Mikrosfere ropinirol hidroklorida za polagano oslobađanje: Utjecaj procesnih parametara

An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 32 full factorial design. The microspheres were made by incorporating the drug in a polar organic solvent, which was emulsified using liquid paraffin as an external oil phase. Effects of various process parameters such as viscosity of the external phase, selection of the internal phase, surfactant selection and selection of stirring speed were studied. Microspheres were evaluated for product yield, encapsulation efficiency and particle size. Various drug/ethylcellulose ratios and PEG concentrations were assayed. In vitro dissolution profiles showed that ethylcellulose microspheres were able to control release of the drug for a period of 12 h.Mikrosfere ropinirol hidroklorida, ljekovite tvari vrlo dobro topljive u vodi, pripravljene su metodom isparavanja otapala, koristeći etilcelulozu i PEG te 32 potpuno faktorijalno dizajniranje. Mikrosfere su pripravljene na sljedeći način: otopina ljekovite tvari u polarnom organskom otapalu emulgirana je s tekućim parafinom kao vanjskom uljnom fazom. Ispitivan je utjecaj različitih procesnih parametara poput viskoznosti vanjske faze, vrste interne faze i površinski aktivne tvari te brzine miješanja. Za pripravljene mikrosfere određeno je iskorištenje, učinkovitost inkapsuliranja i veličina čestica. Isprobavani su različiti odnosi ljekovite tvari i etilceluloze te koncentracija PEG-a. In vitro pokusi su pokazali da je oslobađanje ljekovite tvari kontrolirano tijekom 12 h

Genomic and molecular characterization of preterm birth.

Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. By using whole blood samples, we integrated whole-genome sequencing (WGS), RNA sequencing (RNA-seq), and DNA methylation data for 270 PTB and 521 control families. We analyzed this combined dataset to identify genomic variants associated with PTB and secondary analyses to identify variants associated with very early PTB (VEPTB) as well as other subcategories of disease that may contribute to PTB. We identified differentially expressed genes (DEGs) and methylated genomic loci and performed expression and methylation quantitative trait loci analyses to link genomic variants to these expression and methylation changes. We performed enrichment tests to identify overlaps between new and known PTB candidate gene systems. We identified 160 significant genomic variants associated with PTB-related phenotypes. The most significant variants, DEGs, and differentially methylated loci were associated with VEPTB. Integration of all data types identified a set of 72 candidate biomarker genes for VEPTB, encompassing genes and those previously associated with PTB. Notably, PTB-associated genes RAB31 and RBPJ were identified by all three data types (WGS, RNA-seq, and methylation). Pathways associated with VEPTB include EGFR and prolactin signaling pathways, inflammation- and immunity-related pathways, chemokine signaling, IFN-γ signaling, and Notch1 signaling. Progress in identifying molecular components of a complex disease is aided by integrated analyses of multiple molecular data types and clinical data. With these data, and by stratifying PTB by subphenotype, we have identified associations between VEPTB and the underlying biology

International longitudinal registry of patients with atrial fibrillation and treated with rivaroxaban: RIVaroxaban Evaluation in Real life setting (RIVER)

Background Real-world data on non-vitamin K oral anticoagulants (NOACs) are essential in determining whether evidence from randomised controlled clinical trials translate into meaningful clinical benefits for patients in everyday practice. RIVER (RIVaroxaban Evaluation in Real life setting) is an ongoing international, prospective registry of patients with newly diagnosed non-valvular atrial fibrillation (NVAF) and at least one investigator-determined risk factor for stroke who received rivaroxaban as an initial treatment for the prevention of thromboembolic stroke. The aim of this paper is to describe the design of the RIVER registry and baseline characteristics of patients with newly diagnosed NVAF who received rivaroxaban as an initial treatment. Methods and results Between January 2014 and June 2017, RIVER investigators recruited 5072 patients at 309 centres in 17 countries. The aim was to enroll consecutive patients at sites where rivaroxaban was already routinely prescribed for stroke prevention. Each patient is being followed up prospectively for a minimum of 2-years. The registry will capture data on the rate and nature of all thromboembolic events (stroke / systemic embolism), bleeding complications, all-cause mortality and other major cardiovascular events as they occur. Data quality is assured through a combination of remote electronic monitoring and onsite monitoring (including source data verification in 10% of cases). Patients were mostly enrolled by cardiologists (n = 3776, 74.6%), by internal medicine specialists 14.2% (n = 718) and by primary care/general practice physicians 8.2% (n = 417). The mean (SD) age of the population was 69.5 (11.0) years, 44.3% were women. Mean (SD) CHADS2 score was 1.9 (1.2) and CHA2DS2-VASc scores was 3.2 (1.6). Almost all patients (98.5%) were prescribed with once daily dose of rivaroxaban, most commonly 20 mg (76.5%) and 15 mg (20.0%) as their initial treatment; 17.9% of patients received concomitant antiplatelet therapy. Most patients enrolled in RIVER met the recommended threshold for AC therapy (86.6% for 2012 ESC Guidelines, and 79.8% of patients according to 2016 ESC Guidelines). Conclusions The RIVER prospective registry will expand our knowledge of how rivaroxaban is prescribed in everyday practice and whether evidence from clinical trials can be translated to the broader cross-section of patients in the real world

