Anticholinergic Syndrome Due to the Use of Datura Stramonium Seeds for Constipation: A Story of Prolonged ICU Stay

Datura stramonium is grown widely in some regions of Turkey. Datura stramonium seed is used in the treatment of various diseases such as constipation and acne and causes anticholinergic toxicity when taken in overdose. In the literature, patients presenting with mild symptoms are the majority, and intensive care follow-up is often not required for these patients. In this case report, we present a 50-year-old male patient who received around 200 Datura stramonium seeds for the treatment of chronic constipation. When the patient admitted to the emergency department, he was unconscious, and his pupils were dilated. The patient who had severe vomiting and contractions was intubated. With the diagnosis of anticholinergic syndrome, physostigmine 0.5 mg (one dose) and 1 mg (two times) were administered to the patient with central nervous system findings. The patient who developed sepsis due to aspiration pneumonia during the follow-up stayed in the intensive care unit for 40 days with the support of mechanical ventilator for 37 days. The patient was discharged after 26 days of treatment in the physical therapy service Accidental ingestion of Datura stramonium seed used for herbal therapy in high doses may cause life-threatening consequences due to its anticholinergic effects or complications related to these effects

Respiratory Depression Caused by Heroin Use

Summary Heroin is a semisynthetic narcotic analgesic and heroin abuse is common due to its pleasure-inducing effect. For the last 30 years heroin abuse has become an important worldwide public health problem. Heroin can be administered in many different ways as preferred. Heroin affects many systems including respiratory system, cardiovascular system and particulary the central nervous system. Overdose use of heroin intravenously can be fatal due to respiratory depression. In this letter, we wanted to engage attention to respiratory depression caused by heroin abuse and potential benefits of using naloxone. [TAF Prev Med Bull 2012; 11(2.000): 248-250

Effect of (Mo, W) substitution for Nb on glass forming ability and magnetic properties of Fe-Co-based bulk amorphous alloys fabricated by centrifugal casting

In this study, effects of simultaneous Mo and W substitution for Nb additions on the stability and magnetic properties of Fe-Co-based bulk metallic glass (BMG) alloys fabricated by centrifugal casting are investigated. The saturation magnetization (J(s)) and coercivity (H(c)) for the as-cast Fe(36)CO(36)B(19.2)Si(4.8)X(4) (X = Nb or Mo(0.5)W(0.5)) BMG alloys and melt-spun Fe(36)Co(36)B(19.2)Si(4.8)Mo(2)W(2) were in the range of 1.02-1.57T and 11.13-1685 A/m, respectively. The Fe(36)Co(36)B(19.2)Si(4.8)X(4) (X = Nb or Mo(0.5)W(0.5)) BMG alloys in the shape of wedge with the maximum thickness of 1.5-2 mm were obtained successfully by means of conventional centrifugal casting. Replacing Nb with Mo(0.5)W(0.5) deteriorates magnetic properties in bulk form and reduces the GFA of the alloy due to promoting the precipitation of non-magnetic compounds, while it results in good soft magnetic properties in melt-spun ribbon form

Demographics of patients with heart failure who were over 80 years old and were admitted to the cardiology clinics in Turkey

WOS: 000468584300005PubMed ID: 30930455Objective: Heart failure (HF) has a high prevalence and mortality rate in elderly patients; however, there are few studies that have focused on patients older than 80 years. The aim of this study is to describe and compare the age-specific demographics and clinical features of Turkish elderly patients with HF who were admitted to cardiology clinics. Methods: The Epidemiology of Cardiovascular Disease in Elderly Turkish population (ELDER-TURK) study was conducted in 73 centers in Turkey, and it recruited a total of 5694 patients aged 65 years or older. In this study, the clinical profile of the patients who were aged 80 years or older and those between 65 and 79 years with HF were described and compared based on the ejection fraction (EF)-related classification: HFrEF and HFpEF (is considered as EF: >= 50%). Results: A total of 1098 patients (male, 47.5%; mean age, 83.5 +/- 3.1 years) aged 80 years and 4596 patients (male, 50.2 %; mean age, 71.1 +/- 4.31 years) aged 65-79 years were enrolled in this study. The prevalence of HF was 39.8% for patients who were >= 80 years and 27.1% for patients 65-79 years old. For patients aged >= 80 years with HF, the prevalence rate was 67% for hypertension (HT), 25.6% for diabetes mellitus (DM), 54.3% for coronary artery disease (CAD), and 42.3% for atrial fibrilation. Female proportion was lower in the HFrEF group (p=0.019). The prevalence of HT and DM was higher in the HFpEF group (p= 80 years with HFrEF (p<0.01). Conclusion: HF is common in elderly Turkish population, and its frequency increases significantly with age. Females, diabetics, and hypertensives are more likely to have HFpEF, whereas CAD patients are more likely to have HFrEF.Turkish Society of CardiologyThis study was supported by Turkish Society of Cardiology

Demographics of patients with heart failure who were over 80 years old and were admitted to the cardiology clinics in Turkey

Objective: Heart failure (HF) has a high prevalence and mortality rate in elderly patients; however, there are few studies that have focused on patients older than 80 years. The aim of this study is to describe and compare the age-specific demographics and clinical features of Turkish elderly patients with HF who were admitted to cardiology clinics. Methods: The Epidemiology of Cardiovascular Disease in Elderly Turkish population (ELDER-TURK) study was conducted in 73 centers in Turkey, and it recruited a total of 5694 patients aged 65 years or older. In this study, the clinical profile of the patients who were aged 80 years or older and those between 65 and 79 years with HF were described and compared based on the ejection fraction (EF)-related classification: HFrEF and HFpEF (is considered as EF: >= 50\%). Results: A total of 1098 patients (male, 47.5\%; mean age, 83.5 +/- 3.1 years) aged 80 years and 4596 patients (male, 50.2 \%; mean age, 71.1 +/- 4.31 years) aged 65-79 years were enrolled in this study. The prevalence of HF was 39.8\% for patients who were >= 80 years and 27.1\% for patients 65-79 years old. For patients aged >= 80 years with HF, the prevalence rate was 67\% for hypertension (HT), 25.6\% for diabetes mellitus (DM), 54.3\% for coronary artery disease (CAD), and 42.3\% for atrial fibrilation. Female proportion was lower in the HFrEF group (p=0.019). The prevalence of HT and DM was higher in the HFpEF group (p<0.01), whereas CAD had a higher prevalence in the HFrEF group (p=0.02). Among patients aged 65-79 years, 43.9\% (548) had HFpEF, and 56.1\% (700) had HFrEF. In this group of patients aged 65-79 years with HFrEF, the prevalence of DM was significantly higher than in patients aged >= 80 years with HFrEF (p<0.01). Conclusion: HF is common in elderly Turkish population, and its frequency increases significantly with age. Females, diabetics, and hypertensives are more likely to have HFpEF, whereas CAD patients are more likely to have HFrEF