael
- Grant Susan
- Graves Tina A.
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- Gray Emma
- Gray Lain
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- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
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- Groza Matthew
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- Gu Jun
- Gu Wenyi
- Gu Wenyi
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- Guerra William
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- Halls Karen
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- Hamilton Keelan A.
- Hamilton Matt
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- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
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- Harkins C. Richard
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- Hashimoto Wakako
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- He Fengying
- He Jiaying
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- Hernandez Omar
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- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Holdgate Janet
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- Holloway Ele
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- Holmes Ian
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- Homsi Farah J.
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- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
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- Huang Wei
- Huang Wei
- Huang Zhengping
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- Hunt Paul
- Hunt Sarah
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- Hunter Rov, II
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- Huynh Sandy
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- Hynds Christopher
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- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
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- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
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- Itoh Takehiko
- Iwakawa Shinobu
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- Jackson Laronda R.
- Jackson Terri
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- Jin Jian
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- Kegg Lisa
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- Kelly Shayna P.
- Kelly Susan H.
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- Kettleborough Ross
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- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
- Kube Michael
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- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
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- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lu Yue
- Lucas Robert
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- Lucier Raymond L.
- Ludeman Thom
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- Machrus Migdad
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- Manohar Chitra
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- Marquis-Homeyer Catherine
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- Mauceli Evan
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- McMurray Kimberly L.
- McNinch Jenny
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- Mehta Nalini
- Meidi Patrick
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- Mesirov Jill P.
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- Miller Christie
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- Mungall Andy
- Munidasa Mala
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- Murayama Yuji
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- Müller Ines
- Nagamine Kentaro
- Nagao Syunsuke
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- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
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- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Ohtsubo Masafumi
- Oinn Tom
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
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- Oragunye Njideka
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- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
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- Parkin Kim
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- Parry-Brown Ginny
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- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
- Pecherer Robert M.
- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
- Peng Yi
- Peng Ze
- Peng Ze
- Pennacchio Len A.
- Pennacchio Len A.
- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Perrin William
- Pesavento Brad
- Peters Anna
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- Peterson Jane
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- Pourrajabi Nima M.
- Powell Don
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- Prathalingham Radhika
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- Prigmore Elena
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- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
- Rabata Dina
- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
- Ramasami Umadevi
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- Reily Amy D.
- Reinhardt Astrid
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- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
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- Rise Cecil
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- Road JungShing
- Robert Catherine
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- Robinson Chris
- Robinson Dezere
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- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
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- Rong Li
- Rong Li
- Rosenbloom Kate R.
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- Sasaki Takashi
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- Saurin William
- Savery Glenford G.
- Sawada Nori
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- Saxman Eric
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- Scherer Steven Edward
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- Siepel Adam C.
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- Sonaike Titilola
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
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- Spraggon Lee
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- Stabenau Arne
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- Stalker James
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- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
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- Stege Justin T.
- Steingruber Helen
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
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- Sun Jiu Qin
- Sun Min
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- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
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- Sycamore Neil
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- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
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- Takaoka Tori
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- Tam Serena
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- Tamirisa Aparna
- Tan Olivia
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- Tan Xinyu
- Tan Xinyu
- Tang Hongli
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- Tansey Jennifer
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- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
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- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
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- Thorne Rachel Diane
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- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
- Valles Yvonne
- Van Brunt Andrew
- Van Dilla Marvin
- Van Helmond Zoe
- Van Luchene Ryan
- Vardanian Zachary
- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
- Waligorski Jason E.
- Walker Davian L.
- Walker Keya
- Walker Sarah
- Wall Melanie
- Wall Randy E.
- Wallace John
- Wallis Justine
- Wallis Michelle
- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
- Wang Feng
- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
- Wentz Sara
- Werler Daniela
- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
- Wheatley Carl
- Wheeler David A.
- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
- White Adam
- White Amelia
- White Brian
- White Catherine
- White Flower
- White Jennifer
- White Johnathon
- White P. Scott
- White Scott P.
- White Simon
- Whitehead Sally
- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
- Wilson Wendy
- Wincker Patrick
- Window Philip
- Winster Jenny
- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
- Author
- Abbott Rachel
- Abbott Scott
- Akbani Rehan
- Aksoy B. Arman
- Aldape Kenneth
- Ally Adrian
- Amin Samirkumar
- Anastassiou Dimitris
- Auman J. Todd
- Baggerly Keith A.
- Balasundaram Miruna
- Balu Saianand
- Baylin Stephen B.
- Benz Christopher C.
- Benz Stephen C.
- Berman Benjamin P.
- Bernard Brady
- Bhatt Ami S.
- Birol Inanc
- Black Aaron D.
- Bodenheimer Tom
- Bootwalla Moiz S.
- Bowen Jay
- Bressler Ryan
- Bristow Christopher A.
- Brooks Angela N.
- Broom Bradley
- Buda Elizabeth
- Burton Robert
- Butterfield Yaron S.N.
- Byers Lauren A.
- Carlin Daniel
- Carter Scott L.
- Casasent Tod D.
- Chang Kyle
- Chanock Stephen
- Chen Zhong
- Cherniack Andrew D.
