27 research outputs found
Atom-Dimer Scattering in a Three-Component Fermi Gas
Ultracold gases of three distinguishable particles with large scattering
lengths are expected to show rich few-body physics related to the Efimov
effect. We have created three different mixtures of ultracold 6Li atoms and
weakly bound 6Li2 dimers consisting of atoms in three different hyperfine
states and studied their inelastic decay via atom-dimer collisions. We have
found resonant enhancement of the decay due to the crossing of Efimov-like
trimer states with the atom-dimer continuum in one mixture as well as minima of
the decay in another mixture, which we interpret as a suppression of exchange
reactions of the type |12>+|3> -> |23>+|1>. Such a suppression is caused by
interference between different decay paths and demonstrates the possiblity to
use Efimov physics to control the rate constants for molecular exchange
reactions in the ultracold regime.Comment: 5 pages, 3 figure
Spatial nonlocal pair correlations in a repulsive 1D Bose gas
We analytically calculate the spatial nonlocal pair correlation function for
an interacting uniform 1D Bose gas at finite temperature and propose an
experimental method to measure nonlocal correlations. Our results span six
different physical realms, including the weakly and strongly interacting
regimes. We show explicitly that the characteristic correlation lengths are
given by one of four length scales: the thermal de Broglie wavelength, the mean
interparticle separation, the healing length, or the phase coherence length. In
all regimes, we identify the profound role of interactions and find that under
certain conditions the pair correlation may develop a global maximum at a
finite interparticle separation due to the competition between repulsive
interactions and thermal effects.Comment: Final published version, modified titl
Production of Sodium Bose--Einstein condensates in an optical dimple trap
We report on the realization of a sodium Bose--Einstein condensate (BEC) in a
combined red-detuned optical dipole trap, formed by two beams crossing in a
horizontal plane and a third, tightly focused dimple trap propagating
vertically. We produce a BEC in three main steps: loading of the crossed dipole
trap from laser-cooled atoms, an intermediate evaporative cooling stage which
results in efficient loading of the auxiliary dimple trap, and a final
evaporative cooling stage in the dimple trap. Our protocol is implemented in a
compact setup and allows us to reach quantum degeneracy even with relatively
modest initial atom numbers and available laser power
Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder
Contains fulltext :
236832.pdf (Publisher’s version ) (Open Access
Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence
Contains fulltext :
244227.pdf (Publisher’s version ) (Open Access
Polycystic kidney disease with hyperinsulinemic hypoglycemia caused by a promoter mutation in PMM2
Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are rare, genetically heterogeneous disorders. The co-occurrence of these disorders (HIPKD) in 17 children from 11 unrelated families suggested an unrecognized genetic disorder. Whole-genome linkage analysis in five informative families identified a single significant locus on chromosome 16p13.2 (logarithm of odds score 6.5). Sequencing of the coding regions of all linked genes failed to identify biallelic mutations. Instead, we found in all patients a promoter mutation (c.-167G>T) in the phosphomannomutase 2 gene (PMM2), either homozygous or in trans with PMM2 coding mutations. PMM2 encodes a key enzyme in N-glycosylation. Abnormal glycosylation has been associated with PKD, and we found that deglycosylation in cultured pancreatic β cells altered insulin secretion. Recessive coding mutations in PMM2 cause congenital disorder of glycosylation type 1a (CDG1A), a devastating multisystem disorder with prominent neurologic involvement. Yet our patients did not exhibit the typical clinical or diagnostic features of CDG1A. In vitro, the PMM2 promoter mutation associated with decreased transcriptional activity in patient kidney cells and impaired binding of the transcription factor ZNF143. In silico analysis suggested an important role of ZNF143 for the formation of a chromatin loop including PMM2. We propose that the PMM2 promoter mutation alters tissue-specific chromatin loop formation, with consequent organ-specific deficiency of PMM2 leading to the restricted phenotype of HIPKD. Our findings extend the spectrum of genetic causes for both HI and PKD and provide insights into gene regulation and PMM2 pleiotropy
Protocol for the SEED-trial: Supported Employment and preventing Early Disability
Background: Early withdrawal or exclusion from the labor market leads to significant personal and societal costs. In Norway, the increasing numbers of young adults receiving disability pension is a growing problem. While a large body of research demonstrates positive effects of Supported Employment (SE) in patients with severe mental illness, no studies have yet investigated the effectiveness of SE in young adults with a range of social and health conditions who are receiving benefits. Methods/design: The SEED-trial is a randomized controlled trial (RCT) comparing traditional vocational rehabilitation (TVR) to SE in 124 unemployed individuals between the ages of 18-29 who are receiving benefits due to various social- or health-related problems. The primary outcome is labor market participation during the first year after enrollment. Secondary outcomes include physical and mental health, health behaviors, and well-being, collected at baseline, 6, and 12 months. A cost-benefit analysis will also be conducted. Discussion: The SEED-trial is the first RCT to compare SE to TVR in this important and vulnerable group, at risk of being excluded from working life at an early age