Proof Theory, Transformations, and Logic Programming for Debugging Security Protocols

We define a sequent calculus to formally specify, simulate, debug and verify security protocols. In our sequents we distinguish between the current knowledge of principals and the current global state of the session. Hereby, we can describe the operational semantics of principals and of an intruder in a simple and modular way. Furthermore, using proof theoretic tools like the analysis of permutability of rules, we are able to find efficient proof strategies that we prove complete for special classes of security protocols including Needham-Schroeder. Based on the results of this preliminary analysis, we have implemented a Prolog meta-interpreter which allows for rapid prototyping and for checking safety properties of security protocols, and we have applied it for finding error traces and proving correctness of practical examples

Developing a questionnaire to determine the impact of self-management in diabetes: giving people with diabetes a voice

Background The prevalence of diabetes mellitus (DM) is increasing dramatically, placing considerable financial burden on the healthcare budget of each country. Patient self-management is crucial for the control of blood glucose, which largely determines the chances of developing diabetes-related complications. Self-management interventions vary widely, and a method is required for assessing the impact of self-management. This paper describes the development of a questionnaire intended for use to measure the impact of self-management in diabetes. Methods An iterative development process was undertaken to identify the attributes of self-management using 5 steps. First, a literature review was undertaken to identify and understand themes relating to self-management of DM to inform a topic guide. Second, the topic guide was further refined following consultation with a Patient and Public Involvement group. Third, the topic guide was used to inform semi-structured interviews with patients with Type 1 DM (T1DM) and Type 2 DM (T2DM) to identify how self-management of DM affects individuals. Fourth, the research team considered potential attributes alongside health attributes from an existing measure (Diabetes Health Profile, DHP) to produce an instrument reflecting both health and self-management outcomes simultaneously. Finally, a draft instrument was tested in a focus group to determine the wording and acceptability. Results Semi-structured interviews were carried out with 32 patients with T1DM and T2DM. Eight potential attributes were identified: fear/worry/anxiety, guilt, stress, stigma, hassle, control, freedom, and feeling supported. Four of these self-management attributes were selected with four health attributes (mood, worry about hypos (hypoglycaemic episodes), vitality and social limitations) to produce the Health and Self-Management in Diabetes (HASMID v1) questionnaire. Conclusions HASMID v1 is a short questionnaire that contains eight items each with four response levels to measure the impact of self-management in diabetes for both T1DM and T2DM. The measure was developed using a mixed-methods approach that involved semi-structured interviews with people with diabetes. The measure has high face validity. Ongoing research is being undertaken to assess the validity of this questionnaire for measuring the impact of self-management interventions in economic evaluation

Local Justice Reinvestment Pilot: Final process evaluation report

This is the final report of the process evaluation of the Local Justice Reinvestment pilot commissioned by the Ministry of Justice. The pilot aimed to: test the premise that there were significant potential reductions in crime and reoffending to be made by partners working more effectively together at the local level; understand the extent to which local partners were incentivised to change their behaviours; and test a concept from which evidence could be generated to inform the development of policy on widening the use of Payment by Results, local partnership working and local commissioning decisions The report summarises the governance arrangements at each of the sites, outlines the interventions implemented by the sites during the pilot, summarises how the reward payment from year one was allocated and examines other initiatives that may have impacted on the pilot. It identifies the strengths and challenges in the implementation of the pilot. examines the performance of the sites against the metrics and identifies factors that may have contributed to the results. It outlines the main conclusions and implications for policy based on the lessons learned from both years of the pilot

Developing preference-based measures for diabetes: DHP-3D and DHP-5D

© 2017 Diabetes UK Aims: The aim of this study was to develop two diabetes-specific preference-based measures [the Diabetes Health Profile–3 Dimension (DHP-3D) and the Diabetes Health Profile–5 Dimension (DHP-5D)] for use in the calculation of Quality Adjusted Life Years, a key outcome in economic evaluation. These measures were based on the non-preference-based instrument the Diabetes Health Profile. Methods: For DHP-3D, psychometric and Rasch analyses were used to develop a health state classification system based on the Diabetes Health Profile–18 (DHP-18). The DHP-5D added two dimensions to the DHP-3D to extend the range of impacts measured. Each classification system was valued by 150 general public respondents in the United Kingdom using Time Trade Off (TTO). Multivariate regression was used to estimate utility value sets. The matched dimensions across each measure were compared using z-score tests. Results: The DHP-3D included three dimensions defined as mood, eating and social limitations, and the DHP-5D added dimensions defined as hypoglycaemic attacks and vitality. For both, the random effects generalized least squares regression model produced consistent value sets, with the DHP-3D and DHP-5D ranging from 0.983 (best state) to 0.717 (worst state), and 0.979 to 0.618 respectively. The addition of the two extra dimensions leads to significant differences for the more severe levels of each matched dimension. Conclusions: We have developed two diabetes-specific preference-based measures that, subject to psychometric assessment, can be used to provide condition-specific utility values to complement generic utilities from more widely validated measures such as the EuroQol-5 Dimension