- Chin Lynda
- Cho Dong Yeon
- Cho Juok
- Chu Andy
- Chuah Eric
- Chun Hye Jung E.
- Cibulskis Kristian
- Ciriello Giovanni
- Cleland James
- Cline Melisssa
- Collisson Eric A.
- Craft Brian
- Creighton Chad J.
- Danilova Ludmila
- Davidsen Tanja
- Davis Caleb
- Dees Nathan D.
- Delehaunty Kim
- Demchok John A.
- Dhalla Noreen
- DiCara Daniel
- Ding Li
- Dinh Huyen
- Dobson Jason R.
- Dodda Deepti
- Doddapaneni Harsha Vardhan
- Donehower Lawrence
- Dooling David J.
- Dresdner Gideon
- Drummond Jennifer
- Eakin Andrea
- Edgerton Mary
- Eldred Jim M.
- Eley Greg
- Ellrott Kyle
- Fan Cheng
- Fei Suzanne
- Felau Ina
- Frazer Scott
- Freeman Samuel S.
- Frick Jessica
- Fronick Catrina C.
- Fulton Lucinda L.
- Fulton Robert
- Gabriel Stacey B.
- Gao Jianjiong
- Gastier-Foster Julie M.
- Gehlenborg Nils
- George Myra
- Getz Gad
- Gibbs Richard
- Goldman Mary
- Gonzalez-Perez Abel
- Gross Benjamin
- Guin Ranabir
- Gunaratne Preethi
- Hadjipanayis Angela
- Hamilton Mark P.
- Hamilton Stanley R.
- Han Leng
- Han Yi
- Harper Hollie A.
- Haseley Psalm
- Haussler David
- Hayes D. Neil
- Heiman David I.
- Helman Elena
- Helsel Carmen
- Herbrich Shelley M.
- Herman James G.
- Hinoue Toshinori
- Hirst Carrie
- Hirst Martin
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Iype Lisa
- Jacobsen Anders
- Jeffreys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J.M.
- Ju Zhenlin
- Jung Joonil
- Kahles Andre
- Kahn Ari
- Kalicki-Veizer Joelle
- Kalra Divya
- Kanchi Krishna Latha
- Kandoth Cyriac
- Kane David W.
- Kim Hoon
- Kim Jaegil
- Knijnenburg Theo
- Koboldt Daniel C.
- Kovar Christie
- Kramer Roger
- Kreisberg Richard
- Kucherlapati Raju
- Ladanyi Marc
- Laird Peter W.
- Lander Eric S.
- Larson David E.
- Lawrence Michael S.
- Lee Darlene
- Lee Eunjung
- Lee Semin
- Lee William
- Lehmann Kjong Van
- Leinonen Kalle
- Leiserson Max D.M.
- Leraas Kristen M.
- Lerner Seth
- Levine Douglas A.
- Lewis Lora
- Ley Timothy J.
- Li Haiyan I.
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Jake
- Lin Ling
- Lin Pei
- Liu Wenbin
- Liu Yingchun
- Liu Yuexin
- Lopez-Bigas Nuria
- Lorenzi Philip L.
- Lu Charles
- Lu Yiling
- Luquette Lovelace J.
- Ma Singer
- Magrini Vincent J.
- Mahadeshwar Harshad S.
- Mardis Elaine R.
- Margolin Adam A.
- Marra Marco A.
- Mayo Michael
- McAllister Cynthia
- McGuire Sean E.
- McLellan Michael D.
- McMichael Joshua F.
- Melott James
- Meng Shaowu
- Meyerson Matthew
- Mieczkowski Piotr A.
- Miller Christopher A.
- Miller Martin L.
- Miller Michael
- Mills Gordon B.
- Moore Richard A.
- Morgan Margaret
- Morton Donna
- Mose Lisle E.
- Mungall Andrew J.
- Muzny Donna
- Ng Sam
- Nguyen Lam
- Niu Beifang
- Noble Michael S.
- Noushmehr Houtan
- O'Laughlin Michelle
- Ojesina Akinyemi I.
- Omberg Larsson
- Ozenberger Brad
- Pantazi Angeliki
- Parfenov Michael
- Park Peter J.
- Parker Joel S.
- Paull Evan
- Pedamallu Chandra Sekhar
- Perou Charles M.
- Pihl Todd
- Pohl Craig
- Pot David
- Protopopov Alexei
- Przytycka Teresa
- Radenbaugh Amie
- Ramirez Nilsa C.
- Ramirez Ricardo
- Raphael Benjamin J.
- Reid Jeffrey
- Ren Xiaojia
- Reva Boris
- Reynolds Sheila M.
- Rhie Suhn K.
- Roach Jeffrey
- Robertson A. Gordon
- Rovira Hector
- Ryan Michael
- Rätsch Gunnar
- Saksena Gordon
- Salama Sofie
- Sander Chris
- Santoso Netty
- Schein Jacqueline E.
- Schmidt Heather
- Schultz Nikolaus
- Schumacher Steven E.
