Spectral Types of Planetary Host Star Candidates: Two New Transiting Planets?

Recently, 46 low-luminosity object transits were reported from the Optical Gravitational Lensing Experiment. Our follow-up spectroscopy of the 16 most promising candidates provides a spectral classification of the primary. Together with the radius ratio from the transit measurements, we derived the radii of the low-luminosity companions. This allows to examine the possible sub-stellar nature of these objects. Fourteen of them can be clearly identified as low-mass stars. Two objects, OGLE-TR-03 and OGLE-TR-10 have companions with radii of 0.15 R_sun which is very similar to the radius of the transiting planet HD209458B. The planetary nature of these two objects should therefore be confirmed by dynamical mass determinations.Comment: 4 pages, 3 figures, accepted for publication by A&A Letter

Model for nucleation in GaAs homoepitaxy derived from first principles

The initial steps of MBE growth of GaAs on beta 2-reconstructed GaAs(001) are investigated by performing total energy and electronic structure calculations using density functional theory and a repeated slab model of the surface. We study the interaction and clustering of adsorbed Ga atoms and the adsorption of As_2 molecules onto Ga atom clusters adsorbed on the surface. The stable nuclei consist of bound pairs of Ga adatoms, which originate either from dimerization or from an indirect interaction mediated through the substrate reconstruction. As_2 adsorption is found to be strongly exothermic on sites with a square array of four Ga dangling bonds. Comparing two scenarios where the first As_2 gets incorporated in the incomplete surface layer, or alternatively in a new added layer, we find the first scenario to be preferable. In summary, the calculations suggest that nucleation of a new atomic layer is most likely on top of those surface regions where a partial filling of trenches in the surface has occurred before.Comment: 8 pages, 14 figures, Submitted to Phys. Rev. B (December 15, 1998). Other related publications can be found at http://www.fhi-berlin.mpg.de/th/paper.htm

Computation of gravitational waves from inspiraling binary neutron stars in quasiequilibrium circular orbits : Formulation and calibration

Gravitational waves from binary neutron stars in quasiequilibrium circular orbits are computed using an approximate method which we propose in this paper. In the first step of this method, we prepare general relativistic irrotational binary neutron stars in a quasiequilibrium circular orbit, neglecting gravitational waves. We adopt the so-called conformal flatness approximation for a three-metric to obtain the quasiequilibrium states in this paper. In the second step, we compute gravitational waves, solving linear perturbation equations in the background spacetime of the quasiequilibrium states. Comparing numerical results with post Newtonian waveforms and luminosity of gravitational waves from two point masses in circular orbits, we demonstrate that this method can produce accurate waveforms and luminosity of gravitational waves. It is shown that the effects of tidal deformation of neutron stars and strong general relativistic gravity modify the post Newtonian results for compact binary neutron stars in close orbits. We indicate that the magnitude of a systematic error in quasiequilibrium states associated with the conformal flatness approximation is fairly large for close and compact binary neutron stars. Several formulations for improving the accuracy of quasiequilibrium states are proposed.Comment: 26 pages, to be published in PR

Novel diffusion mechanism on the GaAs(001) surface: the role of adatom-dimer interaction

Employing first principles total energy calculations we have studied the behavior of Ga and Al adatoms on the GaAs(001)-beta2 surface. The adsorption site and two relevant diffusion channels are identified. The channels are characterized by different adatom-surface dimer interaction. Both affect in a novel way the adatom migration: in one channel the diffusing adatom jumps across the surface dimers and leaves the dimer bonds intact, in the other one the surface dimer bonds are broken. The two channels are taken into account to derive effective adatom diffusion barriers. From the diffusion barriers we conclude a strong diffusion anisotropy for both Al and Ga adatoms with the direction of fastest diffusion parallel to the surface dimers. In agreement with experimental observations we find higher diffusion barriers for Al than for Ga.Comment: 4 pages, 2 figures, Phys. Rev. Lett. 79 (1997). Other related publications can be found at http://www.rz-berlin.mpg.de/th/paper.htm

A Possible New Transiting Planet

Recently, 59 low-luminosity object transits were reported from the Optical Gravitational Lensing Experiment (OGLE). Our follow-up low-resolution spectroscopy of 16 candidates provided two objects, OGLE-TR-3 and OGLE-TR-10, which have companions with radii compatible with those of gas-giant planets. Further high-resolution spectroscopy revealed a very low velocity variation (<500m/s) of the host star OGLE-TR-3 which may be caused by its unseen companion. An analysis of the radial velocity and light curve results in M<2.5 M_jup, R<1.6 R_jup, and an orbital separation of about 5 R_sol, which makes it the planet with the shortest period known. This allows to identify the low-luminosity companion of OGLE-TR-3 as a possible new gas-giant planet. If confirmed, this makes OGLE-TR-3 together with OGLE-TR-56 the first extrasolar planets detected via their transit light curves.Comment: 9 pages, 12 figures, A&A in pres

