Pierwsze odkrycie grobu rowkowego z okresu wędrówek ludów w Wielkopolsce (Konarzewo, pow. Poznań ziemski, stan. 5)

The article presents a discovery of the first grooved burial, rectangular in section, from the Great Poland. It is an urn burial with multiple interments; two urns with remains of three individuals are associated with a groove. Four clusters of cremated bones composed of remains of five individuals were placed directly above. Depending upon chosen interpretation, it was a burial of three or eight individuals. The burial has been dated back to the second half of the 5th century AD. It is a manifestation of transformations in the domain of burial rites in the last phase of the Przeworsk culture. They resulted in increasingly atypical and archaeologically indefinable forms of the burial rite. The burial was placed in the west edge of the settlement composed of hall houses made of a post construction, which was founded in the years 340-352 AD. A well cemetery with cremation burials was also discovered at this site. This was a settlement complex composed of a large settlement and at least two cremation cemeteries. It is the first complex of this type in the Przeworsk culture.The article presents a discovery of the first grooved burial, rectangular in section, from the Great Poland. It is an urn burial with multiple interments; two urns with remains of three individuals are associated with a groove. Four clusters of cremated bones composed of remains of five individuals were placed directly above. Depending upon chosen interpretation, it was a burial of three or eight individuals. The burial has been dated back to the second half of the 5th century AD. It is a manifestation of transformations in the domain of burial rites in the last phase of the Przeworsk culture. They resulted in increasingly atypical and archaeologically indefinable forms of the burial rite. The burial was placed in the west edge of the settlement composed of hall houses made of a post construction, which was founded in the years 340-352 AD. A well cemetery with cremation burials was also discovered at this site. This was a settlement complex composed of a large settlement and at least two cremation cemeteries. It is the first complex of this type in the Przeworsk culture

Harmony and Disharmony of General Education in Natural and Technical Sciences

The article presents the advantages of the correlation of education curricula in the field of natural and technical sciences, and the consequences of lack of such a program coherence. Based on a detailed analysis of the latest core curricula regarding the fourth stage of education (secondary school), the areas of an evident disharmony are shown in teaching mathematics and physics as the most representative natural science subjects

Disharmony general education science studies of engineering

Praca przedstawia stan korelacji programów nauczania przedmiotów ścisłych i technicznych na studiach inżynierskich. W oparciu o szczegółową analizę treści kształcenia matematyki i fizyki wskazano obszary rażącej dysharmonii w nauczaniu przedmiotów stanowiących bazę do kształcenia inżynierów.The paper presents the state of the programmes correlation of science and engineering sub-jects on engineering studies. Based on a detailed analysis of the content of education in mathematics and physics indicated areas glaring disharmony in the teaching of main objects of engineering education

First discovery of a grooved burial from the migration period in the Ggreat Poland (Konarzewo, Poznań district, site 5)

The article presents a discovery of the first grooved burial, rectangular in section, from the Great Poland. It is an urn burial with multiple interments; two urns with remains of three individuals are associated with a groove. Four clusters of cremated bones composed of remains of five individuals were placed directly above. Depending upon chosen interpretation, it was a burial of three or eight individuals. The burial has been dated back to the second half of the 5th century AD. It is a manifestation of transformations in the domain of burial rites in the last phase of the Przeworsk culture. They resulted in increasingly atypical and archaeologically indefinable forms of the burial rite. The burial was placed in the west edge o f the settlement composed of hall houses made of a post construction, which was founded in the years 340-352 AD. A well cemetery with cremation burials was also discovered at this site. This was a settlement complex composed of a large settlement and at least two cremation cemeteries. It is the first complex of this type in the Przeworsk culture

Coupled speakers directivity measurements for small acoustic omnidirectional source development