DNA metabarcoding unveils multiscale trophic variation in a widespread coastal opportunist

A thorough understanding of ecological networks relies on comprehensive information on trophic relationships among species. Since unpicking the diet of many organisms is unattainable using traditional morphology‐based approaches, the application of high‐throughput sequencing methods represents a rapid and powerful way forward. Here, we assessed the application of DNA metabarcoding with nearly universal primers for the mitochondrial marker cytochrome c oxidase I in defining the trophic ecology of adult brown shrimp, Crangon crangon, in six European estuaries. The exact trophic role of this abundant and widespread coastal benthic species is somewhat controversial, while information on geographical variation remains scant. Results revealed a highly opportunistic behaviour. Shrimp stomach contents contained hundreds of taxa (>1,000 molecular operational taxonomic units), of which 291 were identified as distinct species, belonging to 35 phyla. Only twenty ascertained species had a mean relative abundance of more than 0.5%. Predominant species included other abundant coastal and estuarine taxa, including the shore crab Carcinus maenas and the amphipod Corophium volutator. Jacobs’ selectivity index estimates based on DNA extracted from both shrimp stomachs and sediment samples were used to assess the shrimp's trophic niche indicating a generalist diet, dominated by crustaceans, polychaetes and fish. Spatial variation in diet composition, at regional and local scales, confirmed the highly flexible nature of this trophic opportunist. Furthermore, the detection of a prevalent, possibly endoparasitic fungus (Purpureocillium lilacinum) in the shrimp's stomach demonstrates the wide range of questions that can be addressed using metabarcoding, towards a more robust reconstruction of ecological networks

Mid-infrared Photometric Analysis of Main Belt Asteroids: A Technique for Color-Color Differentiation from Background Astrophysical Sources

The Spitzer Space Telescope routinely detects asteroids in astrophysical observations near the ecliptic plane. For the galactic or extragalactic astronomer, these solar system bodies can introduce appreciable uncertainty into the source identification process. We discuss an infrared color discrimination tool that may be used to distinguish between solar system objects and extrasolar sources. We employ four Spitzer Legacy data sets, the First Look Survey-Ecliptic Plane Component (FLS-EPC), SCOSMOS, SWIRE, and GOODS. We use the Standard Thermal Model to derive FLS-EPC main belt asteroid (MBA) diameters of 1-4 km for the numbered asteroids in our sample and note that several of our solar system sources may have fainter absolute magnitude values than previously thought. A number of the MBAs are detected at flux densities as low as a few tens of μJy at 3.6 μm. As the FLS-EPC provides the only 3.6-24.0 μm observations of individual asteroids to date, we are able to use this data set to carry out a detailed study of asteroid color in comparison to astrophysical sources observed by SCOSMOS, SWIRE, and GOODS. Both SCOSMOS and SWIRE have identified a significant number of asteroids in their data, and we investigate the effectiveness of using relative color to distinguish between asteroids and background objects. We find a notable difference in color in the IRAC 3.6-8.0 mm and MIPS 24 μm bands between the majority of MBAs, stars, galaxies, and active galactic nuclei, though this variation is less significant when comparing fluxes in individual bands. We find median colors for the FLS-EPC asteroids to be [F(5.8/3.6), F(8.0/4.5), F(24/8)] = (4.9 ± 1.8, 8.9 ± 7.4, 6.4 ± 2.3). Finally, we consider the utility of this technique for other mid-infrared observations that are sensitive to near-Earth objects, MBAs, and trans-Neptunian objects. We consider the potential of using color to differentiate between solar system and background sources for several space-based observatories, including Warm Spitzer, Herschel, and WISE

Study of damage control systems for space station

Damage control systems for detecting and locating overboard and onboard leak and damage modes on space station