400 research outputs found

    Neuromorphometric characterization with shape functionals

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    This work presents a procedure to extract morphological information from neuronal cells based on the variation of shape functionals as the cell geometry undergoes a dilation through a wide interval of spatial scales. The targeted shapes are alpha and beta cat retinal ganglion cells, which are characterized by different ranges of dendritic field diameter. Image functionals are expected to act as descriptors of the shape, gathering relevant geometric and topological features of the complex cell form. We present a comparative study of classification performance of additive shape descriptors, namely, Minkowski functionals, and the nonadditive multiscale fractal. We found that the proposed measures perform efficiently the task of identifying the two main classes alpha and beta based solely on scale invariant information, while also providing intraclass morphological assessment

    Backward pion-nucleon scattering

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    A global analysis of the world data on differential cross sections and polarization asymmetries of backward pion-nucleon scattering for invariant collision energies above 3 GeV is performed in a Regge model. Including the NαN_\alpha, NÎłN_\gamma, Δή\Delta_\delta and ΔÎČ\Delta_\beta trajectories, we reproduce both angular distributions and polarization data for small values of the Mandelstam variable uu, in contrast to previous analyses. The model amplitude is used to obtain evidence for baryon resonances with mass below 3 GeV. Our analysis suggests a G39G_{39} resonance with a mass of 2.83 GeV as member of the ΔÎČ\Delta_{\beta} trajectory from the corresponding Chew-Frautschi plot.Comment: 12 pages, 16 figure

    A versatile method for simulating pp -> ppe+e- and dp -> pne+e-p_spec reactions

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    We have developed a versatile software package for the simulation of di-electron production in pppp and dpdp collisions at SIS energies. Particular attention has been paid to incorporate different descriptions of the Dalitz decay Δ→Ne+e−\Delta \to N e^+e^- via a common interface. In addition, suitable parameterizations for the virtual bremsstrahlung process NN→NNe+e−NN \to NN e^+e^- based on one-boson exchange models have been implemented. Such simulation tools with high flexibility of the framework are important for the interpretation of the di-electron data taken with the HADES spectrometer and the design of forthcoming experiments

    Strange Meson Enhancement in PbPb Collisions

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    The NA44 Collaboration has measured yields and differential distributions of K+, K-, pi+, pi- in transverse kinetic energy and rapidity, around the center-of-mass rapidity in 158 A GeV/c Pb+Pb collisions at the CERN SPS. A considerable enhancement of K+ production per pi is observed, as compared to p+p collisions at this energy. To illustrate the importance of secondary hadron rescattering as an enhancement mechanism, we compare strangeness production at the SPS and AGS with predictions of the transport model RQMD.Comment: 11 pages, including 4 figures, LATE

    Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency.

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    Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity and mortality. To date, no approved treatment is available for pregnant women affected with FGR. The objective of this study was to investigate the contribution of galectin-3 (gal-3), a ÎČ-galactoside binding protein involved in pregnancy, placental function and fetal growth. We demonstrated that lack of gal-3 during mouse pregnancy leads to placental dysfunction and drives FGR in the absence of a maternal preeclampsia syndrome. Analysis of gal-3 deficient dams revealed placental inflammation and malperfusion, as well as uterine natural killer cell infiltration with aberrant activation. Our results also show that FGR is associated with a failure to increase maternal circulating gal-3 levels during the second and third trimester in human pregnancies. Placentas from human pregnancies affected by FGR displayed lower gal-3 expression, which correlated with placental dysfunction. These data highlight the importance of gal-3 in the promotion of proper placental function, as its absence leads to placental disease and subsequent FGR
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