1,500 research outputs found
Verwirklichung einer vollkommenen GlĂŒcksmöglichkeit/A perfect bliss-potential realized: âWunsch, Indianer zu werdenâ im Lichte des Dao Kafkas ĂŒbersetzend gelesen/Transreading âWish, to Become Indianâ in light of Kafkaâs Dao
Walking an unexplored path, Huiwen Helen Zhang contextualizes Kafka's pithy and cryptic parable, âWish, to Become Indianâ in his transplantation of Daoist philosophyâan astonishing cross-cultural enigma that Zhang terms âKafka's Daoââand parses it through a micro-level approach that Zhang terms âtransreading.â Contextualizing âWish, to Become Indianâ in Kafka's dialogue with ancient Chinese philosophers such as Laozi, Liezi, and Zhuangzi enables the reader to comprehend a series of otherwise incomprehensible puzzles. Zhang's scrutiny of Kafka's Dao shows how, through creative writing, Kafka not only penetrates esoteric Daoist classics, but also furthers their spirit in a way that transcends Richard Wilhelm, the pioneer European Sinologist. Transreading âWish, to Become Indianâ illuminates nuances that otherwise might have been overlooked. Wordplay, punctuational oddity, syntactic complexity, lyric density, and the curiously interlaced tenses and cases are all part of the idiosyncratic delivery of Kafka's message. Integrating the four activities of transreadingâlento reading demanded and enhanced by cultural hermeneutics, creative writing required and inspired by poetic translationâunravels Kafka's riddle as a historical-cultural phenomenon.publishedVersio
JT9D engine diagnostics. Task 2: Feasibility study of measuring in-service flight loads
The feasibility of measuring JT9D propulsion system flight inertia loads on a 747 airplane is studied. Flight loads background is discussed including the current status of 747/JT9D loads knowledge. An instrumentation and test plan is formulated for an airline-owned in-service airplane and the Boeing-owned RA001 test airplane. Technical and cost comparisons are made between these two options. An overall technical feasibility evaluation is made and a cost summary presented. Conclusions and recommendations are presented in regard to using existing inertia loads data versus conducting a flight test to measure inertia loads
Accretion and activity on the post-common-envelope binary RR~Cae
Current scenarios for the evolution of interacting close binaries - such as
cataclysmic variables (CVs) - rely mainly on our understanding of low-mass star
angular momentum loss (AML) mechanisms. The coupling of stellar wind with its
magnetic field, i.e., magnetic braking, is the most promising mechanism to
drive AML in these stars. There are basically two properties driving magnetic
braking: the stellar magnetic field and the stellar wind. Understanding the
mechanisms that drive AML therefore requires a comprehensive understanding of
these two properties. RRCae is a well-known nearby (d=20pc) eclipsing DA+M
binary with an orbital period of P=7.29h. The system harbors a metal-rich cool
white dwarf (WD) and a highly active M-dwarf locked in synchronous rotation.
The metallicity of the WD suggests that wind accretion is taking place, which
provides a good opportunity to obtain the mass-loss rate of the M-dwarf
component. We analyzed multi-epoch time-resolved high-resolution spectra of
RRCae in search for traces of magnetic activity and accretion. We selected a
number of well-known activity indicators and studied their short and long-term
behavior. Indirect-imaging tomographic techniques were also applied to provide
the surface brightness distribution of the magnetically active M-dwarf, and
reveals a polar feature similar to those observed in fast-rotating solar-type
stars. The blue part of the spectrum was modeled using a atmosphere model to
constrain the WD properties and its metal enrichment. The latter was used to
improve the determination of the mass-accretion rate from the M-dwarf wind. The
presence of metals in the WD spectrum suggests that this component arises from
accretion of the M-dwarf wind. A model fit to the WD gives Teff=(7260+/-250)K
and logg=(7.8+/-0.1) dex with a metallicity of =(-2.8+/-0.1)dex,
and a mass-accretion rate of dotMacc=(7+/-2)x1e-16Msun/yr.Comment: 14 pages, 7 Figures, 6 Table
The Amazing Old Nova Q Cygni: A Far Ultraviolet Synthetic Spectral Analysis
Q Cygni (Nova Cygni 1876) is the third oldest old novae (after WY Sge and
V841 Oph) with a long orbital period of 10.08 hours and spectroscopic
peculiarities in the optical including the presence of variable wind outflow
revealed by optical P Cygni profiles in the HeI lines and H alpha beta (Kafka
et al. 2003). We have carried out a synthetic spectral analysis of a far
ultraviolet IUE archival spectrum of Q Cygni using our optically thick, steady
state, accretion disk models and model white dwarf photospheres. We find that
the accretion light of a luminous accretion disk dominates the FUV flux of the
hot component with a rate of accretion 2-3 1.E-9 Msun/yr. We find that Q Cygni
lies at a distance of 741 \pm 110 pc . The implications of our results for
theoretical predictions for old novae are presented.Comment: PASP, August 201
Time-resolved measurement of single pulse femtosecond laser-induced periodic surface structure formation
Time-resolved diffraction microscopy technique has been used to observe the
formation of laser-induced periodic surface structures (LIPSS) from the
interaction of a single femtosecond laser pulse (pump) with a nano-scale groove
mechanically formed on a single-crystal Cu substrate. The interaction dynamics
(0-1200 ps) was captured by diffracting a time-delayed, frequency-doubled pulse
from nascent LIPSS formation induced by the pump with an infinity-conjugate
microscopy setup. The LIPSS ripples are observed to form sequentially outward
from the groove edge, with the first one forming after 50 ps. A 1-D analytical
model of electron heating and surface plasmon polariton (SPP) excitation
induced by the interaction of incoming laser pulse with the groove edge
qualitatively explains the time-evloution of LIPSS formation.Comment: 4 pages, 5 figure
Comparative analysis of US real-world dosing patterns and direct infusion-related costs for matched cohorts of rheumatoid arthritis patients treated with infliximab or intravenous golimumab.