- Seidman Jonathan
- Senbabaoglu Yasin
- Seth Sahil
- Sharpe Samantha
- Shen Hui
- Shen Ronglai
- Sheth Margi
- Shi Yan
- Shmulevich Ilya
- Silva Grace O.
- Simons Janae V.
- Sinha Rileen
- Sipahimalani Payal
- Smith Scott M.
- Sofia Heidi J.
- Sokolov Artem
- Soloway Mathew G.
- Song Xingzhi
- Sougnez Carrie
- Spellman Paul
- Staudt Louis
- Stewart Chip
- Stojanov Petar
- Stuart Joshua M.
- Su Xiaoping
- Sumer S. Onur
- Sun Yichao
- Swatloski Teresa
- Tabak Barbara
- Tam Angela
- Tamborero David
- Tan Donghui
- Tang Jiabin
- Tarnuzzer Roy
- Taylor Barry S.
- Thiessen Nina
- Thorsson Vesteinn
- Triche Timothy
- Uzunangelov Vladislav
- Van Den Berg David J.
- Van Waes Carter
- Van't Veer Laura J.
- Vandin Fabio
- Varhol Richard J.
- Vaske Charles J.
- Veluvolu Umadevi
- Verhaak Roeland
- Voet Doug
- Walker Jason
- Wallis John W.
- Waltman Peter
- Wan Yunhu
- Wang Min
- Wang Wenyi
- Wang Zhining
- Waring Scot
- Weinhold Nils
- Weinstein John N.
- Weisenberger Daniel J.
- Wendl Michael C.
- Wheeler David
- Wilkerson Matthew D.
- Wilson Richard K.
- Wise Lisa
- Wolf Denise M.
- Wong Andrew
- Wu Chang Jiun
- Wu Chia Chin
- Wu Hsin Ta
- Wu Junyuan
- Wylie Todd
- Xi Liu
- Xi Ruibin
- Xia Zheng
- Xu Andrew W.
- Yang Da
- Yang Liming
- Yang Lixing
- Yang Tai Hsien Ou
- Yang Yang
- Yao Jun
- Yao Rong
- Yau Christina
- Ye Kai
- Yoshihara Kosuke
- Yuan Yuan
- Yung Alfred K.
- Zack Travis
- Zeng Dong
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jiashan
- Zhang Nianxiang
- Zhang Qunyuan
- Zhang Wei
- Zhao Wei
- Zheng Siyuan
- Zhu Jing
- Zmuda Erik
- Zou Lihua
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies
The Origin and Evolution of Mutations in Acute Myeloid Leukemia
- Author
- Abkowitz
- Abkowitz
- Abramson
- Allford
- Armitage
- Bacher
- Betz
- Bullinger
- Calabrese
- Carretero
- Catlin
- Charles Lu
- Chen
- Christopher A. Miller
- Christopher C. Harris
- Cyriac Kandoth
- Daniel C. Koboldt
- Daniel C. Link
- David E. Larson
- David J. Dooling
- Ding
- Elaine R. Mardis
- Flex
- Foudi
- Fulu Liu
- Funk
- Gary W. Swift
- Gilliland
- Gundry
- Harvey
- Heather K. Schmidt
- Imaizumi
- Ishikawa
- Jack D. Baty
- Jacqueline E. Payton
- Jason R. Walker
- Jasreet Hundal
- Jeffery M. Klco
- Jeong
- Jerry P. Reed
- Joelle M. Kalicki-Veizer
- John F. DiPersio
- John S. Welch
- John W. Wallis
- Joshua F. McMichael
- Jun Xia
- Kelly
- Ken Chen
- Kim D. Delehaunty
- Kogan
- Larson
- Larson
- Ley
- Ley
- Li
- Li Ding
- Lin
- Ling Lin
- Link
- Lisa L. Cook
- Loeb
- Lucinda A. Fulton
- Lukas D. Wartman
- Lynch
- Mardis
- Marková
- Mark A. Watson
- Matthew J. Walter
- McCormick
- Michael D. McLellan
- Michael H. Tomasson
- Michelle D. O’Laughlin
- Millau
- Mortazavi
- Mullighan
- Nobish Varghese
- Nowell
- Patricia A. Alldredge
- Payton
- Pedersen-Bjergaard
- Peter Westervelt
- Pfeifer
- Qunyuan Zhang
- Rakesh Nagarajan
- Richard K. Wilson
- Robert S. Fulton
- Rocquain
- Rowley
- Ryan T. Demeter
- Sallmyr
- Sanz
- Sean D. McGrath
- Sharon E. Heath
- Shashikant Kulkarni
- Shen
- Shih
- Sohal
- Solomon
- Stirewalt
- Suela
- Takayama
- Takizawa
- Tamara L. Lamprecht
- Tammi L. Vickery
- Timothy A. Graubert
- Timothy J. Ley
- Todd N. Wylie
- Tomasson
- Tomlinson
- Trapnell
- Trapnell
- Vincent J. Magrini
- Walter
- Walter
- Walter
- Wartman
- Welch
- William D. Shannon
- Yamashita
- Young
- Zheng
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
- Author
- Aaron Black
- Adrian Ally
- Aly Karsan
- An He
- Andy Chu
- Angela Tam
- Anna L. Chu
- Ari Kahn
- B. A. S. C.
