Fatigue strength of 30ХГСА–40ХМФА welded joints produced by rotary friction welding

Rotary friction welding (RFW) is used in the production of drill pipes for solid mineral prospecting. The need for the creation of the lightened drill strings for high-speed diamond drilling of ultradeep wells dictates the necessity of a greater focus on the study of a weld zone and setting the RFW technological parameters. This paper presents the results of experimental studies of a welded joint of a drill pipe of the H standard size according to ISO 10097, made of the 30ХГСА (pipe body) and 40ХМФА (tool joint) steels under the cyclic loads. The authors evaluated the influence of the force applied to the workpieces in the process of friction of the contacting surfaces (force during heating), and postweld tempering at a temperature of 550 °С on the cyclic life of welded joints, under the conditions of alternate tension-compression at the cycle amplitude stress of ±420 MPa. The study determined that with an increase in the force during heating, the microstructure changes occur in the zone of thermomechanical influence, contributing to an increase in the fatigue strength of welded joints. The authors identified the negative effect of postweld tempering on the fatigue strength of welded joints, which is expressed in the decrease in the number of cycles before failure by 15–40 %, depending on the magnitude of the force during heating. The optimal RFW mode of the specified combination of steels is determined, which provides the largest number of cycles before failure: the force during heating (at friction) Fh=120 kN, forging force Ffor=160 kN, rotational frequency during heating n=800 Rpm, and upset during heating l=8 mm. A series of fatigue tests have been carried out at various values of the cycle amplitude stress of the welded joint produced at the optimal mode and the 30ХГСА steel base metal; limited endurance curves have been plotted. It is shown that the differences in the limited endurance curves of the pipe body material (30ХГСА steel) and the welded joint are insignificant. The obtained results are supplemented by the microhardness measurement data and fractographs of fractured samples, revealing the mechanism of crack propagation under the cyclic loads

Risultati preliminari delle indagini archeologiche ed etnografiche presso il sito di Togolok 1

Modern Turkmenistan is mainly constituted by a desert landscape, yet despite its harsh climate, cultures have been able to construct networks of water channels since the Bronze Age. This has resulted in a man-made landscape that integrates towns and villages. Extensive surveys and recent archaeological excavations have highlighted that between 2400 and 2100 BC (Namazga V period), the region of the Murghab alluvial fan was characterised by the development of complex urban societies. However, starting from the Late Bronze Age, a new group of mobile pastoralists appeared in the Murghab region and settled along the edges of the sedentary sites. Although their presence is well-attested both by survey and excavation data, their degree of interaction with the sedentary farmers is still debated. In modern Turkmenistan, semi-mobile shepherds continue to drive their cattle across the Murghab, using mobile camps for different months. This paper presents the preliminary results of the excavation of the sedentary site of Togolok 1, as well as the first ethnographic study of the mobile communities of the Murghab region

Late Saalian and Eemian palaeoenvironmental history of the Bol'shoy Lyakhovsky Island (Laptev Sea region, Arctic Siberia)

Paleoenvironmental records from permafrost sequences complemented by IRSL and 230Th/U dates from Bol'shoy Lyakhovsky Island (73?20?N, 141?30?E) document the environmental history in the Laptev Sea region for at least the past 200 ka. Pollen spectra and insect fauna indicate that relatively wet grass-sedge tundra habitats predominated during an interstadial c. 200-170 ka ago. Summers were rather warm and wet, while stable isotopes reflect severe winter conditions. The pollen spectra reflect sparser grass-sedge vegetation cover during a late Saalian stadial, c. 170-130 ka ago, with environmental conditions much more sever compared with the previous interstadials. Open Poaceae and Artemisia plant associations dominated vegetation at the beginning of the Eemian Interglacial, c. 130 ka ago. Some shrubs (Alnus fruticosa, Salix, Betula nana) grew in more protected and wetter places as well. The climate was relatively warm during this time, resulting in the melting of the Saalian ice wedges. Later, during the interglacial optimum shrub tundra with Alnus fruticosa and Betula nana s.l. dominated vegetation. Climate was relatively wet and warm. Quantitative pollen-based climate reconstruction suggests that mean July temperatures were 4-5?C higher than the present during the optimum of the Eemian Interglacial, while late Eemian records indicate significant climate deterioration