Purpose: The objectives of this study were to evaluate and compare treatment patterns and infusion-related health care resource expenditures for rheumatoid arthritis (RA) patients initiating golimumab for intravenous use (GLM-IV) and infliximab (IFX) therapy and to assess cost implications from the commercial perspective.
Methods: Adult RA patients with a new episode of GLM-IV or IFX treatment between January 1, 2014 and March 31, 2016 were identified from MarketScan databases and evaluated for maintenance infusion intervals and related costs of treatment. IFX and GLM-IV patients were matched 1:1 on index medication treatment duration, gender, payer type, prior biologic use, and post-index methotrexate use. Paid amounts for drugs and associated administration costs were applied to treatment group dosing patterns.
Results: Final matched treatment groups included 547 GLM-IV and 547 IFX patients (mean age = 55-56 years). Mean (SD) follow-up was 609 (161) days for GLM-IV and 613 (163) days for IFX. Treatment duration was 396 (240) days for GLM-IV and 397 (239) days for IFX. Overall, 80% of GLM-IV and 39% of IFX maintenance infusions were given approximately every 8 weeks; and 6% of GLM-IV and 53% of IFX maintenance infusions occurred more frequently than every 8 weeks (P\u3c0.001). When weighting of the maintenance infusion interval was applied, the mean number of induction plus maintenance infusions during the first year of treatment was estimated at 7.03 for GLM-IV and 9.48 for IFX. From the commercial perspective, drug plus administration costs per infusion were 5,444 for IFX with total annual cost of therapy for GLM-IV patients costing 6,774 less than that for IFX patients in subsequent years.
Conclusion: Annual GLM-IV drug plus administration costs for commercial health plans were significantly less than IFX in RA patients due to differences in real-world dosing and administration. © 2019 Ellis et al
Patient-reported outcome assessment of inflammatory arthritis patient experience with intravenously administered biologic therapy
Objective: To evaluate patient perspectives regarding utilization of intravenous (IV) therapy for inflammatory arthritis (IA). Methods: This was a single-center, non-interventional, patient questionnaire-based study of adult IA patients currently receiving IV biologics. At a single visit, patients completed the questionnaire comprising 30 questions centered on their experience receiving an intravenously administered therapy to treat their IA. The questionnaire included questions on patient demographics, disease characteristics, and previous biologic treatment for IA (subcutaneous [SC] and IV). Patients rated their level of agreement with statements regarding satisfaction with current IV biologic therapy and potential advantages and disadvantages of IV biologic therapy using a 5-point Likert scale (1= strongly disagree, 5= strongly agree). Results: One hundred patients were enrolled and completed the survey; 66% were female and the mean age was 58 years. Before IV treatment, 97% of patients received information regarding therapy options. Ninety patients ranked their satisfaction with current IV therapy as 4 or 5. The proportion of patients with an âextremely favorableâ perception of IV therapy increased from 33% to 71% following initiation of their current medication. Thirty-one patients had previously received SC therapies to treat their IA. Conclusion: These results demonstrated an overall favorable perception of IV therapy among this patient population. Patients previously treated with SC therapy also had a positive shift in the perception of IV therapy after initiating IV therapy. Patientsâ perception and preference for treatment options should be highly considered by the treating physician during or as part of a shared decision-making process. © 2017 Gaylis et al
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