Prognosis of recurrent myocardial infarction based on shortliffe fuzzy models using the electrical characteristics of biologically active points

This report discusses the employment of the electrical characteristics of biologically active points (BAP) in the meridian of the heart to solve the task of prognosticating recurrence of myocardial infarctions during the rehabilitation period using fuzzy decision rule

Segregation of Ni at early stages of radiation damage in NiCoFeCr solid solution alloys

Defect evolution under irradiation is investigated in a set of single-phase concentrated solid solution alloys (SP-CSAs) containing Ni with Co, Fe and/or Cr. We show that atomic segregation of Ni takes place already at very early stages of radiation damage in the 2-4 element SP-CSAs containing Fe or Cr, well below 1 dpa. We arrive at this conclusion by following the evolution of positron annihilation signals as a function of irradiation dose in single crystal samples, complemented by molecular dynamics simulations in the same model systems for high entropy alloys (HEAs). This manifestation of short-range order calls attention to composition fluctuations at the atomic level in irradiated HEAs. Ion irradiation may induce short-range order in certain alloys due to chemically biased elemental diffusion. The work highlights the necessity of updating the assumption of a totally random arrangement in the irradiated alloys, even though the alloys before irradiation have random arrangements of different chemical elements. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd.Peer reviewe

Introducing a polypyrrole (ppy)-manganese ferrite (mnfe2o4) nanocomposite based microwave absorber for studying the effect of the radiation on the modification of the patient’s functional state

In the present work, we have implemented a project aimed at the development of a modular-type technical system designed to generate microwave radiation with specified properties. This article presented the electrophysiological efficiency of super-low intensity radiation in the centimeter range of wavelengths modulated by low-frequency signals similar to the EEG rhythm with cyclical variability of the duty cycl

БИОТЕХНИЧЕСКАЯ СИСТЕМА ГЕНЕРАЦИИ ЭЭГ-ПОДОБНЫХ СИГНАЛОВ

The Purpose – realization of the structure specialized biooperated module to generations EEG-like signal directed on personalization and reinforcement to efficiency of the treatment. In work are used methods of modeling, system technical analysis and constructing.The conclusion: Its were designed models of the formulas of the action, which provide presenting on electrodes for stimulation modulated current by means of signal of the pulse and breathings within the range of changeable frequencies 7–13–7 Hz or 14–26–14 Hz.Цель  –  реализация  структуры  специализированного  биоуправляемого  модуля  генерации  ЭЭГподобных  сигналов,  направленных  на  индивидуализацию  и  усиление  эффективности  лечения. В работе использованы методы моделирования, системотехнического анализа и конструирования. Разработаны модели формул воздействия, которые обеспечивают подачу на стимулирующие электроды модулированных токов посредством сигналов пульса и дыхания в диапазоне плавающей частоты 7–13–7 Гц или 14–26–14 Гц

Informative significance of serum cytokines and their importance for development of metabolic syndrome with arterial hypertension in elderly persons

Metabolic syndrome (MS) is among the main public health challenges worldwide, leading to significant labor losses, increased costs for treatment and rehabilitation of the patients. The aim of the present study was to identify the informative serum interleukins, by determining the odds ratio in elderly patients with MS and hypertension. The main group of 86 patients with MS and arterial hypertension (AH) aged 60-75 years was examined under clinical conditions. The inclusion criteria were as follows: age of 60-75 years, presence of MS, primary hypertension (grade II-III), absence of acute myocardial infarction, malignant neoplasms, disorders of cerebral circulation, kidney failure over last 6 months. Diagnostics of MS and hypertension was carried out in accordance with Expert Guidelines from the Russian Research Society of Cardiology on the MS Diagnosis and Treatment. Our first study of a large range of serum interleukins in elderly patients with MS and hypertension allowed us to reveal the inversely directed changes in pro- and anti-inflammatory cytokine contents. Combined AH/MS in elderly persons is accomplished by sufficient increase of the most proinflammatory cytokines, and vice versa, by significant decrease in anti-inflammatory cytokines in blood serum. This finding clearly points to importance of immunological regulatory systems for initiation of AH with MS at older age. Pro- and anti-inflammatory serum interleukins are actively involved into the AH/MS development in elderly accompanied by their pronounced imbalance. The mentioned immune reactions could underlie the MS/AH condition. High risk of this disorder is connected with changed production of proinflammatory cytokines (IL-8, IL-1β), like as anti-inflammatory serum interleukins (IL-4, IL-10), with predominance of the former. The above interleukins should be considered dominant diagnostic markers of AH/MS in elderly persons. Measurement of serum interleukins and discriminant-based approach allows highly reliable differentiation of elderly patients with AH/MS from similar individuals without this disorder