- B. A. S. C.
- B. S. c. M. S.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
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- B. S. C.
- B. S. C.
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- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. S. C.
- B. A.
- B. A.
- B. A.
- B. E.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- B. S.
- Baltimore
- Baty Jack D.
- Bethesda Md
- Bethesda Md
- Bethesda Md
- Bethesda Md
- Biotechnology Consultant Boston
- Bradley A. Ozenberger
- Bradley M. Broom
- Brenda Ayala
- British Columbia Cancer Agency's Genome Sciences Centre
- Broad Institute of Harvard
- Brown University
- Cambridge Ma
- Carrie Hirst
- Carrie Sougnez
- Center for Computational Molecular Biology
- Charles Lu
- Chicago
- Christopher Adams
- Columbus Oh
- Daniel C. Link M. D.
- Daniel J. Weisenberger
- Darlene Lee
- David A. Pot
- David E. Larson
- David H. Spencer
- David J. Van Den Berg
- Deepak Srinivasan
- Ding Li
- Division of Medical Oncology
- Dominik Stoll
- Dominique L. Berton
- Elaine R. Mardis
- Epigenome Center
- Eric E. Snyder
- Eric Chuah
- Erin Pleasance
- F. A. C. M. G.
- Fairfax Va
- Fred Hutchinson Cancer Research Center
- Frederick Applebaum
- Fulton Lucinda L.
- Fulton Robert
- Gad Getz
- Greg Eley
- Hagop Kantarjian M. D.
- Haiyan I. Li
- Heath Sharon E.
- Heather Schmidt
- Heidi J. Sofia
- Hoadley Katherine
- Houston
- Houston
- Hsin Ta Wu
- Hui Shen
- Hye Jung Chun
- Inanc Birol
- Jacqueline Payton
- Jacquie Schein
- James R. Downing
- Jay Bowen
- Jean Pierre J. Issa
- Jeremy Parker
- Jessica Walton
- John A. Demchok
- John F. Dipersio
- John N. Weinstein
- John W. Wallis
- John Welch
- Johns Hopkins University
- Joshua F. Mcmichael
- Jude Children's Research Hospital S. t.
- Julie Gastier Foster
- Julien Baboud
- Kalicki Veizer Joelle
- Kanchi Krishna Latha
- Kandoth Cyriac
- Karen Mungall
- Ken Chen
- Kenna R. Mills Shaw
- Khanh Nguyen
- Klco Jeffery M.
- Koboldt Daniel C.
- Laird Peter W.
- Ley Timothy
- Lihua Zou
- Liming Yang
- Ling Lin
- Lisa Wise
- Los Angeles
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Louis S. t.
- Lucas Swanson
- Lukas D. Wartman
- M. D. P. h. D.
- M. D. P. h. D.
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- M. D. P. h. D.
- M. D. P. h. D.
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- M. D. P. h. D.
- M. D. P. h. D.
- M. S. c. D. V. M.
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- M. D.
- M. D.
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- M. D.
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- M. S.
- M. S.
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- M. S.
- M. S.
- M. S.
- M. S.
- Marco A. Marra
- Margi Sheth
- Mark A. Jensen
- Mark A. Watson
- Mark D. M. Leiserson B. A.
- Mark Backus
- Martin L. Ferguson
- Martin Carroll
- Martin Hirst
- Massachusetts Institute of Technology
- Matthew C. Nicholls
- Matthew J. Walter
- Memphis
- Michael C. Wendl
- Michael D. Mclellan
- Michael H. Tomasson
- Michael Mayo
- Michelle Le Beau
- Miller Christopher
- Miruna Balasundaram
- Mlf Consulting
- Moiz S. Bootwalla
- Mungall Andrew J.
- Natasja Wye
- National Cancer Institute
- National Cancer Institute
- National Human Genome Research Institute
- National Human Genome Research Institute
- Nianziang Zhang
- Nina Thiessen
- Noreen Dhalla
- P. h. D. M. P. H.
- P. h. D.
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- P. h. D.
- Patrick Plettner
- Peter Westervelt
- Philadelphia
- Philadelphia
- Phillip H. Lai
- Prachi Kothiyal
- Providence Ri
- Ranabir Guin
- Raphael Benjamin J.
- Rashmi N. Sanbhadti
- Readman Chiu
- Rehan Akbani
- Richard A. Moore
- Richard K. Wilson
- Richard Corbett
- Richard Varhol
- Robert A. Holt
- Robertson A. Gordon
- Rohini Raman
- Sciementis Llc
- Sean P. Barletta
- Seattle Cancer Care Alliance
- Seattle
- Shashikant Kulkarni
- Shelley Alonso
- Siteman Cancer Center S. t. Louis
- Siteman Cancer Center S. t. Louis
- Siteman Cancer Center S. t. Louis
- Sra International
- Stacey Gabriel
- Stanley Girshik
- Statham Ga
- Stephen B. Baylin
- Steven Jones
- Steven Kornblau
- Tamara L. Lamprecht
- Tanja Davidsen
- Tara Lichtenberg
- Temple University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Genome Institute at Washington University
- the Research Institute at Nationwide Children's Hospital
- Thomas C. Motter
- Thomas Grossman
- Timothy A. Graubert
- Todd D. Pihl
- Triche Timothy J.