Gianotti Crosti Syndrome

A 5 year old male child presented with erythematous papules on extensor aspect of joints of upper and lower limbs. Examination revealed generalized lymphadenopathy and hepatosplenomegaly. Investigations showed lymphocytosis. He was diagnosed as a case of Gianotti Crosti syndrome

Dependence of electrical conductivity on selenium and sulphur doping in a-Si:H

491-494<span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">Se- and S-doped a-Si:H films were prepared by the decomposition of H2Se and H<span style="font-size:12.5pt;mso-bidi-font-size:5.5pt; font-family:" times="" new="" roman","serif""="">2<span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">S with SiH<span style="font-size:12.5pt;mso-bidi-font-size:5.5pt; font-family:" times="" new="" roman","serif""="">4<span style="font-size: 12.5pt;mso-bidi-font-size:5.5pt;font-family:" times="" new="" roman","serif""=""> gas mixtures by plasma enhanced chemical vapour deposition (PECYD) in a ratio of H2Se/SiH4=1.0×10-4 to 1.0×10-1 and H<span style="font-size:12.0pt;mso-bidi-font-size: 5.0pt;font-family:" times="" new="" roman","serif""="">2S/SiH4=6.81×10-7 <span style="font-size:12.0pt;mso-bidi-font-size:5.0pt;font-family: " times="" new="" roman","serif""=""> to 1.0×10-<span style="font-size:12.0pt;mso-bidi-font-size: 5.0pt;font-family:" times="" new="" roman","serif""="">4.The dielectric constant of Se- and S-doped a-Si:H films vary with doping concentration and can be tailored by changing the gas ratio. The de dark and photoconductivity showed a maximum at H<span style="font-size:12.0pt; mso-bidi-font-size:5.0pt;font-family:" times="" new="" roman","serif""="">2Se/SiH4 = 10-<span style="font-size:12.0pt;mso-bidi-font-size: 5.0pt;font-family:" times="" new="" roman","serif""="">3 and a-Si, S:H at H<span style="font-size:12.0pt;mso-bidi-font-size: 5.0pt;font-family:" times="" new="" roman","serif""="">2S/SiH4 = 1.0×10-<span style="font-size:12.0pt;mso-bidi-font-size: 5.0pt;font-family:" times="" new="" roman","serif""="">4 <span style="font-size:15.0pt;mso-bidi-font-size:8.0pt;font-family: " times="" new="" roman","serif""="">and the activation energy is lower at these doping levels. The room temperature dark and photoconductivity in Se and S-doped a-S:H films have been found to increase <span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">as the gas ratios increase for H<span style="font-size:12.5pt;mso-bidi-font-size: 5.5pt;font-family:" times="" new="" roman","serif""="">2Se/SiH4= 1<span style="font-size:16.0pt;mso-bidi-font-size:9.0pt;font-family: " times="" new="" roman","serif""="">0-<span style="font-size: 12.5pt;mso-bidi-font-size:5.5pt;font-family:" times="" new="" roman","serif""="">3 and H<span style="font-size:12.5pt;mso-bidi-font-size:5.5pt;font-family: " times="" new="" roman","serif""="">2<span style="font-size:15.0pt; mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">S/SiH4=10-4 <span style="font-size:12.0pt;mso-bidi-font-size:5.0pt; font-family:" times="" new="" roman","serif""="">, <span style="font-size: 15.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">after this range in Se-doped, the dark and photoconductivity decrease to the alloy range. </span

Progressive Symmetric Erythrokeratoderma

A case of progressive symmetric erythrokeratoderma is reported for its rarity and clinical interest

Wireless information and safety system for mines

107-117This study presents a wireless information and safety system for mines developed by CIMFR, Dhanbad. System consists of hardware devices and application software. Hardware module is ZigBee-compliant active radio frequency identification (RFID) devices/ transceivers, which can be programmed to act as end device (tag), router or coordinator that enables them to form an IEEE 802.15.4-based mesh network. It uses a unified wireless mesh-networking infrastructure to locate, trace and manage mobile assets and people as well as monitor different environmental conditions using sensors. Another core module is wireless sensor network (WSN) software, which is developed for tracking of underground miners and moveable equipment by wireless sensor networking in mines. Software is especially designed for tracking of miners and vehicles, route tracking in opencast mines, preventing fatal accidents and vehicle collisions, environmental monitoring, observing miners’ unsafe practice, sending alert message, and preparing computerized miners’ duty hour

Profile Of Sexually Transmitted Diseases In And Around Lucknow

A retrospective study was undertaken from the year 1988 to 1998 to study the pattern of sexually transmitted diseases in and around Lucknow. Among 1890 patients examined, chancroid predominated followed by syphilis, gonorrhoea, genital warts, herpes genitalis, LGV and non-specific urethritis. The incidence of donovanosis was the lowest