A Rare Presentation of Crohn's Disease

Free peritoneal perforation is a rare complication of Crohn's disease with a report of only 100 cases in the literature. It needs an emergency exploration and an unaware general surgeon is confounded in intraoperative decision-making. We present our experience when this rarity struck us in a district hospital and briefly review the guidelines of optimal management of this complication of Crohn's disease

Almost ï¨-duals of some sequence spaces

Ansari and Shukla [1] have generalized the notion of ï¡-duals and developed the concept of almostï¨ï€­duals by using the concept of absolutely almost convergence. P Chandra and B.C. Tripathy [8] have introduced the concept of ï¨-duals. We have introduced the concept of almost ï¨-duals and determined almost ï¨-duals of some sequence spaces

Drugs in pregnancy and lactation

Drug use during pregnancy and lactation is an almost inevitable event. Some of the drugs may have adverse effects on the baby on exposure. It is therefore necessary for the physician to be aware of the changes in pharmacokinetics and pharmacodynamics during pregnancy. Knowledge about the known teratogens and drugs safe to be used during pregnancy is essential on the part of the prescribing physician. There are many factors affecting drug passage into the milk and thus affecting the child in some cases. There are also some drugs affecting lactation. All this data needs to be carefully studied by the physician

Operator Duals of Vector Sequence Spaces

T. Balasubramaniam and A. Pandiarani [1] have defined the sequence spaces G(x). l (x), G(x) and have studied some topological property of their Köthe-Toeplitz duals in operator form. In this paper we define the new sequence spaces G0(x, p), Ge(x, p) and G¥(x,p) and have studied some topological property of their Köthe-Toeplitz duals in operator form

An Abattoir Based Study on Brucellosis, Bovine Tuberculosis and Paratuberculosis in Buffaloes and Cattle at Faisalabad, Pakistan

A study was carried out to investigate the prevalence of these diseases at Faisalabad abattoirs in buffaloes and cattle. For this purpose, 400 consecutive animals, including 200 buffaloes and 200 cattle were included in the study. Blood and diseased organ, tissue samples were collected for further processing. For a study on the prevalence of brucellosis, the serum samples were screened by RBPT (Rose Bengal Precipitation Test). The overall prevalence of brucellosis recorded was 10% and 11% in buffaloes and cattle, respectively. The prevalence of brucellosis did not vary between male and females, three age groups and three weight groups each in buffalo and cattle. However, the odds of contracting brucellosis were 3.8 vs 1 for cattle than buffalo at an age below 5 years. On the basis of specific gross and histopathological lesions in different organs/tissues, including lungs, liver, lymph nodes and intestine, the prevalence of bovine tuberculosis and paratuberculosis were assessed. The suspected prevalence of bovine tuberculosis was 1.5% and 1%, while it was 3.75% and 4.1 % in case of paratuberculosis in buffaloes and cattle, respectively. The cattle revealed significant (P = 0.05) difference between age groups on the basis of suspected lesions of tuberculosis in lungs with young cattle showing the lesions more than adult, but it was not so in buffaloes. The odds of contracting paratuberculosis in males were 3.74 vs 1 of buffalo than cattle. The other comparisons were not marked between age groups, sex and weight groups between buffaloes and cattle. The prevalence of these diseases is not unexpected in abattoir and is a threat not only for workers at the slaughterhouse, meat sellers (butchers) but also to the general public

Preliminary Study on the Mechanical Activation and High‐Temperature Treatment of Saponite‐Containing Tailings Generated during Kimberlite Ore Dressing

This study investigates transformations of a pre-mechanically activated saponite-containing material with subsequent high-temperature treatment. The thermogravimetric analysis confirmed that the mechanical activation of saponite leads to the destruction of its layered structure, accompanied by the release of silicon dioxide and magnesium oxide in free form. The values of surface activity for mechanically activated saponite-containing material are also calculated. It is shown that when mechanically activated saponite-containing material is mixed with water, minerals of the serpentine group are formed, and further high-temperature treatment leads to the formation of minerals of the olivine group. It is experimentally shown that high-temperature treatment leads to the creation of a more durable structure of the saponite-containing material. This is due to decreased porosity and pore size, and sorption of moisture from the environment is also reduced. The study showed that saponite-containing waste materials can be effectively treated to create composite materials based on magnesia binders. Thus, with this method, the waste is effectively recycled into various green building material and can be used as supplementary cementitious material or fine aggregate replacement in concrete

Weighing the Milky Way

We describe an experiment to measure the mass of the Milky Way galaxy. The experiment is based on calculated light travel times along orthogonal directions in the Schwarzschild metric of the Galactic center. We show that the difference is proportional to the Galactic mass. We apply the result to light travel times in a 10cm Michelson type interferometer located on Earth. The mass of the Galactic center is shown to contribute 10^-6 to the flat space component of the metric. An experiment is proposed to measure the effect.Comment: 10 pages, 1 figur

Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes:A randomised cross-over trial

BACKGROUND: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of glucagon, insulin, incretins, ghrelin, C-peptide and adipokines from the same study. METHODS: In a randomised, open-label, cross-over study, 13 patients with type 2 diabetes were randomly assigned to eat a Palaeolithic diet based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts, or a diabetes diet designed in accordance with current diabetes dietary guidelines during two consecutive 3-month periods. The patients were recruited from primary health-care units and included three women and 10 men [age (mean ± SD) 64 ± 6 years; BMI 30 ± 7 kg/m(2); diabetes duration 8 ± 5 years; glycated haemoglobin 6.6 ± 0.6 % (57.3 ± 6 mmol/mol)] with unaltered diabetes treatment and stable body weight for 3 months prior to the start of the study. Outcome variables included fasting plasma concentrations of leptin, adiponectin, adipsin, visfatin, resistin, glucagon, insulin, C-peptide, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and ghrelin. Dietary intake was evaluated by use of 4-day weighed food records. RESULTS: Seven participants started with the Palaeolithic diet and six with the diabetes diet. The Palaeolithic diet resulted in a large effect size (Cohen’s d = −1.26) at lowering fasting plasma leptin levels compared to the diabetes diet [mean difference (95 % CI), −2.3 (−5.1 to 0.4) ng/ml, p = 0.023]. No statistically significant differences between the diets for the other variables, analysed in this study, were observed. CONCLUSIONS: Over a 3-month study period, a Palaeolithic diet resulted in reduced fasting plasma leptin levels, but did not change fasting levels of insulin, C-peptide, glucagon, incretins, ghrelin and adipokines compared to the currently recommended diabetes diet. Trial registration: ClinicalTrials.gov NCT00435240 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12933-016-0398-1) contains supplementary material, which is available to authorized users