- University of Southern California
- University of Texas M. D. Anderson Cancer Center
- University of Texas M. D. Anderson Cancer Center
- University of Chicago
- University of Pennsylvania
- Vancouver Canada
- Vandin Fabio
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Washington University
- Yaron Butterfield
- Yongjun Zhao
- Yunhu Wan
- Zhining Wang
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear. METHODS: We analyzed the genomes of 200 clinically annotated adult cases of de novo AML, using either whole-genome sequencing (50 cases) or whole-exome sequencing (150 cases), along with RNA and microRNA sequencing and DNA-methylation analysis. RESULTS: AML genomes have fewer mutations than most other adult cancers, with an average of only 13 mutations found in genes. Of these, an average of 5 are in genes that are recurrently mutated in AML. A total of 23 genes were significantly mutated, and another 237 were mutated in two or more samples. Nearly all samples had at least 1 nonsynonymous mutation in one of nine categories of genes that are almost certainly relevant for pathogenesis, including transcription-factor fusions (18% of cases), the gene encoding nucleophosmin (NPM1) (27%), tumor-suppressor genes (16%), DNA-methylation-related genes (44%), signaling genes (59%), chromatin-modifying genes (30%), myeloid transcription-factor genes (22%), cohesin-complex genes (13%), and spliceosome-complex genes (14%). Patterns of cooperation and mutual exclusivity suggested strong biologic relationships among several of the genes and categories. CONCLUSIONS: We identified at least one potential driver mutation in nearly all AML samples and found that a complex interplay of genetic events contributes to AML pathogenesis in individual patients. The databases from this study are widely available to serve as a foundation for further investigations of AML pathogenesis, classification, and risk stratification. (Funded by the National Institutes of Health.) Copyright © 2013 Massachusetts Medical Society
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
- Author
- Aaron D. Black
- Abel Gonzalez Perez
- Adam Margolin
- Adrian Ally
- Akbani Rehan
- Akinyemi I. Ojesina
- Alan P. Hoyle
- Alexei Protopopov
- Alfred K. Yung
- Ami S. Bhatt
- Amie Raden Baugh
- Anders Jacobsen
- Andre Kahles
- Andrea Eakin
- Andrew J. Mungall
- Andrew W. Xu
- Andrew Wong
- Angela N. Brooks
- Angela Hadjipanayis
- Angela Tam
- Angeliki Pantazi
- Ari Kahn
- Artem Sokolov
- B. Arman Aksoy
- Barbara Tabak
- Barry S. Taylor
- Benjamin P. Berman
- Benjamin Gross
- Benz Christopher C
- Boris Reva
- Brad Ozenberger
- Bradley Broom
- Brady Bernard
- Brian Craft
- Byers Lauren A.
- Caleb Davis
- Carmen Helsel
- Carrie Soug Nez
- Carrie Hirst
- Catrina C. Fronick
- Chad J. Creighton
- Chandra Sekhar Pedamallu
- Chang Jiun Wu
- Charles J. Vaske
- Charles Lu
- Chen Zhong
- Cheng Fan
- Cherniack Andrew D.
- Chia Chin Wu
- Chip Stewart
- Chris Sander
- Christie Kovar
- Christopher A. Bristow
- Christopher A. Miller
- Chu Andy
- Collisson Eric A.
- Corbin D. Jones
- Craig Pohl
- Cynthia Mcallister
- D. Neil Hayes
- Da Yang
- Daniel C. Koboldt
- Daniel J. Weisenberger
- Daniel Carlin
- Daniel Dicara
- Darlene Lee
- David E. Larson
- David I. Heiman
- David J. Dooling
- David J. Van Den Berg
- David W. Kane
- David Haussler
- David Pot
- David Wheeler
- Deepti Dodda
- Dimitris Anastassiou
- Ding Li
- Divya Kalra
- Dong Yeon Cho
- Dong Zeng
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doug Voet
- Douglas A. Levine
- Elaine R. Mardis
- Elena Helman
- Elizabeth Buda
- Eric S. Lander
- Eric Chuah
- Erik Zmuda
- Eunjung Lee
- Evan Paull
- Gad Getz
- Gideon Dresdner
- Giovanni Ciriello
- Gordon Saksena
- Grace O. Silva
- Greg Eley
- Gunnar Ra \u308 tsch
- Hailei Zhang
- Haiyan I. Li
- Han Liang
- Harshad S. Mahadeshwar
- Harshavardhan Doddapaneni
- Heather Schmidt
- Hector Rovira
- Heidi J. Sofia
- Hoadley Katherine A.
