Savoring the moment: A link between affectivity and depression

Objective: Positive affectivity (PA; disposition to experience positive moods) and negative affectivity (NA; disposition to experience negative moods) may be risk factors for depression. Low PA may impair positive emotion regulation (savoring), potentially exacerbating depression. Understanding the mechanisms in which temporal domains of savoring influence the relationship between affectivity and depression may help advance depression treatments.Method: 1,618 participants (1,243 females; 70.0% Caucasian, 19.1% Asian, 4.5% African American, 0.9% Pacific Islander, 0.7% American Indian or Alaskan Native, 4.9% Biracial) ages 17 - 40 (M = 18.99, SD = 1.33) completed questionnaires. An exploratory path analysis was run with PA and NA as exogenous variables, savoring domains as mediators, and depression the outcome.Results: PA and NA were associated with depression and all three savoring temporal domains. Momentary savoring distinctly mediated the relationship between both PA and NA and depression.Limitations: The data are self-report and cross-sectional, precluding causal inference. Post-hoc power analysis indicated that the present study was underpowered. The use of a college sample primarily comprised of Caucasian women limits generalizability.Conclusions: Affectivity was associated with the temporal domains of savoring and indirectly associated with depression via momentary savoring. All temporal domains of savoring may bolster PA and mitigate NA. Momentary savoring may reduce depression symptoms in individuals with low PA and high NA

Evaluation of Esophageal Motility Utilizing the Functional Lumen Imaging Probe

© 2016 by the American College of Gastroenterology. Objectives:Esophagogastric junction (EGJ) distensibility and distension-mediated peristalsis can be assessed with the functional lumen imaging probe (FLIP) during a sedated upper endoscopy. We aimed to describe esophageal motility assessment using FLIP topography in patients presenting with dysphagia.Methods:In all, 145 patients (aged 18-85 years, 54% female) with dysphagia that completed up per endoscopy with a 16-cm FLIP assembly and high-resolution manometry (HRM) were included. HRM was analyzed according to the Chicago Classification of esophageal motility disorders; major esophageal motility disorders were considered "abnormal". FLIP studies were analyzed using a customized program to calculate the EGJ-distensibility index (DI) and generate FLIP topography plots to identify esophageal contractility patterns. FLIP topography was considered "abnormal" if EGJ-DI was < 2.8 mm 2 /mm Hg or contractility pattern demonstrated absent contractility or repetitive, retrograde contractions.Results:HRM was abnormal in 111 (77%) patients: 70 achalasia (19 type I, 39 type II, and 12 type III), 38 EGJ outflow obstruction, and three jackhammer esophagus. FLIP topography was abnormal in 106 (95%) of these patients, including all 70 achalasia patients. HRM was "normal" in 34 (23%) patients: five ineffective esophageal motility and 29 normal motility. In all, 17 (50%) had abnormal FLIP topography including 13 (37%) with abnormal EGJ-DI.Conclusions:FLIP topography provides a well-tolerated method for esophageal motility assessment (especially to identify achalasia) at the time of upper endoscopy. FLIP topography findings that are discordant with HRM may indicate otherwise undetected abnormalities of esophageal function, thus FLIP provides an alternative and complementary method to HRM for evaluation of non-obstructive dysphagia.Link_to_subscribed_fulltex

Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects

Esophago-pharyngeal regurgitation is implicated in various otolaryngologic and respiratory disorders. The pathophysiological mechanisms causing regurgitation are still largely unknown

The Neuroscience of Positive Emotions and Affect:Implications for Cultivating Happiness and Wellbeing

This review paper provides an integrative account regarding neurophysiological correlates of positive emotions and affect that cumulatively contribute to the scaffolding for happiness and wellbeing in humans and other animals. This paper reviews the associations among neurotransmitters, hormones, brain networks, and cognitive functions in the context of positive emotions and affect. Consideration of lifespan developmental perspectives are incorporated, and we also examine the impact of healthy social relationships and environmental contexts on the modulation of positive emotions and affect. The neurophysiological processes that implement positive emotions are dynamic and modifiable, and meditative practices as well as flow states that change patterns of brain function and ultimately support wellbeing are also discussed. This review is part of "The Human Affectome Project" (http://neuroqualia.org/background.php), and in order to advance a primary aim of the Human Affectome Project, we also reviewed relevant linguistic dimensions and terminology that characterizes positive emotions and wellbeing. These linguistic dimensions are discussed within the context of the neuroscience literature with the overarching goal of generating novel recommendations for advancing neuroscience research on positive emotions and wellbeing

Be mindful and SMiLe: Changes in PA, NA, and depression after eight weeks of Headspace

This study examined the efficacy of Headspace by comparing self-report levels of positive affect (PA), negative affect (NA), and depression before and after eight weeks of Headspace use. Prior research shows that PA and NA are modifiable intervention targets for those with major depressive disorder (MDD). Meditation is also theorized to reduce depression symptoms, enhance PA, and reduce NA in those with MDD. Consistent with prior research, we found a significant reduction in depression symptoms, increase in PA, and decrease in NA. This suggests that Headspace is an effective treatment for depression that can be used to bolster positive emotions

Savoring: A Significant Mediator Associated with the Efficacy of Mindfulness Based Interventions on Depressive Symptomatology

Today, depression is a societal crisis and many individuals affected are unable to receive accessible treatment. Savoring is an awareness of positive experiences and the use of positive emotion regulation strategies to enhance positive feelings and research has shown that higher levels of savoring are correlated with less self-reported depressive symptoms. This study examined how the capacity to savor impacts depressive symptoms over the course of an eight-week app-based mindfulness intervention. Our analysis revealed those subject to the intervention showed a greater change in their capacity to savor and depressive symptoms relative to controls. Thus, savoring plays a significant role in mediating the effects of a mindfulness intervention on depression symptomatology

Functional esophageal disorders

Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by structural disorders, histopathology-based motor disturbances, or gastroesophageal reflux disease. Gastroesophageal reflux disease is the preferred diagnosis when reflux esophagitis or excessive esophageal acid exposure is present or when symptoms are closely related to acid reflux events or respond to antireflux therapy. A singular, well-defined pathogenetic mechanism is unavailable for any of these disorders; combinations of sensory and motor abnormalities involving both central and peripheral neural dysfunction have been invoked for some. Treatments remain empirical, although the efficacy of several interventions has been established in the case of functional chest pain. Management approaches that modulate central symptom perception or amplification often are required once local provoking factors (eg, noxious esophageal stimuli) have been eliminated. Future research directions include further determination of fundamental mechanisms responsible for symptoms, development of novel management strategies, and definition of the most cost-effective diagnostic and treatment approache