16 research outputs found
ΠΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΠΈΠ½Π° (Π€Π»ΡΠΈΠΌΡΡΠΈΠ»Π°) ΠΏΡΠΈ ΠΈΠ΄ΠΈΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠΈΠ±ΡΠΎΠ·ΠΈΡΡΡΡΠ΅ΠΌ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠ΅
The aim of this study was to investigate free radical and lipid disorders in idiopathic pulmonary fibrosis (IPF), to assess clinical efficacy of Fluimucil and to substantiate its administration in different stages of the disease. We observed 127 IPF patients, of them 59 were treated typically with prednisolone, colchicines, or azathioprin, 68 ones received immunosuppressors and Fluimucil. The diagnosis of IPF was verified morphologically in open lung biopsy samples. The patientsβ age was 25 to 74 yrs, the mean age, 46.7 Β± 9.8 yrs. A control group included 20 healthy donors, the mean age, 41.2 Β± 1.2 yrs. N-acetylcysteine (Fluimucil, Zambon group) was administered initially IV 1800 mg a day for 14 days, then orally 1 800 mg a day for a month, then 600 mg a day for 3 months. Clinical and free radical conditions were monitored before the treatment and 3, 6 and 12 months starting the therapy. Fluimucil improved thrombocyte antioxidant activity and plasma antioxidant activity, reduced CT signs of IPF, provided a stable growth in FEV1 and FVC (by 10 % and 12 % respectively) and DLco. Fluimucil was well-tolerated, adverse effects (nausea, stomach ache) were noted in 7 patients (10.2 %). Thus, the results confirmed antioxidant efficacy of Fluimucil in IPF. The long-term administration of Fluimucil combined with the immunosuppressive drugs in IPF patients was safe and reasonable as this inhibited progression of the disease.Π¦Π΅Π»Ρ Π½Π°ΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΡΡΠΎΡΠ½ΠΈΡΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΈ Π»ΠΈΠΏΠΈΠ΄Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΏΡΠΈ ΠΈΠ΄ΠΈΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠΈΠ±ΡΠΎΠ·ΠΈΡΡΡΡΠ΅ΠΌ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠ΅ (ΠΠ€Π), ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ»ΡΠΈΠΌΡΡΠΈΠ»Π° ΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°ΡΡ Π΅Π³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ°Π΄ΠΈΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 127 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΠ€Π, ΠΈΠ· Π½ΠΈΡ
59 ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ (ΠΏΡΠ΅Π΄Π½ΠΈΠ·ΠΎΠ»ΠΎΠ½, ΠΊΠΎΠ»Ρ
ΠΈΡΠΈΠ½, Π°Π·Π°ΡΠΈΠΎΠΏΡΠΈΠ½), 68 β ΠΈΠΌΠΌΡΠ½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠ²Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π€Π»ΡΠΈΠΌΡΡΠΈΠ»ΠΎΠΌ. ΠΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π²Π΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΎΡΠΊΡΡΡΡΡ
Π»Π΅Π³ΠΎΡΠ½ΡΡ
Π±ΠΈΠΎΠΏΡΠΈΠΉ. ΠΠΎΠ·ΡΠ°ΡΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π»ΡΡ ΠΎΡ 25 Π΄ΠΎ 74 Π»Π΅Ρ, Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ β 46,7 Β± 9,8 Π»Π΅Ρ. ΠΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 20 ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ½ΠΎΡΠΎΠ², ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ β 41,2 Β± 1,2 Π³ΠΎΠ΄Π°. N-Π°ΡΠ΅ΡΠΈΠ»ΡΠΈΡΡΠ΅ΠΈΠ½ (Π€Π»ΡΠΈΠΌΡΡΠΈΠ», Β«ZambonΒ») Π½Π°Π·Π½Π°ΡΠ°Π»ΡΡ ΠΏΠΎ Π΄Π²ΡΡ
ΡΡΠ°ΠΏΠ½ΠΎΠΉ ΡΡ
