Electrodynamic Structure of an Outer Gap Accelerator: Location of the Gap and the Gamma-ray Emission from the Crab Pulsar

We investigate a stationary pair production cascade in the outer magnetosphere of a spinning neutron star. The charge depletion due to global flows of charged particles, causes a large electric field along the magnetic field lines. Migratory electrons and/or positrons are accelerated by this field to radiate curvature gamma-rays, some of which collide with the X-rays to materialize as pairs in the gap. The replenished charges partially screen the electric field, which is self-consistently solved together with the distribution functions of particles and gamma-rays. If no current is injected at neither of the boundaries of the accelerator, the gap is located around the conventional null surface, where the local Goldreich-Julian charge density vanishes. However, we first find that the gap position shifts outwards (or inwards) when particles are injected at the inner (or outer) boundary. Applying the theory to the Crab pulsar, we demonstrate that the pulsed TeV flux does not exceed the observational upper limit for moderate infrared photon density and that the gap should be located near to or outside of the conventional null surface so that the observed spectrum of pulsed GeV fluxes may be emitted via a curvature process. Some implications of the existence of a solution for a super Goldreich-Julian current are discussed.Comment: 17 pages, 12 figures, submitted to Ap

Kinematics of massive star ejecta in the Milky Way as traced by 26^26Al

Context. Massive stars form in groups and their winds and supernova explosions create superbubbles up to kpc in size. The fate of their ejecta is of vital importance for the dynamics of the interstellar medium, for chemical evolution models, and the chemical enrichment of galactic halos and the intergalactic medium. However, ejecta kinematics and the characteristic scales in space and time have not been explored in great detail beyond ~10 Ka. Aims: Through measurement of radioactive 26Al with its decay time constant at ~106 years, we aim to trace the kinematics of cumulative massive-star and supernova ejecta independent of the uncertain gas parameters over million-year time scales. Our goal is to identify the mixing time scale and the spatio-kinematics of such ejecta from the pc to kpc scale in our Milky Way. Methods: We use the SPI spectrometer on the INTEGRAL observatory and its observations along the Galactic ridge to trace the detailed line shape systematics of the 1808.63 keV gamma-ray line from 26Al decay. We determine line centroids and compare these to Doppler shift expectations from large-scale systematic rotation around the Galaxy centre, as observed in other Galactic objects. Results: We measure the radial velocities of gas traced by 26Al, averaged over the line of sight, as a function of Galactic longitude. We find substantially higher velocities than expected from Galactic rotation, the average bulk velocity being ~200 km s-1 larger than predicted from Galactic rotation. The observed radial velocity spread implies a Doppler broadening of the gamma-ray line that is consistent with our measurements of the overall line width. We can reproduce the observed characteristics with 26Al sources located along the inner spiral arms, when we add a global blow-out preference into the forward direction away from arms into the inter-arm region, as is expected when massive stars are offset towards the spiral-arm leading edge. With the known connection of superbubbles to the gaseous halo, this implies angular-momentum transfer in the disk-halo system and consequently also radial gas flows. The structure of the interstellar gas above the disk affects how ionizing radiation may escape and ionize intergalactic gas.Peer reviewe

Pregnancy-associated breast cancer - Special features in diagnosis and treatment

For obvious psychological reasons it is difficult to associate pregnancy - a life-giving period of our existence with life-threatening malignancies. Symptoms pointing to malignancy are often ignored by both patients and physicians, and this, together with the greater difficulty of diagnostic imaging, probably results in the proven delay in the detection of breast cancers during pregnancy. The diagnosis and treatment of breast cancer are becoming more and more important, as the fulfillment of the desire to have children is increasingly postponed until a later age associated with a higher risk of carcinoma, and improved cure rates of solid tumors no longer exclude subsequent pregnancies. The following article summarizes the special features of the diagnosis and primary therapy of pregnancy-associated breast cancer with particular consideration of cytostatic therapy

Closed-circuit television arc guidance adapter kit for a computerized welding skate Final report

Closed circuit television arc guidance adapter kit for computerized welding skat

Optimized bone sampling protocols for the retrieval of ancient DNA from archaeological remains

The methods presented here seek to maximize the chances for the recovery of human DNA from ancient archaeological remains while limiting input sample material. This was done by targeting anatomical sampling locations previously determined to yield the highest amounts of ancient DNA (aDNA) in a comparative analysis of DNA recovery across the skeleton. Prior research has suggested that these protocols maximize the chances for the successful recovery of ancient human and pathogen DNA from archaeological remains. DNA yields were previously assessed by Parker et al. 2020 in a broad survey of aDNA preservation across multiple skeletal elements from 11 individuals recovered from the medieval (radiocarbon dated to a period of circa (ca.) 1040-1400 CE, calibrated 2-sigma range) graveyard at Krakauer Berg, an abandoned medieval settlement near Peißen Germany. These eight sampling spots, which span five skeletal elements (pars petrosa, permanent molars, thoracic vertebra, distal phalanx, and talus) successfully yielded high-quality ancient human DNA, where yields were significantly greater than the overall average across all elements and individuals. Yields were adequate for use in most common downstream population genetic analyses. Our results support the preferential use of these anatomical sampling locations for most studies involving the analyses of ancient human DNA from archaeological remains. Implementation of these methods will help to minimize the destruction of precious archaeological specimens.Introduction Protocol 1. Considerations before sample processing 2. Pretreatment 3. Bone powder generation Representative Results Discussio

Wind measurement system

A system for remotely measuring vertical and horizontal winds present in discrete volumes of air at selected locations above the ground is described. A laser beam is optically focused in range by a telescope, and the output beam is conically scanned at an angle about a vertical axis. The backscatter, or reflected light, from the ambient particulates in a volume of air, the focal volume, is detected for shifts in wavelength, and from these, horizontal and vertical wind components are computed

Beyond Patient Reported Pain: Perfusion Magnetic Resonance Imaging Demonstrates Reproducible Cerebral Representation of Ongoing Post-Surgical Pain

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Effects of degradable Mg-Ca alloys on dendritic cell function

Degradable magnesium alloys are new materials for implants used in orthopedic and trauma surgery. The aim of this study was to investigate the influence of degradable magnesium alloys on the function of dendritic cells (DC) as these cells represent the major antigen presenting cells of the body. MgP (pure magnesium), MgCa 0.6 (0.6% calcium), MgCa 0.8 (0.8% calcium), MgCa 1.0 (1% calcium), and MgCa 1.2 (1.2% calcium) alloys were degraded in cell culture medium. In parallel, murine bone marrow-derived DC were incubated with increasing concentrations (0.1-10 mmol/L) of magnesium chloride and calcium chloride, respectively. Incubation of DC with degradation media over 6 days had no influence on cell viability and only marginal influence on DC migration. Also, the production of TNFα and expression of CD86 was not enhanced by incubation with degraded magnesium alloys. The mixed leukocyte reaction revealed that there was also no increase of the T-cell proliferation in comparison to untreated controls. However, there was a trend toward macrophage development at the expense of DC expansion and an enhanced DC migration was induced by incubation with higher magnesium concentrations. Particularly the latter should be verified in in vivo experiments. © The Author(s), 2010