Combined simultaneous transcranial and transsphenoidal resection of large-to-giant pituitary adenomas

Background: While large-to-giant pituitary adenomas (PAs) may be safely removed by experienced surgeons through a single route, the procedure is technically challenging. We present the outcome of a simultaneous combined transcranial and transsphenoidal approach and discuss its applications. Methods: A retrospective review was conducted on 12 consecutive patients. Surgical complications, visual and endocrinological functions, and tumour control were reviewed. Results: There were four men and eight women, with a mean age of 47.6 years. All but one patient had non-functioning PAs. The mean tumour height was 4.1 cm (range: 2.3-5.5). The predominant presenting symptoms were visual field loss in eight patients, headache in three patients and mental confusion in one patient. There was no operative mortality. Post-operative cerebrospinal fluid leakage occurred in one patient. Five of the eight patients who presented with visual field loss achieved full recovery, and three had partial improvement. Two patients developed permanent diabetes insipidus after surgery. Panhypopituitarism occurred in one patient. Gross total removal (GTR) was achieved in five, and subtotal removal (STR) in seven patients. Seven patients received post-operative external irradiation. All patients who had GTR remained tumour-free and all those with STR had stable diseases after a mean follow-up period of 53.1 months (range: 14.1-92.1). Conclusion: The simultaneous 'above and below' approach is a safe and effective surgical strategy for large-to-giant PAs, particularly when expertise in endoscopic transsphenoidal surgery is unavailable. Its use, however, should be limited to a carefully selected group of patients, and tailored to individual user's expertise and experience. © 2011 The Author(s).published_or_final_versio

Distinctive effects of regularity and consistency in orthography-phonology mapping in a logographic writing system: an ERP study

Poster Session E - Motor Control, Speech Production, Sensorimotor Integration: no. E23In alphabetic scripts, phonological regularity and consistency of print-to-sound mapping are not clearly separable. In contrast, these variables are operationally distinct in Chinese. About 80% of Chinese characters are phonograms, containing a semantic radical that provides a clue to the meaning of the character and a phonetic radical providing a clue to the pronunciation (e.g. 趾 zi2 ‘toe’ has a semantic radical 足meaning ‘foot’ and a phonetic radical 止 zi2). The orthographyphonology mapping in Chinese can be characterized in terms of regularity defined as the congruence between the pronunciation of a phonogram and that of its phonetic radical, and ...postprin

Learning to read a logographic writing system as a second language: an ERP study of L2 Chinese proficient readers

Poster Session E - Language Development, Plasticity, Multilingualism: no. E33For native readers of alphabetic scripts, learning to read a logographic system such as Chinese is challenging. This is not only because Chinese characters look drastically unlike from words in alphabetic scripts, but also because mappings between orthographic and phonological units in the two systems are different. In this study, we investigated two measures of orthography-phonology mapping-- phonological regularity and consistency--in relatively proficient late-acquired second language (L2) readers of Chinese in lexical decision (LD) and delayed naming (DN) tasks. Most Chinese characters are phonograms, which have a phonetic radical that carries phonological ...postprin

Processing sublexical phonology in L2 Chinese character reading: An ERP study

Poster Session 2: no. ps2p7Compared to alphabetic scripts, the distinct forms of Chinese characters as orthographic units and the fundamental difference in the mappings between orthographic, phonological, and semantic units lead to specific demands in L2 Chinese processing. The current study examined the sensitivity to and time course of two measures of orthography-phonology mapping-- phonological regularity and consistency-- for relatively proficient L2 readers of Chinese. Most Chinese characters are phonograms, which have a phonetic radical that carries phonological information. Regularity in these phonograms is defined by the congruence between the pronunciation of a phonogram and that of its phonetic radical. Consistency is the extent to which the pronunciation of the phonogram is shared by other …postprin

10 simple rules to create a serious game, illustrated with examples from structural biology

Serious scientific games are games whose purpose is not only fun. In the field of science, the serious goals include crucial activities for scientists: outreach, teaching and research. The number of serious games is increasing rapidly, in particular citizen science games, games that allow people to produce and/or analyze scientific data. Interestingly, it is possible to build a set of rules providing a guideline to create or improve serious games. We present arguments gathered from our own experience ( Phylo , DocMolecules , HiRE-RNA contest and Pangu) as well as examples from the growing literature on scientific serious games

Optimization of admixture and three-layer particleboard made from oil palm empty fruit bunch and rubberwood clones

Empty fruit bunch (EFB) is a biomass that is widely available and has the potential to be used as industrial raw material especially in wood-based industries. This study focuses on producing a particleboard by incorporating EFB with two different rubberwood clones: Prang Besar (PB) 260 and RRIM 2002, respectively. PB 260 is a commercially planted clone and wood from matured (>25 year-old) trees are used by wood-based panel manufacturers. RRIM 2002 is a new clone planted at the Malaysian Rubber Board (MRB) research trial plots and consists of only 4-year-old trees. Two types of particleboards (admixture and three-layer) with different ratios were produced. The Japanese Industrial Standard (JIS-5908 2003 particleboard) was used to evaluate mechanical and dimensional stability properties of the particleboards. From the study, it was found that admixture particleboards showed superior properties compared to three-layer particleboards. Layering EFB and rubberwood significantly decreased board performance for all properties (except internal bonding). The optimum ratios of EFB and both rubberwood clones are found to be 1:1 (50% EFB: 50% rubberwood). Meanwhile, increasing the rubberwood clones ratio to 70% lowered board performance especially for EFB (30%):RRIM 2002 clone (70%) boards which showed the lowest values for all properties for both admixture and three-layer board

Effectiveness of an asthma education programme

published_or_final_versio

Worldwide Esophageal Cancer Collaboration : clinical staging data

Peer reviewe

Dynamics of mechanical waves in periodic grapheme nanoribbon assemblies

We simulate the natural frequencies and the acoustic wave propagation characteristics of graphene nanoribbons (GNRs) of the type (8,0) and (0,8) using an equivalent atomistic-continuum FE model previously developed by some of the authors, where the C-C bonds thickness and average equilibrium lengths during the dynamic loading are identified through the minimisation of the system Hamiltonian. A molecular mechanics model based on the UFF potential is used to benchmark the hybrid FE models developed. The acoustic wave dispersion characteristics of the GNRs are simulated using a Floquet-based wave technique used to predict the pass-stop bands of periodic mechanical structures. We show that the thickness and equilibrium lengths do depend on the specific vibration and dispersion mode considered, and that they are in general different from the classical constant values used in open literature (0.34 nm for thickness and 0.142 nm for equilibrium length). We also show the dependence of the wave dispersion characteristics versus the aspect ratio and edge configurations of the nanoribbons, with widening band-gaps that depend on the chirality of the configurations. The thickness, average equilibrium length and edge type have to be taken into account when nanoribbons are used to design nano-oscillators and novel types of mass sensors based on periodic arrangements of nanostructures