Π΅ΠΌΠ΅: Π²Π½ΡΡΡΠΈΠ²Π΅Π½Π½ΠΎ Π² Π΄ΠΎΠ·Π΅ 1 800 ΠΌΠ³ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 14 Π΄Π½Π΅ΠΉ, Π·Π°ΡΠ΅ΠΌ β ΡΠ΅r os ΠΏΠΎ 1 800 ΠΌΠ³ Π² ΡΡΡΠΊΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΡΡΠ° ΠΈ ΠΏΠΎ 600 ΠΌΠ³ Π² ΡΡΡΠΊΠΈ Π² ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ 3 ΠΌΠ΅Ρ. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π΄ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΡΠ΅ΡΠ΅Π· 3, 6 ΠΈ 12 ΠΌΠ΅Ρ. ΠΎΡ Π½Π°ΡΠ°Π»Π° ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π€Π»ΡΠΈΠΌΡΡΠΈΠ» ΠΎΠΊΠ°Π·ΡΠ²Π°Π» ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π½Π° Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠΎΠ², ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ ΠΈΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠ΅Π³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ Π½Π° Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΠΠ€Π Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠ°ΠΌΠΈ ΠΈ Π°Π½ΡΠΈΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΠ»Π°Π·ΠΌΡ. Π’Π°ΠΊΠΆΠ΅ Π€Π»ΡΠΈΠΌΡΡΠΈΠ» ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²Π»ΠΈΡΠ» Π½Π° ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎ-ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π»ΡΠ²Π΅ΠΎΠ»ΠΈΡΠ°. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π€Π»ΡΠΈΠΌΡΡΠΈΠ», ΠΊ ΠΊΠΎΠ½ΡΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΎΡΠΌΠ΅ΡΠ΅Π½ ΡΡΠΎΠΉΠΊΠΈΠΉ ΠΏΡΠΈΡΠΎΡΡ ΠΠΠ ΠΈ Π€ΠΠΠ (Π½Π° 10 % ΠΈ 12 % ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ) ΠΈ DLΡΠΎ. Π€Π»ΡΠΈΠΌΡΡΠΈΠ» Ρ
ΠΎΡΠΎΡΠΎ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠ»ΡΡ Π±ΠΎΠ»ΡΠ½ΡΠΌΠΈ, ΠΏΠΎΠ±ΠΎΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Π² Π²ΠΈΠ΄Π΅ ΡΠΎΡΠ½ΠΎΡΡ, Π±ΠΎΠ»Π΅ΠΉ Π² ΡΠΏΠΈΠ³Π°ΡΡΡΠΈΠΈ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΡΠΎΠ»ΡΠΊΠΎ Ρ 7 (10,2 %) Π±ΠΎΠ»ΡΠ½ΡΡ
. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π€Π»ΡΠΈΠΌΡΡΠΈΠ»Π° ΠΊΠ°ΠΊ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ° ΠΏΡΠΈ ΠΠ€Π. ΠΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΈΡ
Π΄ΠΎΠ· Π€Π»ΡΠΈΠΌΡΡΠΈΠ»Π° Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΈΠΌΠΌΡΠ½Π½ΠΎΡΡΠΏΡΠ΅ΡΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠ΅ΠΉ ΠΏΡΠΈ ΠΠ€Π Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎ ΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎ, Ρ. ΠΊ. ΠΏΡΠ΅ΠΏΡΡΡΡΠ²ΡΠ΅Ρ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ
Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results
The chromosphere is a thin layer of the solar atmosphere that bridges the
relatively cool photosphere and the intensely heated transition region and
corona. Compressible and incompressible waves propagating through the
chromosphere can supply significant amounts of energy to the interface region
and corona. In recent years an abundance of high-resolution observations from
state-of-the-art facilities have provided new and exciting ways of
disentangling the characteristics of oscillatory phenomena propagating through
the dynamic chromosphere. Coupled with rapid advancements in
magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly
investigate the role waves play in supplying energy to sustain chromospheric
and coronal heating. Here, we review the recent progress made in
characterising, categorising and interpreting oscillations manifesting in the
solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review
Genomics and proteomics approaches to the study of cancer-stroma interactions
<p>Abstract</p> <p>Background</p> <p>The development and progression of cancer depend on its genetic characteristics as well as on the interactions with its microenvironment. Understanding these interactions may contribute to diagnostic and prognostic evaluations and to the development of new cancer therapies. Aiming to investigate potential mechanisms by which the tumor microenvironment might contribute to a cancer phenotype, we evaluated soluble paracrine factors produced by stromal and neoplastic cells which may influence proliferation and gene and protein expression.