Mean platelet volume and vitamin D level

Cure, Medine Cumhur/0000-0001-9253-6459; cure, erkan/0000-0001-7807-135XWOS: 000332681100003PubMed: 24624344Background: Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. Methods: This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MIN was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of 20 ng/mL, respectively. Results: the vitamin D level in Group 1 (7.7 +/- 1.9 ng/mL) was lower than that in Group 2 (15.1 +/- 1.6 ng/mL, P<0.001) and Group 3 (25.6 +/- 6.3 ng/mL, P<0.001). the MPV in Group 3 (7.5 +/- 1.0 fL) was lower than that in Group 1 (8.1 +/- 1.1 fL, P<0.001) and Group 2 (7.9 +/- 1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (beta = -0.109, P = 0.019) was independently associated with increased MPV. Conclusions: There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV

Clinical Outcomes and Effectiveness of Renal Artery Stenting in Patients With Critical Atherosclerotic Renal Artery Stenosis: Does it İmprove Blood Pressure Control and Renal Function Assessed by Estimated Glomerular Filtration Rate?

INTRODUCTION: Atherosclerotic renal artery stenosis (ARAS) is associated with uncontrolled hypertension and chronic renal failure. AIM: To evaluate the influence of gender and presence of chronic renal failure on the outcomes of percutaneous transluminal renal artery stenting (PTRAS) due to atherosclerosis. MATERIAL AND METHODS: A total of 28 ARAS patients underwent PTRAS and 36 stents were placed. Basal characteristics, laboratory data and blood pressure of patients were recorded. The differences between genders and improvement/deterioration of renal functions and blood pressure were analyzed. The predictors of outcomes were determined. RESULTS: Baseline characteristics were similar between men and women. Significant improvement of systolic and diastolic blood pressure control was achieved after PTRAS (153.04 ±17.07 mm Hg vs. 124.75 ±11.40 mm Hg, p = 0.001 and 92.50 ±10.76 mm Hg vs. 77.54 ±8.23 mm Hg, p < 0.001, respectively). Although mean estimated glomerular filtration rate (eGFR) and creatinine levels did not significantly improve at the 6-month follow-up visit compared to baseline values, of the 28 patients 13 (46.4%) patients had improvement of renal functions. CONCLUSIONS: Our results suggest that PTRAS is a safe procedure and may offer blood pressure control but beneficial effects of PTRAS on renal function may be anticipated in a selected group of patients, especially those with a low eGFR

Extrinsic Mechanism Obstructing the Opening of a Prosthetic Mitral Valve: An Unusual Case of Suture Entrapment

Obstruction to a prosthetic cardiac valve is a well-recognized complication of cardiac valve replacement. Malfunction of the mobile component of a prosthetic valve to open or close correctly may occur in consequence of intrinsic or extrinsic causes (thrombus, vegetation, entrapment of left ventricular myocardium, suture entanglement, and pannus formation) that may result prosthetic valve stenosis and/or insufficiency. In the case we report a 48-year-old female with valve dysfunction occurred early after surgery, as one valve leaflet was only able to partially open due to suture entrapment. (Echocardiography 2012;29:E28-E29

Fragmented QRS for Risk Stratification in Patients Undergoing First Diagnostic Coronary Angiography

Background: Only a small proportion of patients referred for coronary angiography with suspected coronary artery disease (CAD) have the diagnosis of obstructive CAD confirmed by the exam. For this reason, further strategies for risk stratification are necessary