The usefulness of serum adenosine deaminase 2 (ADA2) activity in adults for the diagnosis of pulmonary tuberculosis

AbstractRapid diagnosis of Mycobacterium tuberculosis remains an obstacle for therapy of tuberculosis (TB). Adenosine deaminase isoform 2 (ADA2) is produced by activated macrophages and has been used for diagnosis of TB from extra-pulmonary sites. However, few studies adequately address whether serum ADA2 activity is useful for diagnosis of active pulmonary tuberculosis (PTB). We prospectively measured serum ADA2 activity in 110 patients with pulmonary disease (65 cases with active PTB and 45 cases with other respiratory diseases) and 78 healthy volunteers (eight with tuberculin skin test positive). The serum ADA2 for the diagnosis of PTB had the sensitivity of 36·9%, the specificity of 84·5%, the positive predictive value of 10·9% and the negative predictive value of 96·2%. We concluded that serum ADA2 activity is neither useful to diagnosis of active PTB nor to differentiate from other respiratory diseases

Research priorities for HIV/M. tuberculosis co-Infection

This document summarizes priority areas for joint research and concerted actions to counteract the public health threat of AIDS/TB as identified within the European Support Action “EUCO-Net” funded under the 7th Framework Programme of the European Commission

Cryptococcosis: a review of the brazilian experience for the disease Criptococose: revisão sobre a experiência brasileira sobre a doença

Cryptococcosis is a systemic mycosis caused by Cryptococcus neoformans. The disease occurs in patients with cellular immunodeficiency. The incidence of cryptococcosis arises with aids, and mycosis is one of the opportunistic infections that defines AIDS. After the HAART era the occurrence of cryptococcosis decreased all over the world, but it still continues to be a prevalent disease in Brazil. Thus, we consider this paper to be very important as a result of our reviewing of Brazilian literature regarding some relevant aspects of that disease.<br>Criptococose é micose sistêmica causada por Cryptococcus neoformans. A doença ocorre em pacientes com deficiência da imunidade celular. Com o aparecimento da doença AIDS, a incidência de criptococose aumentou, e a micose é uma das infecções oportunistas que definem um caso de AIDS. Após a era HAART, criptococose parece estar diminuindo no mundo todo, mas continua sendo uma doença prevalente no Brasil. Este artigo visa a análise da contribuição dos autores brasileiros sobre vários aspectos da doença