Koncentracija teških metala u tkivu oslića Merluccius merluccius (Linnaeus, 1758) iz Oranskog zaljeva (Sredozemno more): procjena potencijalnog rizika za ljudsko zdravlje

To evaluate the potential human health risk to hake consumers, the bioaccumulation of heavy metals (Cd, Pb, and Zn) was measured in the edible tissues of hake Merluccius merluccius (Linnaeus, 1758) caught from Oran Bay on the western Algerian Mediterranean coast. Results revealed that the average metal concentrations varied significantly among sex and in target organs. The concentrations of metal accumulation take place preferentially in the liver compared to the muscle of hake species, with the highest levels found for Zn, followed by Pb and Cd. The Estimated daily intake (EDI) of each trace metal did not exceed the tolerable daily intake (TDI). Human health risk assessment from heavy metal exposure through fish consumption from Oran Bay for adults showed no significant non-carcinogenic adverse health risk since all calculated values for Target Hazard Quotient (THQ) and Total Target Hazard Quotient (TTHQ) were <1.Da bi se odredio potencijalni rizik za ljudsko zdravlje pri konzumaciji oslića, određena je bioakumulacija teških metala (Cd, Pb i Zn) u jestivom tkivu oslića Merluccius merluccius (Linnaeus, 1758) ulovljenog u zapadnom Sredozemlju u alžirskom zaljevu Oran. Rezultati pokazuju da prosječne koncentracije metala značajno variraju ovisno o spolu i testiranom organu oslića. Metali se više akumuliraju u jetri oslića nego u mišićima, a najviše razine utvrđene su za cink, nakon čega slijede olovo i kadmij. Procijenjeni dnevni unos (eng. Estimated daily intake, EDI) svakog metala nije premašio prihvatljivi dnevni unos (eng. Tolerable daily intake, TDI). Procjena rizika za ljudsko zdravlje zbog izloženosti teškim metalima pri konzumaciji ribe iz zaljeva Oran pokazala je da za odrasle osobe nema značajnog nekancerogenog ali štetnog zdravstvenog rizika jer su sve izračunate vrijednosti za kvocijent ciljane opasnosti (eng. Target hazard quotient, THQ) i ukupni kvocijent ciljane opasnosti (eng. Total target hazard quotient, TTHQ) bile <1

Monitoring the biological effects of pollution on the Algerian west coast using mussels <i>Mytilus galloprovincialis</i>

The Algerian west coast is the prime recipient of several forms of pollution; hence, the necessity for an impact assessment ofthis coastal pollution using a suite of recommended marine biomarkers, including lysosomal membrane stability in living cells by the Neutral Red Retention Time (NRRT) method, the evaluation of micronucleus (MN) frequency, and the determination ofacetylcholinesterase (AChE) activity in mussels Mytilus galloprovincialis, sampled from the large, polluted Oran Harbour (OH) and the Maârouf (Mrf) marine mussel farm between July 2005 and April 2006. The difference in the variations of the annual physical parameters between OH and Mrf corresponds to the influence of the domestic and industrial sewage discharged by the city of Oran. The biological data of the mussels (condition index, protein content) recorded at both sites were related to their natural reproductive cycle. This indicated that intrinsic variation between the sites due to different mussel development phases was minimal. The variation in the AChE activity of some organs of OH and Mrf mussels, with minimal inhibition in July and a higher NRRT recorded in the granular haemocytes in the Mrf than in the OH mussels during the autumn and spring, depends on the quality of the biotope and on generic stress factors. Moreover, the variation in MN frequency, in general reflecting a non-significant seasonal and spatial genotoxic effect of the contamination at the two sampling sites, requires further investigations regarding biotic and abiotic variations

Response to systemic therapies in granulomatous cheilitis : Retrospective multicenter series of 61 patients

International audienc

Response to systemic therapies in granulomatous cheilitis : Retrospective multicenter series of 61 patients

Letter to the editorInternational audienc

Sequencing of the smallest apicomplexan genome from the human pathogen Babesia Microti

International audienceWe have sequenced the genome of the emerging human pathogen Babesia microti and compared it with that of other protozoa. B. microti has the smallest nuclear genome among all Apicomplexan parasites sequenced to date with three chromosomes encoding ∼3500 polypeptides, several of which are species specific. Genome-wide phylogenetic analyses indicate that B. microti is significantly distant from all species of Babesidae and Theileridae and defines a new clade in the phylum Apicomplexa. Furthermore, unlike all other Apicomplexa, its mitochondrial genome is circular. Genome-scale reconstruction of functional networks revealed that B. microti has the minimal metabolic requirement for intraerythrocytic protozoan parasitism. B. microti multigene families differ from those of other protozoa in both the copy number and organization. Two lateral transfer events with significant metabolic implications occurred during the evolution of this parasite. The genomic sequencing of B. microti identified several targets suitable for the development of diagnostic assays and novel therapies for human babesiosis