Five year retrospective study of mortality in systemic inflammatory rheumatologic disorders

Background: Inflammatory systemic rheumatologic disorders are responsible for significant morbidity and premature deaths. The present study was done to assess causes of mortality in these patients.Methods: In the retrospective study, the death records of patients with inflammatory rheumatologic illnesses from January 2012 to January 2017 were studied. The demographic details, disease activity, organ involvement, treatment received and evidence of infection were noted.Results: 50 records were analyzed (25 systemic lupus erythematosus (SLE), 13 rheumatoid arthritis (RA), four immune myositis, three systemic sclerosis (SS), two takayasu’s arteritis (TA), two ankylosing spondylitis (AS) and one granulomatosis with polyangiitis (GPA)). The me an age of death was 39.94 years. Sixteen patients had disease related organ damage, 17 had active disease. Infection was present in 31 patients (gram negative organisms most commonly isolated), being the major contributor of mortality. Only two patients succumbed to acute coronary syndrome.Conclusions: Infection, disease activity and organ damage due to the disease are the major contributors to of death in hospitalized patients with inflammatory rheumatological disorders

Attitudes of general dental practitioners towards biopsy procedures

Objectives: A dentist is required to detect and recognise oral lesions and inform the patient accordingly by providing a diagnosis and adequate treatment plan. Biopsy serves as an important aid in achieving this goal; however, its use is not so widespread in general dental practice. The objective of the present study was to explore the attitudes of general dental practitioners in Belgaum city towards biopsy for diagnosis of oral lesions. Material and methods: A self designed questionnaire was administered to 74 general dental practitioners in Belgaum city, in the southern region of India, consisting of several items addressing the socio-demographic and professional aspects and their attitudes towards oral biopsy procedures. Results: The response rate was exceptionally high i.e. 90.54%. All the dentists felt that biopsy was an important tool in diagnosis of oral lesions but many still did not venture to undertake it on their own and preferred referring it to a specialist or higher care centre. This was mainly due to lack of experience and patient factors. There were also conflicting results regarding referral diagnostic pathology services and preservation of the biopsy specimens. Conclusion: This emphasizes the need for higher levels of importance to be placed on this aspect in undergraduate and postgraduate dental curriculum. Organisation of specific training or continuing dental education programmes to enhance their practical skills could aid in increasing the utility of this important tool in diagnosis of oral lesion

Difference Spectrophotometric Method for Estimation of Amitriptyline Hydrochloride in Bulk Drug

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Oral Juvenile Hyaline Fibromatosis: A Rare Entity

Juvenilna hijalina fibomatoza iznimno je rijedak poremećaj kod dojenčadi i djece, a javlja se prema zakonima autosomno recesivnog nasljeđivanja. Izgleda poput multiple kožne ili subkutane tumorne tvorbe, sporo se razvija i češća je u području glave i vrata te gornjeg dijela trupa. Često je povezana s gingivnom hipertrofijom, teškom fleksularnom kontrakturom udova i koštanom lezijom. Nema mentalne retardacije. Histološki se te lezije sastoje od obilne eozinofilne osnovne tvari s neravnomjerno raspršenim fibroblastima. Ekscidirane lezije u ranim stadijima bogatije su stanicama. Točno podrijetlo eozine hijaline tvari nije poznato. Nedavno je pronađen defekt kromosoma 4q21 povezan s lokusom gena – 2 za kapilarnu morfogenezu. Diferencijalna dijagnoza za juvenilnu hijalinu fibromatozu uključuje i infantilnu sistemsku hijalinozu, za koju se zna da je alelna. Trenutačno nema široko prihvaćene učinkovite terapije ni za juvenilnu hijalinu fibromatozu ni za infantilnu sistemsku hijalinozu. Juvenilna hijalina fibromatoza i infantilna sistemska hijalinoza ponekad se teško razlikuju jer su vrlo slične. Mi izvještavamo o slučaju juvenilne hijaline fibromatoze kod 10-godišnje djevojčice s pretežno gingivalnom hiperplazijom.Juvenile hyaline fibromatosis is an exceedingly rare disorder of infants and children which appears to have autosomal recessive inheritance. It is characterized by multiple, slowly growing dermal or subcutaneous tumors, especially in the head and neck region and upper trunk, often associated with gingival hypertrophy, severe flexural limb contractures and bone lesions. There is no mental retardation. Histologically, these lesions are composed of copious eosinophilic, homogenous ground substance with unevenly dispersed fibroblasts. Lesions excised in early stages are more cellular. The precise nature of the eosinophilic hyaline material is not known. Recently, a defect on chromosome 4q21 associated with the locus of the capillary morphogenesis gene – 2, has been demonstrated. The differential diagnosis of juvenile hyaline fibromatosis includes infantile systemic hyalinosis, which is now known to be allelic. Currently, no widely accepted effective treatment exists for juvenile hyaline fibromatosis or infantile systemic hyalinosis. Infantile systemic hyalinosis and juvenile hyaline fibromatosis are sometimes difficult to separate since they show significant overlap. We report one such unusual case of juvenile hyaline fibromatosis in a 10 year old female presenting mainly with gingival hyperplasia

