836 research outputs found
The role of microorganisms in the weathering of rocks. 1 - Microflora of the surface layer of rocks
Microbiological analyses of surface layers of rocks to determine role of microorganisms in weathering of rock
The role of microorganisms in the weathering of rocks. 2 - Focal distribution of microorganisms on the surface of rocks
Microorganism growth in synthetic medium using rock as mineral nutrient source, and rock weathering due to microorganism
EAS spectrum in the primary energy region above 10 to the 15th power eV by the Akeno and Yakutsk array data
The extensive air showers spectrum on scintillation desity Rko in primary energy region E sub approx. 10 to the 15th power - 10 to the 20th power eV on the Yakutsk array data and recent results of the Akeno is given
All particle energy spectrum of cosmic rays in 10 to the 15th power - 10 to the 20th power eV region
Average estimations of the shower energy components are presented and their sum gives E sub 0 (Rho sub 600) - an average function of the relation of E sub 0 with the shower size parameter Rho sub 600 measured at the Yakutsk extensive air showers (EAS) array. Using this relation to the EAS spectrum obtained at the Akeno and Yakutsk arrays the energy spectrum of the cosmic ray total flux within 15 lg (E sub 0,eV) 20 by the EAS methods is recovered
Fluctuations of development maximum depth and nuclear composition of primary cosmic radiation
The extensive air showers (EAS) cascade curves from the Cerenkov light lateral distribution measurements are recovered and the maximum depth fluctuations of the shower development theta x sub m both on the Cerenkov and charged EAS components are defined. At E sub 0 approximates 10 to the 18th power eV the mean content of protons is greater than 85%, and p-air cross section theta sub 0 p-air 750mb
On athermic mechanism of materials radiation embrittlement
To elucidate the mehanisms of radiation embrittlement of materials the temperature dependence of mechanical properties of irradiated materials has been studiedyesBelgorod State Universit
Π‘Π ΠΠΠΠΠ’ΠΠΠ¬ΠΠ«Π ΠΠΠΠΠΠ ΠΠΠΠΠ‘ΠΠ ΠΠΠΠ’ΠΠ ΠΠ‘Π’Π ΠΠΠΠ-Π ΠΠΠΠ‘Π’ΠΠΠ’ΠΠΠΠ Π ΠΠΠ ΠΠΠΠΠ§ΠΠΠ ΠΠΠΠΠΠ«
The exosomes involvement in the pathogenesis of tumors is based on their property to incorporate into theΒ recipient cells resulting in the both genomic and epigenomic changes.Β Earlier we have shown that exosomesΒ from different types of estrogen-independent breastΒ cancer cells (MCF-7/T developed by long-term tamoxifenΒ treatment, and MCF-7/M)Β developed by metformin treatment were able to transfer resistance to the parentΒ MCF-7Β cells. To elucidate the common features of the both types of resistant exosomes, theΒ proteome andΒ microRNA cargo of the control and both types of the resistant exosomes wereΒ analyzed. Totally, more thanΒ 400 proteins were identified in the exosome samples. Of theseΒ proteins, only two proteins, DMBT1 (Deleted inΒ Malignant Brain Tumors 1) and THBS1Β (Thrombospondin-1), were commonly expressed in the both resistantΒ exosomes (less thanΒ 5% from total DEPs) demonstrating the unique protein composition of each type of theΒ resistant exosomes. The comparative analysis of the miRNA differentially expressed inΒ the both MCF-7/T andΒ MCF-7/M resistant exosomes revealed 180 up-regulated and 202Β down-regulated miRNAs. Among them,Β 4 up-regulated and 8 down-regulated miRNAs wereΒ associated with progression of hormonal resistance ofΒ breast tumors. The bioinformaticalΒ analysis of 4 up-regulated exosomal miRNAs revealed 2 miRNAs, mir-Β 101and mir-181b, which up-regulated PI3K signalingΒ supporting the key role of PI3K/Akt in the developmentΒ of the resistant phenotype of breast cancer cells.Π£ΡΠ°ΡΡΠΈΠ΅ ΡΠΊΠ·ΠΎΡΠΎΠΌ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ Π½Π° ΠΈΡ
ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡ Π²Π½ΡΡΡΡΒ ΠΊΠ»Π΅ΡΠΎΠΊ-ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠΎΠ², Π²ΡΠ·ΡΠ²Π°Ρ Π² ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΊΠ°ΡΠΊΠ°Π΄ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ. Π Π°Π½Π΅Π΅Β ΠΌΡΒ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΡΠΊΠ·ΠΎΡΠΎΠΌΡ, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΠ΅ΠΌΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ ΡΡΡΡΠΎΠ³Π΅Π½-Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΡ
ΡΡΠ±Π»ΠΈΠ½ΠΈΠΉΒ ΠΊΠ»Π΅ΡΠΎΠΊΒ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ (MCF-7/T, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊΒ Π²Β ΠΏΡΠΈΡΡΡΡΡΠ²ΠΈΠΈ Π°Π½ΡΠΈΡΡΡΡΠΎΠ³Π΅Π½Π° ΡΠ°ΠΌΠΎΠΊΡΠΈΡΠ΅Π½Π°, ΠΈ MCF-7/M, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΠΎΠΉ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΊΡΠ»ΡΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½ΠΈΡΒ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΒ ΠΌΠ΅ΡΡΠΎΡΠΌΠΈΠ½ΠΎΠΌ), ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ Π² ΡΠΎΠ΄ΠΈΡΠ΅Π»ΡΡΠΊΠΈΡ
ΠΊΠ»Π΅ΡΠΊΠ°Ρ
MCF-7.Β Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅Β Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠΎΡΡΠ°Π²Π° ΡΠΊΠ·ΠΎΡΠΎΠΌ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
Β ΠΊΠ»Π΅ΡΠΎΠΊ Π±ΡΠ» ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Β ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΡΠ΅ΠΎΠΌΠ° ΠΈ ΠΏΡΠΎΡΠΈΠ»Ρ ΠΌΠΈΠΊΡΠΎΠ ΠΠ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΡΠΊΠ·ΠΎΡΠΎΠΌ ΠΈΒ ΡΠΊΠ·ΠΎΡΠΎΠΌ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΡΒ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΡΠ±Π»ΠΈΠ½ΠΈΠΉ. Π ΡΠ΅Π»ΠΎΠΌ Π² ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
ΡΠΊΠ·ΠΎΡΠΎΠΌ Π±ΡΠ»ΠΎ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΎΒ Π±ΠΎΠ»Π΅Π΅ 400 Π±Π΅Π»ΠΊΠΎΠ², ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
Β ΡΠΎΠ»ΡΠΊΠΎ 2 Π±Π΅Π»ΠΊΠ°, DMBT1 (Deleted in Malignant Brain Tumors 1) ΠΈ THBS1Β (Thrombospondin-1), Π±ΡΠ»ΠΈΒ Π³ΠΈΠΏΠ΅ΡΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Ρ Π² ΠΎΠ±ΠΎΠΈΡ
ΡΠΈΠΏΠ°Ρ
ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΡΠΊΠ·ΠΎΡΠΎΠΌ (ΠΌΠ΅Π½Π΅Π΅ 5 % ΠΎΡΒ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π±Π΅Π»ΠΊΠΎΠ²,Β Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π² ΡΠΊΠ·ΠΎΡΠΎΠΌΠ°Ρ
ΡΠ΅Π·ΠΈΡΡΠ΅ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ), ΡΡΠΎΒ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΌΒ ΡΠΎΡΡΠ°Π²Π΅ ΡΠΊΠ·ΠΎΡΠΎΠΌΠ°Π»ΡΠ½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ² Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ.Β Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·Β ΡΠΎΡΡΠ°Π²Π° ΠΌΠΈΠΊΡΠΎΠ ΠΠ, Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Π² ΠΎΠ±ΠΎΠΈΡ
Π²Π°ΡΠΈΠ°Π½ΡΠ°Ρ
Β ΡΠΊΠ·ΠΎΡΠΎΠΌ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ,Β Π²ΡΡΠ²ΠΈΠ» 180 Π³ΠΈΠΏΠ΅ΡΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠ ΠΠ ΠΈ 202 ΠΌΠΈΠΊΡΠΎΠ ΠΠ Ρ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ. Π‘ΡΠ΅Π΄ΠΈ Π½ΠΈΡ
4Β Π³ΠΈΠΏΠ΅ΡΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΈ 8 Π³ΠΈΠΏΠΎΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠ ΠΠΒ ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Ρ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌΒ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ.Β ΠΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· 4Β Π³ΠΈΠΏΠ΅ΡΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠ ΠΠ Π²ΡΡΠ²ΠΈΠ» 2 ΠΌΠΈΠΊΡΠΎΠ ΠΠ, mir-101ΠΈΒ mir-181b, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ
Π² ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ PI3KΒ ΡΠΈΠ³Π½Π°Π»ΠΈΠ½Π³Π°, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡ ΠΎ Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠΎΠ»ΠΈ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ Π²Β ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈΒ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ°ΠΊΠ° ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ.
Hypothesis of functional organ as a psychophysiological scientific basis of medical qigong
Application features of medical qigong in world and in Russia were described. Special exercises and practice qigong regarded as psychotherapeutic complex of psychic self-regulation techniques. It was hypothesized of the channels of qigong as functional organs, formed as a result of systematic training
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