972 research outputs found
Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers
Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementary approach that reduces misclassification and incorporates individual differences in alcohol metabolism. Therefore, we evaluated the relationship between previously identified alcohol consumption-related metabolites and colorectal cancer and adenoma using serum metabolomics data from two studies. Data on colorectal cancer were obtained from a nested case-control study of 502 US adults (252 cases, 250 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Data on colorectal adenoma were obtained from a case-control study of 197 US adults (120 cases, 77 controls) from the Navy Colon Adenoma Study. Unconditional multivariable logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for eight alcohol consumption-related metabolites identified in a previous analysis: ethyl glucuronide; 4-androstene-3beta,17beta-diol disulfate 1; 5-alpha-androstan-3beta,17beta-diol disulfate; 16-hydroxypalmitate; bilirubin (E,Z or Z,E); cyclo (-leu-pro); dihomo-linoleate (20:2n6); and palmitoleate (16:1n7). We found no clear association between these alcohol consumption-related metabolites and either endpoint. However, we did observe an inverse association between cyclo (-leu-pro) and colorectal adenoma that was only observed in the highest metabolite quantile (OR 4th vs. 1st Quantile = 0.30, 95% CI: 0.12–0.78; P-trend = 0.047), but no association for colorectal cancer. In conclusion, there were no adverse associations between alcohol consumption-related metabolites and colorectal cancer or adenoma
Holographic R-symmetric flows and the \u3c4_U conjecture
We discuss the holographic counterpart of a recent conjecture regarding R-symmetric RG flows in four-dimensional supersymmetric field theories. In such theories, a quantity \u3c4U can be defined at the fixed points which was conjectured in [1] to be larger in the UV than in the IR, \u3c4U UV>\u3c4U IR. We analyze this conjecture from a dual supergravity perspective: using some general properties of domain wall solutions dual to R-symmetric RG flows, we define a bulk quantity which interpolates between the correct \u3c4 U at the UV and IR fixed points, and study its monotonicity properties in a class of examples. We find a monotonic behavior for theories flowing to an interacting IR fixed point. For gapped theories, the monotonicity is still valid up to a finite value of the radial coordinate where the function vanishes, reflecting the gap scale of the field theory. \ua9 2013 SISSA, Trieste, Italy
On renormalization group flows and the a-theorem in 6d
We study the extension of the approach to the a-theorem of Komargodski and
Schwimmer to quantum field theories in d=6 spacetime dimensions. The dilaton
effective action is obtained up to 6th order in derivatives. The anomaly flow
a_UV - a_IR is the coefficient of the 6-derivative Euler anomaly term in this
action. It then appears at order p^6 in the low energy limit of n-point
scattering amplitudes of the dilaton for n > 3. The detailed structure with the
correct anomaly coefficient is confirmed by direct calculation in two examples:
(i) the case of explicitly broken conformal symmetry is illustrated by the free
massive scalar field, and (ii) the case of spontaneously broken conformal
symmetry is demonstrated by the (2,0) theory on the Coulomb branch. In the
latter example, the dilaton is a dynamical field so 4-derivative terms in the
action also affect n-point amplitudes at order p^6. The calculation in the
(2,0) theory is done by analyzing an M5-brane probe in AdS_7 x S^4.
