Tailored versus generic knowledge brokering to integrate mood management into smoking cessation interventions in primary care settings : Protocol for a cluster randomized controlled trial

Background: Both tobacco smoking and depression are major public health problems associated with high morbidity and mortality. In addition, individuals with depression are almost twice as likely to smoke and less likely to achieve smoking cessation. In the Smoking Treatment for Ontario Patients program, an established smoking cessation program in Ontario, Canada, 38% of smokers in primary care settings have current or past depression with 6-month quit rates that are significantly lower than those without depression (33% versus 40%, P<.001). Integrating self-help mood management (eg, relaxation exercises and mood monitoring) with smoking cessation treatment increases long-term quit rates by 12%-20%. However, integration in real-world settings has not been reported. It is unclear which knowledge translation strategy would be more effective for motivating clinicians to provide resources on mood management to eligible patients. Objective: The objectives of this study are to investigate the following comparisons among depressed smokers enrolled in a smoking cessation program: 1) the effectiveness of generalized, exclusively email-based prompts versus a personalized knowledge broker in implementing mood management interventions; 2) the effectiveness of the two knowledge translation strategies on smoking quit rates; and 3) the incremental costs of the two knowledge translation strategies on the implementation of mood management interventions. Methods: The study design is a cluster randomized controlled trial of Family Health Teams participating in the Smoking Treatment for Ontario Patients program. Family Health Teams will be randomly allocated 1:1 to receive either generalized messages (related to depression and smoking) exclusively via email (group A) or be assigned a knowledge broker who provides personalized support through phone- and email-based check-ins (group B). The primary outcome, measured at the site level, is the proportion of eligible baseline visits that result in the provision of the mood management intervention to eligible patients. Results: Recruitment for the primary outcome of this study will be completed in 2018/2019. Results will be reported in 2019/2020. Conclusions: This study will address the knowledge gap in the implementation strategies (ie, email-based prompts versus a knowledge broker) of mood management interventions for smokers with depression in primary care settings. Trial Registration: ClinicalTrials.gov NCT03130998; https://clinicaltrials.gov/ct2/show/NCT03130998 (Archived on WebCite at www.webcitation.org/6ylyS6RTe)

Renormalized field theory and particle density profile in driven diffusive systems with open boundaries

We investigate the density profile in a driven diffusive system caused by a plane particle source perpendicular to the driving force. Focussing on the case of critical bulk density $\bar{c}$ we use a field theoretic renormalization group approach to calculate the density $c(z)$ as a function of the distance from the particle source at first order in $\epsilon=2-d$ ($d$: spatial dimension). For $d=1$ we find reasonable agreement with the exact solution recently obtained for the asymmetric exclusion model. Logarithmic corrections to the mean field profile are computed for $d=2$ with the result $c(z)-\bar{c} \sim z^{-1} (\ln(z))^{2/3}$ for $z \rightarrow \infty$.Comment: 32 pages, RevTex, 4 Postscript figures, to appear in Phys. Rev.

(In)finiteness of Spherically Symmetric Static Perfect Fluids

This work is concerned with the finiteness problem for static, spherically symmetric perfect fluids in both Newtonian Gravity and General Relativity. We derive criteria on the barotropic equation of state guaranteeing that the corresponding perfect fluid solutions possess finite/infinite extent. In the Newtonian case, for the large class of monotonic equations of state, and in General Relativity we improve earlier results

Time-ordering and a generalized Magnus expansion

Both the classical time-ordering and the Magnus expansion are well-known in the context of linear initial value problems. Motivated by the noncommutativity between time-ordering and time derivation, and related problems raised recently in statistical physics, we introduce a generalization of the Magnus expansion. Whereas the classical expansion computes the logarithm of the evolution operator of a linear differential equation, our generalization addresses the same problem, including however directly a non-trivial initial condition. As a by-product we recover a variant of the time ordering operation, known as T*-ordering. Eventually, placing our results in the general context of Rota-Baxter algebras permits us to present them in a more natural algebraic setting. It encompasses, for example, the case where one considers linear difference equations instead of linear differential equations

Locating the minimum : Approach to equilibrium in a disordered, symmetric zero range process

