Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis

How to Cite This Article: Sayehmiri F, Babaknejad N, Bahrami S, Sayehmiri K, Darabi M, Rezaei-Tavirani M. Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis. Iran J Child Neurol. Autumn 2015;9(4):1-9.AbstractObjectiveThere is probably a relationship between zinc/cupper concentration in individualswith autism. The present review was written to estimate this probability by using meta-analysis method.Martials & MethodsIn this meta-analysis of Fixed Effect Model, by searching PubMed, Scopusand Google scholar databases, 11 articles were selected and verified publishedin 1978 to 2012. I² statistics were calculated to examine heterogeneity. Theinformation was analyzed by R and STATA Ver. 11.2.ResultsDue to non-uniform measurement methods of Zn/Cu concentrations, theconcentration of these elements was measured in various subgroups (plasma,hair and general) in both study cases and controls. There was a significantstatistical difference between plasma OR=0.252 (95% CI: -0.001-0.504) andhair OR=0.27(95% CI: 0.059-0.481, P=0.01) concentrations of Zn/Cu statusesbetween controls and autistic patients. Using a Fixed Effects Model, the overall integration of data from the two groups was significant as risk factorOR=0.31(95% CI:0.16-0.46, P=0.001).ConclusionSignificant correlation existed between Zn/Cu levels and the development ofautistic disorders in general analysis. Therefore, Zn/Cu levels could be mentioned as a pathogenesis reason of autism spectrum disorders

The prevalence of physical and psychological violence during pregnancy in Iran and the world: A systematic review and meta-analysis

Background and aims: Violence against women is a public health crisis, because it affects the mother and fetus simultaneously and causes undesirable consequences. This study was performed to determine the prevalence of physical and psychological violence during pregnancy in the world and Iran in systematic review and meta-analysis. Methods: This study was a systematic review and meta-analysis that was conducted on the English and Persian articles published from 1990 up to 2015. In this aim by searching the information at SID, Medlib, Irandoc, Google scholar, Pubmed, ISI, Iranmedex, Scopus and Magiran, using key words the prevalence of physical and psychological violence during pregnancy in the world and Iran were extracted all related articles independently by 2 trained researchers. The results of studies combined using the STATA and Spss20 software. Results: In the initial searching of 276 articles, 46 articles related to Iran with a sample size 40457, 83 articles related to other regions of the world and totally 124 with a sample size 417832 Person relevant articles met inclusion criteria for study. The prevalence of physical violence during pregnancy was estimated in the world 18% (CI95%: 16%-19%) and in Iran 23% (CI95%: 20%-27%) and prevalence of psychological violence during pregnancy were estimated in the world 38% (CI95%:35%-41%) and in Iran 44% (CI95%: 38%-50%). Conclusion: According to the present meta-analysis results, the prevalence of physical and psychological violence during pregnancy in Iran is more than the world. Thus, it is recommended that the relevant authorities by implementation the intervention programs such as the establishment of Prevention Center for Social Damages, implementation the family education programs before marriage and pregnancy prevent of violence during pregnancy

Efficacy of Hepatitis B Vaccination in Under Five-Year-Old Children in Iran: A Systematic Review and Meta-Analysis Study

Context: Hepatitis B viral infection, specially in children, is an unsolved global health issue. National and international vaccination programs, as the main means to prevent this infection, have been operating for years. This meta-analysis study was launched to investigate the vaccination efficacy in under five-year-old children in Iran. Evidence Acquisition: In this research, all national databases including, SID, Magiran, Iran medex, Iran doc, and Medlib, as well as international databases, including PubMed, Medline, and ISI were searched for published articles associated with evaluation of seroconversion rates after hepatitis-B vaccination in Iranian children. The search was performed in the Persian and/or English language and in under five-year-old children in Iran. The variance of each study was calculated using the binomial distribution formula. The results of studies were combined using random-effects meta-analysis model. Data were analyzed using STATA version 12. Results: In the present research, 11 studies, performed from 2000 to 2017, were investigated. The number of samples in these 11 studies were 3063 children (1592 males and 1471 females). In the studies, the efficacy range of the hepatitis-B vaccine in under five-year-old children in Iran was 89 (95 CI: 86 -93) with high heterogeneity (P value for heterogeneity was 0.001, I-2 = 92.9). Range of efficacy for males and females was 85 (95 CI: 78 to 91) and 88 (95 CI: 83 to 93), respectively. Conclusions: The hepatitis B virus (HBV) vaccination program in Iran seems to be highly effective although some questions, such as the effect of gender on responsiveness to vaccine and heterogeneity of different data, remain unclear