Given the confirmation in two distinct models, we attempt to use dispersion
relations to prove that the anomaly flow is positive in general. Unfortunately
the 4-point matrix element of the Euler anomaly is proportional to stu and
vanishes for forward scattering. Thus the optical theorem cannot be applied to
show positivity. Instead the anomaly flow is given by a dispersion sum rule in
which the integrand does not have definite sign. It may be possible to base a
proof of the a-theorem on the analyticity and unitarity properties of the
6-point function, but our preliminary study reveals some difficulties.Comment: 41 pages, 5 figure
Exactly Marginal Deformations and Global Symmetries
We study the problem of finding exactly marginal deformations of N=1
superconformal field theories in four dimensions. We find that the only way a
marginal chiral operator can become not exactly marginal is for it to combine
with a conserved current multiplet. Additionally, we find that the space of
exactly marginal deformations, also called the "conformal manifold," is the
quotient of the space of marginal couplings by the complexified continuous
global symmetry group. This fact explains why exactly marginal deformations are
ubiquitous in N=1 theories. Our method turns the problem of enumerating exactly
marginal operators into a problem in group theory, and substantially extends
and simplifies the previous analysis by Leigh and Strassler. We also briefly
discuss how to apply our analysis to N=2 theories in three dimensions.Comment: 23 pages, 2 figure
Bounds on 4D Conformal and Superconformal Field Theories
We derive general bounds on operator dimensions, central charges, and OPE
coefficients in 4D conformal and N=1 superconformal field theories. In any CFT
containing a scalar primary phi of dimension d we show that crossing symmetry
of implies a completely general lower bound on the central
charge c >= f_c(d). Similarly, in CFTs containing a complex scalar charged
under global symmetries, we bound a combination of symmetry current two-point
function coefficients tau^{IJ} and flavor charges. We extend these bounds to
N=1 superconformal theories by deriving the superconformal block expansions for
four-point functions of a chiral superfield Phi and its conjugate. In this case
we derive bounds on the OPE coefficients of scalar operators appearing in the
Phi x Phi* OPE, and show that there is an upper bound on the dimension of Phi*
Phi when dim(Phi) is close to 1. We also present even more stringent bounds on
c and tau^{IJ}. In supersymmetric gauge theories believed to flow to
superconformal fixed points one can use anomaly matching to explicitly check
whether these bounds are satisfied.Comment: 47 pages, 9 figures; V2: small corrections and clarification
Holographic three-point functions of semiclassical states
We calculate the holographic three-point functions in N = 4 super-Yang-Mills
theory in the case when two of the operators are semiclassical and one is dual
to a supergravity mode. We further discuss the transition to the regime when
all three operators are semiclassical.Comment: 17 pages, 3 figures; v2: refs. added, discussion in sec. 2.1
expanded; v3: misprint in (2.28) corrected, published versio
Sabotage in Contests: A Survey
A contest is a situation in which individuals expend irretrievable resources to win valuable prize(s). ‘Sabotage’ is a deliberate and costly act of damaging a rival’s' likelihood of winning the contest. Sabotage can be observed in, e.g., sports, war, promotion tournaments, political or marketing campaigns. In this article, we provide a model and various perspectives on such sabotage activities and review the economics literature analyzing the act of sabotage in contests. We discuss the theories and evidence highlighting the means of sabotage, why sabotage occurs, and the effects of sabotage on individual players and on overall welfare, along with possible mechanisms to reduce sabotage. We note that most sabotage activities are aimed at the ablest player, the possibility of sabotage reduces productive effort exerted by the players, and sabotage may lessen the effectiveness of public policies, such as affirmative action, or information revelation in contests. We discuss various policies that a designer may employ to counteract sabotage activities. We conclude by pointing out some areas of future research
Solar fusion cross sections. II. The pp chain and CNO cycles
We summarize and critically evaluate the available data on nuclear fusion
cross sections important to energy generation in the Sun and other
hydrogen-burning stars and to solar neutrino production. Recommended values and
uncertainties are provided for key cross sections, and a recommended spectrum
is given for 8B solar neutrinos. We also discuss opportunities for further
increasing the precision of key rates, including new facilities, new
experimental techniques, and improvements in theory. This review, which
summarizes the conclusions of a workshop held at the Institute for Nuclear
Theory, Seattle, in January 2009, is intended as a 10-year update and
supplement to Reviews of Modern Physics 70 (1998) 1265.Comment: 54 pages, 20 figures, version to be published in Reviews of Modern
Physics; various typos corrected and several updates mad
Peroxisome Proliferator-Activated Receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes
Background: PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host inflammatory response.
Methods: PPARα, β and γ mRNA levels were measured in peripheral blood cells of CF patients and healthy subjects via RT-PCR. PPARα protein expression and subcellular localization was determined via western blot and immunofluorescence, respectively. The activity of PPARα was analyzed by gel shift assay.
Results: In lymphocytes, the expression of PPARα mRNA, but not of PPARβ, was reduced (-37%; p < 0.002) in CF patients compared with healthy persons and was therefore further analyzed. A similar reduction of PPARα was observed at protein level (-26%; p < 0.05). The transcription factor was mainly expressed in the cytosol of lymphocytes, with low expression in the nucleus. Moreover, DNA binding activity of the transcription factor was 36% less in lymphocytes of patients (p < 0.01). For PPARα and PPARβ mRNA expression in monocytes and neutrophils, no significant differences were observed between CF patients and healthy persons. In all cells, PPARγ mRNA levels were below the detection limit.
Conclusion: Lymphocytes are important regulators of the inflammatory response by releasing cytokines and antibodies. The diminished lymphocytic expression and activity of PPARα may therefore contribute to the inflammatory processes that are observed in CF
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