1,657 research outputs found
Rocket and FUSE Observations of IC 405: Differential Extinction and Fluorescent Molecular Hydrogen
We present far-ultraviolet spectroscopy of the emission/reflection nebula IC
405 obtained by a rocket-borne long-slit spectrograph and the Far Ultraviolet
Spectroscopic Explorer. Both data sets show a rise in the ratio of the nebular
surface brightness to stellar flux (S/F_*) of approximately two orders of
magnitude towards the blue end of the far-UV bandpass. Scattering models using
simple dust geometries fail to reproduce the observed S/F_* for realistic grain
properties. The high spectral resolution of the FUSE data reveals a rich
fluorescent molecular hydrogen spectrum ~1000" north of the star that is
clearly distinguished from the steady blue continuum. The S/F_* remains roughly
constant at all nebular pointings, showing that fluorescent molecular hydrogen
is not the dominant cause for the blue rise. We discuss three possible
mechanisms for the ``Blue Dust'': differential extinction of the dominant star
(HD 34078), unusual dust grain properties, and emission from nebular dust. We
conclude that uncertainties in the nebular geometry and the degree of dust
clumping are most likely responsible for the blue rise. As an interesting
consequence of this result, we consider how IC 405 would appear in a spatially
unresolved observation. If IC 405 was observed with a spatial resolution of
less than 0.4 pc, for example, an observer would infer a far-UV flux that was
2.5 times the true value, giving the appearance of a stellar continuum that was
less extinguished than radiation from the surrounding nebula, an effect that is
reminiscent of the observed ultraviolet properties of starburst galaxies.Comment: 8 pages, 9 figures, using emulateapj, ApJ - accepte
Using Sensors and Generators of H2O2 to Elucidate the Toxicity Mechanism of Piperlongumine and Phenethyl Isothiocyanate
Aims: Chemotherapeutics target vital functions that ensure survival of cancer cells, including their increased reliance on defense mechanisms against oxidative stress compared to normal cells. Many chemotherapeutics exploit this vulnerability to oxidative stress by elevating the levels of intracellular reactive oxygen species (ROS). A quantitative understanding of the oxidants generated and how they induce toxicity will be important for effective implementation and design of future chemotherapeutics. Molecular tools that facilitate measurement and manipulation of individual chemical species within the context of the larger intracellular redox network present a means to develop this understanding. In this work, we demonstrate the use of such tools to elucidate the roles of H[subscript 2]O[subscript 2] and glutathione (GSH) in the toxicity mechanism of two ROS-based chemotherapeutics, piperlongumine and phenethyl isothiocyanate. Results: Depletion of GSH as a result of treatment with these compounds is not an important part of the toxicity mechanisms of these drugs and does not lead to an increase in the intracellular H[subscript 2]O[subscript 2] level. Measuring peroxiredoxin-2 (Prx-2) oxidation as evidence of increased H[subscript 2]O[subscript 2], only piperlongumine treatment shows elevation and it is GSH independent. Using a combination of a sensor (HyPer) along with a generator (D-amino acid oxidase) to monitor and mimic the drug-induced H[subscript 2O[subscript 2] production, it is determined that H[subscript 2]O[subscript 2] produced during piperlongumine treatment acts synergistically with the compound to cause enhanced cysteine oxidation and subsequent toxicity. The importance of H[subscript 2]O[subscript 2] elevation in the mechanism of piperlongumine promotes a hypothesis of why certain cells, such as A549, are more resistant to the drug than others. Innovation and Conclusion: The approach described herein sheds new light on the previously proposed mechanism of these two ROS-based chemotherapeutics and advocates for the use of both sensors and generators of specific oxidants to isolate their effects. Antioxid. Redox Signal. 24, 924â938.National Science Foundation (U.S.). Graduate Research Fellowship ProgramBurroughs Wellcome Fund (Career Award at the Scientific Interface
HST/ACS Images of the GG Tauri Circumbinary Disk
Hubble Space Telescope Advanced Camera for Surveys images of the young binary
GG Tauri and its circumbinary disk in V and I bandpasses were obtained in 2002
and are the most detailed of this system to date. The confirm features
previously seen in the disk including: a "gap" apparently caused by shadowing
from circumstellar material; an asymmetrical distribution of light about the
line of sight on the near edge of the disk; enhanced brightness along the near
edge of the disk due to forward scattering; and a compact reflection nebula
near the secondary star. New features are seen in the ACS images: two short
filaments along the disk; localized but strong variations in disk intensity
("gaplets"); and a "spur" or filament extending from the reflection nebulosity
near the secondary. The back side of the disk is detected in the V band for the
first time. The disk appears redder than the combined light from the stars,
which may be explained by a varied distribution of grain sizes. The brightness
asymmetries along the disk suggest that it is asymmetrically illuminated by the
stars due to extinction by nonuniform circumstellar material or the illuminated
surface of the disk is warped by tidal effects (or perhaps both). Localized,
time-dependent brightness variations in the disk are also seen.Comment: 28 pages, 7 figures, accepted for publication in the Astronomical
Journa
Male Competition Reverses Female Preference For Male Chemical Cues
Females must choose among potential mates with different phenotypes in a variety of social contexts. Many male traits are inherent and unchanging, but others are labile to social context. Competition, for example, can cause physiological changes that reflect recent wins and losses that fluctuate throughout time. We may expect females to respond differently to males depending on the outcome of their most recent fight. In Bolitotherus cornutus (forked fungus beetles), males compete for access to females, but copulation requires female cooperation. In this study, we use behavioral trials to determine whether females use chemical cues to differentiate between males and whether the outcome of recent male competition alters female preference. We measured female association time with chemical cues of two sizeâmatched males both before and after maleâmale competition. Females in our study preferred to associate with future losers before males interacted, but changed their preference for realized winners following male competitive interactions. Our study provides the first evidence of change in female preference based solely on the outcome of maleâmale competition
M87: A Misaligned BL LAC?