The association between iron deficiency anemia and febrile seizure

Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6 in the FS group, 66.7 in the afebrile seizure group and 41.2 in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 95% confidence interval (CI) = 0.34-1.68; p = 0.493 and that for FS compared to seizure was 0.265 (95% CI = 0.085-0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended

ATTRIBUTION OF MENTAL DISORDERS IN SUICIDE OCCURRENCE

The present study aimed to determine attribution of mental disorders in suicide occurrence. By a cross-sectional study, all suicide records (n = 5188), between 1993 and 2009 in Ilam province, were investigated. Multiple logistic regression analysis was adopted. Totally, 27.5 of the suicides occurred due to mental disorders. This was significantly higher in males (29.3), individuals born in 1996(44) and 1990s (30.3), those aged 30 years and above (33.2) and suicide attempters (28.3), respectively and separately. The risk of suicide due to mental disorders was observed for females (OR = 0.85, CI = 0.74-0.97), those born in 1994 (OR = 2.82, CI = 1.27-6.24), completed suicides (OR = 0.81, CI = 0.68-0.97) and the age group 25 to 29 years old (OR = 0.82, CI = 0.66-1.01). Suicide due to mental disorders was higher among males compared to females, the rate of which was directly proportional to attempted suicide and age. It is therefore recommended that health educations be seriously carried on targeted groups

The global trend of infertility: an original review and meta-analysis

Background and aims: Infertility is one of the most important conditions in reproductive system and there is no reliable estimates for global prevalence of infertility. Therefore, knowing the prevalence of infertility is important and can be effective in decision making. Methods: We systematically reviewed all published papers in Medline database and Scopus (1988–2010). Univariate and multivariate approaches were applied to assess the causes of heterogeneity among the selected studies. Meta-regression was used to examine the relationship between the prevalence of infertility and the year of study. Data manipulation and statistical analyses were performed using Stata 11.1. Results: The study population was not similar in all papers. Studies evaluated the prevalence of infertility in the general population, the total female population, women and couples. Some studies defined infertility as failure to conceive within 12 months of regular sexual life without contraception methods while other studies defined it as failure to conceive within 24 months of regular sexual life without contraception methods. Overall, 52 studies met our inclusion criteria and the pooled worldwide of infertility was obtained about 10. The correlation between prevalence of secondary infertility and year of study was significant (P=0.039). Conclusions: Approximately 10 of the world's population suffers from infertility. Due to the negative impact of infertility on couples in various aspects of life, and the need for treatment and support programs, accurate estimate of infertility is essential worldwide