We consider the dynamics of the disordered, one-dimensional, symmetric zero range process in which a particle from an occupied site $k$ hops to its nearest neighbour with a quenched rate $w(k)$. These rates are chosen randomly from the probability distribution $f(w) \sim (w-c)^{n}$, where $c$ is the lower cutoff. For $n > 0$, this model is known to exhibit a phase transition in the steady state from a low density phase with a finite number of particles at each site to a high density aggregate phase in which the site with the lowest hopping rate supports an infinite number of particles. In the latter case, it is interesting to ask how the system locates the site with globally minimum rate. We use an argument based on local equilibrium, supported by Monte Carlo simulations, to describe the approach to the steady state. We find that at large enough time, the mass transport in the regions with a smooth density profile is described by a diffusion equation with site-dependent rates, while the isolated points where the mass distribution is singular act as the boundaries of these regions. Our argument implies that the relaxation time scales with the system size $L$ as $L^{z}$ with $z=2+1/(n+1)$ for $n > 1$ and suggests a different behaviour for $n < 1$.Comment: Revtex, 7 pages including 3 figures. Submitted to Pramana -- special issue on mesoscopic and disordered system

A Parsec-Scale Study of the 5/15 GHz Spectral Indices of the Compact Radio Sources in M82

Observations of the starburst galaxy, M82, have been made with the VLA in its A-configuration at 15 GHz and MERLIN at 5 GHz enabling a spectral analysis of the compact radio structure on a scale of < 0.1'' (1.6 pc). Crucial to these observations was the inclusion of the Pie Town VLBA antenna, which increased the resolution of the VLA observations by a factor of ~2. A number of the weaker sources are shown to have thermal spectra and are identified as HII regions with emission measures ~10^7 cm^-6 pc. Some of the sources appear to be optically thick at 5 GHz implying even higher emission measures of ~10^8 cm^-6 pc. The number of compact radio sources in M82 whose origin has been determined is now 46, of which 30 are supernova related and the remaining 16 are HII regions. An additional 15 sources are noted, but have yet to be identified, meaning that the total number of compact sources in M82 is at least 61. Also, it is shown that the distribution of HII regions is correlated with the large-scale ionised gas distribution, but is different from the distribution of supernova remnants. In addition, the brightest HII region at (B1950) 09h 51m 42.21s +69 54' 59.2'' shows a spectral index gradient across its resolved structure which we attribute to the source becoming optically thick towards its centre.Comment: Accepted for publication in MNRAS. 15 pages, 9 figure

A deep Chandra observation of the Perseus cluster: shocks and ripples

We present preliminary results from a deep observation lasting almost 200 ks, of the centre of the Perseus cluster of galaxies around NGC 1275. The X-ray surface brightness of the intracluster gas beyond the inner 20 kpc, which contains the inner radio bubbles, is very smooth apart from some low amplitude quasi-periodic ripples. A clear density jump at a radius of 24 kpc to the NE, about 10 kpc out from the bubble rim, appears to be due to a weak shock driven by the northern radio bubble. A similar front may exist round both inner bubbles but is masked elsewhere by rim emission from bright cooler gas. The continuous blowing of bubbles by the central radio source, leading to the propagation of weak shocks and viscously-dissipating sound waves seen as the observed fronts and ripples, gives a rate of working which balances the radiative cooling within the inner 50 kpc of the cluster core.Comment: Accepted for publication in MNRAS (minor changes) Higher picture quality available from http://www-xray.ast.cam.ac.uk/papers/per_200ks.pd

Birkhoff type decompositions and the Baker-Campbell-Hausdorff recursion

We describe a unification of several apparently unrelated factorizations arisen from quantum field theory, vertex operator algebras, combinatorics and numerical methods in differential equations. The unification is given by a Birkhoff type decomposition that was obtained from the Baker-Campbell-Hausdorff formula in our study of the Hopf algebra approach of Connes and Kreimer to renormalization in perturbative quantum field theory. There we showed that the Birkhoff decomposition of Connes and Kreimer can be obtained from a certain Baker-Campbell-Hausdorff recursion formula in the presence of a Rota-Baxter operator. We will explain how the same decomposition generalizes the factorization of formal exponentials and uniformization for Lie algebras that arose in vertex operator algebra and conformal field theory, and the even-odd decomposition of combinatorial Hopf algebra characters as well as to the Lie algebra polar decomposition as used in the context of the approximation of matrix exponentials in ordinary differential equations.Comment: accepted for publication in Comm. in Math. Phy