THE MANAGEMENT OF PRIMARY DYSMENORRHOEA (KASHTARTAVA) - A PROSPECTIVE MULTICENTRIC OPEN OBSERVATIONAL STUDY

Objective: To evaluate the clinical usefulness of Rajahpravartini vati in the management of primary dysmenorrhoea (Kashtartava) and changes in the quality of life of the subjects. Study design: A multi-centric prospective single arm observational study. Setting and participants: 359 subjects aged between 16 - 35 years suffering from painful menstruation at least for three consecutive regular menstrual cycles were included in the study. Intervention: Rajahpravartini Vati a classical Ayurvedic formulation was administered 250 mg b.d. with lukewarm water for 90 days followed by subsequent 90 days without intervention. Outcome measures: The management of menstrual pain assessing by 10 points Visual Analogue Scale and improvement in the quality of life using SF-36 (RAND) questionnaire. Results: The mean VAS score of pain at baseline was 6.94±1.98, decreasing to 1.7±2.22 at 90th day which further decreased and maintained to 1.24±1.9 up to 180th day. Associated symptoms like nausea, vomiting, constipation, giddiness, breast tenderness, diarrhea, headache and fainting were completely relieved. The improvements of quality of life in 8 domains viz. pain, general health, physical functioning, social functioning, emotional wellbeing, energy/fatigue, limitation due to physical health and emotional problems at the end of 90th day of intervention was also significant (p<0.001) in comparison to baseline. No adverse event occurred during the treatment period. Conclusion: Rajahpravartini Vati has shown a positive role for the treatment of dysmenorrhoea and to improve the quality of life of the subjects

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

SHAISHANIK KARYACHYA SANDARBHAT ASHASAKIYA SANSTHANCHYA YOGDANACHA ABHYAS KARANE

"Vidyevina mati geli, mati vina gati geli, gati vina vitta gele, vitta vina kshudra khachale, itake anartha yeka avidyene kele.

SMS FOR ANDROID APPLICATION BY USING 3D-AES, PGP AND STEGNOGRAPHY

Today the age of information technology has transformed the ways we communicate with each other. We send emails, send SMS, send message using social networking sites and many more. The uses of computers, smart phones and clouds have become an integral part of our life for sharing information with each other. Thus introduction of all these means have also given rise to misuse of information by third party which can steal our private information.Thus we are thinking of using cryptography for securing our information. Today there are many cryptographic algorithms available for securing data but those are common from AES to RSA. So we are thinking of enhancing the security by using an advanced version of AES called as 3D-AES which generates a symmetric key by shuffling the original key array three times and making the key better each time it is shuffled. Thus the final output key will be more strong then a normal AES key. It will help secure the data more accurately than the normal one. The studies should reflect a lower encryption time and more security then the normal one. The other technique is used PGP for encryption and Compress the encrypted message to reduce its length, using Shannon fano algorithm technique