Biological resources of the Hyssopus l on the south of European Russia and prospects of its introduction

The south of European Russia (geographically - the southern part of the Central Russian Upland) has large biological and plant genetic resources. There is a concept considering the region as the second anthropogenic microgen center of formation of economically valuable plants. In the south of the Central Russian Upland, the genus Hyssopus L. is represented by two species: Hyssopus cretaceus Dubjan. and Hyssopus officinalis L. Accomplished the study of biological resources of species of the genus Hyssopus L. in vivo and in vitr

The Role of Vascular Endothelial Growth Factor and Antithrombin III In The Pathogenesis of the Ovarian Hyperstimulation Syndrome

Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of controlled ovarian hyperstimulation (COH). Its pathogenesis is not clarified yet. In the recent years a number of studies focused on the vascular endothelial growth factor (VEGF) and antihtrombin III (AT III) indicators. VEGF is homodimeric, heparin-binding glycoprotein, stimulating vascular permeability. Antithrombin III is protease inhibitor of activated clotting factors. This study aimed at examining the VEGF-A165 and AT III indicators with two OHSS patients. Two methods were used for the determination of the indicators of VEGF-A165 and AT III: ELISA for VEGF and chromogenic assay for ATT III. Kits of R/D Systems and American Diagnostica Inc. were used to estimate VEGF and AT III indicators in serum and plasma. There were higher indicators of VEGF-A165 (180pg/ml) and reduction of AT III indicators (48%) in the patient with a severe form of OHSS than in the control group while these indicators were normal in the patient with a moderate form of OHSS. Our results confirmed some published data concerning the importance of VEGF and AT III in the genesis of OHSS. This study should include a larger group of patients in order tofollow-up statistically and authentically the variations of the indicators of both factors and their importance for OHSS

АДИКТИВНИЙ СТАТУС ПРЕДСТАВНИКІВ КОМАНДНОГО І РОБІТНИЧОГО СКЛАДУ МОРСЬКОГО ТОРГОВЕЛЬНОГО ФЛОТУ З РІЗНИМ РІВНЕМ ПСИХОСОЦІАЛЬНОГО СТРЕСУ

Purpose: to investigate the intensity of addictive status in sailors of the merchant fleet with different levels of psychosocial stress, in order to determine the necessity of creating systemic measures for the protection of their mental health, specific for this contingent. Materials and Methods. Based on informed consent in compliance with the principles of bioethics and deontology, 200 representatives of the merchant fleet were surveyed during 2016–2019: 110 members of the command staff and 90 workers. The study involved the use of clinical-psychopathological and psychodiagnostic methods. Result. As a result of the research, it was found that the representatives of the merchant fleet during the post-voyage period increased intensity of the addictive status on objects of chemical and non-chemical origin, the level of which is directly associated with the severity of the psychosocial stress. The general trend of the dynamics of the addictive status in the representatives of the merchant fleet, both in terms of chemical and non-chemical origin, is an increase in the intensity of addictive realization with increasing psychosocial stress. The addictive status intensity in workers of the merchant fleet is significantly higher than in the command staff (except for work), in all the addictive realization range and stress load ranges. Among persons with low psychosocial stress, regardless of professional specificity, the intensity of the addictive status with addictive objects of both chemical and non-chemical origin is within safe use, which is significantly different from the addictive status in persons with moderate and severe levels of psychosocial stress. The addiction by chemical objects (tobacco, coffee/tea) in persons with moderate psychosocial stress is expressed within the limits of harmful effects, with severe psychosocial stress – dangerous use, and non-chemical ones – within the limits of harmful effects, with increasing indicators associated with increasing psychosocial stress. Conclusion. Identified patterns should be taken into account when developing specific measures of psychotherapy and psychoprophylaxis for this contingent, which is the perspective of this study.Мета: дослідити напруженість адиктивного статусу (АС) у моряків торговельного морського флоту з різним рівнем психосоціального стресу (ПС) для визначення необхідності створення специфічних для даного контингенту системних заходів з охорони їхнього психічного здоровʼя. Матеріали і методи. На засадах інформованої згоди з дотриманням принципів біоетики і деонтології протягом 2016–2019 рр. було обстежено 200 осіб представників морського торговельного флоту: 110 членів командного складу (КТФ) та 90 робітників (РТФ). Дослідження включало використання клініко-психопатологічного і психодіагностичного методів. Результати. У результаті дослідження встановлено, що у представників торговельного морського флоту в міжрейсовий період виявлена підвищена напруженість АС за обʼєктами хімічного і нехімічного походження, рівень якої прямо асоційований з вираженістю ПС. Загальним трендом динаміки АС у представників торговельного морського флоту, як за обʼєктами хімічного, так і нехімічного походження, є збільшення інтенсивності адиктивної реалізації з наростанням психосоціального стресового навантаження. Напруженість АС у РТФ є значно вищою, ніж у КТФ (крім роботи), в усіх межах адиктивної реалізації та діапазонах стресового навантаження. Серед осіб із низьким ПС, незалежно від професійної специфіки, напруженість АС адиктивними обʼєктами і хімічного, і нехімічного походження знаходиться в межах безпечного вживання, що значно відрізняється від АС в осіб з помірним і тяжким рівнем ПС. Захопленість хімічними обʼєктами (тютюн, кава/чай) в осіб із помірним рівнем ПС виражена в межах вживання зі шкідливими наслідками, з тяжким ПС – небезпечного вживання, а нехімічними – в межах вживання зі шкідливими наслідками зі зростанням показників асоційовано зі збільшенням ПС. Висновки. Виявлені закономірності повинні враховувати при розробці специфічних заходів психотерапії і психопрофілактики для даного контингенту, що становить перспективу цього дослідження

