2,308 research outputs found
Should I grow wildflowers? Agrilink, your growing guide to better farming
Each Agrilink kit has been designed to be both comprehensive and practical. As the kits are arranged to answer questions of increasing complexity, they are useful references for both new and experienced producers of specific crops. Agrilink integrates the technology of horticultural production with the management of horticultural enterprises.
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This publication has been reprinted as a digital book without any changes to the content published in 2000. We advise readers to take particular note of the areas most likely to be out-of-date and so requiring further research: see detailed information on first page of the kit. Even with these limitations we believe this information kit provides important and valuable information for intending and existing growers.
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Performance Characteristics of a Cluster of 5-kW Laboratory Hall Thrusters
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76117/1/AIAA-19752-159.pd
Nonmonotonic d_{x^2-y^2} Superconducting Order Parameter in Nd_{2-x}Ce_xCuO_4
Low energy polarized electronic Raman scattering of the electron doped
superconductor Nd_1.85Ce_0.15CuO_4 (T_c=22 K) has revealed a nonmonotonic
d_{x^2-y^2} superconducting order parameter. It has a maximum gap of 4.4 k_BT_c
at Fermi surface intersections with antiferromagnetic Brillouin zone (the ``hot
spots'') and a smaller gap of 3.3 k_BT_c at fermionic Brillouin zone
boundaries. The gap enhancement in the vicinity of the ``hot spots'' emphasizes
role of antiferromagnetic fluctuations and similarity in the origin of
superconductivity for electron- and hole-doped cuprates.Comment: 4 pages, 4 figure
Midgap edge states and pairing symmetry of quasi-one-dimensional organic superconductors
The singlet s-, d- and triplet p-wave pairing symmetries in
quasi-one-dimensional organic superconductors can be experimentally
discriminated by probing the Andreev bound states at the sample edges. These
states have the energy in the middle of the superconducting gap and manifest
themselves as a zero-bias peak in tunneling conductance into the corresponding
edge. Their existence is related to the sign change of the pairing potential
around the Fermi surface. We present an exact self-consistent solution of the
edge problem showing the presence of the midgap states for p_x-wave
superconductivity. The spins of the edge state respond paramagnetically to a
magnetic field parallel to the vector d that characterizes triplet pairing.Comment: 6 pages, 4 figures. V.2: New section on spin response is added and
references are updated. V.3: Final version accepted to PRB. Typos are
corrected and important note is added in proof
Quantum key distribution and 1 Gbit/s data encryption over a single fibre
We perform quantum key distribution (QKD) in the presence of 4 classical
channels in a C-band dense wavelength division multiplexing (DWDM)
configuration using a commercial QKD system. The classical channels are used
for key distillation and 1 Gbps encrypted communication, rendering the entire
system independent from any other communication channel than a single dedicated
fibre. We successfully distil secret keys over fibre spans of up to 50 km. The
separation between quantum channel and nearest classical channel is only 200
GHz, while the classical channels are all separated by 100 GHz. In addition to
that we discuss possible improvements and alternative configurations, for
instance whether it is advantageous to choose the quantum channel at 1310 nm or
to opt for a pure C-band configuration.Comment: 9 pages, 7 figure
Feasibility of quantum key distribution through dense wavelength division multiplexing network
In this paper, we study the feasibility of conducting quantum key
distribution (QKD) together with classical communication through the same
optical fiber by employing dense-wavelength-division-multiplexing (DWDM)
technology at telecom wavelength. The impact of the classical channels to the
quantum channel has been investigated for both QKD based on single photon
detection and QKD based on homodyne detection. Our studies show that the latter
can tolerate a much higher level of contamination from the classical channels
than the former. This is because the local oscillator used in the homodyne
detector acts as a "mode selector" which can suppress noise photons
effectively. We have performed simulations based on both the decoy BB84 QKD
protocol and the Gaussian modulated coherent state (GMCS) QKD protocol. While
the former cannot tolerate even one classical channel (with a power of 0dBm),
the latter can be multiplexed with 38 classical channels (0dBm power each
channel) and still has a secure distance around 10km. Preliminary experiment
has been conducted based on a 100MHz bandwidth homodyne detector.Comment: 18 pages, 5 figure
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease.
Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of mitochondrial DNA (mtDNA) deletions. We now addressed the question, whether alterations in a component of the mitochondrial import machinery -TOM40- might contribute to the mitochondrial dysfunction and damage in PD. For this purpose, we studied levels of TOM40, mtDNA deletions, oxidative damage, energy production, and complexes of the respiratory chain in brain homogenates as well as in single neurons, using laser-capture-microdissection in transgenic mice overexpressing human wildtype α-Syn. Additionally, we used lentivirus-mediated stereotactic delivery of a component of this import machinery into mouse brain as a novel therapeutic strategy. We report here that TOM40 is significantly reduced in the brain of PD patients and in α-Syn transgenic mice. TOM40 deficits were associated with increased mtDNA deletions and oxidative DNA damage, and with decreased energy production and altered levels of complex I proteins in α-Syn transgenic mice. Lentiviral-mediated overexpression of Tom40 in α-Syn-transgenic mice brains ameliorated energy deficits as well as oxidative burden. Our results suggest that alterations in the mitochondrial protein transport machinery might contribute to mitochondrial impairment in α-Synucleinopathies
Evaluation of the ACS NSQIP Surgical Risk Calculator in Elderly Patients Undergoing Hepatectomy for Hepatocellular Carcinoma
Background: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) surgical risk calculator (SRC) aims to help predict patient-specific risk for morbidity and mortality. The performance of the SRC among an elderly population undergoing curative-intent hepatectomy for hepatocellular carcinoma (HCC) remains unknown.
Methods: Patients > 70 years of age who underwent hepatectomy for HCC between 1998 and 2017 were identified using a multi-institutional international database. To estimate the performance of SRC, 12 observed postoperative outcomes were compared with median SRC-predicted risk, and C-statistics and Brier scores were calculated.
Results: Among 500 patients, median age was 75 years (IQR 72-78). Most patients (n = 324, 64.8%) underwent a minor hepatectomy, while 35.2% underwent a major hepatectomy. The observed incidence of venous thromboembolism (VTE) (3.2%) and renal failure (RF) (4.4%) exceeded the median predicted risk (VTE, 1.8%; IQR 1.5-3.1 and RF, 1.0%; IQR 0.5-2.0). In contrast, the observed incidence of 30-day readmission (7.0%) and non-home discharge (2.5%) was lower than median-predicted risk (30-day readmission, 9.4%; IQR 7.4-12.8 and non-home discharge, 5.7%; IQR 3.3-11.7). Only 57.8% and 71.2% of patients who experienced readmission (C-statistic, 0.578; 95%CI 0.468-0.688) or mortality (C-statistic, 0.712; 95%CI 0.508-0.917) were correctly identified by the model.
Conclusion: Among elderly patients undergoing hepatectomy for HCC, the SRC underestimated the risk of complications such as VTE and RF, while being no better than chance in estimating the risk of readmission. The ACS SRC has limited clinical applicability in estimating perioperative risk among elderly patients being considered for hepatic resection of HCC.info:eu-repo/semantics/publishedVersio
Guessing imagined and live chance events: adults behave like children with live events
An established finding is that adults prefer to guess before rather than after a chance event has happened. This is interpreted in terms of aversion to guessing when relatively incompetent: After throwing, the fall could be known. Adults (N=71, mean age 18;11, N=28, mean age 48;0) showed this preference with imagined die-throwing as in the published studies. With live die-throwing, children (N=64, aged 6 and 8 years; N=50, aged 5 and 6 years) and 15-year-olds (N=93, 46) showed the opposite preference, as did 17 adults. Seventeen-year-olds (N=82) were more likely to prefer to guess after throwing with live rather than imagined die-throwing. Reliance on imagined situations in the literature on decision-making under uncertainty ignores the possibility that adults imagine inaccurately how they would really feel: After a real die has been thrown, adults, like children, may feel there is less ambiguity about the outcome
Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease
Photoreactive psoralens can form interstrand crosslinks (ICLs) in double-stranded DNA. In eubacteria, the endonuclease UvrABC plays a key role in processing psoralen ICLs. Psoralen-modified triplex-forming oligonucleotides (TFOs) can be used to direct ICLs to specific genomic sites. Previous studies of pyrimidine-rich methoxypsoralen–modified TFOs indicated that the TFO inhibits cleavage by UvrABC. Because different chemistries may alter the processing of TFO-directed ICLs, we investigated the effect of another type of triplex formed by purine-rich TFOs on the processing of 4′-(hydroxymethyl)-4,5′,8-trimethylpsoralen (HMT) ICLs by the UvrABC nuclease. Using an HMT-modified TFO to direct ICLs to a specific site, we found that UvrABC made incisions on the purine-rich strand of the duplex ∼3 bases from the 3′-side and ∼9 bases from the 5′-side of the ICL, within the TFO-binding region. In contrast to previous reports, the UvrABC nuclease cleaved the TFO-directed psoralen ICL with a greater efficiency than that of the psoralen ICL alone. Furthermore, the TFO was dissociated from its duplex binding site by UvrA and UvrB. As mutagenesis by TFO-directed ICLs requires nucleotide excision repair, the efficient processing of these lesions supports the use of triplex technology to direct DNA damage for genome modification
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