Bone Scaffolds Based on Degradable Vaterite/PEG‐Composite Microgels

Vaterite, a metastable modification of calcium carbonate, embedded in a flexible microgel packaging with adjustable mechanical properties, functionality, and biocompatibility, provides a powerful scaffolding for bone tissue regeneration, as it is easily convertible to bone‐like hydroxyapatite (HA). In this study, the synthesis and physical analysis of a packaging material to encapsulate vaterite particles and osteoblast cells into monodisperse, sub‐millimeter‐sized microgels, is described whereby a systematic approach is used to tailor the microgel properties. The size and shape of the microgels is controlled via droplet‐based microfluidics. Key requirements for the polymer system, such as absence of cytotoxicity as well as biocompatibility and biodegradability, are accomplished with functionalized poly(ethylene glycol) (PEG), which reacts in a cytocompatible thiol–ene Michael addition. On a mesoscopic level, the microgel stiffness and gelation times are adjusted to obtain high cellular viabilities. The co‐encapsulation of living cells provides i) an in vitro platform for the study of cellular metabolic processes which can be applied to bone formation and ii) an in vitro foundation for novel tissue‐regenerative therapies. Finally, the degradability of the microgels at physiological conditions caused by hydrolysis‐sensitive ester groups in the polymer network is examined

Expression of adipocytokines in heart fat depots depending on the degree of coronary artery atherosclerosis in patients with coronary artery disease.

In coronary artery disease (CAD) the adipocytokine content in the heart fat depot is altered, but it has not been established whether these changes are associated with the degree of atherosclerotic damage to the coronary artery (CA). Were examined 84 patients with CAD, and according to the degree of atherosclerotic state based on the SYNTAX Score scale, were divided: 39 moderate (≤22 points), 20 severe (23-31 points) and 25 extremely severe (≥32 points). Biopsies of subcutaneous (SAT), epicardial (EAT) and perivascular adipose tissue (PVAT) were obtained during elective coronary artery bypass grafting (CABG). The expression of adipocytokine was determined using real-time PCR. The concentration of the studied adipocytokines in adipocyte culture medium was measured by ELISA. Statistical analysis was performed using logistic regression analysis. In the adipocytes of the cardiac depot of patients with CAD, an increase in the expression and secretion of leptin and IL-6 and a decrease in adiponectin, with a maximum manifestation in severe and extremely severe CA lesions, was observed. EAT adipocytes were characterized by minimal expression of the adiponectin gene maximal gene expression leptin and IL-6 compared to SAT and PVAT adipocytes

Multipotent Mesenchymal Stromal Cells for the Prophylaxis of Acute Graft-versus-Host Disease—A Phase II Study

The efficacy and the safety of the administration of multipotent mesenchymal stromal cells (MMSCs) for acute graft-versus-host disease (aGVHD) prophylaxis following allogeneic hematopoietic cell transplantation (HSCT) were studied. This prospective clinical trial was based on the random patient allocation to the following two groups receiving (1) standard GVHD prophylaxis and (2) standard GVHD prophylaxis combined with MMSCs infusion. Bone marrow MMSCs from hematopoietic stem cell donors were cultured and administered to the recipients at doses of 0.9–1.3×106/kg when the blood counts indicated recovery. aGVHD of stage II–IV developed in 38.9% and 5.3% of patients in group 1 and group 2, respectively, (=0.002). There were no differences in the graft rejection rates, chronic GVHD development, or infectious complications. Overall mortality was 16.7% for patients in group 1 and 5.3% for patients in group 2. The efficacy and the safety of MMSC administration for aGVHD prophylaxis were demonstrated in this study