- Hollie A. Harper
- Hoon Kim
- Houtan Noushmehr
- Hsin Ta Wu
- Huyen Dinh
- Hye Jung E. Chun
- Ilya Shmulevich
- Ina Felau
- Inanc Birol
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Jake Lin
- James Cle Land
- James G. Her man
- James Melott
- Janae V. Simons
- Jason R. Dobson
- Jason Walker
- Jay Bowen
- Jean Claude Zenklusen
- Jeffrey Reid
- Jeffrey Roach
- Jennifer Drummond
- Jessica Frick
- Jiabin Tang
- Jianhua Zhang
- Jianjiong Gao
- Jim M. Eldred
- Jing Zhu
- Joel S. Parker
- Joelle Kalicki Veizer
- John A. Demchok
- John W. Wallis
- Jonathan Seidman
- Joonil Jung
- Joshua F. Mcmichael
- Julie M. Gastier Foster
- Jun Li
- Jun Yao
- Junyuan Wu
- Juok Cho
- Kai Ye
- Kalle Leinonen
- Kandoth Cyriac
- Keith A. Baggerly
- Kenneth Aldape
- Kim Delehaunty
- Kjong Van Lehmann
- Ko suke Yoshihara
- Krishna Latha Kanchi
- Kristen M. Ler aas
- Kristian Cibulskis
- Kyle Chang
- Kyle Ellrott
- Laird Peter W.
- Lam Nguyen
- Lawrence Donehower
- Leiserson Max D. M.
- Leng Han
- Lihua Zou
- Liming Yang
- Ling Lin
- Lisa Iype
- Lisa Wise
- Lisle E. Mose
- Liu Xi
- Lixing Yang
- Lopez Bigas Nuria
- Lora Lewis
- Louis Staudt
- Love lace J. Luquette
- Lucinda L. Ful ton
- Ludmila Danilova
- Lynda Chin
- Marc Ladanyi
- Marco A. Marra
- Margaret Morgan
- Margi Sheth
- Margolin Adam A.
- Mark A. Jensen
- Mark P. Hamilton
- Martin L. Miller
- Martin Hirst
- Mary Edgerton
- Mary Goldman
- Mathew G. Soloway
- Matthew D. Wilkerson
- Matthew Meyerson
- Mclellan Michael D.
- Melisssa Cline
- Michael C. Wendl
- Michael S. Lawrence
- Michael S. Noble
- Michael Mayo
- Michael Miller
- Michael Parfenov
- Michael Ryan
- Michelle O\u2019Laughlin
- Mills Gordon B.
- Min Wang
- Miruna Balasundaram
- Moiz S. Bootwalla
- Myra George
- Nathan D. Dees
- Netty Santoso
- Ng Sam
- Nianxiang Zhang
- Nikolaus Schultz
- Nils Gehlenborg
- Nils Weinhold
- Nilsa C. Ramirez
- Nina Thiessen
- Niu Beifang
- Noreen Dhalla
- Omberg Larsson
- Paul Spellman
- Payal Sipahimalani
- Pei Lin
- Perou Charles M.
- Petar Stojanov
- Peter J. Park
- Peter Waltman
- Philip L. Lorenzi
- Piotr A. Mieczkowski
- Preethi Gunaratne
- Psalm Haseley
- Qunyuan Zhang
- Rachel Abbott
- Rachel Abbott
- Raju Kucherlapati
- Ranabir Guin
- Raphael Benjamin J.
- Ricardo Ramirez
- Richard A. Moore
- Richard J. Varhol
- Richard K. Wilson
- Richard Gibbs
- Richard Kreisberg
- Rileen Sinha
- Robert A. Holt
- Robert Burton
- Robert Fulton
- Robertson A. Gordon
- Roeland Verhaak
- Roger Kramer
- Rong Yao
- Ronglai Shen
- Roy Tarnuzzer
- Ruibin Xi
- Ryan Bressler
- S. Onur Sumer
- Sahil Seth
- Saianand Balu
- Saman tha Sharpe
- Samirku mar Amin
- Samuel S. Freeman
- Scot Waring
- Scott L. Carter
- Scott M. Smith
- Scott Abbott
- Scott Frazer
- Sean E. Mcguire
- Semin Lee
- Seth Lerner
- Shaowu Meng
- Sheila M. Reynolds
- Shelley M. Herbrich
- Shen Hui
- Singer Ma
- Siyuan Zheng
- Sofie Salama
- Stacey B. Gabriel
- Stanley R. Hamilton
- Stephen B. Baylin
- Stephen C. Benz
- Stephen Chanock
- Steven E. Schumacher
- Steven J. M. Jones
- Stuart R. Jeffreys
- Stuart Joshua M.
- Suhn K. Rhie
- Suzanne Fei
- Tai Hsien Ou Yang
- Tamborero David
- Tanja Davidsen
- Tara M. Lichtenberg
- Teresa Przytycka
- Teresa Swatloski
- Theo Knijnenburg
- Timothy J. Ley
- Timothy Triche J. r.
- Tod D. Casasent
- Todd Pihl
- Todd Wylie
- Tom Bodenheimer
- Toshinori Hinoue
- Travis Zack
- Umadevi Veluvolu
- Uzunangelov Vladislav
- Van Waes Carter
- Van'T Veer Laura J.
- Vandin Fabio
- Ves teinn Thorsson
- Vincent J. Magrini
- Wei Li
- Wei Zhang
- Wei Zhao
- Weinstein John N.