</p> <p>Methods</p> <p>The study was carried out on the epithelial cancer cell line (Hep-2) and fibroblasts isolated from a primary oral cancer. We combined a conditioned-medium technique with subtraction hybridization approach, quantitative PCR and proteomics, in order to evaluate gene and protein expression influenced by soluble paracrine factors produced by stromal and neoplastic cells.</p> <p>Results</p> <p>We observed that conditioned medium from fibroblast cultures (FCM) inhibited proliferation and induced apoptosis in Hep-2 cells. In neoplastic cells, 41 genes and 5 proteins exhibited changes in expression levels in response to FCM and, in fibroblasts, 17 genes and 2 proteins showed down-regulation in response to conditioned medium from Hep-2 cells (HCM). Nine genes were selected and the expression results of 6 down-regulated genes (<it>ARID4A</it>, <it>CALR</it>, <it>GNB2L1</it>, <it>RNF10</it>, <it>SQSTM1</it>, <it>USP9X</it>) were validated by real time PCR.</p> <p>Conclusions</p> <p>A significant and common denominator in the results was the potential induction of signaling changes associated with immune or inflammatory response in the absence of a specific protein.</p
Coronal Density and Temperature Profiles Calculated by Forward Modeling EUV Emission Observed by SDO/AIA
We present a model for the intensity of optically thin extreme ultraviolet (EUV) emission for a plasma atmosphere. We apply our model to the solar corona as observed using the six optically thin EUV channels of the Solar Dynamics Observatory/Atmospheric Imaging Assembly instrument. The emissivity of the plasma is calculated from the density and temperature using CHIANTI tables and the intensity is then determined by integration along the line of sight. We consider several different profiles for the radial density and temperature profiles, each of which are constrained by the observational data alone with no further physical assumptions. We demonstrate the method first by applying it to a quiet region of the corona, and then use it as the background component of a model including coronal holes, allowing the plasma densities and temperatures inside and outside the hole to be estimated. We compare our results with differential emission measure inversions. More accurate estimates for the coronal density and temperature profiles have the potential to help constrain plasma properties such as the magnetic field strength when used in combination with methods such as seismology
ANTIHYPERTENSIVE EFFICACY AND VASOPROTECTIVE PROPERTIES OF A NEW COMBINATION OF BETA-BLOCKER, BISOPROLOL (2,5/5 MG) AND DIURETIC, HYDROCHLOROTHIAZIDE (6,25 MG)
Aim. To study influence of the fixed bisoprolol (BIS) + hydrochlorothiazide (HCT) combination on blood pressure (BP) level and a blood flow in middle cerebral artery in patients with a arterial hypertension (HT), 1 degree.Material and methods. 18 patients with HT 1 degree (7 men, 11 women; age 50,1Β±5,7 y.o.) were included in the non-comparative open study. All patients received a combination of selective beta1-adrenoblocker (BIS 2.5-5 mg) and diuretic (HCT 6,25 mg). Initially and in 12 weeks of the treatment all patients had a standard clinical examination, ambulatory BP monitoring, ultrasonography of mesencephalic arteries for evaluation of the cerebrovascular blood flow reactivity.Results. The target BP level (<140/90 mm Hg) in 12 weeks of the treatment (12 patients received BIS 5 mg/HCT 6,25 mg, 6 patients - BIS 2,5 mg/HCT 6,25 mg) was reached in 100% of patients. Besides, significant increase in cerebral blood flow reactivity was found in tests with hyper- and hypoventilation.Conclusion. The fixed BIS/HCT combination has high antihypertensive and vasoprotective efficacy