Farmers’ willingness to supply biomass for energy generation: evidence from South and Central Poland

The objective of this survey-based study was to investigate farmers’ willingness to supply biomass for power generation in the south and in the centre of Poland. In total, 210 farmers participated in this study by filling in a self-instructed questionnaire. The results indicate that the majority of farmers (two-thirds) in both regions appeared unwilling to collect, store and transport biomass to the market or to the energy production facility. It is likely that an unstable biomass market marked by low demand and low prices has led to unwillingness by farmers to engage in bioenergy production in Poland. Increasing the role of biomass as a renewable energy resource and recovering the farmers’ confidence in the market would require fixing the shortcomings in the biomass market and the provision of clear public policies that aim at long-term market stability

Farmers' perceptions of the challenges facing the biomass market in Poland; a case study from South and Central Poland

Farmers’ perceptions and values are a fundamental part of a polycentric approach aimed at improving the financial feasibility of biomass-based enterprises. In this survey-based study, 210 farmers from central (Torun province) and southern (Upper Silesia region) Poland completed a self- instructed questionnaire dealing with their perceptions of the challenges currently facing the biomass market and their willingness to change from traditional farming to feedstock production for energy generation. The results indicate that only 12% of the farmers are willing to switch to biocrop cultivation. Moreover, selected socio-economic and demographic variables (gender, age) had an impact on their willingness to adopt energy crops. All the presented challenges appeared to be of high relevance to the farmers who participated in this study. However, farmers from Torun province attributed substantial relevance to the social transformation in the agriculture sector, and to the lack of seasonal workers. In the Upper Silesia region, the lack of a well-established biomass market was of greatest relevance. A cross-tabulation method revealed statistical differences between the perceived value of farming and the farmers’ perceptions toward the challenges facing the biomass market. These findings are insightful for policies that aim to address the shortcomings in current biomass market development in Poland

Bridging senses of place and mobilities scholarships to inform social-ecological systems governance:A research agenda

Uncertainty and change are increasingly commonplace as communities respond to impacts of social-ecological change including climate change, and dangerous levels of pollution. Given the extent of these crises, new approaches are needed to support responses. Here we identify challenges and discuss insights that the nexus of Senses of place (SoP) and mobilities research offers in navigating such uncertainty. We conducted a two-round Delphi, followed by a workshop, and collaborative writing process with a global network of researchers with expertise in either or both SoP and mobilities research. Participants identified five challenges at the place-mobility nexus that emerge when a social-ecological system is disrupted. We use the 2022 Odra River fish die-off to exemplify the identified challenges: 1) accounting for power dynamics, inequalities and motility; 2) doing justice to more-than human actors; 3) integrating multiple and sometimes nested spatial scales; 4) considering temporalities of place and mobilities, and 5) embracing multisensoriality. To address these challenges, we recommend drawing on diverse methods and knowledge co-creation processes that combine more-than-human perspectives, multisensoriality, and engage in the dynamic relations between places to understand people-place disruptions in the face of socio-spatial precarity. Addressing such knowledge gaps requires stronger collaboration of mobilities and place researchers.</p

Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34

Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis

PGC-1&alpha; (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator of many genes involved in energy management and mitochondrial biogenesis. PGC-1&alpha; expression is associated with cellular senescence, organismal aging, and many age-related diseases, including AMD (age-related macular degeneration), an important global issue concerning vision loss. We and others have developed a model of AMD pathogenesis, in which stress-induced senescence of retinal pigment epithelium (RPE) cells leads to AMD-related pathological changes. PGC-1&alpha; can decrease oxidative stress, a key factor of AMD pathogenesis related to senescence, through upregulation of antioxidant enzymes and DNA damage response. PGC-1&alpha; is an important regulator of VEGF (vascular endothelial growth factor), which is targeted in the therapy of wet AMD, the most devastating form of AMD. Dysfunction of mitochondria induces cellular senescence associated with AMD pathogenesis. PGC-1&alpha; can improve mitochondrial biogenesis and negatively regulate senescence, although this function of PGC-1&alpha; in AMD needs further studies. Post-translational modifications of PGC-1&alpha; by AMPK (AMP kinase) and SIRT1 (sirtuin 1) are crucial for its activation and important in AMD pathogenesis