- Wen bin Liu
- Wenyi Wang
- William Lee
- Wolf Denise M.
- Xiao jia Ren
- Xiaoping Su
- Xingzhi Song
- Yan Shi
- Yang Yang
- Yaron S. N. Butterfield
- Yasin Senbabaoglu
- Yau Christina
- Yi Han
- Yichao Sun
- Yiling Lu
- Yingchun Liu
- Yuan Yuan
- Yuexin Liu
- Yunhu Wan
- Zhang Jiashan
- Zheng Xia
- Zhenlin Ju
- Zhining Wang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
© 2014 Elsevier Inc. Recent genomic analyses of pathologically defined tumor types identify 'within-a-tissue' disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-oforigin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pancancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies
Integrated genomic characterization of endometrial carcinoma
- Author
- Abramov Mikhail
- Adams Christopher
- Akbani Rehan
- Akbani Rehan
- Akbani Rehan
- Aksoy B. Arman
- Ally Adrian
- Annala Matti
- Antipin Yevgeniy
- Ardlie Kristin
- Auman J. Todd
- Ayala Brenda
- Balasundaram Miruna
- Balu Saianand
- Barnabas Nandita
- Barr Thomas
- Bartlett John M. S.
- Baylin Stephen B.
- Bell Daphne W.
- Benz Christopher C.
- Benz Christopher C.
- Benz Stephen
- Berchuck Andrew
- Berchuck Andrew
- Beroukhim Rameen
- Beroukhim Rameen
- Berry-Green Charlenia
- Birol Inanc
- Birrer Michael
- Black Aaron D.
- Blanc Victoria
- Bodenheimer Tom
- Bogomolniy Faina
- Boice Lori
- Bootwalla Moiz S.
- Borowsky Mark
- Bowen Jay
- Broaddus Russell
- Broaddus Russell
- Broaddus Russell
- Broom Bradley M.
- Buda Elizabeth
- Butterfield Yaron S. N.
- Button Michael
- Cadungog Mark
- Carlsen Rebecca
- Carney Michael E.
- Carter Candace
- Carter Scott L.
- Casasent Tod D.
- Cerami Ethan
- Cerami Ethan
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chin Lynda
- Chin Lynda
- Cho Juok
- Chu Andy
- Chu Anna L.
- Chuah Eric
- Chun Hye-Jung E.
- Cibulskis Kristian
- Ciriello Giovanni
- Clarke Blaise A.
- Curley Erin
- Czerwinski Christine
- Dao Fanny
- Dao Linda
- Davidsen Tanja
- Deardurff John
- Demchok John A.
- Dhalla Noreen
- Dhir Rajiv
- DiCara Daniel
- Ding Li
- Ding Li
- Ding Li
- DiSaia Phillip
- Dooling David
- Dowdy Sean C.
- Dowdy Sean C.
- Dresdner Gideon
- Edwards Robert
- Eley Greg
- Elishaev Esther
- Farkas Adam
- Ferguson Martin L.
- Fisher Jennifer
- Frazer Scott
- Frick Jessica
- Fulton Lucinda
- Fulton Robert
- Gabriel Stacey B.
- Gabriel Stacey B.
- Gao Jianjiong
- Gardner Johanna
- Garg Karuna
- Gastier-Foster Julie M.
- Gentry Jeff
- Getz Gad
- Getz Gad
- Getz Gad
- Gilks C. Blake
- Gilks C. Blake
- Goldstein Ted
- Goodfellow Paul J.
- Goodfellow Paul J.
- Goodman Marc T.
- Goodman Marc T.
- Gostout Bobbie
- Green Alex
- Gross Benjamin
- Grossman Thomas
- Guin Ranabir
- Guyer Mark S.
- Hadjipanayis Angela
- Harper Hollie A.
- Hart-Kothari Melissa
- Haussler David
- Hayes D. Neil
- Heiman David
- Helsel Carmen
- Hernandez Bryan
- Hirst Carrie
- Hoadley Katherine A.
- Hoadley Katherine A.
- Hobensack Aaron
- Holt Robert A.
- Hoyle Alan P.
- Huang Mei
- Huelsenbeck-Dill Lori
- Iacocca Mary
- Jacobsen Anders
- Jefferys Stuart R.
- Jensen Mark A.
- Jing Rui
- Jones Corbin D.
- Jones Steven J. M.
- Ju Zhenlin
- Kahn Ari B.
- Kahn Ari B.
- Kalicki-Veizer Joelle
- Kalloger Steve E.
- Kandoth Cyriac
- Kandoth Cyriac
- Kandoth Cyriac
- Karlan Beth Y.
- Karlan Beth Y.
- Kneile Kelley
- Kodeeswaran Sugy
- Kothiyal Prachi
- Kucherlapati Raju
- Kucherlapati Raju
- Kucherlapati Raju
- Kuck Harkness
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Laird Peter W.
- Laird Peter W.
- Lander Eric
- Lawrence Mike
- Lawrence Mike
- Lee Darlene
- Lee Semin
- Leraas KristenM.
- Lester Jenny
- Levine Douglas A.
- Levine Douglas A.
- Levine Douglas A.
- Li Haiyan I.