New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses

Introduction: Myofibrillar myopathies are characterized by progressive muscle weakness and impressive abnormal protein aggregation in muscle fibers. In about 10 % of patients, the disease is caused by mutations in the MYOT gene encoding myotilin. The aim of our study was to decipher the composition of protein deposits in myotilinopathy to get new information about aggregate pathology. Results: Skeletal muscle samples from 15 myotilinopathy patients were included in the study. Aggregate and control samples were collected from muscle sections by laser microdissection and subsequently analyzed by a highly sensitive proteomic approach that enables a relative protein quantification. In total 1002 different proteins were detected. Seventy-six proteins showed a significant over-representation in aggregate samples including 66 newly identified aggregate proteins. Z-disc-associated proteins were the most abundant aggregate components, followed by sarcolemmal and extracellular matrix proteins, proteins involved in protein quality control and degradation, and proteins with a function in actin dynamics or cytoskeletal transport. Forty over-represented proteins were evaluated by immunolocalization studies. These analyses validated our mass spectrometric data and revealed different regions of protein accumulation in abnormal muscle fibers. Comparison of data from our proteomic analysis in myotilinopathy with findings in other myofibrillar myopathy subtypes indicates a characteristic basic pattern of aggregate composition and resulted in identification of a highly sensitive and specific diagnostic marker for myotilinopathy. Conclusions: Our findings i) indicate that main protein components of aggregates belong to a network of interacting proteins, ii) provide new insights into the complex regulation of protein degradation in myotilinopathy that may be relevant for new treatment strategies, iii) imply a combination of a toxic gain-of-function leading to myotilin-positive protein aggregates and a loss-of-function caused by a shift in subcellular distribution with a deficiency of myotilin at Z-discs that impairs the integrity of myofibrils, and iv) demonstrate that proteomic analysis can be helpful in differential diagnosis of protein aggregate myopathies

Effect of strain on surface diffusion in semiconductor heteroepitaxy

We present a first-principles analysis of the strain renormalization of the cation diffusivity on the GaAs(001) surface. For the example of In/GaAs(001)-c(4x4) it is shown that the binding of In is increased when the substrate lattice is expanded. The diffusion barrier \Delta E(e) has a non-monotonic strain dependence with a maximum at compressive strain values (e 0) studied. We discuss the consequences of spatial variations of both the binding energy and the diffusion barrier of an adatom caused by the strain field around a heteroepitaxial island. For a simplified geometry, we evaluate the speed of growth of two coherently strained islands on the GaAs(001) surface and identify a growth regime where island sizes tend to equalize during growth due to the strain dependence of surface diffusion.Comment: 10 pages, 8 figures, LaTeX2e, to appear in Phys. Rev. B (2001). Other related publications can be found at http://www.rz-berlin.mpg.de/th/paper.htm

Energy Release on the Surface of a Rapidly Rotating Neutron Star during Disk Accretion: A Thermodynamic Approach

The total energy E of a star as a function of its angular momentum J and mass M in the Newtonian theory: E = E(J, M) [in general relativity, the gravitational mass M of a star as a function of its angular momentum J and rest mass m, M = M(J, m)], is used to determine the remaining parameters (angular velocity, equatorial radius, chemical potential, etc.) in the case of rigid rotation. Expressions are derived for the energy release during accretion onto a cool (with constant entropy), rapidly rotating neutron star (NS) in the Newtonian theory and in general relativity. A separate analysis is performed for the cases where the NS equatorial radius is larger and smaller than the radius of the marginally stable orbit in the disk plane. An approximate formula is proposed for the NS equatorial radius for an arbitrary equation of state, which matches the exact one at J = 0.Comment: 12 pages, 0 figures (Astronomy Letters in press

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms

Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though deeper understanding of TERT transcription requires a systems view. However, control over individual interactions in complex networks is not easily achievable. Mathematical modelling provides an attractive approach for analysis of complex systems and some models may prove useful in systems pharmacology approaches to drug discovery. In this report, we used transfection screening to test interactions among 14 TERT regulatory transcription factors and their respective promoters in ovarian cancer cells. The results were used to generate a network model of TERT transcription and to implement a dynamic Boolean model whose steady states were analysed. Modelled effects of signal transduction inhibitors successfully predicted TERT repression by Src-family inhibitor SU6656 and lack of repression by ERK inhibitor FR180204, results confirmed by RT-QPCR analysis of endogenous TERT expression in treated cells. Modelled effects of GSK3 inhibitor 6-bromoindirubin-3′-oxime (BIO) predicted unstable TERT repression dependent on noise and expression of JUN, corresponding with observations from a previous study. MYC expression is critical in TERT activation in the model, consistent with its well known function in endogenous TERT regulation. Loss of MYC caused complete TERT suppression in our model, substantially rescued only by co-suppression of AR. Interestingly expression was easily rescued under modelled Ets-factor gain of function, as occurs in TERT promoter mutation. RNAi targeting AR, JUN, MXD1, SP3, or TP53, showed that AR suppression does rescue endogenous TERT expression following MYC knockdown in these cells and SP3 or TP53 siRNA also cause partial recovery. The model therefore successfully predicted several aspects of TERT regulation including previously unknown mechanisms. An extrapolation suggests that a dominant stimulatory system may programme TERT for transcriptional stability

Electronic and structural properties of vacancies on and below the GaP(110) surface

We have performed total-energy density-functional calculations using first-principles pseudopotentials to determine the atomic and electronic structure of neutral surface and subsurface vacancies at the GaP(110) surface. The cation as well as the anion surface vacancy show a pronounced inward relaxation of the three nearest neighbor atoms towards the vacancy while the surface point-group symmetry is maintained. For both types of vacancies we find a singly occupied level at mid gap. Subsurface vacancies below the second layer display essentially the same properties as bulk defects. Our results for vacancies in the second layer show features not observed for either surface or bulk vacancies: Large relaxations occur and both defects are unstable against the formation of antisite vacancy complexes. Simulating scanning tunneling microscope pictures of the different vacancies we find excellent agreement with experimental data for the surface vacancies and predict the signatures of subsurface vacancies.Comment: 10 pages, 6 figures, Submitted to Phys. Rev. B, Other related publications can be found at http://www.rz-berlin.mpg.de/th/paper.htm