Ambiente educacional como recurso de desenvolvimento para o processo de aprendizagem

Following overseas examples, educational institutions in Russia are trying to interact with other organizations implementing practical competence approach. The relevance of the topic lies in the fact that modern educational environment is constantly changing both due to the dynamics of everyday and professional conditions. Due to competence approach constant monitoring and new resources are required for the development of each subject in this educational environment. The goal of the work is to create means for open social and educational environment realization which allows achieving positive results for all participants in the project. In this article, the authors raise the issue of modern educational environment creation as a resource for each subject of the educational process development.The article attempts to improve students’, teachers’ and others participants’ interested in educational environment development interaction. We try to achieve a qualitatively new level of participants’ skills and competencies development in this process. For this, analysis of the essence and structure of educational process in a higher educational institution was carried out. After that, the authors propose, within the framework of a project implemented by Nizhny Novgorod State Pedagogical University on the organization and development of the social and educational environment, to conduct special computer literacy courses for the elderly. The courses offered combine the activities of a large number of people who, working for a common result, achieve the development of individual qualities. The results obtained are the basis for further improvement of educational environment.Siguiendo ejemplos en el extranjero, las instituciones educativas en Rusia están tratando de interactuar con otras organizaciones implementando un enfoque de competencia práctica. La relevancia del tema radica en el hecho de que el entorno educativo moderno está cambiando constantemente debido a la dinámica de las condiciones cotidianas y profesionales. Debido al enfoque de competencia, el monitoreo constante y nuevos recursos son necesarios para el desarrollo de cada asignatura en este entorno educativo. El objetivo del trabajo es crear medios para la realización de un entorno social y educativo abierto que permita lograr resultados positivos para todos los participantes en el proyecto. En este artículo, los autores plantean el tema de la creación de un entorno educativo moderno como un recurso para cada tema del desarrollo del proceso educativo.El artículo intenta mejorar la interacción entre los estudiantes, los maestros y otros participantes interesados en el desarrollo del entorno educativo. Intentamos alcanzar un nivel cualitativamente nuevo de desarrollo de habilidades y competencias de los participantes en este proceso. Para ello, se realizó un análisis de la esencia y estructura del proceso educativo en una institución de educación superior. Posteriormente, los autores proponen, en el marco de un proyecto implementado por la Universidad Pedagógica Estatal Nizhny Novgorod sobre la organización y el desarrollo del entorno social y educativo, realizar cursos especiales de alfabetización informática para personas mayores. Los cursos ofrecidos combinan las actividades de un gran número de personas que, trabajando por un resultado común, logran el desarrollo de cualidades individuales.Na sequência de exemplos no exterior, instituições educacionais na Rússia estão tentando interagir com outras organizações implementando uma abordagem de competência prática. A relevância do tema reside no fato de que o ambiente educacional moderno está em constante mudança, tanto devido à dinâmica das condições cotidianas e profissionais. Devido à abordagem de competência, monitoramento constante e novos recursos são necessários para o desenvolvimento de cada disciplina nesse ambiente educacional. O objetivo do trabalho é criar meios para a realização de um ambiente social e educacional aberto que permita alcançar resultados positivos para todos os participantes do projeto. Neste artigo, os autores levantam a questão da criação de ambientes educacionais modernos como recurso para cada sujeito do processo de desenvolvimento educacional.O artigo tenta melhorar a interação dos alunos, professores e outros participantes interessados na interação do desenvolvimento do ambiente educacional. Tentamos alcançar um nível qualitativamente novo de desenvolvimento de habilidades e competências dos participantes neste processo. Para isso, foi realizada a análise da essência e estrutura do processo educacional em uma instituição de ensino superior. Em seguida, os autores propõem, no âmbito de um projeto implementado pela Universidade Pedagógica Estadual Nizhny Novgorod, a organização e desenvolvimento do ambiente socioeducacional, para a realização de cursos especiais de alfabetização em informática para idosos. Os cursos oferecidos combinam as atividades de um grande número de pessoas que, trabalhando por um resultado comum, alcançam o desenvolvimento de qualidades individuai