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Liu Guoyan
- Liu Yuexin
- Liu Yuexin
- Liu Yuexin
- Lu Yiling
- MacKenzie Jean
- Mahadeshwar Harshad S.
- Mallard Will
- Mallery David
- Mardis Elaine R.
- Mardis Elaine R.
- Mardis Elaine R.
- Marra Marco A.
- Matsuno Rayna K.
- Mayo Michael
- McAllister Cynthia
- McLellan Michael D.
- Meng Shaowu
- Meuter Alexandra
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mills Gordon B.
- Mills Gordon B.
- Mills Gordon B.
- Moiseenko Fedor
- Monovich Laura
- Moore Richard A.
- Mose Lisle E.
- Mungall Andrew J.
- Mutch David
- Mutch David
- Nemirovich-Danchenko Elena
- Nicholson Dana
- Noble Michael
- Noble Michael
- O'Laughlin Michelle
- Olvera Narciso
- Onofrio Robert C.
- Orsulic Sandra
- Ozenberger Bradley A.
- Parfitt Jeremy
- Park Peter
- Parker Joel S.
- Pashtan Itai
- Pashtan Itai
- Pashtan Itai
- Penny Robert
- Perou Charles M.
- Petrelli Nicholas
- Petrelli Nicholas
- Pihl Todd D.
- Plettner Patrick
- Pollock Pamela M.
- Pontius Joan
- Pot David A.
- Potapova Olga
- Protopopov Alexei
- Pyatt Robert E.
- Ramirez Nilsa C.
- Rathmell W. Kimryn
- Ren Xiaojia
- Reva Boris
- Reynolds Sheila M.
- Roach Jeff
- Robertson A. Gordon
- Robertson A. Gordon
- Robertson A. Gordon
- Rotin Daniil
- Saksena Gordon
- Salvesen Helga B.
- Salvesen Helga B.
- Sam Ng
- Sander Chris
- Schein Jacqueline E.
- Schmidt Heather
- Schultz Nikolaus
- Schultz Nikolaus
- Schultz Nikolaus
- Schumacher Steven E.
- Seth Sahil
- Shaw Kenna R. Mills
- Shen Hui
- Shen Hui
- Shen Hui
- Shen Ronglai
- Shen Ronglai
- Sheth Margi
- Shi Yan
- Shinbrot Eve
- Shmulevich Ilya
- Simons Janae V.
- Sinha Rileen
- Sipahimalani Payal
- Sivachenko Andrey
- Snyder Eric E.
- Sofia Heidi J.
- Soloway Mathew G.
- Song Xingzhi
- Soslow Robert A.
- Soslow Robert A.
- Sougnez Carrie
- Srinivasan Deepak
- Stojanov Petar
- Stuart Joshua
- Stuart Joshua
- Sumer S. Onur
- Szeto Christopher
- Tabak Barbara
- Tabler Teresa R.
- Tam Angela
- Tan Donghui
- Tang Jiabin
- Taylor Barry S.
- Teoman Attila
- Thorne Leigh
- Topal Michael D.
- Triche Timothy J., Jr.
- Unruh Anna K.
- Van Den Berg DavidJ.
- Van Le Linda
- Vanhoose Nathan
- Varhol Richard J.
- Voet Doug
- Wakefield Chris
- Wang Chen
- Waring Scot
- Weinhold Nils
- Weinhold Nils
- Weinstein John N.
- Weisenberger Daniel J.
- Wheeler David A.
- White Peter
- Wilson Richard K.
- Winckler Wendy
- Winterhoff Boris
- Winterhoff Boris
- Wise Lisa
- Witkin Gary
- Wu Junyuan
- Xi Ruibin
- Yang Liming
- Yang Lixing
- Yau Christina
- Yau Christina
- Ye Kai
- Zeng Dong
- Zhang Hailei
- Zhang Jianhua
- Zhang Jianhua
- Zhang Nianxiang
- Zhang Wei
- Zhang Wei
- Zhang Wei
- Zmuda Erik
- Zorn Kristin
- Zou Lihua
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2012
- Field of study
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.National Institutes of Health (U.S.) (Grant 5U24CA143799-04)National Institutes of Health (U.S.) (Grant 5U24CA143835-04)National Institutes of Health (U.S.) (Grant 5U24CA143840-04)National Institutes of Health (U.S.) (Grant 5U24CA143843-04)National Institutes of Health (U.S.) (Grant 5U24CA143845-04)National Institutes of Health (U.S.) (Grant 5U24CA143848-04)National Institutes of Health (U.S.) (Grant 5U24CA143858-04)National Institutes of Health (U.S.) (Grant 5U24CA143866-04)National Institutes of Health (U.S.) (Grant 5U24CA143867-04)National Institutes of Health (U.S.) (Grant 5U24CA143882-04)National Institutes of Health (U.S.) (Grant 5U24CA143883-04)National Institutes of Health (U.S.) (Grant 5U24CA144025-04)National Institutes of Health (U.S.) (Grant U54HG003067-11)National Institutes of Health (U.S.) (Grant U54HG003079-10)National Institutes of Health (U.S.) (Grant U54HG003273-10