Acoustic monopole construction is unsolved task, which engineers try to solve for many years. In the past they constructed many innovative solutions, such as spark or laser-gap sound sources, but those concepts caused many equipment troubles. It is impossible to select type of the measurements signal for this kind of sound sources, also any sparks and laser beams can provide strong electromagnetic distortions around the operation zone. In current state of art we are trying to provide non-standard solutions while traditional omnidirectional sound source, based on spatial configuration of electroacoustic transducers, is not described correctly and can be expanded. Paper presents concept of acoustic monopole source based on coupled configuration for electrodynamic loudspeakers, similar to isobaric setup but non-constant volume between the speakers. By using FEM modelling we will present directivity patterns and project ideas, describing how overall results corresponds with geometrical parameters of speaker configuration and parameters. Presentation summary contain results of prototype device directivity patterns measurements. Received characteristics shows big potential in using cone-to-cone coupled speaker setup to reach acoustic monopole in frequency range defined by distance between transducers. Achieved knowledge allows to provide broadband, easy to build and small acoustic monopole with many possible applications

Emerging technologies for salivaomics in cancer detection.

Salivary diagnostics has great potential to be used in the early detection and prevention of many cancerous diseases. If implemented with rigour and efficiency, it can result in improving patient survival times and achieving earlier diagnosis of disease. Recently, extraordinary efforts have been taken to develop non-invasive technologies that can be applied without complicated and expensive procedures. Saliva is a biofluid that has demonstrated excellent properties and can be used as a diagnostic fluid, since many of the biomarkers suggested for cancers can also be found in whole saliva, apart from blood or other body fluids. The currently accepted gold standard methods for biomarker development include chromatography, mass spectometry, gel electrophoresis, microarrays and polymerase chain reaction-based quantification. However, salivary diagnostics is a flourishing field with the rapid development of novel technologies associated with point-of-care diagnostics, RNA sequencing, electrochemical detection and liquid biopsy. Those technologies will help introduce population-based screening programs, thus enabling early detection, prognosis assessment and disease monitoring. The purpose of this review is to give a comprehensive update on the emerging diagnostic technologies and tools for the early detection of cancerous diseases based on saliva

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

In this study, we tested five compounds belonging to a novel series of piperazine arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The biphenylmethylene derivative (BM-19) and the fluorenylmethylene derivative (BM-38) were found to possess the strongest efflux pump inhibitor (EPI) activities in the AcrAB-TolC-overproducing Escherichia coli strain 3-AG100, whereas BM-9, BM-27, and BM-36 had no activity at concentrations of up to 50 μM in a Nile red efflux assay. MIC microdilution assays demonstrated that BM-19 at 1/4 MIC (intrinsic MIC, 200 μM) was able to reduce the MICs of levofloxacin, oxacillin, linezolid, and clarithromycin 8-fold. BM-38 at 1/4 MIC (intrinsic MIC, 100 μM) was able to reduce only the MICs of oxacillin and linezolid (2-fold). Both compounds markedly reduced the MIC of rifampin (BM-19, 32-fold; and BM-38, 4-fold), which is suggestive of permeabilization of the outer membrane as an additional mechanism of action. Nitrocefin hydrolysis assays demonstrated that in addition to their EPI activity, both compounds were in fact weak permeabilizers of the outer membrane. Moreover, it was found that BM-19, BM-27, BM-36, and BM-38 acted as near-infrared-emitting fluorescent membrane probes, which allowed for their use in a combined influx and efflux assay and thus for tracking of the transport of an EPI across the outer membrane by an efflux pump in real time. The EPIs BM-38 and BM-19 displayed the most rapid influx of all compounds, whereas BM-27, which did not act as an EPI, showed the slowest influx

Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes

Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT2A receptors are known for an extremely long LSD residence time, enabling minute doses to exert a long-lasting effect. In this work, we explore the changes in anxiety-like processes induced by the previously reported antipsychotic, D2AAK1. In vivo studies revealed that the effect of D2AAK1 on the anxiety is mediated through serotonin 5-HT1A and 5-HT2A receptors, and that it is time-dependent (anxiogenic after 30 min, anxiolytic after 60 min) and dose-dependent. The funnel metadynamics simulations suggest complicated ligand-5HT(2A)R interactions, involving an allosteric site located under the third extracellular loop, which is a possible explanation of the time-dependency. The binding of D2AAK1 at the allosteric site results in a broader opening of the extracellular receptor entry, possibly altering the binding kinetics of orthosteric ligands