5 research outputs found
B12 Vitamin and Folat Prevelance of Children and Adolescents in Diyarbakır
The most common cause of megaloblastic anemia in childhood are vitamin B12 and folat deficiency. Folat and vitamin B12 play a role in DNA synthessis in gastrointestinal, urogenital,nerves and hemotopoetic cells. The diagnosis of megaloblastic anemia is easy and the treatment cost is low.In this study, the prevalence of vitamin B12 and folat deficiencies in 889 students were determined. Vitamin B12 and folat levels in blood samples were measured via RİAThe average age were betwen 12 and 22 years. Of this students 294(%33,1) were female and 595 (%66,9) were male. The incidence of vitamin B12 deficiency was found to be 2.2%, while folat deficiency was 21.8%. The mean vitamin B12 level was 331,51±144,05 pg/mL (325,60±138,91 in pg/mL male, 343,48±153,48 pg/mL in female), the mean folat level was 5,42±2,12 ng/ml (5,23±2,11 ng/ml in male, 5,80±2,10 ng/ml in female).The prevelance of folat deficiency in our region was higher than other countries, possibly due to low socioeconomical status, improper or inadequate food intake and low educational status
Nadir faktör eksikliği tanılı 36 olgunun değerlendirilmesi
Introduction: Rare factor deficiencies are predominantly autosomal recessively inherited disorders with a frequency of approximately 1: 500000 to 1: 2000000 in the general population. They account for 3-5% of all inherited coagulation disorders. In this study, we aimed to evaluate the demographic features and clinical findings of 36 patients who were followed up and treated with the diagnosis of rare factor deficiency. Materials and Methods: A total of 36 patients aged between 0-16 years diagnosed with rare coagulation deficiencies were evaluated in terms of demographic, physical examination, clinical follow-up, and laboratory findings at the Dicle University Pediatric Hematology Unit. Ethics committee approval was obtained from Dicle University for the study on 16.03.2018 with decision no 115. Results: Rare factor deficiencies were diagnosed in 36 (35 %) of 103 patients who were followed up with coagulation disorders. Hemophilia a, hemophilia b, and von Willebrand disease constituted 67 of our patients. Familial consanguinity was present in 75, 6 %, and positive family history was found at 16.6% of the patients. 11 (32.4%) of our patients were diagnosed under the age of one year. Most of our patients diagnosed with factor X deficiency (38.8%). The most common symptoms were mucocutaneous bleeding (50%). Intracranial hemorrhage was detected in 7 (%19,5) patients. Conclusions: Early diagnosis and treatment are very important in the case of rare factor deficiency since severe bleeding complications such as intracranial hemorrhage may develop. Rare factor deficiencies are seen more frequently in places where consanguineous marriage is more common than the general population. Families should be informed about this issue, and family screening should be done early.Giriş: Nadir faktör eksiklikleri; çoğunlukla otozomal resesif geçiş gösteren,prevalansı 1/ 500.000 -1/2.000.000 arasında değişen pıhtılaşma faktör eksiklikleridir. Kalıtsal pıhtılaşma faktör eksikliklerinin %3-5’ini oluşturmaktadır. Bu çalışmada, nadir faktör eksikliği tanısı ile takip ve tedavi ettiğimiz hastaların demografik özellikleri ve klinik bulguları değerlendirilmiştir. Gereç ve Yöntem: Çalışmamızda, Dicle Üniversitesi Tıp Fakültesi Çocuk Hematolojisi ve Onkolojisi biriminde nadir faktör eksikliği tanısı ile takip ve tedavi edilen, yaşları 0-16 yıl arasında değişen toplam 36 hasta değerlendirilmiştir. Hastaların demografik özellikleri,klinik izlem sonuçları ve labaratuar verileri incelenmiştir.Çalışma için Dicle Üniversitesi’nden 16.03.2018 tarihinde 115 nolu karar ile etik kurul onayı alınmıştır. Bulgular: Kalıtsal faktör eksikliği nedeniyle takip ve tedavi ettiğimiz 103 hastanın 36’sında (% 35) nadir faktör eksikliği tanısı mevcuttu. Hastalarımızın 67’sini hemofili A, hemofili B ve von Willebrand hastalığı oluşturuyordu. Anne ve babaların akrabalık oranı % 75,6 olup,aile öyküsü %16.6 olarak bulunmuştur. Hastalarımızın 11’i (%32,4) bir yaşından önce tanı almıştır.Hasta grubumuzda %38,8 oranı (14 hasta) ile FX eksikliği en fazla görülmektedir.Tanı anında en sık başvuru semptomunu %50 ile cilt-mukoza kanamaları oluşturmaktaydı. Ciddi kanamalardan intrakranial kanama yedi (%19,5) hastada görülmüştür. Sonuç: İntrakranial kanama gibi ciddi kanama komplikasyonlarıyla seyretmesinden dolayı nadir faktör eksikliğinde erken tanı ve tedavi çok önemlidir. Nadir faktör eksiklikleri, akraba evliliğinin fazla görüldüğü yerlerde genel popülasyona oranla sık görülmektedir. Ailelerin bu konuda bilgilendirilmesi,aile taramalarının erken dönemde yapılması gerekliliktir
New constraints on micro-seismicity and stress state in the western part of the North Anatolian Fault Zone: Observations from a dense seismic array
Capillary Bedside Blood Glucose Measurement in Neonates: Missing a Diagnosis of Galactosemia
A number of factors may lead to inaccuracy in measurement of capillary blood glucose with a glucometer. Measurement of other carbohydrate molecules such as galactose and fructose along with glucose can potentially be a cause of error. We report a newborn patient who was referred to our hospital with conjugated bilirubinemia, hepatomegaly and high capillary blood glucose levels measured with a glucometer. Simultaneous biochemical measurements revealed normal blood glucose levels. Further investigation led to a diagnosis of classical galactosemia. Capillary blood glucose level measured with glucometer also dropped to normal values following cessation of breastfeeding and initiation of feeding with a lactose-free formula.WoSScopusPubMe