ELF: The electronic learning facilitator

As the world‐wide computer network becomes ubiquitous, new tools have been developed, such as the World Wide Web (WWW), for the delivery of multimedia hypertext‐based documents. Similarly, there has been an explosion in the amount of email, bulletin boards, and Usenet News available. This has led to a major problem of information overload: we are slowly but surely being overwhelmed by the amount of information available to us

The Definition, Current Knowledge and Implementation of Welfare for Farm Animals--A Personal View

Being humane to farm animals (welfare) must include (1) having a sound knowledge of their normal and anomalous behavior responses in a farm context and heeding this in a practical way and (2) adopting handling procedures which elicit minimal distress in the species concerned. Building up an ethogram of predictable responses and recording the patterns of behavior during key events, mating, birth, and care of the young are essential. There are still gaps in the recorded ethograms offarm animals. Objective measurements of distress, including an index of its seriousness, are also a priority. The results from animal preference tests can provide some answers on which to base practical husbandry in the areas of housing design, optimal temperatures, the need for companions, factors which elicit aggression, acceptable feeds, and species\u27 sensory capacities. Handling preference tests could also be undertaken. Overcoming inertia is a problem for both the owners and the animals if changes are to be made within established systems of production. Gross cruelty can be countered by legislation, but the motivation for ongoing good welfare of farmed animals must come from within the workers/owners on the site. Trying to force it by legislation may be counter-productive. A five-point program for promoting practical animal welfare is outlined

A Simple Bargaining Mechanism That Elicits Truthful Reservation Prices

We describe a simple 2-stage mechanism that induces two bargainers to be truthful in reporting their reservation prices in a 1st stage. If these prices criss-cross, the referee reports that they overlap, and the bargainers proceed to make offers in a 2nd stage. The average of the 2nd-stage offers becomes the settlement if both offers fall into the overlap interval; if only one offer falls into this interval, it is the settlement, but is implemented with probability 1/2; if neither offer falls into the interval, there is no settlement. Thus, if the bargainers reach the 2nd stage, they know their reservation prices overlap even if they fail to reach a settlement, possibly motivating them to try again.Bargaining; truth-telling mechanisms; probabilistic implementation; incomplete information.

A five-year review of quality of reporting of research using clinician surveys in high-ranked dermatology journals

Surveys of clinicians play a pivotal role in dermatology research, including to determine expert opinion, identify areas of uncertainty in clinical practice, define research priorities, investigate feasibility and explore areas of clinical equipoise. Despite the commonality of research involving surveys distributed to dermatologists, we previously identified the issue of poor‐quality survey design and lack of sufficient validation prior to distribution. Furthermore, a review of postal surveys of healthcare professionals from 1996 to 2005 has shown declining response rates, introducing potential non‐responder bias. To support stronger methodological quality and reporting of clinician survey, we developed a checklist for authors, based on our experience and published literature

Autopiquer - a robust and reliable peak detection algorithm for mass spectrometry

We present a simple algorithm for robust and unsupervised peak detection by determining a noise threshold in isotopically resolved mass spectrometry data. Solving this problem will greatly reduce the subjective and time consuming manual picking of mass spectral peaks and so will prove beneficial in many research applications. The Autopiquer approach uses autocorrelation to test for the presence of (isotopic) structure in overlapping windows across the spectrum. Within each window, a noise threshold is optimized to remove the most unstructured data whilst keeping as much of the (isotopic) structure as possible. This algorithm has been successfully demonstrated for both peak detection and spectral compression on data from many different classes of mass spectrometer and for different sample types and this approach should also be extendible to other types of data that contain regularly spaced discrete peaks

Role-Playing: A Smorgasbord of Learning Types

One tertiary institution sought to research the perceptions that tertiary students have of role-plays as a means of learning. Role-plays were used across a range of disciplines at that institution including: teacher training, business and chemistry. Each of these disciplines used a role-play in their classes and then collected opinions from the students on the usefulness of the activity. It was discovered that students value role-plays as a means to challenge preconceived ideas, encourage creative thinking, assist students in applying theory to practice, make lessons fun and provide active learning experiences that increase student learning and engagement

Determination of protein thiol reduction potential by isotope labeling and intact mass measurement

Oxidation/reduction of thiol residues in proteins is an important type of post-translational modification that is implicated in regulating a range of biological processes. The nature of the modification makes it possible to define a quantifiable electrochemical potential, E⊕, for oxidation/reduction that allows cysteine-containing proteins to be ranked based on their propensity to be oxidized. Measuring oxidation of cysteine residues in proteins is difficult using standard electrochemical methods but recently top-down mass-spectrometry has been shown to enable the quantification of E⊕ for thiol oxidations. In this paper we demonstrate that mass spectrometry of intact proteins can be used in combination with an isotopic labeling strategy and an automated data analysis algorithm to measure E⊕ for the thiols in both E Coli Thioredoxin 1 and Human Thioredoxin 1. Our methodology relies on accurate mass measurement of proteins using LC-MS analyses and does not necessarily require top-down fragmentation. As well as analyzing homogeneous protein samples, we also demonstrate that our methodology can be used to determine thiol E⊕ measurements in samples which contain mixtures of proteins. Thus the combination of experiential methodology and data analysis regime have the potential to make such measurements in a high-throughput manner and in a manner more accessible to a broad community of protein scientists

A Simple Bargaining Mechanism That Elicits Truthful Reservation Prices

We describe a simple 2-stage mechanism that induces two bargainers to be truthful in reporting their reservation prices in a 1st stage. If these prices criss-cross, the referee reports that they overlap, and the bargainers proceed to make offers in a 2nd stage. The average of the 2nd-stage offers becomes the settlement if both offers fall into the overlap interval; if only one offer falls into this interval, it is the settlement, but is implemented with probability 1/2; if neither offer falls into the interval, there is no settlement. Thus, if the bargainers reach the 2nd stage, they know their reservation prices overlap even if they fail to reach a settlement, possibly motivating them to try again