Immune pleiotropic effect of telmisartan in arterial hypertension

Arterial hypertension (AH) is among the life-threatening diseases and requires permanent antihypertensive therapy, including telmisartan. However, the effect of telmisartan upon systemic interleukin profile in elderly hypertensive patients requires further study, due to the limited data on previously analyzed interleukins. The aim of our study was to evaluate the immune pleiotropic effect of telmisartan upon miultiple pro- and anti-inflammatory blood interleukins in the patients with hypertension. The study included examination of 74 patients aged 60-74 years suffering from hypertension treated with telmisartan (80 mg/day in the morning time). The immune response to telmisartan assessed by the blood contents of different interleukins was evaluated following 6 months of treatment. These markers were determined by flow cytometry using “Becton Dickinson FACS Canto 2” device (USA). The pleiotropic immune effect of telmisartan upon the interleukin profile in hypertensive patients aged 60-74 was established by statistically significant changes in multiple pro-inflammatory and anti-inflammatory interleukins. Following 6 months of telmisartan therapy, the patients with arterial hypertension have shown a statistically significant decrease in blood cytokines, i.e., IL-1 в was reduced to 8.1±0.6 pg/ml vs initial 10.5±0.8 pg/ml; IL-2, to 8.6±0.8 pg/ml vs initial 11.8±1.1 pg/ml; IL-6, to 18.4±0.5 pg/ml vs initial 21.2±0.7 pg/ml; IL-8, to 3.5±0.6 pg/ml vs 5.4±0.5 pg/ml. We have also revealed a statistically significant decrease of blood TNFα levels to 5.3±0.5 pg/ml versus initial 6.8±0.4 pg/ml in the elderly patients with hypertension after 6 months of antihypertensive therapy with telmisartan. Moreover, the levels of pro-inflammatory systemic interleukins and, especially, IL-4 showed an increase from 4.6±0.5 pg/ml to 7.0±0.6 pg/ml in the course of telmisartan therapy in these patients. In summary, one may suggest that telmisartan exerts a significant immune pleiotropic effect in the patients with hypertension, confirmed by the systemic changes of interleukin contents. The pleiotropic effects of telmisartan have been established in patients with arterial hypertension, expressed as a significant decrease in IL-1, IL-2, IL-6, IL-8, TNFα levels, along with increased IL-4 and IL-10 contents. The results obtained showed a significant pleiotropic effect of telmisartan in the patients with arterial hypertension upon several interleukins, thus expanding the role of immune inflammation in this disorder, as well as its reversal with telmisartan therapy

РАЗРАБОТКА МОДЕЛЕЙ ОПТИМИЗАЦИИ В БИОТЕХНИЧЕСКОЙ СИСТЕМЕ ИГРОВОГО АВТОМОБИЛЬНОГО ТРЕНИНГА

The Purpose – its were developed multiparametric models and algorithms of the optimization playing training biooperated. In work are used methods of the system analysis, modeling, system technical analysis and constructing, mathematical statistics, methods of the computer analysis heart rate variability by means of sensor of the pulse and breathings.The Conclusion: its were designed two models of strategy playing, one – with installation on avoid of the failures and the second – on achievement of the success. The algorithms of the success and efficiency were formed for period of the termination of the biooperated play. Цель – разработка мультипараметрических моделей и алгоритмов оптимизации игрового биоуправляемого тренинга. В работе использованы методы системного анализа, моделирования, методы системотехнического анализа и конструирования, математической статистики, методы компьютерного ритмотестирования с помощью датчиков пульса и дыхания.Разработаны две модели игровой стратегии, одна – с установкой на избегание неудачи и вторая – на достижение успеха. Сформированы алгоритмы успешности и эффективности проведенного биоуправляемого автомобильного тренинга

An action of superlow power extremely high-frequency radiation on some microbes in vitro, human erythrocytes, and the functional status of a person

This paper is devoted to the analysis of advanced scientific research about the role of superlow intensity extremely high frequency effects on biological objects, including peopl

Gyrokinetic analysis and simulation of pedestals to identify the culprits for energy losses using 'fingerprints'

Fusion performance in tokamaks hinges critically on the efficacy of the edge transport barrier (ETB) in suppressing energy losses. The new concept of 'fingerprints' is introduced to identify the instabilities that cause transport losses in the ETBs of many of today's experiments, from among widely posited candidates. Analysis of the gyrokinetic-Maxwell equations and gyrokinetic simulations of experiments reveals that each mode type produces characteristic ratios of transport in the various channels: density, heat, and impurities. This, together with experimental observations of transport in some channel or of the relative size of the driving sources of channels, can identify or determine the dominant modes causing energy transport. In multiple H-mode cases with edge-localized modes that are examined, these fingerprints indicate that magnetohydrodynamic (MHD)-like modes are apparently not the dominant agent of energy transport; rather, this role is played by micro-tearing modes (MTMs) and electron temperature gradient (ETG) modes, and in addition, possibly by ion temperature gradient/ trapped electron modes (ITG/TEM) on JET (Joint European 'Torus). MHD-like modes may dominate the electron particle losses. Fluctuation frequency can also be an important means of identification, and is often closely related to the transport fingerprint. The analytical arguments unify and explain previously disparate experimental observations on multiple devices, including DIII-D, JET, and ASDEX-U. Detailed simulations of two DIII-D ETBs also demonstrate and corroborate this.Peer reviewe