Suicide Attempts in Ilam Province, West of Iran, 2010-2014: A Time Trend Study

Background: Suicide has become an increasingly widespread form of morbidity in the developing countries. There has been an increasing trend in morbidity and mortality due to suicide in Iran over the past few decades. This study surveyed attempts and completed suicide over a 5-year period. Methods: Through a cross-sectional study, overall identified suicides by systematic registration suicide data (SRSD) in Ilam Province, western Iran from 21 March 2010 to 11 December 2014 were enrolled. Multiple logistic regression analysis was used for measuring the association between the risk factors of interest and suicide. The statistical software package was Stata 11.2. Results: A Suicide attempts have slightly increased in Ilam during 2010-2014, during which, 6,818 attempted suicides occurred of which 546 were completed. The odds of completed suicide was higher among older age groups than younger ones so that the crude OR estimates of completed suicide among people aged 50 to 59 yr against people aged <20 yr was (OR=6.99; 95 CI: 3.02, 11.07). The crude and adjusted odds ratio (OR) estimates of completed suicide in males against females were (OR=3.22; 95 CI: 2.58, 3.93) and (OR=3.66; 95 CI: 3.03, 4.11), respectively. Significant excess risk also appeared with academic against illiterate attempters (OR= 2.31; 95 CI: 1.35, 3.95). Results showed no increasing trend in the suicide method. Some methods such as self-immolation had decreasing trend over time, although it was not statistically significant (P= 0.089). Conclusions: We observed the variety of suicide risk factors that calls for more diversity in preventative programs. Distribution of suicide methods is diverse across the period of the study

The Prevalence of Restless Legs Syndrome in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Study

Introduction: Restless legs syndrome is a sensory-motor disorder that causes sleep disorder. The syndrome in patients undergoing hemodialysis associates with depression, sleep deprivation, performance disorder, day fatigue, excessive daytime sleepiness, stress, anxiety, and higher risk of cardiovascular diseases. The objective of this systematic meta-analysis study was to estimate prevalence of restless legs syndrome in patients undergoing hemodialysis. Methods: Twenty-six relevant articles published between 2000 and 2015 indexed in Iranian (MagIran and IranMedex) and international databases (SID, Google Scholar, ScienceDirect, PubMed, Pre Quest, and Scopus) were selected. Data analysis was carried out through metaanalysis (random effect model) and heterogeneity of the studies was determined using I2 index. The obtained data were analyzed in STAT (11.2). Results: Prevalence of the syndrome according to the found articles was 50 (95 CI: 38-61) in Iranian and 30 (95 CI: 23-37) in international databases. There was an ascending trend of prevalence of the syndrome corresponding to the publication year of the articles (P= 0.419), while the trend based on age of the patients was descending (P= 0.604). However, the variations were not significant. Conclusion: Given the high prevalence and considerable effects of restless legs syndrome on patients undergoing hemodialysis, it is recommended that these patients be screened for the syndrome

Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis

Statement of the Problem: Periodontal diseases are complex oral diseases characterized by bacterial-induced inflammatory destruction of tooth-supporting tissues. Porphyromonas gingivalis (P. gingivalis) is a common gram-negative anaerobic oral bacteria strongly associated with periodontal disease. Purpose: The present study was conducted to estimate prevalence of P. gingivalis in patients with periodontal diseases by using meta-analysis method. Martials and Method: Different databases including PubMed, EmBase, Scopus, the Institute for Scientific Information (ISI) Web of Science, and the Cochrane Library were searched to identify original English-language studies addressing prevalence of P. gingivalis in periodontal diseases up to December 2014. The random effects model was applied in the meta-analysis and the heterogeneity between studies was assessed using a Cochran test and the I(2) index. Funnel plots and Egger test were used to examine publication bias. Statistical analyses were performed using STATA version 12. Results: Forty-two eligible studies published during 1993- 2016 were selected for meta-analysis. Considering all the included studies, the total sample size was 5,884 individuals containing 2,576 healthy people with a mean age of 37.21+/-7.45 years and 3,308 periodontal patients with a mean age of 44.16+/-8.35 years. Overall, the prevalence of P. gingivalis was 78 95% CI: 74-81 in periodontal diseases group and 34% 95% CI: 26-41 in healthy individuals. There was a significantly higher prevalence of P.gingivalis in individuals with periodontal diseases compared to healthy subjects 78% versus 34%, respectively. Conclusion: This study indicates that P. gingivalis is highly present in subjects with periodontal diseases and it also appears in periodontally healthy people, although to a lesser extent. Thus, the presence of P. gingivalis increases the chance of periodontal disease and it can be considered as a main potential risk factor