Effect of surfactants on refractory material properties

Results are provided for a study of the effect of Termoplast series plastifiers on structure formation for specimens based on chamotte and fired bauxite under laboratory and industrial conditions. A favorable effect is demonstrated for test additions both on compaction during pressing, and also on object strength properties after firing.With introduction of Termoplast T3 into commercial mixes in an amount of 0.5% total object porosity is reduced from 256-30 to 10-15%, and ultimate strength in compression increases from 30-35 to 40-50 MPa. © 2013 Springer Science+Business Media New York

Innovative organic binders for metallurgy and the refractories industry

Questions related to the use of binders for briquetting in industry are considered. Results of pilot-plant and industrial tests of domestically produced innovative binders are presented. © 2013 Springer Science+Business Media New York

Studying of the anti-ischemic action of <I>Rhaponticum uniflorum</I> and <I>Serratula centauroides</I> dry extracts on a model of bilateral occlusion of the carotid arteries

The aim of the study to evaluate the anti-ischemic effect of Serratula centauroides and Rhaponticum uniflorum dry extracts for bilateral carotid artery occlusion.Materials and methods. The studies were carried out on 77 Wistar rats. Rh. uniflorum and S. centauroides dry extracts at doses 50, 100, 200 mg/kg were administered intragastrically for 14 days prior to bilateral occlusion of the carotid arteries. To assess the anti-ischemic effect of the investigated agents, the total mortality, the dynamics of survival, the survival time, the animals’ neurological status were determined using a modified McGraw scale and the brain hydration degree.Results. S. centauroides at a dose 200 mg/kg reduced the percentage of animals’ death by 2.8 times (p ≤ 0.05) compared with the control. Life expectancy in animals treated with S. centauroides at doses 100 and 200 mg/kg and Rh. uniflorum at dose 100  mg/kg increased by 46, 52 and 64  %, respectively, compared to the control. The neurological deficit lowest severity was observed in animals treated with S. centauroides at dose 200 mg/kg. The most pronounced statistically significant decrease in the brain hydration level was observed in animals treated with Rh.  uniflorum at doses 100 and 200 mg/kg and S. centauroides at dose 100 mg/kg.Conclusion. S. centauroides and Rh. uniflorum dry extracts have an anti-ischemic effect in cerebral ischemia

An organ culture system to model early degenerative changes of the intervertebral disc

ABSTRACT: INTRODUCTION: Back pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at symptomatic relief. This shortcoming stems in large part from our lack of understanding of the biochemical and molecular events that drive the disease process. The goal of this study is to develop a model of early disc degeneration using an organ culture. This approach is based on our previous studies that indicate that organ culture closely models molecular events that occur in vivo in an ex vivo setting. METHODS: To mimic a degenerative insult, discs were cultured under low oxygen tension in the presence of TNF-α, IL-1β and serum limiting conditions. RESULTS: Treatment resulted in compromised cell survival and changes in cellular morphology reminiscent of degeneration. There was strong suppression in the expression of matrix proteins including collagen types 1, 2, 6 and 9, proteoglycans, aggrecan and fibromodulin. Moreover, a strong induction in expression of catabolic matrix metalloproteinases (MMP) 3, 9 and 13 with a concomitant increase in aggrecan degradation was seen. An inductive effect on NGF expression was also noticed. Although similar, nucleus pulposus and annulus fibrosus tissues showed some differences in their response to the treatment. CONCLUSIONS: Results of this study show that perturbations in microenvironmental factors result in anatomical and gene expression change within the intervertebral disc that may ultimately compromise cell function and induce pathological deficits. This system would be a valuable screening tool to investigate interventional strategies aimed at restoring disc cell function

The Boltzmann equation for colourless plasmons in hot QCD plasma. Semiclassical approximation

Within the framework of the semiclassical approximation, we derive the Boltzmann equation describing the dynamics of colorless plasmons in a hot QCD plasma. The probability of the plasmon-plasmon scattering at the leading order in the coupling constant is obtained. This probability is gauge-independent at least in the class of the covariant and temporal gauges. It is noted that the structure of the scattering kernel possesses important qualitative difference from the corresponding one in the Abelian plasma, in spite of the fact that we focused our study on the colorless soft excitations. It is shown that four-plasmon decay is suppressed by the power of $g$ relative to the process of nonlinear scattering of plasmons by thermal particles at the soft momentum scale. It is stated that the former process becomes important in going to the ultrasoft region of the momentum scale.Comment: 41, LaTeX, minor changes, identical to published versio