The nuclear region of M87 was observed with the Faint Object Spectrograph
(FOS) on the Hubble Space Telescope (HST) at 6 epochs, spanning 18 months,
after the HST image quality was improved with the deployment of the corrective
optics (COSTAR) in December 1993. From the FOS target acquisition data, we have
established that the flux from the optical nucleus of M87 varies by a factor ~2
on time scales of ~2.5 months and by as much as 25% over 3 weeks, and remains
unchanged (<= 2.5%) on time scales of ~1 day. The changes occur in an
unresolved central region <= 5 pc in diameter, with the physical size of the
emitting region limited by the observed time scales to a few hundred
gravitational radii. The featureless continuum spectrum becomes bluer as it
brightens while emission lines remain unchanged. This variability combined with
the observations of the continuum spectral shape, strong relativistic boosting
and the detection of significant superluminal motions in the jet, strongly
suggest that M87 belongs to the class of BL Lac objects but is viewed at an
angle too large to reveal the classical BL Lac properties.Comment: 12 pages, 3 Postscript figure
The association between green space and cause-specific mortality in urban New Zealand: an ecological analysis of green space utility
<b>Background:</b>
There is mounting international evidence that exposure to green environments is associated with health benefits, including lower mortality rates. Consequently, it has been suggested that the uneven distribution of such environments may contribute to health inequalities. Possible causative mechanisms behind the green space and health relationship include the provision of physical activity opportunities, facilitation of social contact and the restorative effects of nature. In the New Zealand context we investigated whether there was a socioeconomic gradient in green space exposure and whether green space exposure was associated with cause-specific mortality (cardiovascular disease and lung cancer). We subsequently asked what is the mechanism(s) by which green space availability may influence mortality outcomes, by contrasting health associations for different types of green space.
<b>Methods:</b>
This was an observational study on a population of 1,546,405 living in 1009 small urban areas in New Zealand. A neighbourhood-level classification was developed to distinguish between usable (i.e., visitable) and non-usable green space (i.e., visible but not visitable) in the urban areas. Negative binomial regression models were fitted to examine the association between quartiles of area-level green space availability and risk of mortality from cardiovascular disease (n = 9,484; 1996 - 2005) and from lung cancer (n = 2,603; 1996 - 2005), after control for age, sex, socio-economic deprivation, smoking, air pollution and population density.
<b>Results:</b>
Deprived neighbourhoods were relatively disadvantaged in total green space availability (11% less total green space for a one standard deviation increase in NZDep2001 deprivation score, p < 0.001), but had marginally more usable green space (2% more for a one standard deviation increase in deprivation score, p = 0.002). No significant associations between usable or total green space and mortality were observed after adjustment for confounders.
<b>Conclusion</b>
Contrary to expectations we found no evidence that green space influenced cardiovascular disease mortality in New Zealand, suggesting that green space and health relationships may vary according to national, societal or environmental context. Hence we were unable to infer the mechanism in the relationship. Our inability to adjust for individual-level factors with a significant influence on cardiovascular disease and lung cancer mortality risk (e.g., diet and alcohol consumption) will have limited the ability of the analyses to detect green space effects, if present. Additionally, green space variation may have lesser relevance for health in New Zealand because green space is generally more abundant and there is less social and spatial variation in its availability than found in other contexts
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